Online reviews of health care facilities
Negative patient experiences in online health care facility reviews frequently revolve around poor communication and administrative issues. Positive reviews emphasize supportive staff interactions.
Interaction Networks
Articles tagged with Interaction Networks
Pioneering scientist reveals breakthrough link between psychedelics and immune system in treating fear
Researchers have found that psychedelic compounds can reverse a cascade involving brain-resident cells and immune cells, increasing fear behavior when chronic stress disrupts signaling. This finding represents a paradigm shift in understanding psychedelics' therapeutic potential.
From steel solid waste to green cement: A catalytic leap towards low-carbon cement production
Researchers propose a novel approach to reduce carbon emissions in cement manufacturing by leveraging iron naturally present in cement raw materials. The method enables the co-thermal conversion of CaCO₃ with CH₄ under a methane atmosphere, resulting in high-value syngas as a byproduct and significantly reducing carbon footprint.
Activity stabilizes mixtures
Researchers at MPI-DS discovered that non-reciprocal interactions between particles can homogenize mixtures and control particle organization. This study offers a new route to understanding how complex patterns and structures emerge and maintain cellular functions.
SourceMax Planck Institute for Dynamics and Self-Organization·JournalPhysical Review Letters·TypeComputational simulation/modeling·DateApr 22, 2025
Team discovers novel global cooperative phenomena of cell interactions in cervical cancer cells
A Japanese research team has discovered a novel global cooperative phenomenon of cell interactions in cervical cancer cells. The framework used in their studies could prove useful for investigating hidden states of a group of cells and may lead to novel cancer therapies.
FunMap reveals a functional network of genes and proteins in human cancer
The study revealed a comprehensive functional network of 10,525 genes constructed using supervised machine learning that integrates protein datasets and RNA sequencing data from 11 cancer types. The approach identified protein modules and a hierarchical modular organization linked to cancer hallmarks and clinical characteristics.
SourceBaylor College of Medicine·JournalNature Cancer·TypeComputational simulation/modeling·DateDec 11, 2024
'Shallow' sports and 'deep' social hierarchies: Not all pecking orders are created equal
A new study by University of Michigan researchers introduces a framework to compare and analyze competitive interactions across various fields, from sports to social hierarchies. The 'depth of competition' model reveals that human games and sports are surprisingly shallow, while animal competitions exhibit much deeper stratification.
New grant will help researchers understand ways to reduce e-cigarette and cigarette use among teens
A new grant will investigate the role of social media in teen e-cigarette and cigarette use. Researchers will analyze social influences, particularly through online networks, to understand how teens are influenced to smoke and use e-cigarettes. The study aims to develop effective interventions to reduce nicotine product use among teens.
Protein interactions: Who is partying with whom and who is ruining the party?
Researchers at ETH Zurich have developed a method to study protein interactions using LiP mass spectrometry, identifying thousands of interaction interfaces between proteins. They found that stress situations alter around five dozen protein complexes and their interactions, with a key player being the SAGA complex.
Scientists uncover auditory “sixth sense” in geckos
Researchers found that geckos utilize the saccule, a part of their inner ear traditionally linked to balance, to detect low-frequency vibrations. This 'sixth sense' plays a complementary role in the geckos' normal hearing and sensory perception.
New research shows how oral cancer cells avoid immune system
Researchers at Macquarie University discovered that oral cancer cells use protein interactions to block the immune response, offering new clues for treatment. The study found that a protein called STAT3 and its partner proteins may be involved in pathways that help cancer avoid the immune system.
SourceMacquarie University·JournalJournal of Oral Biosciences·TypeExperimental study·DateSep 17, 2024
Researchers map brain circuits that signal immediate danger and create memories to help avoid threats
A study in Current Biology mapped a brain circuit responsible for detecting threats and forming fear memories. The hippocampus and subiculum are key structures involved, with the subiculum transferring information to the hypothalamus.
Chinese Medical Journal review provides valuable insights into the development of new anti-angiogenic drugs
Researchers highlight the need to develop new anti-angiogenic agents to improve cancer treatment efficacy, citing knowledge gaps in human clinical trials. The review recommends considering tumor mutations, microenvironment, and patient profiles to select optimal AAD combinations.
WVU scientists taking a close look at what causes immune cells to attack the central nervous system
Researchers study T cells and monocytes interaction in the meninges before they attack the brain and spinal cord, potentially leading to new disease progression targets. The findings could provide a pathway to treating other neurological diseases like Alzheimer's and Parkinson's.
Research identifies possible new pathway to treatment of colorectal cancer
Researchers at Virginia Tech have discovered a possible new pathway to treat colorectal cancer by targeting the NF-kB-inducing kinase (NIK) protein. The study, led by Irving Coy Allen, identifies changes in a significant signaling pathway in human patients and presents potential targets for therapeutics.
Putting the brakes on chronic inflammation
Researchers at Weill Cornell Medicine discovered that interleukin-23 acts on group 3 innate lymphoid cells to balance pro-inflammatory effects and maintain gut health. This interaction is impaired in chronic inflammatory bowel diseases, providing new insights into the disease and potential therapeutic targets.
Unveiling the role of AGO's post-translational modifications in plant gene regulation
A new study reveals that AGO's N-terminal extension interacts with PRMT5 to catalyze arginine dimethylation, affecting RNA-guided mechanisms. This process fine-tunes gene regulation in plants, impacting development and stress responses.
SourceCenter for Research in Agricultural Genomics (CRAG)·JournalNucleic Acids Research·TypeExperimental study·DateJun 3, 2024
A molecular route to decoding synaptic specificity and nerve cell communication
A team of researchers from Tokyo Institute of Technology identified the molecular mechanisms involved in synaptic communication using Drosophila. They found that Side-IV/Beat-IIb immunoglobulin superfamily protein molecules play a crucial role in inducing synapse formation and regulating preferential signaling among neuron pairs.
Screen time and parent-child talk when children are ages 12 to 36 months
A recent study published in JAMA Pediatrics found a strong negative association between screen time and parent-child talk among children aged 12-36 months. Children exposed to more screen time had fewer adult words, vocalizations, and back-and-forth interactions with parents.
World’s first metamaterial developed to enable real-time shape and property control
A breakthrough metamaterial has been developed to enable real-time shape and property control, surpassing existing materials' limitations. The material's adaptable capabilities make it suitable for applications in robotics and other fields requiring flexibility.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalAdvanced Materials·DateFeb 28, 2024
Controlling root growth direction could help save crops and mitigate climate change
Researchers have found a highly conserved ethylene signaling pathway that can be targeted to control the direction of root growth, creating deeper root systems that hold on to carbon and remove carbon dioxide from the atmosphere. This breakthrough could help engineer crops more resilient to climate change and drought.
Faulty DNA disposal system causes inflammation
Scientists discovered a novel mechanism for removing mtDNA from mitochondria, which can initiate an immune response promoting inflammation. The discovery reveals new targets for therapeutics to disrupt the inflammatory pathway and mitigate inflammation during aging and diseases.
University of Cincinnati stroke experts present at international conference
Researchers discovered two new genetic pathways associated with worse ICH outcomes, including a pathway affecting blood coagulation and cellular interactions. Population data showed a decrease in aneurysmal SAH strokes and a rise in non-aneurysmal subarachnoid hemorrhages, offering encouraging evidence for intervention success.
Understanding jasmonic acid: A switch that activates autophagy in Arabidopsis petals
A team of researchers from Nara Institute of Science and Technology discovered a phytohormone-mediated switch controlling autophagy, leading to terminal cell differentiation for petal abscission. They found that jasmonic acid promotes petal abscission by activating autophagy at the base of petals.
SourceNara Institute of Science and Technology·JournalNature Communications·TypeExperimental study·DateFeb 7, 2024
Rice study unlocks breakthrough for breast cancer bone metastases
Researchers at Rice University have discovered a promising new immunological pathway to treat stubborn bone tumors in breast cancer patients. The glyco-immune checkpoint axis, involving protein Siglec-15, plays a crucial role in hiding bone tumors from the immune system.
SourceRice University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 24, 2024
Using spectroscopy to measure visual recognition
A team of scientists used functional near-infrared spectroscopy (fNIRS) to measure brain activity in two key visual regions, the lateral occipital complex (LOC) and fusiform face area (FFA). The study found that fNIRS successfully measured LOC activity but had limitations in detecting FFA activity due to its depth. This research has th...
Salk scientists uncover key brain pathway mediating panic disorder symptoms
Researchers have discovered a brain circuit that mediates panic disorder, consisting of specialized neurons that send and receive the neuropeptide PACAP. Inhibiting PACAP signaling reduces panic symptoms, offering promising findings for future treatments.
Mapping of the gene network that regulates glycan clock of ageing
A new study has identified three genes, MANBA, TNFRSF13B, and EEF1A1, as crucial in the regulation of IgG galactosylation, a trait associated with ageing. The research used GWAS to analyze IgG glycosylation phenotypes in a large sample size, increasing the understanding of this complex posttranslational modification.
TTUHSC researcher to study new pathway to inhibit protein found in many cancers
Researchers at TTUHSC are studying a new approach to inhibit STAT3, a protein associated with 70% of human tumors. Disrupting STAT3 synthesis on ribosomes could lead to new cancer treatments.
A promising target to fight inflammatory bowel diseases
The Cusack group at EMBL Grenoble has provided insights into the interactions of XIAP and RIPK2 molecules involved in gut signalling pathways. This research sheds light on how these molecules interact, revealing a promising drug target for treating inflammatory bowel diseases.
Four novel receptors may link endometrial cancer to PCOS
Researchers identified four novel receptors potentially linking endometrial cancer with polycystic ovary syndrome, highlighting a major pathway involved in the increased EC risk in PCOS. The PI3K-AKT signaling pathway is consistent with a link between PCOS and EC.
Sahmyook University researchers uncover molecular pathways underlying depression
A study published in Brain, Behavior, and Immunity found that inflammation-related genes play a significant role in depression. The researchers discovered correlations between immune-related genes, DNA methylation patterns, and brain structure abnormalities in patients with major depressive disorder.
Study sheds light on cellular interactions that lead to liver transplant survival
Researchers identify key protein interactions that control the body's immune response during liver transplantation, leading to improved transplant survival rates. The study found that a specific communication pathway between CEACAM1 and TIM-3 proteins plays a crucial role in controlling the immune response.
SourceUniversity of California - Los Angeles Health Sciences·JournalGastroenterology·TypeExperimental study·DateJul 19, 2023
Virtual exploration of chemical reactions
Researchers from Hokkaido University developed a centralized, interactive platform to explore and analyze chemical reaction pathways. The Searching Chemical Action and Network (SCAN) platform utilizes AFIR calculations to provide an interactive reaction pathway map that can be searched and viewed.
SourceHokkaido University·JournalDigital Discovery·TypeComputational simulation/modeling·DateJul 3, 2023
Biological network in cells helps body adapt to stresses on health
Scientists at the University of Utah Health have discovered a complex network of protein-metabolite interactions within cells that enable them to respond to environmental cues and maintain homeostasis. The study, published in Science, highlights the importance of these interactions in regulating metabolic processes and preventing disease.
Scientists observe “quasiparticles” in classical systems for the first time
Researchers at Ulsan National Institute of Science and Technology (UNIST) have observed quasiparticles in a classical system made of microparticles driven by viscous flow. The hydrodynamic forces among the particles create pair excitations that propagate through the crystal, stimulating the creation of new pairs.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalNature Physics·DateMar 7, 2023
A human interactome to prioritise drug discovery
Researchers created a network of interacting proteins to understand the function of genes and link specific biological processes to diseases. They identified groups of proteins interacting with genes linked to over 1,000 human traits, providing insights into new targets for drug discovery and potential repurposing opportunities.
Autophagy: The molecular regulation of self-eating
A team of researchers has identified a molecular switch that regulates autophagy in plants, bridging two quality control pathways. The study reveals that this regulatory mechanism is conserved in eukaryotes and essential for preventing cells from 'eating' healthy cellular components.
SourceGregor Mendel Institute of Molecular Plant Biology·JournalThe EMBO Journal·TypeExperimental study·DateFeb 10, 2023
Ant pupae secrete fluid as "milk" to nurture young larvae
Researchers discovered that ant pupae secrete a fluid that is consumed by both adults and larvae, highlighting the interconnectedness of different developmental stages within an ant colony. The fluid, derived from molting, is rich in nutrients and psychoactive substances, essential for larval growth and adult metabolism.
Decoding secretome-mediated neuron-immune cellular interaction network
Scientists used single-cell integrative secretion profiling technology to map the interaction between neurons and immune cells, revealing heterogeneity in secreted factors and their roles in regulating neuronal function. The study found that infiltrating macrophages inhibit neuronal secretion of exosomes, while microglia promote neuros...
SourceDalian Institute of Chemical Physics, Chinese Academy Sciences·JournalProceedings of the National Academy of Sciences·TypeCommentary/editorial·DateNov 15, 2022
Gene interactions classify bowel tumors for personalized medicine
Researchers developed a new taxonomy of bowel cancer using gene interaction networks, grouping tumors into six distinct clinical and molecular subtypes. This classification system could aid in precision medicine by tailoring treatments to individual patients.
Zinc enhances albumin’s protective role against Parkinson's disease
Researchers have discovered that zinc ions tune the ability of human serum albumin to prevent α-synuclein aggregation, a process linked to Parkinson's disease. Zinc binding alters HSA's chaperone function, blunting fibril formation and slowing down protein deposition that can lead to neurodegeneration.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalInternational Journal of Biological Macromolecules·DateOct 16, 2022
“Kipferl”: Guiding the defense against jumping genes
Researchers at IMBA found that Kipferl helps distribute Rhino to piRNA clusters, avoiding sequestration to Satellite arrays. This control mechanism ensures the effective silencing of jumping genes and maintains genome stability.
SourceIMBA- Institute of Molecular Biotechnology of the Austrian Academy of Sciences·JournaleLife·TypeExperimental study·DateOct 4, 2022
PITT pathway: Pitt scientists discover how cells repair longevity-promoting ‘recycling system’
Researchers at the University of Pittsburgh have identified a universal mechanism for lysosomal repair, known as the PITT pathway, which helps maintain cellular longevity. The study reveals that damaged lysosomes are quickly repaired through the PITT pathway, but defects in this process can contribute to age-related diseases such as Al...
Aging-US | WRNing for the right DNA repair pathway choice
A recent study published in Aging-US reveals the crucial role of WRN in making choices between classical and alternative non-homologous end joining (NHEJ) DNA repair pathways. The research provides new insights into progeroid syndromes, such as Werner syndrome, and their connection to aging.
Species thrive through social connections
A Kyoto University study shows that even though biodiversity increases with more interactions, mean interaction strength decreases. The interaction capacity hypothesis proposes that this weakening of interspecific interactions may be due to increased community diversity.
SourceKyoto University·JournalProceedings of the Royal Society B Biological Sciences·TypeExperimental study·DateMay 24, 2022
Building bridges, not silos
A new study by MIT scholars confirms that physical proximity plays a crucial role in workplace collaboration. The study found that email exchanges occur more often among researchers whose workspaces are connected through indoor halls rather than outdoor paths.
"Hotspot mapping" accelerates early-phase drug design
Researchers from CCDC, Exscientia, and Oxford University have developed an automated method for informing the design of compound selectivity across protein families. The 'Hotspot API' uses ensemble hotspot maps to quantify the propensity for compounds to exploit interactions in preferred binding sites.
SourceCCDC - Cambridge Crystallographic Data Centre·JournalJournal of Chemical Information and Modeling·DateMar 2, 2022
Colorectal cancer research reveals promising targetable pathway for prevention and treatment
Scientists have discovered a new therapeutic approach to aid the immune system in fighting cancer, offering hope for better solutions for patients. Researchers found that blocking the EP4 molecule can 'free' the immune system and restore its cancer-fighting functions.
Context-dependent behavior can make cooperation flourish
Researchers at the University of Pennsylvania found that changing social strategies between settings can lead to more cooperative behavior in a society. In a model with spillover between domains, cooperation is favored when actors can observe and imitate each other's behaviors in different contexts.
SourceUniversity of Pennsylvania·JournalScience Advances·TypeComputational simulation/modeling·DateFeb 9, 2022
Shaping the development trajectories of exchange relationships
The study identifies generic paths for relationship evolution, including decay, passive learning, and the formation of evolved conditions such as indifference and familiarity. Firms can leverage customized governance solutions to shape relationship trajectories, promoting learning and forbearance to increase partner familiarity.
One mutation or two? Researchers in Spain discover why some genes require one or two hits to promote cancer
A study by Spanish researchers has deciphered the landscape of third-order interactions in cancer, revealing that many genes involved in cancer may require one or two hits depending on other mutations. This discovery opens the way to more precise genetic diagnosis and new therapeutic targets.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature Communications·DateDec 15, 2021
Study sheds light on precise personalized hepatocellular carcinoma medicine
Researchers have identified distinct metabolic phenotypes in hepatocellular carcinoma subtypes, providing insights into precise personalized treatment options. The study revealed a poor prognosis subtype strongly correlated with immune pathway up-regulation and unsaturated fatty acid accumulation.
SourceDalian Institute of Chemical Physics, Chinese Academy Sciences·JournalAdvanced Science·DateJul 12, 2021
Study reveals roadmap of muscle decline with age
A comprehensive study in mice reveals a roadmap of muscle decline with age, identifying key molecular mechanisms and potential new treatments. Klotho supplementation improved muscle strength in old but not oldest-old mice, suggesting earlier intervention may prevent declines.
Researchers establish intracellular interaction network in breast cancer
Researchers at HSE University have identified key molecules responsible for breast cancer metastasis by developing an algorithm that recreates the networks of intercellular interactions in cancer cells. The program detects prognostic genes, with transcription factor E2F1 playing a major role in predicting patient outcomes.
There is no one-size-fits-all road to sustainability on "Patchwork Earth"
A recent paper from McGill University suggests that a one-size-fits-all approach to sustainability is not feasible due to regional complexities. The researchers propose envisioning diverse desirable futures, nurturing seeds of sustainability, and navigating emerging pathways to create a more sustainable future. This approach acknowledg...
How horse manure helps giant pandas tolerate cold
Giant pandas roll in horse manure to acclimatize to cold temperatures, with beta-caryophyllene and caryophyllene oxide playing a crucial role. The compounds inhibit the pandas' thermosensitive receptor pathway, leading to increased cold tolerance.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateDec 7, 2020
Innovative machine-learning approach for future diagnostic advances in Parkinson's disease
Researchers used machine learning to analyze mitochondrial interaction networks and identified specific patterns associated with Parkinson's disease. These patterns were correlated with clinical scores and allowed for accurate diagnosis of PD patients.
Environment drivers of ecological complexity in marine intertidal communities
A new study by Swansea University found that environmental factors such as sea surface temperature and cold water upwelling events significantly impact the structure of interaction networks in marine intertidal communities. The researchers analyzed data from 970km of shoreline and discovered that these abiotic drivers modulate species ...
A new tool for data scientists and biologists and more
A new computational tool developed by USC researchers solves the 'community detection' problem, identifying patterns and relationships among entities with greater accuracy than existing tools. The Ollivier-Ricci curvature-based method can be leveraged by various groups, including biologists, doctors, and political strategists.