Articles tagged with Myeloid Leukemia
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Marina Konopleva joins the Eradicating MRD in AML TeamLab to develop new ways to detect and target Minimal Residual Disease. MECCC has developed multiple targeted agents that have become standard of care for older AML patients, and will partner with Break Through Cancer to deepen understanding of MRD drivers.
The ECOG-ACRIN Cancer Research Group and PrECOG, LLC will present several abstracts at the 66th American Society of Hematology Meeting & Exposition. Promising results from a phase 2 study in acute myeloid leukemia and new data from the practice-changing E1910 phase 3 trial show improved outcomes for patients with B-cell acute lymphobla...
Researchers found that blood cancer cells rewired their gene regulatory networks to evade drug treatment in Acute Myeloid Leukemia (AML), disrupting normal differentiation and growth. The study identified key findings, including changes in open chromatin regions and the loss of binding of RUNX1 and AP-1 transcription factors.
The myeloMATCH program offers a portfolio of biomarker-driven treatment trials to accelerate precision medicine in myeloid malignancies. Patients can enroll in clinical trials throughout their cancer treatment journey, with test results returned quickly to assign them to the most appropriate trial.
TP53 mutations are commonly associated with therapy-related AML and complex cytogenetics. Researchers found improved long-term outcomes when allo-HCT was performed during Complete Remission 1 (CR1), despite limited effective therapies for TP53-mutated AML.
A global study identified molecular predictors of survival among Black patients with acute myeloid leukemia (AML), suggesting a need to modify current AML risk layers. Ancestry-specific genetic factors and testing these in clinical trials are recommended.
Natural Killer (NK) cell-based therapies have shown promise in preclinical and clinical studies for treating Acute Myeloid Leukemia (AML), offering a potential cure with minimal prior antigen sensitization. However, the dysfunction of NK cells in AML patients poses a significant challenge that must be overcome to unlock their full ther...
The SWOG S1712 trial found that adding ruxolitinib to standard tyrosine kinase inhibitor (TKI) treatment significantly increased the percentage of patients with deep molecular responses, warranting treatment discontinuation. This combination may lead to improved health-related quality of life and reduced healthcare costs.
A Phase II trial found that a novel combination of decitabine, venetoclax, and ponatinib achieved complete remission in 80% of patients with advanced-phase chronic myeloid leukemia. The treatment showed promise even in patients with high-risk features and those who had received multiple prior therapies.
A four-year grant will help researchers find new clues to the interplay between Down syndrome and myeloid leukemia, focusing on enhancing antileukemic activity of chemotherapy drug cytarabine. The goal is to identify a novel treatment strategy to improve patient outcomes and prevent relapses in ML-DS patients.
Researchers have found a potential compound that pairs well with an IRAK4 inhibitor to kill AML cells by reducing c-Myc levels, a protein also driving cancer growth. The three-year LLS grant will allow further research into the effects of IRAK4 targeting on c-Myc.
Researchers suggest that hematopoietic stem and progenitor cells in the AML niche may retain an inflammatory memory, potentially leading to long-term functional consequences. This finding has significant implications for understanding the biology of acute myeloid leukemia (AML) and developing new cancer therapies.
Acute myeloid leukemia (AML) cells rely on structures called P-bodies to isolate mRNAs that encode proteins suppressing their growth. The discovery of this mechanism may lead to new anti-cancer therapies targeting P-body formation in AML.
Researchers highlight DDX41's distinct contribution to myeloid neoplasms with germline predisposition. The discovery sheds light on unique pathogenesis and disease phenotype associated with DDX41 variants.
A novel strategy using venetoclax and azacitidine demonstrates significant anti-cancer effect with mild toxicity for relapsed/refractory AML patients. The treatment showed markedly better survival rates after one year compared to a control group, with improved 'graft-versus-leukemia effects' via alterations of immune cells.
A new editorial paper discusses molecular and cytogenetic analyses used to identify distinct subtypes of acute myeloid leukemias (AML) and myelodysplastic syndromes (MDS). Researchers found that around 15% of AML cases remain genetically unclassifiable, emphasizing the need for further research.
Researchers found that inhibiting the AGTR1 receptor with losartan disrupted cancer growth, slowed development and prolonged survival in mice. This targeted gene therapy also protected the heart against chemotherapy-induced cardiotoxicity.
Researchers at Purdue University have developed a patent-pending compound called HSN748 to treat drug-resistant acute myeloid leukemia (AML). The compound has been validated in tests with IU School of Medicine and demonstrated 100% survivability after 120 days. AML is a cancer that begins in bone marrow and can be difficult to treat du...
A study published in Blood Neoplasia reveals that older adults with acute myeloid leukemia can benefit from standard treatment, with roughly a quarter experiencing durable prolonged survival. The conventional treatment of venetoclax combined with a hypomethylating agent (HMA) is safe and effective for those over 80 years old.
A recent study published in Blood Neoplasia found that older adults with acute myeloid leukemia (AML) can derive benefit from the VEN-HMA regimen, which is the standard of care for older AML patients. The treatment was shown to durably prolong survival in approximately 20-25% of treated patients.
Dana-Farber researchers discovered a molecular complex called PI3Kgamma that supports the survival of certain leukemia cells. The team found that eganelisib, an existing medicine, can inhibit this complex and has shown promise in animal models and clinical trials.
A new study published in JAMA Oncology highlights the importance of testing for measurable residual disease (MRD) in patients with acute myeloid leukemia (AML) undergoing bone marrow transplants. The researchers found that detecting MRD can help predict cancer recurrence and improve patient outcomes.
Researchers highlight the role of post-transcriptional RNA modifications in AML pathogenesis, identifying m6A and m7G regulators as potential therapeutic targets. Targeted therapies, including selective inhibitors and Traditional Chinese Medicine compounds, show promise in promoting cell differentiation and reversing AML phenotypes.
Researchers discovered MIA-602's effectiveness against Doxorubicin-resistant acute myeloid leukemia (AML), demonstrating reduced cell viability and tumor volume. The study suggests MIA-602 as a potential alternative treatment approach for AML, potentially circumventing chemotherapy side effects.
Researchers have discovered a new immunotherapy approach to overcome resistant leukemia by targeting the mutated TP53 gene. Combining pharmacological therapies with genetically engineered CAR T-cells increases effectiveness against cancer cells, offering promising strategies for patients with resistant disease.
Researchers identify mitochondrial priming as a key driver of multi-drug resistance in relapsed acute myeloid leukemia. A new technique called dynamic BH3 profiling reveals anti-cancer drugs capable of overcoming resistance.
A novel gene-based prognostic tool has been developed to personalize treatment in pediatric acute myeloid leukemia (AML). The five-gene transcriptional signature improves prognostic accuracy and identifies high-risk patients. It also streamlines the panel of genetic markers without compromising predictive efficacy.
Researchers discovered genes encoding growth regulators normally not present in myeloid cells are expressed by leukaemic stem cells, allowing them to grow. Repurposed drugs targeting these receptors show promise in blocking stem cell growth and preventing disease relapse in specific types of AML.
Researchers discovered a link between single cancer cell mutations and clinical response to epigenetic therapy in myelodysplastic syndrome. Patients showing treatment benefits had decreased mutation counts in stem cells and immature granulocytes, suggesting early tumor elimination is key to therapy success.
A new proteogenomics study provides insights into how drug resistance develops in acute myeloid leukemia, offering a potential path forward for treatment. Researchers identified specific proteins and molecular locations that play a key role in determining protein activity, which could help doctors switch to alternative medications.
Researchers at the John Theurer Cancer Center have co-authored a study on oral decitabine-cedazuridine therapy, which is now shown to be pharmacologically and pharmacodynamically equivalent to its intravenous counterpart. This innovation has significant potential for patient benefit and improved comfort in cancer treatment.
A research team at HKUMed has identified PLK4 as a novel therapeutic target for acute myeloid leukaemia (AML) carrying the TP53 mutation. The study found that PLK4 inhibition induces DNA damage, cell ageing and abnormal cell division, triggering the immune system via the cGAS-STING pathway.
Researchers discuss reductive carboxylation of glutamine as a potential target in acute myeloid leukemia (AML), an aggressive cancer with poor patient outcomes. The approach aims to weaken tumor cell survival mechanisms, potentially leading to novel therapies and improved patient outcomes.
The study classifies pediatric acute myeloid leukemia (pAML) into 23 distinct molecular categories, revealing unique biological characteristics and drivers of the disease. This classification provides a path forward for clinicians to identify distinct pAML sub-types and guide treatment decisions.
Researchers at Tokyo Medical and Dental University characterize myeloid/natural killer (NK) cell precursor acute leukemia (MNKPL) using multiomics approaches, revealing distinct molecular features. This work provides crucial details for accurate diagnoses and therapeutic decisions.
A new AI-based method developed by IT specialists and physicians at the University of Münster can predict genetic features in leukaemia patients using high-resolution bone marrow images. The method extracts genetic aberrations from large datasets, enabling early diagnosis and targeted treatment without waiting for genetic analyses.
A new study found that removing the RUNX1 transcription factor and its target gene can lead to a network collapse, causing cancer cell death in a type of aggressive leukemia. This breakthrough identifies specific protein targets for potential treatments.
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
A new study led by Dr. Mikkael Sekeres found that patients with a common form of acute myeloid leukemia reported better quality of life when treated with quizartinib, which targets the FLT3-ITD mutation. The study also showed minimal side effects and improved survival rates compared to those who didn't receive the drug.
A new therapy, venetoclax, has improved survival rates for Non-Hispanic Black patients with acute myeloid leukemia, narrowing the racial disparity. The study analyzed over 3,000 adult patients diagnosed between 2014 and 2022 and found a significant increase in two-year overall survival rates.
Researchers at University of Cincinnati Cancer Center present Phase 2 clinical trial results for a new BTK inhibitor treatment that offers potential for improved efficacy and safety in chronic lymphocytic leukemia. The study also explores the use of IRAK4 inhibitors to target acute myeloid leukemia cells, with promising results.
Researchers from the Mass General Cancer Center presented studies on psychiatric and substance use disorders as independent predictors of treatment response and outcomes in United States Veterans with Newly Diagnosed Acute Myeloid Leukemia (AML) treated with Venetoclax Combinations. Additionally, a Phase 1 Study of CAR-T-ddBCMA for the...
A recent study by Goethe University Frankfurt has identified a mechanism that could be a suitable starting point for developing novel drugs against leukemia cells. The researchers discovered that the mutated NPM1 gene variant drives pro-autophagic activity, enabling cancer cells to recycle their structures and meet their needs.
Researchers at Montefiore Einstein Comprehensive Cancer Center are conducting a phase 1 clinical trial of danvatirsen, a STAT3 inhibitor, to treat relapsed and treatment-resistant forms of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The trial aims to determine the safety and efficacy of the experimental treatment ...
Researchers at Goethe University Frankfurt have identified a specific gene locus, MYNRL15, that is critical to the survival and replication of leukemia cells. Inhibiting this gene has been shown to deactivate genes necessary for AML cell survival, offering a new possibility for fighting leukemia.
A novel droplet digital PCR assay detects KMT2A fusion markers in AML patients, enabling sensitive MRD detection and guiding treatment decisions. This breakthrough may improve patient outcomes by assessing response to therapy and long-term surveillance.
Researchers identified how low TET2 levels fuel rapid growth of acute myeloid leukemia in animal models. The study found that TET2 deficiency sets off biochemical changes enhancing the cancer's ability to spread. This discovery highlights potential therapeutic targets for treating aggressive bone marrow cancer.
A novel association of t(5;17) with t(8;21) has been reported in an acute myeloid leukemia (AML) patient, resulting in a RUNX1-RUNX1T1 rearrangement. The patient received chemotherapy and stem cell transplantation, highlighting the importance of this rare translocation.
A University of Minnesota-led study demonstrated the safety of microbiota transplant therapy (MTT) in patients with acute myeloid leukemia (AML) and recipients of hematopoietic cell transplantation (HCT). MTT showed improved gut bacteria balance but did not significantly reduce infections. The study's results will inform a larger follo...
Researchers investigate MCL-1i-induced Mcl-1 protein accumulation and its implications in B-cell malignancies. The study reveals a complex mechanism contributing to MCL-1 protein stability upon treatment with MCL-1 inhibitors.
A team from the University of Tsukuba has discovered that the enzyme ELOVL6 plays a significant role in the development of acute myeloid leukemia, a type of blood cancer. The study found that high levels of ELOVL6 are linked to shorter survival rates for leukemia patients.
Dr. John H. Bushweller's team at UVA Cancer Center is developing novel drugs to block abnormal proteins that cause pediatric leukemia. The new approach aims to improve efficacy and reduce toxicity, potentially leading to better patient outcomes.
A new method, CloneTracer, distinguishes between cancerous and healthy stem cells in acute myeloid leukemia (AML). The study reveals two distinct stem cell compartments and shows that progenitor cells respond better to therapy. This finding paves the way for developing new techniques to predict patient response to chemotherapy.
Researchers found that resistance to leukemia treatment occurs due to rapid increase in mitochondria breakdown and turnover, allowing cells to evade death signals. A new combination of chloroquine and venetoclax restores the drug's ability to kill cancer cells by targeting a specific mitochondrial process.
Acute myeloid leukemia is a cancer that affects blood cells and can lead to infection, anemia, and easy bleeding. The Georgia Cancer Center has received a $2.3 million grant to study how cancer cells resist treatment and propose new options to improve patient survival.
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
A new study reveals that targeting the SWI/SNF protein complex can disrupt PU-1-directed enhancer programs in AML cells, leading to therapeutic responses and rapid tumor regression. The findings also show that these inhibitors have manageable side effects on normal blood cells.
Scientists from USC Stem Cell laboratory discovered a mechanism linking leukemic mutations to varying disease potentials, identifying RNA splicing regulator Rbm25 as a critical factor. The study found that over-contributing clones of blood stem cells produce excessive myeloid cells, leading to potential leukemia development.
Researchers at German Cancer Research Center have developed a marker that predicts which patients with acute myeloid leukemia (AML) will respond to the new therapy. The marker, known as the MAC score, measures the ratio of specific proteins in leukemia stem cells and can be used to determine treatment success.
Researchers have identified two potential molecular targets, CSF1R and CD86, that can be used to develop CAR-T cells effective against acute myeloid leukemia. The study's findings demonstrate the potential of AI-assisted analysis in discovering new treatment options.