Articles tagged with Molecular Genetics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers have discovered a surprising mechanism by which the molecular machine Dis3L2 unwinds and destroys RNA molecules. By changing shape, Dis3L2 reveals an RNA-splitting wedge, allowing it to execute its tasks in a more dynamic and versatile way.
A new statistical analysis tool has uncovered the distribution and intermixing of Jomon hunter-gatherers and East Asian immigrant farmers in Japan. The study found that regions with higher Jomon ancestry are more prone to obesity, while those with higher East Asian ancestry are more susceptible to exacerbated asthma.
Researchers examined three epigenetic age acceleration measurements and found inverse associations with lung cancer risk in men and younger participants. However, these findings did not support a positive association between epigenetic age measures and lung cancer risk in the study.
Researchers developed a novel technology to engineer proteins targeting specific DNA sequences, offering a new approach to gene therapies. The system generates engineered zinc fingers that bind to any given sequence of DNA, potentially treating diseases caused by genetic mutations.
A new DNA biosensor developed by NIST, Brown University, and the French government-funded research institute CEA-Leti boasts accurate and inexpensive design. The modular device can measure biomarkers in a scalable and high-sensitivity manner.
Researchers have discovered that ancient crocodilian hemoglobin required 21 interconnected mutations to develop its hyper-efficient oxygen-binding properties. This complexity, not found in other vertebrates, enabled crocodilians to exploit their onboard oxygen stores for extended periods underwater.
A landmark study found a strong genetic correlation between higher education and protective causal association with several gut disorders. The research reveals that better education reduces the risk of diseases such as Alzheimer's and inflammatory bowel disease (IBD).
Researchers at Cedars-Sinai have created a detailed molecular profile of endometriosis, identifying key differences between major subtypes and potential therapeutic targets. The new database will lead to improved care for millions of women suffering from the disease.
A new study reveals that smallpox originated more than 3,800 years ago, confirming historical sources and shedding light on the disease's history. The researchers used genetic analysis to trace the evolution of the virus, finding that different strains descended from a single common ancestor.
A 16-year longitudinal study found associations between DNA methylation-based measures and neuropsychologically-validated cognitive decline in midlife. The results suggest that these measures may serve as biomarkers for a molecular aging mechanism, potentially identifying individuals at risk of cognitive impairment and dementia.
Researchers at the University of Tokyo have developed artificial DNA that can target and kill cancer cells by binding to microRNA molecules. The DNA triggers an immune response that not only kills cancer cells but also prevents further growth of cancerous tissue.
Researchers at Florida State University have found that aspartame, a common artificial sweetener, can cause anxiety-like behavior in mice. The study, published in the Proceedings of the National Academy of Sciences, suggests that aspartame's effects extend up to two generations from exposure, affecting male mice and their offspring.
Researchers modeled how genetic changes affecting protein synthesis speed can lead to misfolding and altered activity levels in proteins. This finding suggests the importance of kinetics alongside sequence for determining protein structure and function, with potential implications for fields such as biopharmaceutics and medicine.
The German Research Foundation renewed CRC 1361 for an additional four years to explore mechanisms of DNA repair and genome stability. The consortium aims to elucidate how cells safeguard genetic information and promote human health by understanding DNA damage signaling pathways.
Johannes Gutenberg University Mainz has been awarded funding for three Collaborative Research Centers in the life sciences, including CRC 1551 and CRC/Transregio 355. The centers will focus on investigating polymer concepts in cellular function and heterogeneity of regulatory T cells in distinct microenvironments.
The new CRC 1551 will study the polymer properties of DNA, RNA, and proteins to understand their interaction in cells. The researchers aim to describe and understand nonequilibrium processes in cells triggered by complex interplay of cellular polymers.
Researchers developed a pedigree for aquarium-bred corals, revealing relationships between individuals and identifying genetic differences. The study provides insights into maximizing genetic diversity and adaptability in corals bred for conservation, crucial for their resilience to threats like ocean warming and acidification.
Researchers at VCU Massey Cancer Center have found strong evidence for testing a novel drug in liver cancer treatment. MDA-9 inhibition may be an effective approach for hepatocellular carcinoma (HCC), with potential synergies with other therapeutics.
Researchers at WashU Medicine identified a visual pathway in mice brains that is activated when animals see others scratching, triggering a reflex response. This discovery advances understanding of itching triggers and may point to solutions for itch-related conditions in humans.
Researchers have developed a new safety system for CAR-T cells, called VIPER CAR-T cells, that can be turned on or off. This allows doctors to target cancer more aggressively while minimizing side effects. The new system uses an FDA-approved antiviral drug to control the cell's activity.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Scientists have developed Live-seq, an innovative approach that keeps cells alive during RNA extraction for further study. This technique uses FluidFM to manipulate tiny volumes of fluids in a sample under the microscope, allowing for the insertion and extraction of mRNA from single cells without killing them.
Researchers develop technique to control pH at microsites, enabling high-throughput biomolecular synthesis and enzymatic DNA synthesis. This allows for increased experimental throughput and speeding up processes in DNA synthesis.
The American College of Physicians (ACP) has issued a position paper on the ethical use of genetic testing and precision medicine in internal medicine. The guidelines address key issues such as incidental findings, education for physicians and patients, and counseling needs. ACP emphasizes the need for ongoing surveillance and anticoag...
Researchers found that high temperatures induce epigenetic changes in zebrafish embryos, leading to sex reversal and altering the sex ratio. This study provides insights into the mechanisms behind climate change's impact on species with genotype-by-environment sex determination.
A new study published in the Journal of the American Heart Association found that people with high genetic risk for stroke can reduce their risk by 30-45% by adopting a healthy cardiovascular lifestyle. The study followed 11,568 adults over 28 years and showed that modifying lifestyle risk factors can offset genetic risk.
Scientists from OIST and colleagues reveal that Kamptozoa and Bryozoa belong together, contrary to previous studies. Using high-quality sequencing technology, they found the two phyla split from mollusks and worms earlier than thought, forming a distinct group.
A novel single-cell RNA sequencing technique, TAS-Seq, has been developed to provide higher-precision data than current methods. The new method detects more genes and identifies highly variable genes, making it a sensitive high-throughput scRNA method.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
A recent study by Indiana University researchers found that the structure of DNA storage in archaea affects its evolution rate. The study discovered that compacted DNA compartments change at a faster rate than less compacted ones. This discovery has potential impacts on research on genetic diseases like cancer.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
Researchers at Gwangju Institute of Science and Technology have developed a new bioinformatics pipeline, CRESSP, to investigate the mechanism underlying autoimmune diseases following SARS-CoV-2 infection. The tool identified potential epitopes responsible for COVID-related autoimmune diseases and predicted cross-reactive epitopes of di...
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
Researchers have identified the Xist gene as a critical regulator of fetal development in mice, leading to miscarriage and abnormal placentas when epigenetic instructions are missing. The study's findings suggest that failed Xist imprinting can be 'cured' by targeting specific genes involved in histone modifications.
Researchers studied peptide bond formation between tRNA molecules and a ribosomal RNA segment, revealing the potential for minihelices to bind to the primordial peptidyl transferase center. The study suggests that functional interactions between tRNA and PTC could have been 'revised' in evolution.
Researchers used CRISPR gene editing to understand how deletions in one area of the genome affect nearby genes. They found that deleting a small region led to increased foetal globin expression and reduced adult globin levels, suggesting a key mechanism for asymptomatic patients with sickle cell disease.
Researchers found that mutation frequencies in mitochondrial DNA of developing egg cells are lower and increase less with age compared to non-reproductive cells. This suggests a protective mechanism may keep reproductive cells relatively stable, potentially related to human propensity to reproduce at later ages.
Researchers found early and persistent activation of neutrophils in patients who developed severe COVID-19. The study suggests that identifying specific gene signatures could lead to effective treatments targeting high-risk patients. This discovery may also inform the development of simple blood tests to prioritize treatment.
Researchers discovered that an inorganic polyphosphate released by nerve cells contributes to the death of motor neurons in people with ALS and frontotemporal dementia. The study found that lowering levels of this toxin may be an innovative therapeutic strategy for diverse types of ALS/FTD.
Researchers found that the Klotho gene can suppress glioblastoma cell viability and induce apoptosis, leading to a significant decrease in tumor growth. The study contributes to the development of new diagnostic and treatment approaches for malignant brain tumors.
Scientists at the University of Texas at Austin have redesigned a key component of the widely used CRISPR-based gene-editing tool Cas9 to be thousands of times less likely to target the wrong stretch of DNA. The new version, called SuperFi-Cas9, is as efficient as the original but reduces off-target interactions, making it potentially ...
A COVID-19 genetic risk variant inherited from Neandertals reduces the risk of contracting HIV by 27%. This variant is associated with fewer CCR5 receptors, which can lower the risk of HIV infection.
Researchers created a novel molecular diagnostic platform that can detect COVID-19 genes after only 8 cycles of amplification, significantly reducing the time required for diagnosis. The new SERS-PCR platform uses gold nanoparticles to produce high-sensitivity signals, providing an important tool in the fight against the pandemic.
Researchers confirm that Chevalier barley came from a single plant, analyzing seed samples older than 150 years. The study reveals how the single plant's genetic signature was preserved and used to create modern malting barley varieties.
Researchers at South Ural State University have identified biomarkers for post-traumatic stress disorder (PTSD) in veterans with long-lasting symptoms. Gamma-aminobutyric acid levels were found to be the most sensitive indicator, differing from reference values even years after traumatic events.
A UMass Chan clinical trial demonstrates the safety and efficacy of an antisense oligonucleotide in suppressing mutant C9ORF72, a common cause of familial ALS. The treatment led to reduced levels of neurotoxins and stable or improved ALS functional scores.
A new study at the University of Chicago has found that individuals of European and African genetic ancestry respond differently to influenza infection, with a stronger type I interferon pathway activation in those of European ancestry. This variation in immune response may contribute to disparities in influenza outcomes between differ...
Researchers from the University of Rochester have further evidence that genes are evolving defensive mechanisms to counteract harmful genetic elements. The study found that specific genes developed weapons-like structures to combat 'parasites' in the human genome, highlighting the ongoing 'arms race' between these two forces.
Researchers discovered regulation of cytokinin is central to balancing nitrogen acquisition. Legumes restrict nodules when nitrogen is abundant, acquiring instead from the soil.
Researchers sequenced the genomes of an ancient date palm leaf and found evidence of hybridization with wild relatives. The study sheds light on the evolution of date palms in North Africa, showing that genetic material from another species was present 2,200 years ago.
Researchers found that genes can be triggered by specific patterns of light exposure, producing varying levels of activity. The output was not directly correlated to the input, and controlling frequency gave precise control over gene activity.
A new study from Salk Institute researchers found that a critical threshold of miR-218 levels determines the development of ALS in animal models. The study sheds light on the complex control of gene expression and its implications for treating neurological disorders.
Researchers identified a novel lncRNA, Teshl, which plays a crucial role in the development of Y-bearing sperm and regulates sex chromosome gene expression. The study provides new insights into sex ratio variations and suggests that genetics may be a key factor in human male infertility.
Adam Guenzel, PhD has received the prestigious Richard King Trainee Award for his outstanding publication on Krabbe disease diagnosis and monitoring. The award recognizes Dr. Guenzel's research contributions to improving newborn screening protocols and novel biochemical assays.
Dr. Chaya N. Murali, a pediatric geneticist, received the 2020 Richard King Award for her outstanding research on patient-reported outcomes in children with osteogenesis imperfecta. Her award-winning article demonstrated the utility of a new data collection instrument.
Researchers at the University of Florida identified cells targeted by a male hormone and found that excess hormone exposure during fetal development can cause vaginal defects in females. The study found a specific window of hormonal influence and a type of cell responsible for guiding the developing vagina to its correct position.
Two papers address challenges in interpreting clinical genome and exome sequencing results. The CSER Consortium has developed approaches for using sequencing to diagnose rare diseases, cancer, and other conditions. A new set of guidelines may help different labs interpret sequencing results consistently.
The ACMG Foundation presents the first recipient of the David L. Rimoin Inspiring Excellence Award to Dr. Marcus Miller for his platform presentation on Metabolomic Analysis Uncovers Significant Trimethylamine N-oxide Production. The award supports research in metabolomics and human genetic disorders.
The FASEB MARC Program has awarded $3,700 to two students, Hilmarie Muniz-Talavera and Zuania Cordero Badillo, from underrepresented groups. The program aims to increase diversity in biomedical research.
Despite a quarter century of evolution, bacteria in Richard Lenski's lab continue to adapt and become more fit. Researchers used a 'frozen fossil record' of bacteria samples from different generations to measure their trajectory, finding that they never reach a fitness peak but instead follow a power law function.