Articles tagged with Dermatology
A clinical trial has shown that methotrexate is a useful and safe treatment for children with severe atopic dermatitis, offering better objective disease control compared to ciclosporin. The study found no concerning safety signals, making methotrexate an attractive alternative for patients in settings where healthcare resources are li...
Researchers found decreased in situ and invasive melanoma diagnoses during the pandemic, which may reflect reduced skin cancer screening. Thick melanomas increased primarily due to a decrease in thin melanomas, rather than an absolute increase in thicker ones.
New research by UMass Amherst economist Brandyn Churchill links state-level 'SUNucate' laws to increased interest in sun protection, with a notable increase in sunscreen use among high school students. The legislation is associated with higher Google search volumes and awareness among historically low-users.
Researchers developed a novel approach to quantify human skin's hydraulic permeability, discovering the dermis layer has the highest water absorption. The method uses atomic force microscopy and poroelastic theory to analyze skin samples, with potential applications for assessing skin moisturizing additives.
A global team of experts outlines a roadmap for creating a comprehensive and inclusive reference work on human skin cell composition. The proposed Human Skin Cell Atlas will provide a standardized framework for semi-automated mapping of patient-specific changes in skin diseases, supporting personalized medicine.
A new study has identified four genetic variants associated with the direction of human scalp hair whorls, revealing a polygenic inheritance pattern. The findings may help unravel biological processes related to abnormal neurological development.
The Estee Lauder Companies' New Incubation Ventures has launched a breakthrough prize for innovative active ingredient companies, R&D labs and scientists pushing the boundaries of Indian consumers. The prize program aims to discover and support the next generation of Indian beauty brands.
Researchers developed a reinforcement learning model that incorporates human decision-making criteria to improve AI accuracy in skin cancer diagnoses. The study showed increased sensitivity for melanoma and basal cell carcinoma, leading to more accurate diagnoses and optimal treatment decisions.
The study identified two genes, SOX9 and KLF5, that contribute to the development of hidradenitis suppurativa. These genes play a role in hair follicle and epidermal development, respectively, and their mutations may lead to improper development of hair follicles and inflammation.
A recent study found that increased skin cancer screening is not enough to address racial disparities in melanoma survival rates. Researchers suggest that educating physicians about presentation of melanoma in skin of color and making sure people have access to a dermatologist when they have a suspicious lesion could be more effective.
Researchers found that daily consumption of dealcoholized muscadine wine for six weeks improved skin elasticity and barrier function, while reducing inflammation and oxidative stress. Although wrinkles were not significantly affected, participants showed significant improvements in skin smoothness.
A new study found that 21.3% of respondents used skin lightening agents, often for conditions like acne or hyperpigmentation, but most users were unaware of potential toxic ingredients and risks. The study highlights the need for cultural mindfulness in dermatology care to ensure safe and effective treatment across all communities.
A study published in the Journal of the American Academy of Dermatology found that curettage and cryosurgery is an effective and safe treatment method for basal cell carcinoma. The procedure involves scraping the lesion with a curette followed by freezing, resulting in good outcomes with minimal side effects.
Researchers developed a non-invasive diagnostic method that analyzes sebum for biomarkers of early-onset atopic dermatitis in infants. The study revealed distinct gene expression profiles associated with AD, allowing for early detection and potential treatment monitoring.
A recent study has uncovered three previously unreported genetic loci associated with eyebrow thickness in Europeans, as well as rediscovering two of the four genetic loci previously found in non-Europeans. The research expands genetic knowledge on human eyebrow variation, with implications for dermatology and other fields.
Researchers at Northwestern University have discovered a way to soften stiff hair follicle stem cells, enabling them to grow hair again. By boosting the production of microRNA-205, they promote hair growth in both young and old mice, offering potential for human hair regrowth.
A large-scale clinical trial has found that spironolactone is an effective treatment for persistent acne in women, offering an alternative to antibiotics. The study, funded by the National Institute for Health and Care Research, recruited over 400 women with acne that had persisted for more than six months.
Researchers developed six prediction models using machine learning algorithms to distinguish between atopic dermatitis lesions and non-lesions, achieving high AUC values. The models showed a positive correlation between sample quality and SCORAD scores, indicating improved treatment efficacy.
Researchers at Osaka Metropolitan University have discovered that CD9-positive exosomes derived from cancer-associated fibroblasts can inhibit the growth of malignant melanoma cells. This finding holds promise for developing new treatments for skin cancer.
A new study published in the New England Journal of Medicine found that lebrikizumab was effective in treating moderate to severe atopic dermatitis, improving skin clarity and reducing itching. The study involved two phase 3 trials with over 700 participants and showed promising results for the treatment.
A team of dermatologists developed an AI model to detect complications from bacterial or viral infections in atopic dermatitis patients. The model distinguishes between eczema and skin lesions caused by blood cancer, improving patient management and health outcomes.
A new study published in Arthritis & Rheumatology reports significant improvements in disease activity for patients with refractory juvenile dermatomyositis treated with abatacept therapy. The randomized controlled trial demonstrates the potential of abatacept as a treatment option for this rare and debilitating condition.
A study found that individuals with a history of atopic diseases, such as allergic asthma or rhinitis, had significantly lower rates of melanoma and skin cancer compared to non-atopic individuals. The risk of melanoma was up to 50% lower in atopic patients, and the overall risk of skin cancer was also reduced.
A study by University of Gothenburg researchers found a significant association between methotrexate use and an increased risk of basal cell carcinoma, squamous cell carcinoma, and cutaneous malignant melanoma. The study suggests that higher doses of methotrexate may increase the risk of SCC and BCC, while no dose-response relationship...
Researchers at the University of South Australia are developing new biomarkers to improve melanoma detection and avoid delayed treatment. The current markers used in clinical practice are not always sensitive or specific, leading to fatal consequences if cancerous cells are missed.
Researchers developed bioprinted artificial skin that mimics human skin, reducing animal testing in cosmetics and pharmaceutical industries. The model achieved similar results as traditionally produced models, passing international validation tests, including barrier function and irritant response assessment.
A University of Missouri-developed dermatology program using the ECHO model has improved accuracy and timeliness of primary care physician diagnoses, correcting misdiagnoses and recommending proper treatments. The program, established in 2015, has been implemented in seven countries.
Research found that nonablative fractional lasers (NAFL) reduce the risk of subsequent keratinocyte carcinoma development. NAFL-treated patients had about half the risk of developing a new facial keratinocyte carcinoma compared to untreated controls.
Regular use of vitamin D supplements was associated with a significantly reduced risk of melanoma and better skin cancer classification compared to non-users. However, the study did not find a significant association between vitamin D use and other skin changes or severity of photoaging.
Patients with moderate to severe atopic dermatitis showed significant improvement in signs and symptoms while taking rocatinlimab, a novel monoclonal antibody therapy. The treatment has the potential to change the genetic makeup of the disease, leading to lasting results without continued use.
Early application of skin moisturizers is an effective strategy for preventing atopic dermatitis (AD) in high-risk infants. A systematic review and network meta-analysis found that three types of emollients, including cream, emulsion, and mixed types, are comparable in preventing AD; however, emollient emulsion may be the optimal option.
Research found persistent diversity gaps in the dermatology workforce pipeline, with females and UIM students underrepresented. Medical students from diverse backgrounds had increased odds of caring for underserved populations and practicing public health.
Urban-living Indigenous children and young people in high-income countries are disproportionately affected by atopic dermatitis and bacterial skin infections, which can lead to serious complications. This systematic review highlights the need for co-designed research with Indigenous communities to address these health inequities.
A team from Massachusetts General Hospital developed an AI-based method to predict which patients with early-stage melanoma are most likely to experience a recurrence. Machine learning algorithms extracted predictive signals from clinicopathologic features, including tumor thickness and rate of cancer cell division.
Researchers highlight climate-sensitive dermatological manifestations initiated or exacerbated by floods, wildfires, and extreme heat events. These events disproportionately affect marginalized populations, exacerbating existing health disparities.
Researchers found a drastic decrease in bacterial abundance on the skin of patients with graft-versus-host disease, while an increased occurrence of staphylococci was observed. This discovery may lead to improved treatment measures for GVHD, which affects approximately 30-70% of stem cell transplant recipients.
A study by MedUni Vienna's Department of Dermatology reveals that tick saliva inhibits the skin's defense function, making it easier for pathogens to multiply. Climate change increases the danger from ticks, which now pose a threat in higher-altitude regions of Austria and well into late autumn.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
A team of scientists from China published a perspective paper on the use of AI in skin diseases, highlighting its potential to assist clinicians. They propose several recommendations to improve AI-assisted diagnosis systems, including establishing a robust database and adapting algorithms to existing real-world databases.
Lenabasum has been shown to improve skin symptoms in patients with amyopathic dermatomyositis, demonstrating significant reductions in inflammation and disease severity. The study's findings suggest that lenabasum is a well-tolerated treatment option for refractory skin disease.
A new survey of 17,000 Europeans found that 8 in 10 believe tans are attractive and healthy, despite decades of awareness campaigns linking sun exposure to skin cancer and aging. The study also revealed low levels of adherence to sun protection habits, with only 1 in 10 using all forms of protection.
The International Journal of Dermatology calls on dermatologists to take action against climate change by reducing carbon emissions through increased use of telehealth. The authors also emphasize the need for funding prioritization for climate-health research to improve healthcare sustainability and decarbonize the profession.
A recent study has found that vitamin D deficiency is associated with lower overall survival rates in melanoma patients. The research, presented at the European Academy of Dermatology and Venereology Congress, suggests that vitamin D levels play a significant role in determining patient outcomes.
Researchers identified an immune biomarker in newborns that can predict the onset and severity of pediatric atopic eczema. The Barrier dysfunction in Atopic newBorns (BABY) study found elevated levels of TARC at 2 months to be more than twice as likely to develop eczema by age 2.
A new imaging technique called LC-OCT significantly improved the accuracy of basal cell carcinoma (BCC) diagnosis by 12% compared to clinical and dermoscopic examinations. The technique provided detailed 3D images at a cellular level, enabling more accurate differentiation between BCCs and other skin conditions.
A recent study found that private equity firms acquiring physician-owned medical practices increase patient volume and billing for visits, raising concerns about the corporatization of healthcare. The study examined 578 physician practices acquired by private equity firms between 2016 and 2020.
A study by Japanese researchers from Fujita Health University sheds light on the molecular mechanisms of contact dermatitis, revealing that neutrophil extracellular traps play a key role in the condition. The team's findings suggest that inhibiting NET formation could be a new therapeutic strategy for treating contact dermatitis.
A survey study published in JAMA Dermatology found that Asian patients with psoriasis spend significantly less face-to-face time with dermatologists compared to patients of other races and ethnicities. The study highlights the need for improved healthcare access and cultural competence in dermatology care.
A case series of six patients reported rare skin reaction complications after receiving the Pfizer/BioNTech COVID-19 mRNA vaccine. The study aims to shed light on these unusual side effects.
Researchers from the University of Gothenburg found that assessing melanoma thickness is challenging for both human dermatologists and machine-learning algorithms. Despite differences in success rates, both groups achieved comparable results when evaluating dermoscopic images, highlighting the need for further study to improve diagnost...
Researchers found clots in small venous and arterial blood vessels in normal-looking skin from patients with severe COVID-19, distinguishable from other forms of respiratory illness. Antiviral proteins and interferon-induced inflammatory proteins were also detected, associated with disease severity.
This survey study examined associations between demographic and clinical variables and eczema burden in adults. Key findings include identifying factors contributing to eczema severity, which can inform targeted interventions.
A systematic review evaluated patient-reported outcome measures assessing health-related quality of life for adults and adolescents with acne. The review found that these measures can provide valuable insights into the impact of acne on patients' lives, highlighting the need for better standardization and evaluation of these tools.
A randomized, placebo-controlled pilot study found that NB-UVB phototherapy decreased mortality in hospitalized COVID-19 patients with no adverse events reported. The treatment was effective in both vaccinated and unvaccinated patients, with reduced pathologic inflammation and improved intracellular killing of pathogens.
A study has found that there is no single best moisturiser for children with eczema, highlighting the importance of patient education and choice. The trial, funded by the National Institute for Health and Care Research, compared four types of moisturisers and found that reactions were common regardless of type.
A new study found that people over 50 are more likely to use sunscreen if they believe it prevents sunburn, while those who think it takes too much time are less likely. The researchers suggest using reminders from romantic partners or focusing on skin cancer risk as effective messaging strategies.
A new machine-learning tool can speed up the diagnosis of psoriatic arthritis by identifying patients up to 4 years prior to a clinician's diagnosis. The tool, PredictAI, analyzed medical records and accurately identified 32-51% of confirmed PsA patients.
Dermatologists identify a possible link between acne and omega-3 fatty acids, finding that 94% of patients had below-recommended levels in their blood. A healthy diet rich in legumes and avoiding sunflower oil may help manage the condition. The study suggests that omega-3 supplements could be beneficial for treating acne.
Researchers found that normal-appearing lupus skin contains the same inflammatory signals as skin with rashes, suggesting a primed state for inflammation. The study's findings provide new insights into how UV light triggers rashes in lupus patients and highlight the potential for precision medicine in treating the disease.
Recent studies found that pathologists perceive an overdiagnosis of melanoma, with many diagnosing cases as non-invasive melanoma despite variability in diagnoses. A study involving over 100 dermatopathologists showed a majority agree on the issue, but awareness may not be enough to reduce overdiagnosis.