Articles tagged with Immune System
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Researchers at EPFL have created a prototype vaccine that can travel to the desired location and activate immune cells, overcoming two major obstacles in therapeutic cancer vaccines. The Polycondensate Neoepitope (PNE) combines a patented technique with an algorithm for predicting mutated tumor antigens.
Researchers found that bats' unique immune response drives viruses to replicate faster, making them deadlier in humans. The study suggests that disrupting bat habitats could increase the threat of zoonosis.
A study published in Nature Communications reveals a major link between protein FHR4 and age-related macular degeneration, affecting 1.5 million people in the UK alone. The findings show that higher levels of FHR4 in the blood increase the risk of AMD by activating part of the immune system.
Researchers charted immune system development in sub-Saharan African children to improve vaccine efficacy. Their findings suggest that a child's age, location, and health status influence their immune response to vaccines.
A new study by Swiss TPH and partners found that age, location, and anaemia status significantly impact childhood immune system development. The research suggests that considering these factors can improve the efficacy of childhood vaccinations, particularly in low- and middle-income countries where anaemia is prevalent.
A fungal pathogen, Cryptococcus neoformans, has been found to use an enzyme called chitosan deacetylase to alter its cell wall structure, making it invisible to the human immune system. Researchers have identified a new chitosan deacetylase that is crucial for the fungus's ability to evade detection.
Researchers found that significantly reducing dietary methionine slows the progression of inflammatory and autoimmune disorders like multiple sclerosis. Methionine fuels T cells, which can cause inflammation and damage if it lingers.
Researchers discovered that activating a mosquito's immune system can prevent the transmission of disease-causing parasites like Dirofilaria immitis and Brugia malayi. By boosting the immune response, mosquitoes can block parasite development, potentially stopping diseases like canine heartworm and human lymphatic filariasis.
A severely infected patient revealed a rare genetic variation in immune deficiency, linked to CMV control. Researchers sequenced the man's genes and found a mutation in NOS2, a critical component of macrophages that kill microbes.
Research finds that low levels of infection can cause chronic bladder dysfunction and magnify sensations felt by patients with urinary tract infections. Understanding how nerves transmit different sensations to the brain could help limit bladder dysfunction in overactive bladder patients.
Researchers developed immunocompromised mice by disabling genes involved in autophagy, which allows them to fight off Listeria monocytogenes bacteria. The study suggests a permanently active immune system can be beneficial against certain pathogens, but also poses risks of chronic inflammation.
Scientists at the University of Münster have developed a vaccine-like treatment that stimulates plants' natural immune system using a specific pattern in chitosan, a biopolymer. This breakthrough could lead to reduced chemical pesticide use and improved plant growth, as well as potential applications in scar-free wound healing.
Researchers propose combining fever resistance with temporary tolerance promoted by controlled hypothermia for studying and treating severe conditions like sepsis. This innovative concept aims to understand human physiology's integrated defense strategies against infection.
Scientists have found a novel method to combat glioblastoma, a deadly brain tumor, by introducing VEGF-C into the cerebrospinal fluid of mice. This approach significantly extended survival rates when combined with immune system checkpoint inhibitors, offering new hope for treatment options.
Researchers at Karolinska Institutet discovered that MAIT cells respond with dynamic activity and reprogramming of gene expression during acute HIV infection. The study sheds light on the immune system's response to this phase of HIV infection.
Scientists found that nerve cells release infection-fighting cytokines to combat bacterial invaders, rather than immune cells. This discovery provides new insights into the body's response to food poisoning and other illnesses.
Researchers identified growth differentiation factor 15 (GDF15) as a key player in delaying type 1 diabetes onset in diabetic mice. Treatment with GDF15 reduced development of diabetes by 53% in non-obese diabetic mice, providing a potential target for prevention and treatment.
Research shows that maternal microbiota provides immunity to newborns against E. coli, a disease-causing microbe. The study reveals that antibodies are passed on to offspring through milk and the placenta, offering protection beyond just breastfeeding.
Scientists from the German Cancer Research Center have identified a receptor on murine immune cells that activates a protective mechanism preventing unwanted immune responses against the body's own tissues. Dectin-1 binds to annexins on dying cells, suppressing the immune response and preventing autoimmune reactions.
Scientists have discovered a molecular foundation for bacterial exposure as a potential environmental factor in coeliac disease development. Receptors from immune T cells can recognize protein fragments from certain bacteria that mimic gluten, leading to aberrant recognition and health problems.
A team led by CSHL Professor David Jackson has identified a gene in corn that contributes to both plant development and immune system control. Manipulating this gene, Gß, could increase crop yields by reprogramming the balance between growth and defense.
Researchers found that the sympathetic nervous system can limit the generation of effector responses by inhibiting the action of cells attacking an antigen. This discovery opens up opportunities for novel therapies in autoimmune diseases like multiple sclerosis.
Researchers found that a molecularly similar regulator to PD-1, PD-1H, can cause immune system attacks in lupus patients. This discovery suggests novel ways to restore function and provide new therapy for the disease.
A recent study found that probiotics and prebiotics have distinct effects on the immune systems of male and female piglets, contradicting previous assumptions. This research highlights the importance of considering sex in nutritional trials and may lead to personalized treatment approaches for infants.
Researchers at Duke University Medical Center developed an immunogen that selectively bound to antibodies with necessary mutations, which led to the production of potent neutralizing antibodies. The study demonstrates the ability to engineer the immune system to create an environment where effective antibodies can be made.
A new pathway in the central nervous system removes brain waste substances through the creation of corpora amylacea (CA), aggregates formed by glucose polymers. CA acts as waste substance containers that are expelled from the nervous system and removed by the immune system.
Researchers describe how ancestral origins impact the likelihood of developing immune-related diseases, including Crohn's disease and cardiovascular diseases. The human immune system is evolving depending on a person's location or lifestyle, leading to new diseases emerging as our lifespans increase.
Scientists have identified nearly thousand ISG15 sites on protein targets during bacterial infection, revealing a link between ISG15, cellular metabolism, and autophagy. This discovery may lead to novel antimicrobial drugs.
Professor Muzlifah Haniffa has made significant contributions to biomedical science, including mapping the maternal-fetal interface and discovering new immune cells in the skin. Her work aims to improve understanding of health and disease, particularly in childhood kidney cancer.
Researchers develop a new technique to detect activated complement pathway in patients with thrombotic microangiopathies (TMA), allowing clinicians to determine potential use of existing treatment for other diseases. The technique could lead to improved diagnosis and treatment of secondary TMAs, such as pre-eclampsia and HELLP syndrome.
Patients with diverse HLA genes respond better to immune checkpoint inhibitors, surviving longer with improved treatment outcomes.
A new phase 2 clinical trial shows that technology can induce immune tolerance to gluten in individuals with celiac disease, reducing inflammation and protecting the small intestine. The treatment, called CNP-101, is a biodegradable nanoparticle containing gluten that convinces the immune system it's safe.
New research from UChicago shows how genetic differences in the immune system shape the collections of bacteria that colonize the digestive system. Genetic variations in innate immunity play a key role in determining microbial composition.
A new study has found that nearly 70% of children with an immune deficiency had two or more bouts of invasive pneumococcal disease. The research suggests that a weakened immune system increases the risk of life-threatening bacterial infections such as pneumonia, meningitis, and sepsis.
Research found that 45-year-old slow walkers have 'accelerated aging' on a 19-measure scale, with poorer lung function, teeth, and immune systems compared to faster walkers. Early life neurocognitive testing also predicted walking speed at age 45.
Researchers at CNIO and the University of Würzburg have solved the 3D structure of the T7SS nanomachine used by Mycobacterium tuberculosis to evade the immune system. This finding provides crucial information for developing new therapeutic strategies against tuberculosis, a disease that kills over 1.6 million people worldwide each year.
The study aims to examine the efficacy of a drug that inhibits an enzyme used by brain tumors to protect themselves from the immune response. Adding the inhibitor to chemotherapy and radiation therapy may enable lower doses, better quality of life, and improved survival for children with recurrent or newly diagnosed brain tumors.
Researchers from Aarhus University discovered that Parkinson's patients have an immune imbalance in their blood, affecting the regulation of immune cells and anti-inflammatory molecules. This finding advocates for immune modulation as a potential alternative treatment for the disease.
New research reveals that maternal exposure to industrial pollution can harm offspring's immune system and pass on the weakness to subsequent generations. The study, conducted in mice, suggests that this multigenerational weakening of the immune system could explain variations in responses to flu infection.
Researchers at King's College London have discovered that β-Galactoside-Binding Protein (βGBP) can selectively target and kill cancer cells while stimulating the immune system to provide long-term protection against cancer recurrence. The study presents a promising new strategy for treating aggressive forms of cancer.
Researchers have created the first cell atlas of the human kidney's immune system, charting the communities of immune cells in different zones. The atlas shows how the immune system develops during early life and strengthens after birth, with implications for tackling kidney disease and transplant rejection.
A recent study found that modern humans acquired a gene variant from Denisovans that increases immune reactions and protective responses to disease-causing microbes. The Denisovan gene variant, I207L, was discovered in families with severe autoimmune conditions and was also present in an extinct human species found in the Altai Mountains.
A study of lemur scents reveals that an individual's distinctive body odor reflects genetic differences in their immune system. Females pay more attention to the scents of males with different immune genes, which could lead to more diverse and resilient offspring.
A new pathway has been identified as a potential treatment target for Crohn's disease, a form of inflammatory bowel disease that affects millions in the US. The study suggests that blocking a specific protein receptor may ameliorate inflammation and fibrosis in CD patients.
Two known gene mutations, KRAS and TP53, induce pathways that enhance pancreatic cancer's ability to invade tissues and evade the immune system. Mutations in these genes are closely linked to pancreatic ductal adenocarcinoma, a type of pancreatic cancer with a low five-year survival rate.
A study published in Frontiers in Immunology found that rural Amish babies had a more diverse and beneficial gut microbiome than urban babies, which led to a more robust development of the respiratory immune system. The researchers used fecal transplants from Amish babies to colonize the guts of newborn pigs, showing a connection betwe...
Scientists deciphered how YopO changes its shape to confuse the immune system, disrupting communication and allowing bacteria to evade digestion. Understanding this process may lead to developing targeted, tailor-made substances to inhibit plague pathogens.
Researchers found that the rate at which a patient's immune system clears slow-growing variants of methicillin-resistant Staphylococcus aureus (MRSA) is crucial in determining whether antibiotics can cure the infection. A new mathematical model suggests that a drug targeting slow-growing MRSA variants may be the most effective treatmen...
A new shingles vaccine has been shown to effectively prevent outbreaks of the painful rash among patients who have undergone stem cell transplantation. The study found that the vaccine reduced the incidence of shingles by 68% and related complications, offering promise for patients with immune-compromising conditions.
Scientists have discovered a newly found function of the US11 protein that impairs antibody immunity, allowing human cytomegalovirus (HCMV) to evade white blood cells and potentially leading to birth defects and immune system dysfunction. This breakthrough has significant therapeutic prospects for treating autoimmune diseases like lupus.
Research at Lund University reveals that prey animals with a weaker immune system have an increased risk of illness due to chronic stress from predator presence. The study found that bold individuals with a greater need for defense exhibit a better immune response.
Research found that female bedbugs can cleverly manage their immune systems in anticipation of mating-related infection, allowing them to resist traumatic insemination and improve reproductive success. This ability may also be shared by other insects and could help control bedbug populations.
Female bed bugs exhibit induced antibacterial humoral immune responses when fed regularly, with a 22% increase in longevity compared to unpredictable feeding schedules. Anticipation of mating-associated infection through feeding cues may influence reproductive immune anticipation.
Researchers identified a crucial protein, Tox, that triggers dysfunctional immune responses in the body. This 'exhaustion mode' can be beneficial as it prevents excessive damage to cells and tissue but also allows tumor growth.
Aphids and insect-infecting viruses like PLRV and MpDNV transmit crop damage worth billions annually. Researchers found a cooperative relationship between the two, increasing the likelihood of viral spread.
Researchers at Arizona State University have developed a new hypothesis to explain the phenomenon of women being more prone to autoimmune diseases like multiple sclerosis and lupus. The Pregnancy Compensation Hypothesis suggests that women's immune systems evolved to facilitate survival during pregnancy, leading to heightened immune su...
Ferroptotic cancer cells can stimulate the immune system, leading to activation of anticancer immunity. However, tumor cells dying by ferroptosis can also cause suppression of an antitumor immune response, contributing to cancer progression.
Researchers Nicolae Morar and Brendan J. M. Bohannan examine five common conceptual frameworks describing the human microbiome, highlighting their benefits and drawbacks. The study suggests a pragmatic approach considering all metaphors to explore therapies for diseases and disorders.
A new study suggests that chronic inflammation disrupts the brain's dopamine system, leading to motivational impairments in depression, schizophrenia, and other disorders. The researchers developed a computational method to test their theory, which may yield insights into treating cases of depression and behavioral disorders.
A new study by immunologists at the Babraham Institute has shown that fecal transplants from young mice can replenish and boost the gut microbiome of older mice, rejuvenating their immune system. The research suggests that targeting the gut microbiome could be a way to treat age-related symptoms and facilitate healthy aging.