Articles tagged with Cell Survival
A new study found that inducing mitochondrial reactive oxygen species (ROS) during embryonic development protects the adult heart from chemotherapy toxicity in mice. The study discovered that stressed mitochondria release citrate, leading to long-term epigenetic changes that promote beneficial mitohormetic adaptations. These findings s...
Researchers uncover ancient energy-sensing signaling cascade in marine oysters that sheds light on human lung adenocarcinoma. The KAT2/HDACIIa–PGK–ALDO axis promotes glycolytic flux to ensure cell survival under energy stress.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
Researchers at Olivia Newton-John Cancer Research Institute discovered that reduced BECLIN1 levels weaken the gut's protective barrier, leading to increased susceptibility to inflammation and disease. This finding may help explain why some people are more susceptible to gut inflammation and associated diseases.
Research reveals multifloral honey's protective effects on human skin cells from UV radiation, promoting cell recovery and preventing aging. The study found that honey increased stemness-related markers and reduced aging-associated genes in skin stem cells and fibroblasts.
Salk Institute researchers discovered chronoferroptosis, a chronic stress pathway in cells that causes neurons to become less resilient over time and more susceptible to neurodegeneration. Iron accumulation was found to lower the cells' defenses, making them more vulnerable to stressors.
A new study using mice found that surviving cells compensate for cell death by sprouting extra branches to promote recovery in the visual brain system. However, female mice showed delayed or incomplete repair compared to males. This suggests a compensatory mechanism following brain injury that differs between sexes.
Australian researchers have discovered a drug combination that can bypass the cellular defenses developed by neuroblastoma tumors, making it more effective against relapsed cases. The combination reduces tumor growth and extends survival time compared to standard treatment alone.
Researchers reprogrammed the epigenetic code to affect tumour growth and survival in multiple myeloma. This study presents a comprehensive map of epigenetic alterations in multiple myeloma, highlighting site-specific increases in DNA and protein methylation that control gene activity.
Researchers have discovered a novel cell-clearance pathway linked to diseases such as Chediak-Higashi Syndrome, which affects immune system function. The study used CRISPR/Cas9 gene-editing technology and live imaging to characterize this pathway and identify key genes involved.
A new study suggests that a drug used to prevent alcohol abuse can also interrupt runaway cell death and inflammation triggered by severe trauma, particularly in female mice. The findings may lead to therapies that could shorten hospital stays and improve survival rates if administered promptly after traumatic injuries.
Salk Institute and UC San Diego researchers captured the first-of-its-kind video of dynein-Lis1 protein interaction, revealing 16 detailed shapes that support designing therapeutics to restore dynein and Lis1 function. The insights gained from this movie will help identify precise locations where drugs can interact with the proteins.
Researchers discovered that cells caught up in sepsis send out messages to other cells, causing them to die and fueling the spiraling inflammation. By understanding this process, scientists may be able to develop a treatment for inflammatory diseases like sepsis.
Scientists discovered a unique way in which yeast cells adapt to starvation by coating their mitochondria with massive molecular complexes called ribosomes. This adaptation has potential implications for cancer treatment as it may help overcome the challenges faced by cancer cells when they are starved of nutrients.
A study published in Nature Communications reveals a cellular signaling pathway that promotes heart cell survival. The Mst1-FoxO1-C/EBP-β interaction stimulates protective mechanisms in cardiac myocytes, potentially paving the way for new therapies.
Researchers discovered BMAL1 is significantly upregulated in senescent cells and modulates the senescence program through AP-1. The study highlights a previously unappreciated role of BMAL1 in regulating cellular senescence and circadian clock components.
LSU Health New Orleans researchers found that a combination therapy using Neuroprotectin D1 and Resolvin D1 boosted brain cell survival, growth, and stability. The therapy showed promising results in reducing lesion volume and improving neurological function in acute ischemic stroke models.
Researchers have discovered that HER3 plays a crucial role in promoting cell survival in metastatic colorectal and pancreatic cancer. The surrounding liver microenvironment activates HER3, making it an emerging therapeutic target for these types of cancer.
Researchers at Ulsan National Institute of Science and Technology (UNIST) have observed quasiparticles in a classical system made of microparticles driven by viscous flow. The hydrodynamic forces among the particles create pair excitations that propagate through the crystal, stimulating the creation of new pairs.
Researchers at La Jolla Institute for Immunology have discovered that OGT regulates mTOR, a key protein for mitochondrial powerhouses, keeping cells healthy. The study may lead to important medical advances in understanding cancers, diabetes, and cardiovascular disease.
Researchers found that a critical enzyme called AAG plays a crucial role in making cells respond to stress by communicating between different parts of the cell. This new understanding could lead to improved cancer treatments using alkylating agents, a class of drugs commonly used in chemotherapy.
Researchers at Niigata University identified a novel Olig2 binding protein called Ddx20, which regulates RNA metabolism and transcription. Ddx20's interaction with Olig2 helps maintain cell survival and prevents apoptosis in neural progenitor cells.
Dr. Zhiqiang Lin has been awarded a $3.2 million NIH grant to investigate the roles of YAP and IRF2BP2 in the cardiac innate immune response, with the goal of reducing cardiac inflammation and promoting heart recovery after a heart attack.
A preclinical study identified a protein complex critical for regulating apoptosis and necroptosis. Inhibiting this complex may help prevent excessive cell death and tissue damage associated with heart attacks, autoimmune disorders, and COVID-19. Researchers believe that targeting the PPP1R3G/PP1γ pathway could lead to new treatments f...
Scientists discovered that surviving bacteria share a common feature: they accumulate acid in their cells, shutting down protein synthesis. This leads to increased survival and can be exploited to develop new antimicrobial treatments.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
A new study by Brigham and Women's Hospital researchers reveals how HIV establishes a persistent reservoir of infected cells that can survive indefinitely. The findings highlight the role of BIRC5 and OX40 in these cells' long-term survival, providing potential targets for future therapy.
Researchers at York University have discovered that beta-blockers may prevent further cell death following a heart attack, potentially leading to better long-term patient outcomes. The study found that the protein complex MEF2 plays a key role in heart cell survival and gene expression.
A new study provides visual simulations of what someone with restored vision might see after undergoing sight recovery therapies, highlighting the limitations of current technologies. The simulations reveal that patients may experience fuzzy or blurred outlines, and temporary visual disappearances.
Researchers at UC San Diego identified microRNA let-7 as a key player in managing cell survival and growth. The molecule controls autophagy through the amino acid sensing pathway, which has emerged as the most potent activator of mTORC1 complex activity.
Scientists have identified a new protective mechanism that could increase cell survival after stroke, highlighting the importance of SUMOylation in promoting nerve cell adaptation and survival. The discovery may lead to new therapies for stroke and other brain diseases.
Researchers at the Trudeau Institute have identified a previously unknown link between the migration of white blood cells to infected tissues and their ability to survive as long-lived memory cells. This discovery aims to improve vaccine efficacy, particularly for the elderly population.
Researchers found that trophoblast stem cells (TSCs) can survive in female mice livers without ovarian hormones, but not in male liver's even after castration. This study suggests a new approach for therapeutic cell transplantation using TSCs.
Researchers have discovered how the DISC complex triggers cell death or survival by switching key molecules' activity levels. Stopping the DISC from functioning properly prevents efficient cell death, resulting in disease conditions like ALPS.
Scientists have identified a genetic switch called hairy that helps oxygen-deprived cells survive by suppressing non-essential activity. The study, using fruit flies as a model, reveals how this metabolic slowdown occurs and may hold clues for human cell survival under low-oxygen conditions.
Researchers at the University of Wisconsin-Madison have developed a new storage method that increases stem cell survival rates by over 20 times, allowing for more efficient and reliable research. The technique uses a gel matrix with trehalose to protect cells from freezing and thawing damage.