Articles tagged with Pediatrics
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Researchers found that underutilized asset building programs could be a solution to help low income families build wealth. The study showed that incorporating these programs into healthcare may make them more accessible to families in need.
Researchers at Children's Hospital of Philadelphia discovered that viral proteins use phase separation to coordinate the complex process of replicating viral genomes and then encapsulating them in a viral particle. This process allows for the orderly and coordinated formation of infectious viral offspring.
Researchers at Indiana University School of Medicine investigated the protein BVES and its crucial role in muscular dystrophy. They discovered that inhibiting proteasome degradation with Bortezomib can alleviate symptoms of BVES-deficient muscular dystrophy.
Researchers have identified a promising new combination of drugs to treat juvenile myelomonocytic leukemia (JMML), a rare form of blood cancer affecting children. The combination of 5-azacitidine and MEK inhibitor PD0325901 reduced cancerous stem cells and improved blood cell abnormalities.
A new study published in CMAJ found that privately sponsored refugees were more likely to receive adequate prenatal care than government-assisted refugees in Ontario. The study analyzed data from over 5000 pregnant women and found a significant difference in the use of prenatal care services between the two groups.
A new study reveals that only one affordable prenatal supplement meets nutritional guidelines, but its high cost and complex dosing regimen make it inaccessible to many. The study calls for improved nutritional care during pregnancy and more research on nutrient-dense foods.
Researchers from the University of North Carolina Health Care announce that patients receiving anti-TNF biologic treatments combined with methotrexate had better outcomes than those treated with adalimumab alone. The study, published in Gastroenterology, provides clear results that can immediately impact patient care.
Researchers have shown lorlatinib to be safe and effective in treating high-risk neuroblastoma with ALK gene mutations. The targeted therapy has led to a major amendment in a phase 3 clinical trial, offering new hope for patients with this often lethal cancer.
A new Rutgers study finds that childhood asthma diagnoses decreased by 52% in the US during the first year of the pandemic compared to previous years. Researchers attribute this decline to fewer colds and the practice of wearing masks, which may have reduced the risk of asthma triggers.
A new study found that LGB preteens ages 10-14 reported 10.4 hours of daily recreational screen time, which was nearly four hours more than their straight peers. The researchers argue that parents should regularly talk to their children about screen usage and develop a family media use plan.
A new study suggests that ketamine could be a promising treatment option for children with traumatic brain injuries, particularly in reducing intracranial pressure. The research found that ketamine can lower ICP during crisis situations, which is crucial for preventing long-term neurologic impairment.
High blood pressure in children is a significant health concern, potentially leading to cardiovascular problems in adulthood. The American Heart Association recommends monitoring blood pressure levels and implementing lifestyle modifications such as a healthy diet, regular physical activity, and weight management.
Researchers found that preserving the meniscus with sutures is more effective in protecting cartilage from future damage in younger patients. Meniscectomies, which remove more than half of the meniscus, were more likely to progress cartilage degeneration.
Delattre is being recognized for his seminal genetic insights into the etiology of pediatric solid tumors, which have had substantial clinical implications. He has also been instrumental in identifying genetic alterations in other childhood cancers, including the BCOR-CCNB3 translocation.
A national analysis of pediatric hospitalizations from 2009 to 2019 found a significant increase in mental health diagnoses, with attempted suicide being the leading cause. The study highlights the growing importance of addressing mental health concerns in children and adolescents.
A new research letter highlights how quickly Colorado's children and teenagers can access a loaded gun, increasing the risk of adolescent suicides and firearm injuries. Nearly one-third of middle and high school students report having access to a gun within 24 hours or under 10 minutes.
A new study analyzed 183,780 non-birth related hospitalizations among 130,826 privately insured children covered aged 18 and under from 2017-2019. The average out-of-pocket spending was $1,300, with some families paying over $3,000. High deductibles and co-insurance payments were the main drivers of higher costs.
Researchers at UMass Amherst have discovered that beneficial microbes in infant gut use nitrogen from human milk to support pediatric nutrition and development. The study provides new insights into the molecular underpinnings of these processes, which could lead to improved infant health around the world.
Researchers found that incubators dampen some sounds but also cause a booming effect at low frequencies, raising noise levels by up to 28 decibels. The study highlights the importance of considering sound in NICU design and use to protect premature infants' hearing.
A new national study finds that lesbian, gay, and bisexual (LGB) youth are twice as likely to report trouble falling or staying asleep than their straight peers. This is attributed to greater depression, stress, and family conflict among LGB youth, which can make it harder for them to get a good night's sleep.
The Octapharma USA grant supports the Immunoglobulin National Society's breakfast symposium on PANS/PANDAS, a subset of pediatric acute-onset neuropsychiatric syndrome associated with strep. The program will focus on diagnosis criteria, pathogenic mechanisms, and current treatment options for challenging cases.
Researchers describe a new approach to constructing a nose in two young patients with congenital arhinia, a rare genetic disorder that causes the absence of the nose. The staged technique involves augmenting the underlying bones of the face and creating an external nose using tissue expansion and grafts.
Researchers from CHOP developed a prediction model that determines which newborn babies are likely to experience seizures in the NICU. The model, built using machine learning methods, can predict seizures with over 90% accuracy, particularly in newborns with hypoxic-ischemic encephalopathy.
Young children with autism spectrum disorder are less likely to undergo vision screening than their peers, despite a high risk of developing serious eye disorders. A recent study found that only 36.5% of children with ASD had completed vision screenings at well visits, compared to 59.5% for children without ASD.
CHOP researchers found that adolescents with strong relationships with their parents have improved mental and physical health, lower substance use, and higher relationship satisfaction. The study analyzed data from over 15,000 participants and controlled for various factors.
A recent review article highlights the significant impact of cancer on Hispanic patients and their caregivers, citing communication barriers, financial difficulties, and sociocultural issues. The study estimates 126,000 new cancer cases diagnosed yearly in Hispanics, placing a substantial burden on family members and friends.
A Rutgers study found that criteria used to diagnose multiple sclerosis in adults may not be sufficient for pediatric patients, who often go undetected in early stages. The study suggests that diagnostic tools used for adults may need to be re-evaluated for children with abnormal MRI findings.
A quality improvement initiative increased NICU social risk screening rates and connected 98% of requesting families with resources. Early engagement with services and cross-sector partnerships led to positive referral outcomes, improving caregiver presence in the NICU.
Children from low-income neighborhoods are more likely to develop preventable heart disease due to high blood pressure, according to a new study. The research highlights the importance of considering neighborhood-related factors when diagnosing hypertension in youth.
Researchers found that consuming vitamin A or its analogs can help prevent painful pancreas inflammation in children and young adults with acute lymphoblastic leukemia (ALL) during chemotherapy treatment. The study revealed that only 1.4% of patients developed pancreatitis when taking vitamin A, compared to 3.4% without it.
A Kaiser Permanente study of over 800,000 children aged 3-17 found that youth with higher BMI were at a 26% increased risk of developing hypertension. The study highlights the importance of preventing hypertension in young people to avoid irreversible organ damage.
Researchers discovered that lipid deposition on medical implant surfaces can signal to the immune system whether to attack or ignore the implant. This knowledge could help develop biomaterials that deflect host immune aggression, reducing malfunction rates for devices like pacemakers and surgical mesh.
The pediatric death rate in the US sharply rose between 2019 and 2021, offsetting years of progress in medicine and public health. The alarming spike is primarily due to deaths from homicide, accidental drug overdoses, motor vehicle accidents, and suicide among those ages 10-19.
Recent review article discusses clinical development in long-acting growth hormone (LAGH) therapy, which mimics natural GH release patterns. LAGH therapies reduce daily injection burden, improving patient compliance and treatment outcomes.
A meta-analysis of 34 studies found a significant association between autism spectrum disorder (ASD) and increased risks of developing diabetes, dyslipidemia, and heart disease. Children with ASD were more likely to develop these metabolic complications, prompting clinicians to monitor them closely.
Researchers say parents' well-intentioned efforts to protect children from harm have inadvertently deprived them of independence and opportunities for self-directed play. This decline in 'child's play' is linked to rising anxiety, depression, and suicide rates among school-aged children.
A novel rare mutation in the ABCA12 gene was identified as a cause of Harlequin Ichthyosis through BGI genetic tests. The mutation leads to a severely dysfunctional protein responsible for the disease's serious phenotype.
A seven-component treatment program, including prompt medical assessment and co-constructing a formulation with the child and family, has been successful in managing FND in children and adolescents. Most healthcare professionals can easily add an FND-informed skill set to their current clinical practice.
Adolescents with blood pressure above 130/85 mmHg are at risk of premature heart damage, which doubles in prevalence over a 7-year period. The study found significant differences in heart damage risks between males and females.
More than half of all reported poisonings affect children ages 5 and younger, with opioids responsible for over half of fatal poisonings. Opioids have contributed to a significant increase in child poisoning deaths despite regulation measures.
Researchers detected and targeted a type of childhood leukemia that becomes resistant to treatment by focusing on a process called splicing. The study suggests a new approach to detecting and targeting therapy-resistant leukemia stem cells, offering hope for improved treatments.
A review highlights the impact of paternal diet, nutrition, and lifestyle on future generations, with strong evidence suggesting a western diet leads to imbalances in nutrient intake. Advanced paternal age is linked to genetic, psychiatric, and metabolic disorders in offspring, emphasizing the need for men's healthcare.
A new consensus statement calls for routine radiological screening of contact children in suspected child physical abuse cases to prevent further harm. Siblings are at risk of experiencing physical abuse, with a strong association between index and contact children.
A new study published in BMC Public Health suggests that problematic social media use in preteens is linked to both positive and negative alcohol beliefs. Researchers found that 97% of social media posts display alcohol in a positive context, contributing to positive perceptions among adolescents.
A recent study found that Black infants in the US were disproportionately affected by necrotizing enterocolitis, with higher mortality rates compared to White infants. Despite overall improvements in NEC-related deaths between 1999 and 2020, racial disparities persisted.
Primary care physicians recommend screening adolescents and young adults for cyberbullying and social media misuse, citing the need for timely intervention due to underreported incidents. Screening tools like R-OBVQ, CBVS, CABS, and MARC can help identify potential risks.
A study reports successful nonsurgical correction of congenital ear malformations in infants using a custom-made splint made from paper clips. The best results were achieved when treatment was initiated before six months of age.
Researchers created a novel approach to deliver anti-cancer drugs directly to brain tumor sites in children, targeting specific locations while sparing normal brain regions. This targeted delivery method enhances the efficacy of existing treatments and reduces adverse side effects.
A clinical study by Indiana University School of Medicine researchers found that oral verapamil can improve pancreatic beta cell function in children with new-onset type 1 diabetes, with a 30% increase in insulin secretion over the first year. The trial involved 88 participants and was published in JAMA.
Children with autism may not process visual illusions in the same way as their peers, indicating a potential issue with predicting and filling in missing visual information. This finding has implications for understanding and supporting individuals on the autism spectrum.
A study of 11,633 children aged 9-11 found that increased screen time was associated with a higher risk of developing suicidal behaviors two years later. Each additional hour of screen time led to a 9% higher risk of reporting suicidal behavior.
Researchers developed a microfluidic model of vascular malformation caused by PIK3CA mutation, allowing them to study disease mechanisms and test treatment efficacy. The model successfully replicated the disease's manifestations and responded to alpelisib, a newly approved PIK3CA inhibitor.
CHOP researchers have identified variants of a chaperone molecule that can enhance the loading of peptides across different HLA types, which could be used in cell therapy and immunization applications. The study found that chicken-derived TAPBPR proteins can react with multiple HLA allotypes and stabilize the empty MHC-I groove, boosti...
A phase 3 clinical trial found that oral empagliflozin provided clinically meaningful and statistically significant improvements in glycemic control in young people with type 2 diabetes. The study demonstrated the safety and efficacy of empagliflozin in this population, while linagliptin did not show significant effects.
Researchers found better survival rates at all points in time for pediatric patients with more serious heart disease, thanks to improved immunosuppression therapies, techniques, and postoperative care. A multidisciplinary team approach also contributed to the better outcomes.
A new clinical trial has shown safety and tolerability of oral GABA and reduced serum glucagon levels in children with recent onset Type 1 diabetes. The study focused on the potential of GABA and GAD to preserve insulin-secreting beta cells and attenuate excessive glucagon release.
Researchers at Children's Hospital of Philadelphia developed two new zebrafish models for studying SURF1 mitochondrial disease, a major cause of Leigh syndrome. The team identified two drugs, cysteamine bitartrate and N-acetylcysteine, that showed potential in preventing neurological decompensation in patients with Leigh syndrome.
A new study explores the complexity of parents' decision-making processes regarding SARS-CoV-2 vaccination for their children. The research highlights the importance of individualized discussions with healthcare providers to help interpret evidence and provide tailored recommendations.
A study published in CANCER found that children with acute lymphoblastic leukemia living along the US-Mexico border had a lower five-year survival rate compared to those in non-border areas. The research highlights existing disparities in pediatric cancer outcomes, particularly among Hispanic and Black communities.
A recent study from Ann & Robert H Lurie Children's Hospital of Chicago suggests that paid family caregiving can be a viable answer to the healthcare worker shortage. The study, which compared children with medical complexity cared for by family-CNA caregivers versus traditional non-family CNAs, found no significant difference in hospi...