Articles tagged with Dermatology
Researchers found three molecules produced by a bacterium in blood that reduced damage and inflammation in human skin cells. The findings, published in the Journal of Natural Products, suggest these compounds are promising candidates for future treatments to counteract skin aging.
Lurie Children's is now a Qualified Treatment Center (QTC) for ZEVASKYN, the first and only cell-based gene therapy for patients with recessive dystrophic epidermolysis bullosa (RDEB). This therapy promises to provide long-term healing of wounds, reduction in pain and reduced risk of infection.
A study published in Nature Communications identifies fibromodulin as a protein that forms a complex with interleukin 1β to stop myofibroblasts from forming excessive scar tissue. This finding could lead to a new way to reduce or prevent excessive scarring, benefiting patients recovering from surgery, injuries, or burns.
Researchers developed and validated a five-point clinician-rated SMF rating scale in a study of 150 volunteers. The internal and external validation showed good intra- and inter-rater consistency, indicating reliable tool for future research on facial aesthetics.
SKINdeep, a new international journal on translational dermatology and clinical studies, is now available online. The journal features original articles, reviews, and perspectives on skin diseases and their therapeutic relevance.
A new study found that a gene-based blood test can accurately predict skin cancer recurrence in stage III melanoma patients. The test measures circulating tumor DNA levels to identify those most likely to respond well to therapy.
Medical students at UC San Diego provide free laser tattoo removal services to justice-impacted adults, gaining hands-on experience in dermatology. The initiative, which has been well-received, enhances medical education, social justice engagement, and patient care in underserved communities.
Researchers found that ultrafine bubble showers significantly suppressed inflammation in mice with atopic dermatitis caused by external factors. The treatment also improved skin protective barrier proteins. However, no significant effects were seen in mice with atopic dermatitis caused by genetic factors.
Researchers found no clear evidence that red wine mitigates cancer risk, and instead observed a distinction in skin cancer risk. White wine consumption was associated with an increased risk of skin cancer compared to red wine, particularly among women. Heavy wine consumption may correlate to high-risk behaviors.
Researchers re-analyzed data for 111 products and found significant associations between production process, ingredient composition, and benzene levels. The study suggests opportunities to improve formulation, production, and distribution of benzoyl peroxide containing products to reduce the likelihood of them degrading into benzene.
A natural compound derived from gut-friendly bacteria significantly slows vitiligo progression and may restore pigmentation in mice. The findings could offer hope to millions affected by the autoimmune disease, which causes visible patches of skin discoloration and carries profound emotional and physical consequences.
The São Paulo Advanced School on Precision Health will bring together 100 students from Brazilian and international universities to discuss precision health through a One Health vision. The school features state-of-the-art science presentations and interactions with world-class researchers and health startup founders.
A new study from Mass General Brigham found that approximately 1-in-5 patients experience acne recurrence after isotretinoin treatment. The researchers identified factors that increase the risk of recurrence, including female gender and lower cumulative dosages.
A Swedish study found that topical steroid withdrawal (TSW) is characterized by symptoms such as redness, pain, and itching, often accompanied by sleep problems. The study aimed to understand the phenomenon of TSW, which many patients consider a cortisone dependence.
Researchers found that SYM2081 suppressed mast cell degranulation and proliferation in mouse models and human skin samples, paving the way for new topical treatments to prevent itching and inflammation. The study suggests that activating GluK2 could be a promising way to prevent rosacea and other inflammatory skin conditions.
The University of Cincinnati College of Medicine has launched a styrofoam recycling project to divert over 900 pounds of EPS waste from landfills each month. The program aims to reuse existing styrofoam materials, reducing the need for styrene and minimizing environmental impact.
A study suggests that low doses of the commonly prescribed hair loss treatment minoxidil are safe and effective for regrowing hair in most breast cancer patients. The researchers found that all participants who took a low dose of oral minoxidil saw improvements in hair growth or stabilization within three to six months.
The digital age is transforming cosmetic dermatology, with technologies like AI and telehealth pushing boundaries. However, challenges arise from social media's influence on skin advice and the need for in-person exams to ensure patient safety.
Researchers identified three subtypes of fibroblasts in skin cancer: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs). The distribution of these subtypes varies with tumor aggressiveness. iCAFs produce signaling factors to activate immune cells, while mCAFs prevent T cell invasion.
The study combines AI with fluorescence photography to enhance skin diagnostics, allowing for earlier detection of skin conditions such as acne, photoaging, and hyperpigmentation. AI can pinpoint early indicators of skin conditions with greater accuracy and monitor changes over time for data-driven decisions.
A new study found that a remote telemedicine tool called SpotCheck is highly accurate in diagnosing melanoma, with experts able to remotely examine skin lesions using dermoscopy. The tool has the potential to address diagnostic and treatment disparities for lower-income populations with limited access to dermatologists.
A geospatial analysis found that areas with more tanning bed facilities experience higher rates of melanoma. The study identified six high-risk clusters and seven low-risk clusters, suggesting a significant association between access to tanning beds and increased melanoma incidence.
A retrospective cohort study found associations between COVID-19 and the long-term risk of various autoimmune and autoinflammatory connective tissue disorders. Long-term monitoring and care are crucial to mitigate these risks, taking into account demographic factors, disease severity, and vaccination status.
Researchers will explore the role of exosomes in delivering regenerative compounds, while also investigating olfactory receptors' unexpected functions in skin health. The conference aims to slow or reverse skin aging through novel approaches to mitochondrial function and microbiota balance.
Research finds that increases in air pollution levels correspond with a higher number of patients visiting the hospital emergency department, particularly for cases of trauma, breathing difficulties, and skin conditions. The study suggests that heavy traffic is directly responsible for increased trauma cases and indirectly contributes ...
A new study found that benzoyl peroxide acne treatments lack stability and degrade into carcinogenic benzene when exposed to heat, UV light, or stored at room temperature. Refrigeration may be a practical solution to minimize unnecessary exposure until safer formulations are developed.
Researchers have developed a new treatment for deep diabetic foot ulcers, using intact fish skin grafts to promote healing. The study found that this innovative approach showed promising results in improving wound closure and reducing infection rates.
A new study suggests the hormone hepcidin may trigger psoriasis by causing iron overload in the skin. This excess iron amplifies the damaging effects of UV sunlight, leading to hyperproliferative chronic diseases like psoriasis. A potential treatment targeting hepcidin could improve treatment options for millions.
A randomized clinical trial found home-based phototherapy to be as effective as office-based treatment for plaque and guttate psoriasis, while reducing patient burden. The study suggests that this approach could become a viable option for everyday clinical practice.
Researchers have identified key molecular targets that could significantly enhance the healing of both acute and chronic wounds. The study found that combinatorial therapy involving FGF7 and an MMP10-neutralising antibody can improve wound healing in both acute and chronic wounds.
Researchers have developed a new method to detect melanoma using tumour-specific antibodies, which can accurately identify stage I and II melanoma patients. The study found that these antibodies showed high sensitivity and specificity in detecting melanoma, with an AUC value of up to 0.981.
A new study demonstrates the potential of semaglutide in treating hidradenitis suppurative (HS) in people with obesity. The results show marked improvements in patient outcomes across several key measures, including reduced flare frequency, improved quality of life, and better glycaemic control.
Researchers from Osaka Metropolitan University have discovered that disruptions in the basement membrane zone between the epidermis and dermis could make it harder for pigment-producing cells to adhere. An enzyme called matrix metalloproteinase 2 (MMP2) may be overexpressed, leading to disturbance of the basement membrane.
A new study found that skin cancer incidence in young adults declined in Sweden around 2015. The decrease in incidence and mortality is attributed to increased awareness of sun protection, reduced access to sunbeds, and changes in lifestyle habits such as spending more time indoors. The study suggests that continued emphasis on sun pro...
Researchers have identified compounds from fish gut bacteria that inhibit tyrosinase and collagenase enzymes, making them potential ingredients for skin care products. The findings suggest that the gut microbes of red seabream and blackhead seabream may produce promising anti-wrinkle and skin-brightening agents.
A large-scale study investigated the relationship between childhood obesity and immune-mediated skin diseases (IMSDs), such as atopic dermatitis and psoriasis. The study found that obese children were more likely to develop these conditions, with changes in body weight affecting their risk of developing these diseases.
Researchers have identified lower levels of certain amino acids in the blood plasma of patients with unexplainable chronic itch, offering a potential breakthrough in treating this debilitating condition. These findings may pave the way for new targeted therapies.
A new clinical algorithm developed at the University of Gothenburg can accurately identify highly aggressive forms of basal cell carcinoma. The algorithm uses a combination of clinical and dermoscopic images to distinguish between low-risk and high-risk tumors, allowing for more effective treatment and better patient outcomes.
A study by Penn researchers found that the bacterium Alcaligenes faecalis promotes wound healing in people with diabetes by inhibiting enzymes that are over-produced in these individuals. The findings could lead to the development of topical or bacterial-based treatments for patients with hard-to-treat wounds.
Following a Mediterranean diet and taking omega-3 fatty acid supplements, participants experienced significant reductions in inflammatory and non-inflammatory skin lesions. Those who reached target omega-3 levels showed the most substantial improvement in acne severity.
Researchers from Nagoya University have successfully treated rare genetic skin disorders epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas. Transplantation of healthy skin has been used as a treatment option for severe burn injuries.
The study uses the Dermatological Vision Dataset and compares vision transformers with traditional CNNs, achieving an impressive 97.8% accuracy on validation sets. Integrating ViTs into dermatology represents a promising step toward more accurate diagnostics.
A clinical trial discovered that the drug abrocitinib, approved for eczema treatment, significantly reduced symptoms of patients with severe itching diseases. Abrocitinib improved symptoms in both prurigo nodularis and chronic pruritus of unknown origin by 78% and 54%, respectively.
Experts at NYU Langone Health have warned of a growing public health threat from hard-to-treat fungal skin infections in the US. Two new reports document cases of highly contagious forms of ringworm and jock itch that can take months to clear up with treatment.
Research published in the Journal of Investigative Dermatology reveals that UV exposure increases energy expenditure by inducing the 'browning' of subcutaneous fat, thereby preventing weight gain. This breakthrough discovery opens up new possibilities for treating obesity and metabolic disorders.
A large register-based study found that young adults with low stress resilience are more likely to develop psoriasis later in life. The study, based on data from over 1.6 million Swedish men, showed a significant link between stress resilience and the risk of developing severe cases of psoriasis.
Adult carriers of BAP1 tumor predisposition syndrome show a high incidence of onychopapillomas, a benign nail tumor. This finding suggests using these skin abnormalities to identify family members and patients with cancers associated with the syndrome.
A validation study on the WHO app using AI to detect skin diseases showed good reception amongst professionals in Ghana and Kenya. The app aims to improve diagnosis and treatment of neglected tropical diseases and common skin diseases.
Researchers have identified new cellular targets for a vaccine to treat eczema in children, which may limit the severity of symptoms and reduce antibiotic use. The study uncovered specific immune signatures in children with infected flares of eczema, providing a potential blueprint for future therapies.
A new Northwestern Medicine study reveals that 73% of children with skin diseases face stigma and bullying, leading to impaired relationships and mental health issues such as depression and anxiety. The study suggests that clinicians should aggressively treat skin disorders in children and consider referral to evaluation and counseling.
Researchers at Osaka Metropolitan University developed a lysin from a bacteriophage that targets Staphylococcus hominis, a key contributor to body odor. The study's results could lead to a new treatment option for axillary odors, a common dermatological disorder.
A study from the University of Gothenburg found that patient images are severely lacking in scientific articles on atopic dermatitis. This lack of visual aids hinders patients' ability to make informed decisions about their care, as they struggle to understand complex medical terminology and figures. The absence of images also affects ...
A new study from Aarhus University reveals that only 67% of Danes registered with an ectodermal dysplasia diagnosis actually have congenital ectodermal dysplasia. The study identifies key characteristics, including abnormal teeth, skin issues, and nail problems, highlighting the need for collaboration across healthcare disciplines.
Researchers developed an index to optimize picosecond laser treatment for skin blemishes, showing low complication rates and high efficacy. The wavelength-dependent indicators are expected to improve the safety and effectiveness of the treatment.
A new service evaluation from the University of East Anglia found that giving GPs cameras to photograph skin complaints could reduce NHS wait lists. The innovative service involving over 3,000 patients led to faster resolution for patients and prevented many people from having to wait to see a hospital consultant.
A mobile app using AI analyzes images of suspected skin lesions and provides guidance on whether they are melanoma or not. The app was tested in primary care and showed promising results, accurately diagnosing melanoma in all cases and determining harmless lesions with a high probability.
Researchers developed a scoring system to distinguish between two serious skin diseases with similar symptoms. The study analyzed data from 117 patients and found the scoring system could help medical professionals quickly diagnose and choose appropriate treatment.
Current AI dermatology mobile apps can improve access to care, but their efficacy, safety, and transparency are concerns. Regulating these apps is essential to minimize risks and maximize benefits.
A new study published in JAMA Dermatology reveals that children with atopic dermatitis are more likely to experience difficulties in learning and memory. The research suggests that neurodevelopmental comorbidities such as ADHD or learning disabilities may play a key role in this association.
Researchers analyzed published studies on AI in dermatology, finding significant shortcomings when applied to skin of color. Only 30% of AI programs had data specifically for skin of color, and current programs do worse at identifying skin lesions.