Articles tagged with Immune System
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Researchers discovered that when the foreign antigen is more flexible, the germinal centre can employ a greater number of evolution strategies to make antibodies that bind foreign but not self-molecules. The study provides new insights for vaccine design and may help address the major roadblock in generating effective HIV vaccines.
Researchers discovered that a rare COVID-19 related illness in children, known as PIMS-TS, causes severe inflammation and alters the immune system. The study found increased levels of cytokines and reduced white blood cells in affected children, but these changes gradually returned to normal after recovery.
Researchers at NTNU have filmed the process of tuberculosis infection in a cell, revealing how the bacterium evades the body's immune system. The study shows how TB bacteria hide inside macrophages and trigger an explosive immune response to spread further.
A study found that younger and female patients accumulate more cancer-causing genetic mutations, making them less visible to the immune system. This selective pressure leads to poorer response rates to immunotherapy.
Researchers from the University of Otago have discovered that viruses can use a 'decoy' strategy to evade the immune system. By acquiring a membrane inside the nucleus of infected cells, these viruses can travel through different environments and avoid detection by the immune system.
A study published in Immunity identified five humoral immune response markers that can correctly classify convalescent COVID-19 patients and those who did not survive the disease. These markers, including IgM and IgA1 responses to S protein and N protein, were able to predict patient outcomes more accurately than demographic factors.
The study found that immune cells are produced in large quantities but their function is defective, leading to an ineffective immune response against the virus. In severe cases, immature cells with inhibitory effects on the immune response prevail.
Researchers have developed a method to investigate how cancer cells evade the immune system, revealing that some genes can be downregulated over time to avoid detection. The study suggests that targeting these genes could lead to more effective immune therapies.
Researchers found that people with age-related macular degeneration, a disorder caused by overactive complement, are at greater risk of developing severe complications and dying from COVID. Complement inhibitors may help treat patients with severe disease.
Researchers at UVA School of Medicine discovered that brain defenders called microglia release a unique immune molecule to control the parasite in the brain, preventing symptomatic toxoplasmosis. This finding has implications for brain infections, neurodegenerative diseases and autoimmune disorders.
A study finds that immune suppression in older adults is reversible and can be relieved by targeting a specific cell type. This breakthrough could lead to more effective flu vaccines and potentially COVID-19 vaccines, increasing protection for seniors.
Researchers found that psychological recovery can take place while still experiencing stressful conditions, contrary to previous research. Employees reported feeling less powerless and more authentic within two weeks of the crisis beginning.
A study has identified genetic variants that may contribute to the development of chronic immune and inflammatory diseases, such as type 1 diabetes and rheumatoid arthritis, in early childhood. The research found thousands of genetic variants driving gene expression across different conditions.
Researchers identified TLR7 as an essential player in the immune response against SARS-CoV-2. Mutations in this gene can lead to severe illness, highlighting a potential link between genetic factors and COVID-19 severity.
Researchers discovered brain-resident immune cells that play a crucial role in normal brain development and are essential for the regulation of brain functions. The findings suggest a connection between gut bacteria, white blood cells, and neurological diseases.
Researchers have uncovered how immune cells use chemical signals to navigate to the lymph nodes, where they help combat harmful bacteria and viruses. This discovery may pave the way for new treatments and a better understanding of why the immune system sometimes fails.
Researchers discover that alcohol activates microglia in the brain, altering geometry and increasing dopamine diffusion, which may promote addiction. This study provides a new understanding of alcohol's effects on the brain and suggests potential treatments.
Researchers developed a breakthrough technology to resolve the problem of nanoparticles being cleared from the bloodstream too quickly. By exploiting the body's natural process of eliminating old red blood cells, they found an elegant solution that prolongs blood circulation for virtually any nanomedicine.
A Rutgers researcher has found that a weakened immune system, rather than HIV itself, contributes to the prevalence of dental cavities in children. The study, published in Scientific Reports, sampled nearly 300 children and found that those with normal immunity levels had lower cavity rates, regardless of HIV status
Researchers from Peter the Great St.Petersburg Polytechnic University and Tsinghua University created a dynamic light scattering method to determine immune complex sizes in blood serum. The new method can detect diseases, such as autoimmune disorders and cancer, by analyzing changes in immune complex concentrations.
Researchers found that bats' ability to control inflammation may hold clues to developing new treatments for diseases in humans. By understanding the mechanisms underlying bats' unique abilities, scientists may be able to develop therapies to fight diseases like COVID-19.
Researchers developed a stable 'mirror-image' peptide that effectively blocks the interaction between TIGIT and its ligand PVR, inhibiting tumor growth and metastasis. This approach offers an alternative point of attack for cancer immunotherapy, potentially outperforming existing anti-PD-1 therapy.
Scientists at Salk Institute have identified a key gene that modifies regulatory T cells, fine-tuning the immune response. By controlling these cells, they may be able to treat both cancer and autoimmune diseases.
The study reveals that Burkholderia pseudomallei infection sets off a series of events that provoke the host's immune system, causing infected cells to self-destruct. The researchers found that abnormal cell fusion stimulates the type 1 interferon signaling pathway, leading to autophagy and cell death.
New cost-effective technology enables advanced immunology studies on Tasmanian devils and reveals conserved immune pathways across 160 million years of evolution. The system can be applied to any vertebrate species, including humans.
A mouse study found that consuming black raspberries can reduce swelling caused by contact hypersensitivity, a condition that triggers redness and inflammation in the skin. The researchers believe that black raspberries modulate dendritic cells, which help regulate the immune system's response to allergens.
Researchers developed a new method to apply anti-inflammatory substances to implants to reduce undesirable inflammatory reactions. The coatings contain heparin and hyaluronic acid, which inhibit the immune system's response to the implant.
A study has identified genetic variants that predispose to cancer and impair the immune system. The research found up to 57 genetic variants in 13 types of cancer, which affect the body's defenses. The immune system plays a key role in protecting against malignancies, but cancer cells have mechanisms to escape immune responses.
Researchers at La Jolla Institute for Immunology have identified a key protein controlling T follicular helper cell (Tfh) differentiation. The protein Bcl6 acts as a master regulator in the immune system, blocking or promoting gene expression to control immune responses. This study opens the door to designing vaccines and therapies tha...
Researchers found that parasite infection was strongly associated with the overall composition of the microbiome, which could accurately predict a person's country and lifestyle. The study also discovered that the presence of four soil-transmitted gut parasites tended to co-occur at a higher rate than chance.
Researchers from Radboud University Medical Center found that norepinephrine suppresses the function of white blood cells, impairing the body's ability to combat infections. The study suggests that alternative antihypotensive agents like vasopressin may be more effective in sepsis patients.
The ADVOCATE study demonstrates avacopan's effectiveness in reducing corticoid use and achieving sustained remission in patients with AAV, particularly those with renal involvement. The treatment also showed improved outcomes with lower infection rates compared to standard immunosuppressive therapy.
Researchers discover distinct effects of different tumor types on mouse immune system and human breast cancer patients, suggesting potential applications for cancer immunotherapy. Tumors cause widespread disruption of immune system, evolving over time, which can impact treatment efficacy.
A review of 56 randomized clinical trials found that cognitive behavior therapy is superior to other psychotherapies in reducing inflammation and boosting the immune system. CBT was most effective in reducing pro-inflammatory cytokines, which are associated with chronic diseases such as heart disease, cancer, and Alzheimer's disease.
Research suggests that bees specializing in allogrooming exhibit stronger immune systems, which may enable them to withstand higher infection risks. Allogroomer bees occupy central positions in the colony's social network, benefiting a large number of bees.
Researchers found APRIL protein essential for plasmacyte development and immunoglobulin production in humans. A deficiency in APRIL leads to reduced plasmacyte numbers and increased susceptibility to infections.
Researchers at MIT create nanoparticles that stimulate the immune system, making cancer immunotherapy more powerful. By combining these particles with checkpoint inhibitors, they achieved a synergistic effect that halted tumor growth and even stopped tumors from spreading.
The OU College of Medicine has been awarded a $11 million federal grant to create the Oklahoma Center for Microbial Pathogenesis and Immunity. The center will focus on researching various types of infections, including fungal, bacterial, viral, and parasitic infections, and how the immune system recognizes and destroys them.
Researchers at the University of Southampton have discovered a way to convert an antagonist CD40 antibody into an agonist, which can stimulate the immune system and cure cancer more effectively. The study shows that this
A new study reveals that viruses inhibit a critical protein in the body's immune system to evade detection and cause infections. This common denominator offers hope for developing antiviral treatments and vaccines.
Researchers have identified a newly found pneumococcus capsule, the 100th since its discovery, and linked it to oral streptococci. This finding underscores the need for updated vaccines that can keep pace with rapidly changing bacteria.
Researchers mapped lymph node lymphatic vessels in mice and humans at the individual cell level, discovering five distinct groups of cells with similar functions. The study provides valuable insights into immune system function and will aid in developing new treatments for viral diseases and cancer.
A new model for respiratory infection treatment is being developed using mathematical modeling to predict and treat patients at risk of extreme lung inflammation. The University of Pittsburgh's Jason Shoemaker received a $547K NSF CAREER Award to create computational models of the immune response to seasonal influenza viruses.
Researchers at Lund University discovered a unique energy-saving strategy used by Arctic birds during the polar night, involving weakening their immune system. This adaptation allows them to conserve energy on keeping warm and finding food, but may pose risks when climate change alters migratory patterns and disease transmission.
Researchers have identified cathepsin S as a key player in Non-Hodgkin lymphoma's ability to evade the immune system. Inhibiting this protein reduces tumor growth by increasing the activity of immune cells that kill cancer cells.
A recent study published in Nutrients suggests that daily multivitamins with high doses of vitamin C and vitamin D can help fight off infections. The researchers recommend taking 200mg or more of vitamin C and 2,000 international units of vitamin D to support immune function.
Research suggests that individual genetic variation in the immune system may affect susceptibility to and severity of COVID-19. The study found that certain immune system genes, such as human leukocyte antigen genes, vary from person to person and can influence how well the immune system recognizes SARS-CoV-2.
A team of scientists discovered that genetic alterations in the immune system of pipefishes and seahorses allow them to tolerate paternal genetic information and develop their offspring. The study found that genes involved in female mammalian pregnancy are also activated in male pregnancy, suggesting similar molecular mechanisms.
A study published in Arthritis & Rheumatology found a significant increase in autoimmunity prevalence in the US population between 1988 and 2012. The prevalence of antinuclear antibodies (ANA) rose from 11.0% in 1988 to 15.9% in 2011-2012, affecting an estimated 41 million individuals.
Researchers at Mount Sinai have found a way to regulate special immune system cells in lung cancer tumors, suppressing them and allowing tumors to grow. By blocking this pathway, the immune system can be boosted to prevent tumor formation or growth, offering a potential new treatment for immunotherapy.
A high-salt diet can significantly weaken the immune system by reducing the function of granulocytes, a type of immune cell that attacks bacteria. This is according to a new study published in Science Translational Medicine, which found that mice fed a high-salt diet suffered from more severe bacterial infections.
Researchers found that natural killer cells can regulate and restrain inflammation of brain tissue, reducing protein clumping and viral resistance. The study suggests NK cells play a critical role in protecting against Parkinson's disease progression.
Researchers have uncovered the intricate details of interleukin-2's interactions with receptor molecules, providing a blueprint for more targeted therapies. The study shows how IL-2 can act as either a throttle or a brake on the immune response in different contexts.
University of Pittsburgh researchers develop microparticles that can trick the body into accepting transplanted tissue as its own, avoiding the need for lifelong immunosuppression. The treatment logistics are simpler and more efficient than current cell-based therapy methods.
Researchers at Institut Pasteur found that immune cells can attack cancer cells remotely through soluble molecules like interferon-gamma. This discovery supports a key target for future immunotherapy approaches and may enable T lymphocytes to act on a large number of cancer cells.
Researchers found that premature babies can catch up with their immune systems after birth, equivalent to those born at term. The study suggests that preterm and term infants converge in a similar time frame for immune development, and that early identification of infection risk can lead to improved outcomes.
Researchers developed a nanoparticle delivery method that tags implanted human cancer cells with molecular signals, making them visible to the immune system. The treatment showed promise in mice with melanoma and colon cancer, with some surviving up to 60 days without tumor growth.
Researchers at Monash University have discovered a key mechanism that enables hookworms to evade the human immune system. By understanding how these parasites destroy neutrophil extracellular traps, scientists may be able to develop vaccines to boost immunity and prevent reinfection.
Researchers found that immune cells perceive each other's density to regulate their proliferation, leading to more efficient immune reactions. This mechanism could improve cancer immunotherapies by reducing the risk of excessive immune responses.
The round goby's exceptional adaptability is attributed to its immune system, which features up to 30 times more inflammatory genes than comparable species. This enables the fish to deal with pathogens and extreme environmental conditions, facilitating its successful colonization of diverse waters around the world.