Articles tagged with Dermatology
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Patients with Merkel cell carcinoma face a high risk of recurrence, with 95% of cases occurring within the first three years. The study found that advanced age, male sex, immunosuppression, and known primary lesions are associated with higher recurrence rates, highlighting the need for targeted surveillance efforts.
Researchers at UC San Diego have made a groundbreaking discovery about the role of fibroblasts, or fat cells, in controlling bacteria and developing acne. These findings could lead to more targeted treatment options for acne, which affects up to 50 million Americans each year.
A recent study has identified 29 new genetic variants associated with acne, providing potential new targets for treatment and helping clinicians identify individuals at high risk of severe disease. The research, involving over 20,000 individuals with acne, also found a link between genetic risk and disease severity.
Researchers found sublingual immunotherapy with house dust mite extract to be effective in reducing signs and symptoms of atopic dermatitis. The treatment, administered over 18 months, resulted in significant improvements in pruritus and lesions, with rare side effects.
A UC Davis Health study found that taking bile acids or treatments regulating their production levels can help control psoriasis inflammation. Bile acids inhibited skin inflammation by stopping immune T cells from producing proinflammatory protein IL-17A and blocking immune cell movement to the site.
A review of 392 clinical trials found increased representation of diverse groups in dermatology trials for common skin conditions. The study also highlighted persistent disparities in clinical trial participation among underrepresented populations.
Researchers have developed a cream that prevents frostbite injuries in mice when applied to the skin before severe cold exposure. The cream, called SynAFP, reduces frostbite wound size and speeds healing compared to no treatment. Further studies are needed to determine its effects on humans.
A new algorithm, FusionM4Net, has been developed to classify skin lesions with improved diagnostic accuracy. The algorithm uses a multi-stage data fusion process and outperforms previous state-of-the-art algorithms.
Patients with skin-related side effects from immune checkpoint inhibitors tend to live longer, with a 22-50% decrease in mortality. These findings suggest that skin toxicities can be an indicator of treatment efficacy and may help identify patients who are more likely to benefit from their current immunotherapy regimen.
Researchers discovered that wound macrophages undergo different metabolic programs to coordinate tissue repair, including the use of reactive oxygen radicals for blood vessel growth. Macrophages also utilize a different type of mitochondrial exchange for anti-inflammatory and reparative functions in late-stage wound healing.
A new study suggests that sun exposure may reduce the risk of multiple sclerosis in children and young adults by up to 52%. Vitamin D levels are also found to be higher in individuals with increased sun exposure, which may play a role in protecting against autoimmune diseases.
A Michigan Medicine study combined genetic samples from patients of different ethnic backgrounds, identifying two new psoriasis genetic signals. The inclusion of South Asian subjects allowed researchers to pinpoint several genetic variations within HLA genes that are likely to play a causal role in psoriasis.
A new virtual histology technology may reduce the need for invasive skin biopsies, providing a biopsy-free solution for rapid diagnosis of malignant skin tumors. The technology uses deep-learning frameworks to transform images of intact skin into detailed, virtually stained images.
Researchers have identified specific skin microbiome bacteria and their pathways as contributing to ageing skin. The study, published in PLOS ONE, used a novel approach to chart host-microbe co-metabolism in skin aging.
A survey of 1,300 US dermatologists reveals that 74% identify as LGBT and most disclose their status to patients. The study highlights the importance of creating inclusive workplaces for LGBT healthcare professionals.
Scientists from Japan discover IL-36Ra plays a pivotal role in wound healing, and Cl-amidine normalizes exacerbated I/R injury. The study's findings suggest IL-36Ra as a potential therapeutic target for cutaneous I/R injuries.
A new study reveals that certain strains of Cutibacterium acnes (C. acnes) found on healthy skin can prolong the lifespan of Caenorhabditis elegans and help its innate immune system fight against Staphylococcus aureus. RNA sequencing analysis also shows these beneficial strains activate genes related to innate immunity.
Researchers have discovered a new type of skin cell, TIFFs, that may play a role in inflammatory skin diseases such as scleroderma. These cells were found to interact with immune cells and expand in response to inflammation, leading to an exaggerated response and fibrosis.
Burt's Bees research finds that natural origin ingredients like bakuchiol, aloe, and rice milk improve skin health for all skin types and tones. The studies also show that these ingredients can restore skin barrier function and lead to positive subject-reported improvements.
Researchers identified a bacterium on healthy cats that produces antibiotics against severe skin infections in humans and pets. The discovery may lead to new treatments for MRSP infections in dogs and potentially other inflammatory skin diseases.
Researchers discovered that skin-derived T cells can migrate into the bloodstream and cause inflammation in other organs, such as the intestine. The study provides new approaches to therapy and diagnostic options for stem cell transplantation.
A new study reveals that COVID toes symptoms are caused by an immune response involving high levels of autoantibodies and type I interferon. Endothelial cells also play a crucial role in the development of the condition, according to the research published in the British Journal of Dermatology.
A study published in British Journal of Clinical Pharmacology found a potential link between blood pressure medication use and the development of psoriasis. Data from 13 studies suggests that certain types of antihypertensive medications may increase the risk of skin conditions, warranting close monitoring.
Researchers found glycerin, a natural ingredient in many skin lotions, reduces psoriasis symptoms by calming scaly patches and promoting healthy skin cell maturation. The study's results support anecdotal reports from patients with psoriasis, providing objective evidence of glycerin's effectiveness in combatting the condition.
Researchers found chronic spontaneous urticaria is less severe in children, with lower rates of angioedema and thyroid autoimmunity. Children also respond better to antihistamines compared to adults.
Researchers discovered a link between genital warts and the human leukocyte antigen system, suggesting genetic variants influence risk. The study found protective gene variations that enhance immune responses against HPV, while risk alleles increase susceptibility to genital warts.
A new portable photodynamic therapy (PDT) device has been developed to treat basal cell carcinoma (BCC) at home, significantly reducing pain levels during treatment. The pilot study suggests that this at-home treatment is as effective as traditional hospital-based treatment and may have a huge impact on the global treatment of BCC.
A new EADV survey found that 47.9% of Europeans aged 18+ reported at least one skin condition in the past year, with fungal infections being the most common. The study, involving 44,689 adults from 27 countries, also revealed a lack of homogeneous data on the impact of skin diseases on quality of life.
A new study found that direct-to-consumer skin cancer detection apps fail to detect life-threatening cancers like Merkel cell carcinoma and amelanotic melanoma. The apps' high false positive rate poses a significant risk to personal and societal health.
Researchers analyzed real-world data on biologic treatment and COVID-19 vaccine hesitancy in psoriasis patients. Sentiment analysis revealed that vaccine hesitation was driven by concerns about side effects, autoimmune conditions, and lack of trial data.
Researchers identified a new cell type in human skin contributing to AD and psoriasis, highlighting potential therapeutic targets. The study revealed CD14+ type 3 dendritic cells co-producing IL1B and IL23A, essential for PSO pathogenesis.
Severe eczema was associated with symptoms of depression and internalizing behaviors throughout childhood and adolescence. The observational study included 11,000 children from the United Kingdom.
The FDA has granted orphan drug status to Octagam 10%, the first and only IVIg treatment for adult dermatomyositis. The therapy is expected to become the first treatment option for adults with this rare disease, which affects approximately 10 out of every million U.S. residents.
Researchers analyzed claims data to identify key demographic characteristics of patients receiving a sunburn diagnosis. The study found that patients with sunburn tend to be older, female, and have a history of previous sunburns or skin cancers.
A phase II clinical trial of remetinostat gel found a 69.7% response rate to the topical treatment, with complete responses observed across multiple BCC subtypes, and a durable response in nodular BCCs.
A systematic evaluation of COVID-19 studies in patients with psoriasis and psoriatic arthritis found high risk of bias and quality issues. The median score for all studies was 47.2% indicating a high risk of bias, mainly due to selection bias.
The study explores how adult women experience acne's influence on their lives, finding it affects self-esteem and relationships. Adult women describe the negative emotional impacts of acne on their daily lives.
A research team from City University of Hong Kong has designed a simple electromechanical device that can detect skin disorders such as psoriasis by measuring tissue stiffness. The device provides real-time evaluations of deep tissue stiffness, allowing for accurate targeting of lesions and monitoring of skin health status.
A study of 582 participants found that over two-thirds have developed hand dermatitis due to increased hand washing and use of alcohol-based rubs during COVID-19. The study suggests that skin barrier function can help identify suitable modifications to prevent hand eczema.
A modified 5:2 diet has shown promising results in reducing scaling and thickness of skin symptoms in psoriasis patients. The study found a significant reduction in Psoriasis severity after following the MIF diet, with 30% of patients reporting a decrease in itching.
Etrasimod demonstrated clinically meaningful improvements in both clinical signs of atopic dermatitis and patient reported outcomes. The treatment group achieved statistical significance in the percentage change in weekly peak pruritis, Dermatology Life Quality Index (DLQI), and Patient-Oriented Eczema Measure (POEM).
An observational study found that areas with higher levels of UVA rays had a lower risk of Covid-19-related deaths. The researchers suggest sunlight exposure could act as a simple public health intervention to reduce mortality rates, although the exact mechanism is still unclear.
This study assesses dermatologists' perceptions of and experiences with teledermatology in the context of the COVID-19 pandemic. Dermatologists express varying opinions on teledermatology's long-term viability, citing concerns about parity in reimbursements between video and in-person visits.
A new CAD system uses convolutional deep neural networks to identify skin cancer earlier, analyzing multiple lesions and comparing them to a 'ugly duckling' metric. The technology improved upon previous systems with 90.3% sensitivity and 89.9% specificity.
Research suggests that acne can leave lasting psychological scars, particularly for women and adolescents with darker skin, affecting self-esteem and mental health. A new study calls for a comprehensive approach to treating acne, integrating psychology and dermatology.
A new AI algorithm has demonstrated the ability to accurately diagnose skin melanoma, rivaling that of experienced dermatologists. The study used machine learning to analyze 937 images and 200 cases, with results showing no significant difference between human dermatologists and the algorithm in making classifications.
This article revisits the pivotal role of dermatologists in the early HIV/AIDS epidemic, highlighting their contributions to diagnosis, treatment, and public awareness. The study's findings emphasize the importance of dermatologists in addressing skin-related issues during this critical period.
A recent human study found that consuming grapes protected against ultraviolet (UV) skin damage by increasing resistance to sunburn and reducing markers of UV damage. The study attributed these beneficial effects to the natural components polyphenols in grapes, which may act as an edible sunscreen offering additional protection.
A survey of 47% of patients reported increased satisfaction with time efficiency, lack of transportation needs, and effective social distancing. Only a small minority (6.9%) stated they would not recommend telehealth services.
Researchers found that social media-based diagnoses were accurate about 60% of the time, similar to teledermatology consultations. Dermatologists' active involvement in crowdsourced responses led to more accurate diagnoses.
A new study finds that telemedicine can significantly reduce dermatology consult times, from 84 days to under five hours. The study suggests that this approach does not increase utilization or costs, making it a viable option for expanding telemedicine use.
New research suggests that vitamin B3 can protect skin cells from the effects of ultraviolet (UV) exposure. The study found that pre-treatment with nicotinamide, a form of vitamin B3, reduced DNA damage and inflammation in human skin cells exposed to UVB radiation.
Researchers have created a novel, allergen-depleted fragrance with anti-inflammatory properties that soothes xerotic skin. The fragrance, integrated into new Eucerin products, reduces skin redness and improves patient adherence to treatment.
Researchers found that socks coated with zinc oxide nanoparticles significantly reduced bromodosis and pitted keratolysis, two common conditions causing smelly feet. The study demonstrated the antibacterial efficacy of ZnO-NPs, making it a promising compound for textile applications.
Analysis of 990 COVID-19 cases reveals a subset of 'long-haulers' with prolonged dermatological symptoms, including hives and 'COVID toes', persisting for weeks or months. The study highlights the need for further research into COVID-19's impact on skin conditions.
Burt's Bees presents research on bakuchiol, a natural alternative to retinol, with anti-inflammatory properties and improved skin health. The company also highlights the effectiveness of a natural lip balm containing turmeric in providing therapeutic benefits for dry or compromised lips.
A global registry of psoriasis and COVID-19 patients found that over 90% of patients taking immune system drugs survived the pandemic. The risk factors for severe outcomes were similar to those in the general population, with older, male patients and those with certain health conditions being more likely to require hospital admission.
Researchers at Henry Ford Health System used UV-C light to effectively kill COVID-19 on N95 respirators, with two models showing optimal results. The process worked best when paired with fit testing, but may require additional steps like ethanol wipes for maximum safety.
A new study found that follow-up calls made the evening after Mohs micrographic surgery best identified patients with active pain. However, no single group was able to identify bleeding complications or highest pain levels. The study suggests that standard phone calls may not strongly contribute to overall patient satisfaction.
A recent GW survey found that only 25% of young adults consider social media a key factor in choosing a dermatologist. Dermatologists can still leverage social media for patient engagement and education, but it should be used alongside other methods to recruit new patients.