Articles tagged with Dermatology
Researchers discovered that body temperature plays a key role in which tissues are affected by TRPM4 ion channel mutations. The findings explain why disease-causing TRPM4 mutations lead to mutually exclusive conditions, such as severe skin diseases like PSEK and heart disorders like progressive familial heart block.
The new guideline provides evidence-based recommendations for 26 diseases, including pigmentary disorders and skin rejuvenation. The guideline aims to standardize clinical practice in laser and aesthetic medicine, improving treatment outcomes and safety.
The study reveals that hair follicles contain specialized sentinel cells that monitor environmental exposure and microbial presence, potentially linking immune detection to sensory signaling. The discovery may have implications for understanding skin infections, immune disorders, and topical therapeutics.
Scientists have discovered a natural extract that enhances the effectiveness of traditional sunscreens, providing longer-lasting protection against UV radiation. The new generation of sunscreens also offers antioxidant benefits, reducing the risk of skin cancer and premature aging.
A new study found that AI applications enhance consumer understanding of skin conditions by increasing accuracy and confidence. However, imperfect guessing accuracy remains, highlighting the need for further design improvements to facilitate better comprehension.
A new University of Michigan-led research has identified a connection between keratin 16 and type 1 interferon in the molecular pathways of pachyonychia congenita. The study found that losing or altering K16 causes amplification of the inflammatory response, but also helps pump the brakes on that response.
The COCOON trial found that a structured dermatologic prophylaxis regimen reduced moderate-to-severe dermatologic adverse events by half, with fewer grade ≥3 events and treatment discontinuations. This approach could improve tolerability and maintain dose intensity for EGFR-mutant non-small cell lung cancer patients.
Researchers have identified MFSD2A as a transporter protein that enables skin cells to take up lysophosphatidylcholines (LPCs), essential fats in the bloodstream. The study found that LPCs supply linoleic acid, an essential fatty acid needed to maintain and repair the skin barrier.
Researchers reveal that skin-cell calcium channel TRPV3 is activated by plant-derived fragrant molecules, leading to enhanced immune responses and potential new vaccine adjuvants. The study provides a novel understanding of immune crosstalk and offers a safer approach to enhancing vaccine efficacy.
Researchers found that sunscreens with the same SPF of 50 and active ingredients can range from $0.04 to $3.79 per application, highlighting huge variations depending on product price and skin exposure.
A new discovery from Lund University reveals that minor changes in moisture levels can promote lipid molecule reorganization, affecting skin, lung, and tear film protection from dehydration. This understanding can inspire smart materials and improve lipid-based drug delivery systems.
Researchers found that patients with major depressive disorder share immune abnormalities with inflammatory skin diseases, including atopic dermatitis. The study suggests targeting the Th2 pathway and interleukin-4 receptor alpha as potential therapeutic strategies for psychiatric illness.
A study of US veterans has identified a possible link between exposure to Agent Orange and acral melanoma, a rare form of skin cancer. The researchers found that veterans exposed to the herbicide had a 30% higher odds of developing this type of melanoma.
A retrospective study of 161 cases found that dermatofibrosarcoma protuberans (DFSP) of the head and face favors the cheek region, particularly in older patients. The dominant site accounted for 65.38% of all head-and-face DFSPs, suggesting regional anatomic or biological factors influence tumor development.
Researchers explore polyherbal formulations combining multiple plant extracts to combat skin aging, featuring seven key plants with their bioactive phytoconstituents. These formulations offer a synergistic advantage, enhancing efficacy while reducing toxicity risks associated with single compounds.
Researchers at Kobe University have identified a specific bacterial strain, Staphylococcus epidermidis and Corynebacterium tuberculostearicum, as the primary causes of foot odor in Nagashima-type palmoplantar keratosis. Topical application of benzoyl peroxide reduces odor by decreasing C. tuberculostearicum levels.
Skin pigmented spots feature immune cell infiltration, branched blood capillaries, and a disrupted skin barrier, necessitating innovative skincare strategies. The study highlights the need for multi-action ingredients that soothe inflammation, normalize blood vessels, and maintain a healthy skin microbiome.
A new study finds that human tyrosinase plays a central role in metabolizing hydroquinone into reactive intermediates causing dermal pigmentation. The research shows that these compounds accumulate differently depending on molecular size and bind to dermal proteins, forming ochronotic pigments.
A study reports on the underdiagnosis of 'topical steroid withdrawal syndrome' (TSW), a condition triggered by sudden or tapered use of steroid creams for inflammatory skin conditions. TSW can lead to severe symptoms, including skin reddening, burning, itching, and systemic problems like insomnia and depression.
Researchers found that indoor tanning users in their 30s and 40s have more skin mutations than people twice their age, particularly in areas exposed to tanning beds. This can lead to an increased risk of skin cancer, including melanoma.
NEJM Clinician curates highly relevant clinical insights from over 150 peer-reviewed journals to give physicians clear guidance without the noise. The weekly publication delivers summaries and commentary in a concise, 30-minute read, helping healthcare providers stay informed and confident in their decisions.
Rocatinlimab shows durable improvements in skin clearance, itch, and quality of life by targeting OX40 immune receptor in patients with moderate-to-severe atopic dermatitis. The treatment led to significant reductions in eczema severity, itch, pain, and sleep disturbances.
A study found that intimate physical contact reduces cortisol responses, while oxytocin administration promotes wound healing. This integration of relationship dynamics and neurohormonal modulation may lead to future interventions for improved health and recovery.
A major study has found that people with eczema can bathe either daily or weekly without affecting their symptoms. The study, published in the British Journal of Dermatology, involved 438 participants and showed no significant difference in eczema symptoms between the two groups.
A compound found in rosemary leaves may significantly improve the healing of skin wounds and reduce scarring, according to new research. The study found that carnosic acid, a naturally occurring antioxidant in rosemary, can shift the healing process from scarring to healthy skin regeneration.
A novel therapeutic candidate has been developed to treat severe cutaneous adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The compound suppresses disease-specific keratinocyte death, demonstrating its efficacy in preclinical studies.
Researchers at the University of Arizona are developing a new optical technology that can image deep into biological tissues without invasive procedures. This approach aims to overcome current challenges in skin cancer imaging, allowing for earlier detection, precise evaluation, and real-time monitoring of treatment response.
A new study found that over 40% of specialty clinics in the US turn away patients weighing 465 pounds or more due to lack of accessibility features. The study highlights a need for staff training on inclusive care and accommodations for patients with severe obesity.
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
A simple AI model has been shown to accurately assess the aggressiveness of squamous cell carcinoma, a common form of skin cancer. The study found that two clinical features - ulcerated and flat skin surfaces - were strongly associated with more aggressive tumor growth.
The study found that increasing Piezo1 activity leads to a coordinated response, resulting in increased skin surface area and thickness. The findings could ultimately help doctors develop noninvasive therapeutic approaches to create new skin for treating burns and other injuries.
Researchers have developed a new pimple patch system with an array of tiny spikes that grabs onto the pimple and delivers antibacterial or anti-inflammatory compounds. After seven days of treatment, human clinical trials confirmed complete disappearance of pimples.
A new study led by McMaster University researchers compared over 40 treatment options for chronic hives and found that certain treatments are more effective and safer than others. The findings will inform upcoming international clinical guidelines, providing patients and clinicians with a clear 'menu of treatment options' to choose from.
A national review by Northwestern University identifies top dermatologist-recommended skin care ingredients for seven common complaints. Mineral sunscreen and retinoids are among the most effective ingredients, while too many products can irritate skin and worsen concerns.
Researchers developed an in-silico meta-analysis tool to determine optimal laser irradiation conditions for treating nevus of Ota. The study found that picosecond laser treatment demonstrated higher efficacy and equivalent safety compared to nanosecond laser treatment.
Researchers found that autologous fat grafting can reverse dermal adipose tissue dysfunction by inducing autophagy and mitophagy. This process improves skin architecture and reduces fibrosis in conditions like scleroderma.
Researchers discover vitamin C promotes epidermal thickening by reactivating genes essential for skin cell growth, suggesting a promising treatment for thinning skin in older adults. Vitamin C supports active DNA demethylation by sustaining TET enzyme activity.
JMIR Publications' portfolio of journals now includes 21 titles with a Journal Impact Factor. Several journals saw significant increases in impact factor, including JMIR Medical Education, which debuted with a score of 12.5, securing the top-ranked journal spot in its category.
A study found that teenage girls using multiple products on their faces increase the risk of skin irritation and allergy. The average cost of a daily skin care regimen is $168, with some costing over $500.
PanDerm, a new AI model, analyzes multiple types of images to improve skin cancer diagnosis accuracy by 11% when used by doctors. The tool also enhances diagnostic accuracy for non-dermatologist healthcare professionals by 16.5%.
Researchers found three molecules produced by a bacterium in blood that reduced damage and inflammation in human skin cells. The findings, published in the Journal of Natural Products, suggest these compounds are promising candidates for future treatments to counteract skin aging.
Lurie Children's is now a Qualified Treatment Center (QTC) for ZEVASKYN, the first and only cell-based gene therapy for patients with recessive dystrophic epidermolysis bullosa (RDEB). This therapy promises to provide long-term healing of wounds, reduction in pain and reduced risk of infection.
A study published in Nature Communications identifies fibromodulin as a protein that forms a complex with interleukin 1β to stop myofibroblasts from forming excessive scar tissue. This finding could lead to a new way to reduce or prevent excessive scarring, benefiting patients recovering from surgery, injuries, or burns.
Researchers developed and validated a five-point clinician-rated SMF rating scale in a study of 150 volunteers. The internal and external validation showed good intra- and inter-rater consistency, indicating reliable tool for future research on facial aesthetics.
SKINdeep, a new international journal on translational dermatology and clinical studies, is now available online. The journal features original articles, reviews, and perspectives on skin diseases and their therapeutic relevance.
A new study found that a gene-based blood test can accurately predict skin cancer recurrence in stage III melanoma patients. The test measures circulating tumor DNA levels to identify those most likely to respond well to therapy.
Medical students at UC San Diego provide free laser tattoo removal services to justice-impacted adults, gaining hands-on experience in dermatology. The initiative, which has been well-received, enhances medical education, social justice engagement, and patient care in underserved communities.
Researchers found that ultrafine bubble showers significantly suppressed inflammation in mice with atopic dermatitis caused by external factors. The treatment also improved skin protective barrier proteins. However, no significant effects were seen in mice with atopic dermatitis caused by genetic factors.
Researchers found no clear evidence that red wine mitigates cancer risk, and instead observed a distinction in skin cancer risk. White wine consumption was associated with an increased risk of skin cancer compared to red wine, particularly among women. Heavy wine consumption may correlate to high-risk behaviors.
Researchers re-analyzed data for 111 products and found significant associations between production process, ingredient composition, and benzene levels. The study suggests opportunities to improve formulation, production, and distribution of benzoyl peroxide containing products to reduce the likelihood of them degrading into benzene.
A natural compound derived from gut-friendly bacteria significantly slows vitiligo progression and may restore pigmentation in mice. The findings could offer hope to millions affected by the autoimmune disease, which causes visible patches of skin discoloration and carries profound emotional and physical consequences.
The São Paulo Advanced School on Precision Health will bring together 100 students from Brazilian and international universities to discuss precision health through a One Health vision. The school features state-of-the-art science presentations and interactions with world-class researchers and health startup founders.
A new study from Mass General Brigham found that approximately 1-in-5 patients experience acne recurrence after isotretinoin treatment. The researchers identified factors that increase the risk of recurrence, including female gender and lower cumulative dosages.
A Swedish study found that topical steroid withdrawal (TSW) is characterized by symptoms such as redness, pain, and itching, often accompanied by sleep problems. The study aimed to understand the phenomenon of TSW, which many patients consider a cortisone dependence.
Researchers found that SYM2081 suppressed mast cell degranulation and proliferation in mouse models and human skin samples, paving the way for new topical treatments to prevent itching and inflammation. The study suggests that activating GluK2 could be a promising way to prevent rosacea and other inflammatory skin conditions.
The University of Cincinnati College of Medicine has launched a styrofoam recycling project to divert over 900 pounds of EPS waste from landfills each month. The program aims to reuse existing styrofoam materials, reducing the need for styrene and minimizing environmental impact.
A study suggests that low doses of the commonly prescribed hair loss treatment minoxidil are safe and effective for regrowing hair in most breast cancer patients. The researchers found that all participants who took a low dose of oral minoxidil saw improvements in hair growth or stabilization within three to six months.
The digital age is transforming cosmetic dermatology, with technologies like AI and telehealth pushing boundaries. However, challenges arise from social media's influence on skin advice and the need for in-person exams to ensure patient safety.
Researchers identified three subtypes of fibroblasts in skin cancer: myofibroblast-like RGS5+ CAFs, matrix CAFs (mCAFs), and immunomodulatory CAFs (iCAFs). The distribution of these subtypes varies with tumor aggressiveness. iCAFs produce signaling factors to activate immune cells, while mCAFs prevent T cell invasion.
The study combines AI with fluorescence photography to enhance skin diagnostics, allowing for earlier detection of skin conditions such as acne, photoaging, and hyperpigmentation. AI can pinpoint early indicators of skin conditions with greater accuracy and monitor changes over time for data-driven decisions.