Articles tagged with Gynecology
A mouse study suggests that active testosterone therapy can lead to fewer and less developed eggs retrieved during IVF. Discontinuing testosterone therapy appears to have no significant impact on reproductive capacity, however.
Research presented at the Endocrine Society's annual meeting found that COVID-19 pandemic stress led to disturbed ovulation in many women. Nearly two-thirds of participants experienced short luteal phases or anovulation, indicating a significant impact on reproductive health.
A Phase 3 study found fezolinetant to significantly reduce the frequency and severity of moderate-to-severe vasomotor symptoms associated with menopause. The treatment also improved sleep disturbances, supporting its use for treating moderate-to-severe hot flashes.
Researchers found that nearly 80% of women with blocked fallopian tubes could conceive naturally after a simple diagnostic procedure and treatment, called selective salpingography and fallopian tube recanalization. The study suggests that this treatment could provide clarity on infertility and offer a life-changing option for many women.
A new study finds that progesterone does not prevent preterm birth in women who have had a previous preterm birth. The research calls for revised guidelines on the use of vaginal progesterone in these patients.
Research suggests that mothers-to-be on high-salt diets may increase their children's risk of developing hypertension and cardiovascular conditions. The study found that offspring exposed to a high-salt environment in utero had higher blood pressure and increased predisposition to hypertension, even after weaning.
A Phase 3 clinical trial is investigating the effectiveness of a combination of two immunotherapy drugs, nemvaluekin alfa and pembrolizumab, compared to standard chemotherapy for patients with platinum-resistant ovarian cancer. The trial aims to provide a novel treatment option with better efficacy and safety profiles.
A new study found that family medicine physicians face multiple barriers, including lack of training and institutional restrictions, to providing medical abortions. The study highlights the need for stronger exposure and training opportunities to strengthen access to safe abortion options.
A recent poll found that menopause symptoms significantly impact older women's sex lives, with 84% of women experiencing symptoms in the past year. Despite this, only 44% have discussed treatment with their healthcare provider, while 28% reported symptoms interfering with sexual activity.
A new study by Children's Hospital of Philadelphia found that neighborhood poverty and crowding are associated with higher rates of COVID-19 in pregnancy. Researchers analyzed data from over 5,991 pregnant patients and found disparities in SARS-CoV-2 positivity among different racial and ethnic groups.
A new quality improvement study from Cedars-Sinai found that comprehensive nurse training is key to successfully screening women for postpartum depression. The initiative identified framing the screening as part of family wellness and normalizing the transition to parenthood as helpful strategies.
A cohort study of nearly 1,000 pregnant persons in NYC found that neighborhoods most affected by racism and economic inequality had higher rates of COVID-19 infection and preterm births. The researchers linked structural racism and community unemployment to increased risk of preterm birth.
A new study by UCSF and UCLA finds that nearly half of US OB-GYN residency programs may lack abortion training if Roe v. Wade is overturned, posing significant risks for patient care. The researchers estimate that 44.8% of programs are in states where abortion will be banned, while 43.9% of residents have received training in these sta...
A new study found that hysteroscopic and laparoscopic sterilization procedures have higher-than-expected failure rates of five to six percent at 5 years post-procedure. The study, led by Dr. Aileen Gariepy, used Medicaid claims data to compare the effectiveness of these methods.
A new study reveals funding for fertility preservation policies varies across the UK, with Scotland offering the most inclusive approach. The study highlights the need for standardization of policies to ensure equal access to care for patients.
In a study published in BMJ Open, researchers found that abortion rates remained stable in Sweden during the first pandemic wave, with no significant changes in timing or decision-making. Women who sought abortions did not hesitate to proceed, citing supportive care and reassuring healthcare systems.
The ATHENA-MONO trial shows significant improvements in progression-free survival for patients with advanced ovarian cancer treated with Rubraca as maintenance therapy. Benefit was observed across all patients, including those with homologous recombination deficiency and BRCA mutant tumors.
Researchers found that adding atezolizumab to chemoradiation treatment was safe and demonstrated immune activation in women with node-positive, locally advanced cervical cancer. The study also showed increased peripheral blood T-cell receptor clonal expansion and tumor-associated T-cell clones.
The study found that homologous recombination repair mutant type (HRRmt) was prognostic of progression-free survival and predictive for olaparib activity in women with recurrent platinum-sensitive ovarian cancer. Patients with BRCA mutations showed clinically significant activity when treated with experimental drugs.
A recent study found that mutant clones expand in the normal endometrium through a rhizome structure, which arises from a common ancestral clone. This expansion increases the risk of developing endometriosis and endometrial cancer. The study proposes a new model of clonal expansion in the normal endometrium.
A Phase 3 clinical study of selinexor as maintenance therapy for advanced or recurrent endometrial cancer showed a 30% decrease in hazard for progression or death compared to the placebo-controlled group. Patients with functional p53 genes saw the most pronounced effect, with median progression-free survival at 10 months longer.
A recent study published in Obstetrics and Gynecology found that birthing parents are at a higher risk of financial burden due to out-of-pocket medical costs, with low-income families facing the highest risks. Public health insurance, including Medicaid, was associated with lower risks of catastrophic health expenditures.
Researchers found that high levels of anti-Mullerian hormone (AMH) may cause follicles to mature too quickly, leading to problems with ovulation and fertility in women with PCOS. AMH was previously thought to be a passive byproduct of the disorder.
A meta-analysis of over 3,000 studies found that women with one ovary have a 30% lower chance of becoming pregnant and giving birth after IVF. The study suggests that surgical removal of an ovary has an adverse effect on fertility.
The NRG-GOG 0281/LOGS trial demonstrated that trametinib significantly reduces disease progression and improves response rates in women with recurrent low-grade serous carcinoma of the ovary/peritoneum. The study found a trend towards higher overall survival rates when compared to standard of care options.
In Bangladesh, cesarean sections have increased significantly from 3.88% in 2004 to 33% in 2017/18, but the disparity in access between wealthy and poorer women has grown. The study highlights the need for targeted interventions to address this issue.
A 2018 clinical trial found that patients with early-stage cervical cancer who underwent open surgery had higher progression-free survival rates than those who underwent minimally invasive surgery. Researchers now propose a series of steps to reevaluate the use of MIS in cervical cancer treatment.
Researchers found that advanced paternal age and obesity are associated with lower implantation rates in couples experiencing unexplained recurrent pregnancy loss. The study analyzed nearly 800 couples who underwent IVF treatment, revealing a 12.6% increased risk of implantation failure for every one-unit increase in BMI.
The NRG Oncology GOG 0261 trial demonstrated that paclitaxel and carboplatin is a non-inferior alternative to paclitaxel and ifosfamide for treating women with uterine carcinosarcoma. This regimen offers improved progression-free survival and overall survival compared to the current standard of care.
A NIH-funded study discovered a small, temporary increase in menstrual cycle length among women receiving COVID-19 vaccine. The average increase was less than one day, with no change in bleeding days.
Chronic hypertension is driving rising maternal mortality rates in the US, particularly among Black women. The study highlights a 15-fold increase in maternal mortality associated with chronic hypertension over 40 years.
A new study found that COVID-19 vaccination during pregnancy elicits high levels of antibodies in both mother and baby, regardless of when it occurs. The research suggests that pregnant women should not delay vaccination until late pregnancy, as it is likely to be beneficial for themselves and their babies.
A new NRG Oncology clinical trial found that bupropion did not improve sexual desire in female cancer survivors. The trial evaluated the effects of extended-release bupropion on postmenopausal women with low baseline sexual desire scores.
A study of over 200,500 women found an increased risk of death in younger pre-menopausal women when ovaries and fallopian tubes were removed during surgery. In contrast, the procedure is safer for older post-menopausal women, whose ovaries have already stopped producing estrogen.
Researchers at Hokkaido University analyzed hundreds of women with ovarian granulosa cell tumors to improve understanding of the disease progression and response to therapy. They found that early-stage tumors rarely spread beyond the ovaries, and fertility-sparing surgery may be considered for younger patients.
Women living in neighborhoods with more green space experienced fewer PMS symptoms, including anxiety, depression, difficulty sleeping, and breast tenderness. Long-term exposure to green space was found to have beneficial effects on psychological symptoms of PMS.
Scientists used single-cell sequencing to analyze over 150,000 cells from 11 tumor samples, discovering novel mechanisms of tumor development and identifying potential targets for therapy. The findings may lead to personalized medicine and improved treatment options for gynecologic cancers.
The AACR and Pelotonia launch a grants program to recognize five influential female researchers in breast and gynecologic cancers. Nomination deadlines are January 14, 2022, with awards presented at the AACR Annual Meeting 2022.
Researchers have identified metabolic signatures in blood plasma that can predict a patient's response to chemotherapy and prognosis. This discovery enables physicians to personalize treatment and enhance its efficiency, leading to improved outcomes for patients with gynecologic tumors.
Researchers found that nearly 75% of pregnant women with stretch marks reported moderate to prominent embarrassment, which impacted their social activities, self-esteem, and clothing choices. The study highlights the need for open discussions about stretch marks to normalize them and identify potential mental health issues.
A new smartphone app, MyHealthyPregnancy, evaluates preeclampsia risk and patient adherence to low-dose aspirin recommendations. The study found that 37% of high-risk patients were unaware they needed to take the medication, highlighting a need for improved communication between providers and patients.
A recent study analyzing over 10,000 community births in Washington state between 2015 and 2020 found that planned home births with licensed midwives are as safe as births at a licensed birth center. The research team discovered no increased risk for parents or babies associated with the birth setting.
The study reveals that G6PD is associated with elevated expression of genes involved in glutathione-mediated redox metabolism, leading to chemoresistance. Patient-derived spheroids derived from clinical specimens showed diverse heterogeneity in chemoresistance against platinum-based compounds.
A study of over 29,000 American women found that breastfeeding significantly reduces the risk of postpartum depression. Women who breastfed for longer periods had lower rates of postpartum depression, with those breastfeeding for 6-12 months showing the greatest reduction.
A new Northwestern Medicine study found that over half of US women and people who menstruate experienced changes in their menstrual cycle due to COVID-19 pandemic stress. Individuals with higher levels of stress reported heavier bleeding and longer periods.
A recent systematic review and meta-analysis found that COVID-19 infection during pregnancy significantly increases the risk of developing preeclampsia. Women with SARS-CoV-2 infection had a 62% higher odds of developing preeclampsia than those without the infection.
The KEYNOTE-826 study found that adding immunotherapy to standard first-line treatment increases overall survival by eight months for patients with recurrent, persistent or metastatic cervical cancer. The addition of pembrolizumab to chemotherapy also reduced the risk of death and disease progression by 33%.
A multidisciplinary organization has reached consensus on guidelines for performing, interpreting, and reporting MR defecography. The consensus templates aim to standardize care for patients with evacuation disorders of the pelvic floor.
A new health program aims to improve pregnancy outcomes for Black patients by combining four evidence-based strategies, including racially concordant care providers and coordinated care. The five-year study will enroll 432 women and compare their experiences with usual maternity care versus a new model.
Researchers from UNC School of Medicine, MAHEC, and community partners will address racial disparities in maternal care by improving data accountability and providing community-based doula support. The study aims to decrease pregnancy complications for Black women and improve outcomes in maternal care.
Researchers determined that a woman's 'vascular age' is a better indicator for cardiovascular disease risk than her chronological age or years since menopause. Hormone therapy brings increased risk of cardiovascular disease, but 'vascular age' provides a clearer answer for physicians making decisions about hormone therapy.
Researchers found that Veillonellaceae family members contribute to disease by altering inflammation and metabolism in the cervicovaginal region. The study also identified three specific bacteria species - V. atypica, V. montpellierensis, and M. micronuciformis - that increase inflammation and promote cell death.
A study found that nearly half of patients with gynecologic cancer experience financial toxicity, which can lead to worsening health outcomes. Younger patients are at a higher risk due to limited financial safety nets and ability to work.
A recent study found that tens of thousands of women visited the emergency room for fibroid symptoms, with only 1 in 10 leading to hospital admission. The study suggests that many cases could have been managed in an alternative non-urgent health setting.
A Swedish study found a link between HPV infection and increased risk of preterm birth, even in women without previous abnormal cell changes. The study included over 1 million births and suggested that vaccination against HPV may be beneficial for pregnancy outcomes.
Researchers found that the proportion of non-white residents increased among obstetrics and gynecology, surgical, and nonsurgical training programs. The study suggests improvements in diversity and inclusion efforts are needed to address racial and ethnic disparities in medical education.
A recent study published in JAMA Pediatrics examined the association between paternal drinking before pregnancy and the risk of birth defects in Chinese children. The research found a significant correlation, suggesting that fathers' consumption of alcohol prior to conception may pose a potential threat to fetal development.
Decision theory enhances treatment choices by considering multiple possibilities in contradictory diagnostic findings, as shown in a study of 3753 breast cancer patients. The approach outperformed conventional statistics, providing more accurate results and improving patient outcomes.
Vaccines against diseases like influenza and whooping cough have shown to be lifesaving when administered during pregnancy. Pregnant women are at increased risk of preterm birth or pregnancy loss if they develop severe COVID-19, highlighting the need for guidance on vaccine administration.
Researchers at Johns Hopkins Medicine have developed a new experimental therapy that prevents premature birth using nanosized particles of drugs. The treatment decreases contractions in uterine muscles and could be a clinical option for preventing preterm labor.