Articles tagged with Dna Sequencing
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers developed a new technique called CLASSIC that enables large-scale testing of complex DNA circuits in human cells. The approach uses artificial intelligence and machine learning to analyze vast numbers of complete circuits at once, providing scientists with a clearer picture of the rules governing genetic part behavior.
Researchers from The University of Osaka discovered that loss of heterochromatin can trigger genetic changes leading to chromosomal rearrangements and diseases like cancer. Accumulation of R-loops at pericentromeric repeats was found to be a key mechanism in this process.
Researchers have discovered new genetic causes of inherited blindness, identifying changes in RNA genes as a key factor. This breakthrough provides clarity for dozens of families globally and opens new possibilities for diagnostics and counseling in hereditary conditions, offering hope for affected individuals and their loved ones.
A study by University of Florida researchers found that mosquitoes fed on 86 different species of animals, capturing nearly all the vertebrate biodiversity in a small area in central Florida. This innovative method uses mosquitoes to monitor other animals and conserve them.
Researchers found 13 bird species, 11 mammal species, and 2 amphibian species in Danish moss samples, demonstrating its potential for monitoring global biodiversity. The study suggests that moss-based DNA sampling could work globally due to its simplicity, effectiveness, and gentle nature.
A team of researchers from Yokohama National University has discovered a previously unknown species of marine fungus that can kill harmful, bloom-forming algae. The new species, Algophthora mediterranea, was found to be a destructive parasite in a species of algae known to cause toxic blooms with adverse health effects on humans.
Researchers have found that a new DNA sequencing technology can study how transposons move within and bind to the genome, playing critical roles in immune response, neurological function, and genetic evolution. The discovery has significant implications for agricultural advancements and understanding disease development and treatment.
Researchers from the University of Florida discovered critical security vulnerabilities in portable genetic sequencers, exposing them to potential attacks and data breaches. The devices' reliance on insecure connections to laptops or unsecured networks amplifies these risks.
Recent studies using portable nanopore sequencing technologies document and sequence Amazonian wildlife, increasing representation of Peruvian species in global genetic libraries. This initiative empowers conservationists to generate their own data, making informed decisions to combat species extinction.
A recent study by Michigan Medicine researchers has found that CRISPR-Cas9 forms immune memories in bacteria by boosting spacer acquisition when RNA levels are low. This discovery expands our understanding of how bacteria safeguard their immune memory and may inspire new ways to design CRISPR-based molecular recording tools.
Researchers discovered how the genome uses competition between proteins to prevent rogue retrotransposon LINE1 from causing damage. The team found that a modified protein NRBP2 marks and disposes of another protein NRBP1, which is no longer functional due to mutations.
Researchers sequenced the oldest Egyptian genome from a 4,500-4,800 year-old individual, tracing ancestry to North Africa and the Fertile Crescent. The study provides genetic evidence of population mixing in ancient Egypt during this period.
The Princess Máxima Center has implemented whole genome sequencing as the standard of care for children with cancer, enabling precise diagnosis and tailored treatment. This comprehensive approach also provides valuable data for developing new treatments and researching childhood cancer development.
Researchers identified nearly 500 switch-like genes, which express at high or low levels, and linked them to various ailments like vaginal atrophy and COVID-19. The study suggests that hormones and genetic variation drive this 'switch-like' behavior.
A new machine learning algorithm, SAVANA, has been developed to accurately detect structural variations in cancer genomes using long-read sequencing data. The algorithm was tested on 99 human tumour samples and showed high consistency with current clinical standards.
A new AI tool developed by University of Missouri researchers can predict the 3D shape of chromosomes inside individual cells, providing a new view of how genes work. The tool helps identify unique differences in chromosome folding between cells, which controls gene activity and can lead to diseases like cancer.
A recent study found that individuals with a specific type of gut bacteria (Firmicutes) had higher bone mineral density and better metabolic health. The researchers suggest that promoting the growth of butyrate-producing bacteria could be an effective strategy for maintaining bone mass and preventing osteoporosis.
A multidisciplinary team will utilize cutting-edge imaging technology and underwater robotics to discover and describe exotic marine species in the deep ocean. The project aims to transform how scientists understand the ocean's vast midwater region.
Researchers identified four specific genes linked to lethal stomach cancers, enabling potential targeted treatments and less aggressive procedures for some patients. The study's findings support a more personalized approach to treatment based on each patient's tumor biology.
The study reveals that Phoenician culture spread primarily through cultural transmission and assimilation, with little direct genetic contribution from Levantine ancestors. Punic sites showcased a highly heterogeneous genetic profile, with individuals having both Sicilian-Aegean and North African ancestry.
A study published in the Journal of Medical Entomology found a gene mutation in bed bugs that may contribute to their resistance to insecticides. The researchers, led by Warren Booth, discovered the mutation in 134 unique populations of bed bugs collected from North America between 2008-22.
Researchers have discovered RNA pseudouridine as a novel diagnostic target for colorectal cancer. The study found correlations between pseudouridine modifications and clinical markers, enabling potential non-invasive diagnosis. The findings provide a molecular framework for RNA epigenetics-based stratification and targeted interventions.
The discovery of the Curiously Isolated Hairstreak, a new butterfly species, reveals striking genetic diversity and ecological uniqueness. The isolated population has been separated from its closest relatives for up to 40,000 years, resulting in low genetic diversity and reduced adaptability to changing climatic conditions.
A new method for detecting cancer from blood samples has been developed, enabling the detection of extremely low concentrations of circulating tumor DNA. The technique, which combines whole-genome sequencing with error-correcting methods, shows high sensitivity and accuracy in identifying cancer mutations.
A novel AI-based method called scNET combines gene expression data with networks of possible gene interactions to identify biological patterns in response to drug treatments. The system reveals complex mechanisms underlying cellular behavior, providing insights for new therapeutic approaches.
Researchers developed new AI models, InstaNovo and InstaNovo+, to vastly improve accuracy and discovery in protein science. These models excel in tasks such as de novo peptide sequencing, identifying microorganisms, and discovering novel peptides, with implications for personalized medicine, cancer immunology, and beyond.
Researchers found evidence of a genetic mixing event between two ancient populations around 1.5 million years ago, which contributed to the modern human species. The study suggests a more complex story of human evolution than previously thought, with different groups developing separately before reuniting.
Researchers have discovered five new species of fungi in the Piloderma genus, including one rare species found only in old-growth forests. The discoveries suggest that diversity in this genus is greater than previously thought and highlight the risk of species disappearance as forests are logged.
A genomics blood test has improved diagnosis and treatment plans for children with rare diseases, including epilepsy. The test provides genetic diagnoses for 43% of children in under three weeks, leading to significant impacts on treatment.
A comprehensive genetic representation for over 2.5 billion people has been created, capturing genetic diversity and variations found in diverse populations. This pangenome reference aims to enhance early diagnosis and personalized treatments for genetic diseases prevalent in the region.
The discovery challenges our understanding of seaweed in a changing ocean and has implications for predicting its future. The giant clone, found to be a single species with millions of individuals, thrives in low-salinity waters and provides habitat for various marine life.
Researchers used DNA barcodes to narrow down the possible sources of introductions of an invasive banana skipper butterfly, finding evidence of aircraft-borne introductions in Japan and potentially in Mauritius. The study suggests that gravid females may be attracted to airport lights, increasing the risk of spread to new areas.
Researchers used advanced molecular tools to survey health status of endangered Indiana bats, identifying microbiome changes resulting from parasitic infections. The analysis revealed that bats with high loads of a protozoan parasite had a corresponding proliferation of certain bacteria.
A new study found that Neanderthals experienced a drastic loss of genetic variation approximately 110,000 years ago, leading to their eventual extinction. The research measured the morphological diversity in semicircular canals, which revealed lower diversity in classic Neanderthals compared to pre-Neanderthals and early Neanderthals.
A new test called EpiAgePublic estimates biological age using only three DNA sites in the ELOVL2 gene, simplifying traditional methods while maintaining accuracy. The study found that EpiAgePublic accurately tracks aging patterns and can identify factors accelerating the aging process.
Researchers have discovered that giraffes maintain species-specific gut flora, even when eating different sets of plants. This finding has significant implications for the conservation of endangered giraffe species, highlighting the importance of understanding their diets and habitats to ensure their survival.
Researchers analyzed DNA of 370 individuals from 800 years, revealing genetic ties between Huns and Xiongnu Empire. The study found a small but distinct set of individuals carrying East Asian genetic signatures, suggesting some Hun-period individuals in Europe traced their lineage back to late Xiongnu burials.
A study published in iScience reveals that bacterial species are transferred between both individuals during sexual intercourse, and these species can be traced to a partner's unique genital microbiome. This discovery may provide a new tool for identifying perpetrators of sexual assault.
A CABI-led study uses publicly-shared DNA barcodes and citizen science images to detect the establishment of a biological control agent used to tackle Lantana camara. The research found two genetically distinguishable populations of Orphanostigma haemorrhoidalis, one in south-eastern USA and the other widespread in Neotropics.
Researchers discovered a newly recognized Caucasus-Lower Volga population that can be connected to all Indo-European-speaking populations through ancient DNA analysis. This finding marks a significant turning point in understanding the origins of the Indo-Europeans and their spread across Europe and Asia.
Researchers at U of T have developed a new platform called smol-seq that uses DNA sequencing to detect metabolites. This method enables the analysis of hundreds of metabolites simultaneously, making it faster and more precise than current methods.
A high number of poliovirus detections in European countries has highlighted the importance of maintaining high vaccination coverage. The virus can be imported into Europe as long as it circulates globally, posing a risk to unvaccinated populations.
The study maps population distribution, evolutionary histories and vulnerabilities to climate change for three Asian horseshoe crab species. It proposes customized conservation strategies based on genomic baseline dataset, highlighting the importance of Southeast Asia's Sunda Shelf as a critical coastal marine habitat.
Researchers at North Carolina State University suggest that the Irish potato famine pathogen, Phytophthora infestans, originated in the South American Andes Mountains. The study compared genetic material from P. infestans with those of close relative pathogens and found distinct differences between the two.
Researchers analyzed DNA of Chornobyl City and NPP dogs to detect genetic mutations, finding none despite long-term exposure to radiation and other toxins. The study implies that low-level environmental contamination could explain genetic differences between the two dog populations.
A new study published in PLOS ONE found that the genomes of dogs within the Chornobyl Exclusion Zone did not exhibit genetic mutations from radiation exposure. Instead, researchers suggest that low-level environmental toxin exposure over many years may have contributed to genetic differences between dog populations. The findings offer ...
The partnership aims to enhance publication and dissemination of eDNA research, increasing visibility and impact. Pensoft will support SeDNAs conferences and publish special issues in its Metabarcoding and Metagenomics journal.
A genetic fault long believed to drive oesophageal cancer development may actually play a protective role early in the disease, according to new research. The study found that defects in CDKN2A were more common in people with Barrett's oesophagus who never progressed to cancer.
A joint research group clarifies a key mechanism of how retrotransposons preferentially insert in the centromere. The findings reveal strong integration biases for certain genetic elements, shedding light on rapid genome evolution.
Researchers analyzed nuclear genomes of ancient European specimens to shed light on the genetics of early Europeans and their interactions with Neandertals. The study reveals a small, isolated group that interbred with Neandertals but left no present-day descendants.
A novel study found that the TPMT∗8 allele is associated with reduced metabolism of thiopurine drugs, which can lead to toxicity. The research emphasizes the importance of understanding the function of TPMT∗8 to ensure effective pharmacogenomic testing across all ancestries.
CNIO researchers have identified significant inaccuracies in widely used epigenetic clocks, which are now being refined by the team. The new epigenetic clock model provides more accurate measurements, reducing errors by up to 25 years for some tests.
Researchers found that Florida panthers are not at increased risk for contracting chronic wasting disease from eating infected deer. The study provides relief to conservation efforts, as the disease has spread through North America's deer and elk populations.
Researchers found that a regulatory level change enabled C4 plants to photosynthesize more efficiently. By studying this shift, they believe it could be applied to make C3 crops like rice and wheat more resilient to climate change.
A new study reveals dramatic changes to gut and mouth bacteria in people with chronic liver disease, correlating with increased antibiotic resistance and poor clinical outcomes. The findings suggest a need for personalized microbiome-based treatments and rapid diagnosis of infections to improve patient care.
Scientists at the University of Gothenburg have discovered four new species of daisies in South Africa using advanced DNA sequencing techniques. The discovery highlights the importance of integrating traditional observations with modern genetic analysis to better understand plant relationships and biodiversity.
Scientists have discovered multiple instances of genetic interbreeding between Denisovans and modern humans, shaping early human history. Denisovan genes confer advantages in distinct environments, such as tolerance to low oxygen conditions and heightened immunity.
A new AI tool uses microbial communities as a 'microscopic fingerprint' to determine geographical source, opening up possibilities in medicine, epidemiology and forensics. The mGPS system achieves impressive precision, pinning down city sources for 92% of samples and distinguishing between handrails and kiosks in NYC.
A 2023 avian flu outbreak in Washington state killed 56% of a large breeding colony of Caspian terns and had significant impacts on the Pacific-coast population. The virus was also transmitted to harbor seals, causing an inflammatory response in their brains.
A recent study by CU Anschutz scientists found that an ancient gene mutation among First Nations inhabitants of Oceania may make them more susceptible to certain infectious diseases. The allele, KIR3DLI*114, is widespread and unique to Oceania, with up to 30% of individuals carrying it.