Researchers at CU Anschutz Medical Campus investigated SARS-CoV-2 variant interactions with diverse interferons, finding the virus has adapted to evade this key front-line defense. The study suggests COVID-19 clinical trials on interferons may need to be reinterpreted based on circulating variants.
SourceUniversity of Colorado Anschutz Medical Campus·JournalProceedings of the National Academy of Sciences·TypeObservational study·DateJul 25, 2022
A study found that OTUD3 limits RNA virus-triggered innate immunity but promotes DNA virus-triggered innate immunity, highlighting the complexity of host antiviral responses. OTUD3 also interacts with cGAS to remove K48-linked polyubiquitination chains and protect its DNA-binding ability.
SourceChinese Academy of Sciences Headquarters·JournalCell Reports·DateJun 12, 2022
Researchers have found that flu viruses can directly infect heart cells, leading to electrical malfunctions and scarring. The study suggests that clearing the viral infection may be key to reducing flu's effects on the heart.
SourceOhio State University·JournalScience Advances·DateMay 11, 2022
The 100-year-old BCG vaccine has been found to protect newborns and young infants against multiple bacterial and viral infections, including COVID-19. The study identified changes in metabolite and lipid profiles that correlate with innate immune system responses.
SourceBoston Children's Hospital·JournalCell Reports·DateMay 3, 2022
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Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new study found that moderate fitness can offer protection against the dampening effects of chemotherapy on natural immunity. Breast cancer survivors who were moderately fit produced a significantly larger immune response to a typhoid vaccine, while those with lower fitness levels had a reduced response.
SourceOhio State University·JournalBrain Behavior and Immunity·DateApr 26, 2022
Researchers have developed a new treatment for chronic inflammation by targeting the ASC protein with nanobodies, which can dissolve harmful molecular complexes and counteract inflammation. The treatment has shown promising results in mouse models, alleviating symptoms of rheumatoid arthritis and gout.
SourceUniversity of Bonn·JournalEMBO Molecular Medicine·DateApr 19, 2022
A team of researchers identified a stem rust resistance gene from wild goat grass species Aegilops sharonensis, which can be cross-bred into wheat for immunity against deadly crop pathogens. The genetic potential of this hardy relative has been largely unexplored and holds promise for reducing the threat of the stem rust disease.
SourceJohn Innes Centre·JournalNature Communications·TypeExperimental study·DateMar 25, 2022
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Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers discovered that shorter antibiotic courses are associated with fewer antibiotic resistance genes in children, but also found increases in resistance to other antibiotics. The study suggests that treatment duration can impact the microbiome and increase susceptibility to other pathogens.
SourceAmerican Society for Microbiology·JournalmBio·DateMar 24, 2022
Researchers found that innate effector cells can acquire a memory to strengthen gut mucosal defenses against repeated infections over time. This discovery demonstrates a new antibacterial immune defense mechanism and could lead to novel therapeutic approaches to treat intestinal diseases.
SourceInstitut Pasteur·JournalScience·TypeExperimental study·DateFeb 28, 2022
Researchers at University of Texas M. D. Anderson Cancer Center developed a novel PET imaging tool to selectively monitor inflammation and innate immune activity. The new radio-labeled molecule, [18F]4FN, is more specific and robust than existing agents, offering potential for early biomarker detection of immune-related adverse events.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Biotechnology·TypeExperimental study·DateFeb 21, 2022
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Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
Scientists at Washington State University have discovered a novel theory that the innate immune system can respond differently to specific pathogens. This quality, known as immunological specificity, is driven by the nervous system and could provide a basis for finetuning an experimental treatment to fight infection.
SourceWashington State University·JournalCell Reports·TypeExperimental study·DateFeb 8, 2022
Researchers at TUM discover that intestinal bacteria interact with Paneth cells in the gut mucus layer, leading to chronic inflammation. This finding may lead to new treatments for IBD.
SourceTechnical University of Munich (TUM)·JournalScience Immunology·TypeExperimental study·DateFeb 1, 2022
A study by Michigan Medicine researchers found that people with diabetes have more macrophages in their fat tissue, particularly the anti-inflammatory CD206+ subtype. This subtype is unique in terms of gene expression and may play a role in the development of diabetes.
SourceMichigan Medicine - University of Michigan·JournalJCI Insight·TypeData/statistical analysis·DateJan 31, 2022
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at Trinity College Dublin have identified a crucial protein, myeloid cell nuclear differentiation antigen (MNDA), that regulates type I interferon production in response to viral infections. This breakthrough discovery has significant implications for the development of new therapies to boost or suppress immune responses, p...
SourceTrinity College Dublin·JournalNature Communications·DateJan 10, 2022
The SARS-CoV-2 Alpha variant adapted to avoid triggering the innate immune response by increasing expression of antagonism proteins, which disable the body's first line of defense. This allows the virus to replicate under the radar in early stages of infection, significantly increasing its chances of infecting a person.
SourceUniversity College London·JournalNature·TypeExperimental study·DateDec 23, 2021
A new viral disease caused by Tomato brown rugose fruit virus (ToBRFV) has emerged, threatening global tomato production. ToBRFV overcomes the durable Tm-2² resistance gene, which had remained unbroken for over half a century.
SourceAmerican Phytopathological Society·JournalMolecular Plant-Microbe Interactions·TypeExperimental study·DateNov 2, 2021
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Research at Florida Atlantic University found that green sea turtles in polluted environments have impaired immune systems, leading to increased disease susceptibility. The study suggests a positive feedback loop where pollution compromises immunity, making turtles more prone to Green Turtle Fibropapillomatosis.
SourceFlorida Atlantic University·JournalJournal of Wildlife Diseases·TypeExperimental study·DateOct 12, 2021
A study analyzed genetic material from 86 discordant couples infected by SARS-CoV-2 and found associations between certain genetic variants and efficient activation of natural killer cells. These cells play a crucial role in the innate immune response, destroying infected cells to prevent disease development.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalFrontiers in Immunology·DateSep 28, 2021
The study elucidates the mechanism by which CXCL14 binds to CpG DNA and enhances innate immune responses. A complex formation between CpG DNA and CXCL14 is necessary for internalization of CpG DNA, and multiple amino acids stabilize binding.
SourceTokyo Metropolitan Institute of Medical Science·JournalThe Journal of Immunology·DateSep 15, 2021
Researchers discover a new way for an antiviral enzyme to detect and destroy viruses that hide inside cell membranes. The OAS1 p46 isoform enhances the immune response against SARS-CoV-2, flaviviruses, and other RNA viruses.
SourceUniversity of Washington School of Medicine/UW Medicine·TypeExperimental study·DateAug 13, 2021
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
UT Southwestern researchers report the first structural confirmation that endogenous molecules can trigger innate immunity in mammals through the TLR4?MD-2 receptor complex. The discovery has wide-ranging implications for treating and preventing autoimmune diseases such as multiple sclerosis.
SourceUT Southwestern Medical Center·JournalProceedings of the National Academy of Sciences·DateJul 22, 2021
Researchers use zebrafish to study human cancer and discover that the innate immune system actively destroys cancer cells. However, tumor cells can adapt and evade immune detection through a process called 'Immunoediting', leading to immunotherapy resistance.
SourceChampalimaud Centre for the Unknown·JournalNature Communications·DateFeb 19, 2021
Researchers have identified a key function of AIM2, a molecule that plays a vital role in regulating the adaptive immune system. The study reveals that AIM2 is expressed at higher levels in regulatory T cells, which prevent overzealous immune responses and mitigate autoimmune diseases.
SourceUniversity of North Carolina Health Care·JournalNature·DateJan 28, 2021
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
The SARS-CoV-2 virus blocks innate immune activation, preventing the production and signaling of type I interferon, a key component of host defense against viral infections. This suppression allows the virus to replicate unchecked, leading to COVID-19 disease progression.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalJournal of Interferon & Cytokine Research·DateJan 21, 2021
Researchers found human editing enzymes behind a COVID-19 virus mutation that stimulates pro-inflammatory molecule release. The mutation altered innate immune responses, and further study is needed to determine its impact on virus elimination or symptom aggravation.
SourceTohoku University·JournalScientific Reports·DateNov 11, 2020
An international team led by George Hajishengallis showed that training the innate immune system with β-glucan can inspire neutrophils to target tumors. The study found that trained immunity can be transferred through bone marrow transplants, leading to improved tumor-fighting ability.
SourceUniversity of Pennsylvania·JournalCell·DateOct 29, 2020
Researchers found that newborns' immune systems activate soon after birth and increase key factors of innate immunity, including the complement system. This development is critical for protecting against pathogens in infancy, where infections are prevalent.
SourceFrontiers·JournalFrontiers in Immunology·DateOct 22, 2020
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers at Boyce Thompson Institute have discovered a new gene, Pseudomonas tomato race 1 (Ptr1), that imparts resistance to bacterial speck disease. The team identified the gene through a serendipitous discovery of two plants with the gene that survived a devastating outbreak of the disease.
SourceBoyce Thompson Institute·JournalThe Plant Journal·DateSep 2, 2020
Deep-sea anglerfish have evolved a unique immune system that allows them to temporarily or permanently fuse with their mates without experiencing immune rejection. This altered immunity, which lacks adaptive immune functions, has helped facilitate the evolutionary success of these species.
SourceAmerican Association for the Advancement of Science (AAAS)·JournalScience·DateJul 30, 2020
Researchers discovered that M2-type macrophages are more susceptible to ferroptosis and may exacerbate chronic inflammation. A mathematical model was developed to describe the stability of macrophages under different conditions.
SourceSechenov University·JournalNature Chemical Biology·DateMay 16, 2020
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Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
A new antibiotic resistance gene, gar, has been discovered in environmental samples from India and found in several clinical pathogens, including Salmonella and Pseudomonas. This rare gene provides resistance to aminoglycoside antibiotics, which is concerning for treating multi-resistant bacteria.
SourceUniversity of Gothenburg·JournalMicrobiome·DateMar 26, 2020
Scientists have identified specific genes that confer nonhost resistance to wheat leaf rust in barley, a breakthrough that could transform the breeding of durable disease-resistant cereal crops. This discovery has the potential to improve global food security by providing a solution to one of the biggest problems in wheat production.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Plants·DateDec 5, 2019
Antibiotic-resistant genes were found in London's freshwater sources, with the River Thames having the highest levels. The genes come from human and animal waste, which contaminates water bodies through wastewater discharge. Researchers are now experimenting with slow sand filtration to remove these genes.
SourceUniversity College London·JournalJournal of Microbiological Methods·DateJul 25, 2019
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Princeton University researchers have developed a scalable cell culture system that allows for detailed investigation of how host cells respond to infection with HBV and HDV. The system, called SACC-PHH, enables chronic HBV infection for up to 40 days, providing unprecedented opportunities to study host responses to hepatitis viruses.
SourcePrinceton University·JournalHepatology·DateJun 18, 2019
Most examined circRNAs form imperfect RNA duplexes that act as PKR inhibitors, but rapid degradation by RNase L triggers PKR activation. CircRNA overexpression reduces aberrant PKR activation in SLE patient-derived cells.
SourceChinese Academy of Sciences Headquarters·JournalCell·DateApr 25, 2019
The International Cytokine & Interferon Society awards two scientists, Dr. Akiko Iwasaki and Dr. Hao Wu, for their outstanding contributions to cytokine and interferon research. Their work has led to paradigm shifts in understanding immune responses and vaccine design.
SourceInternational Cytokine & Interferon Society·DateApr 23, 2019
Researchers at Kanazawa University discovered that a host mRNA, selenoprotein P (SeP), specifically regulates the RIG-I pathway-dependent innate immune responses. SeP mRNA inhibits the activation of RIG-I by binding to its regulatory domain and negatively regulating innate immunity.
SourceKanazawa University·JournalCell Host & Microbe·DateApr 10, 2019
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers found that even low concentrations of single antibiotics lead to resistance in multiple classes. The team believes alterations in treatment processes can reduce the spread of antibiotic-resistant organisms.
SourceUniversity of Southern California·JournalEnvironmental Science & Technology·DateMar 6, 2019
Researchers have developed a new method called AgRenSeq, which enables the rapid recruitment of disease resistance genes from wild plants and their transfer into domestic crops. This technique has been successfully trialed in a wild relative of wheat and holds promise for protecting multiple crops worldwide.
SourceJohn Innes Centre·JournalNature Biotechnology·DateFeb 4, 2019
A new study reveals that klotho acts as a shield between the brain and immune system, protecting against age-related cognitive decline. The research found that low levels of klotho in the choroid plexus lead to increased brain inflammation, which can impair brain functions.
SourceGladstone Institutes·JournalProceedings of the National Academy of Sciences·DateNov 12, 2018
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CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A new study has identified genetic locations of resistance genes in the common bean, allowing breeders to develop varieties with built-in weevil protection. This will enable farmers to store seeds more effectively, reducing losses and improving food security.
SourceAmerican Society of Agronomy·JournalCrop Science·DateOct 24, 2018
Researchers from Australia and the UK have isolated three related rust resistance genes that confer distinct recognition specificities to the stripe rust pathogen. This breakthrough could enable accurate monitoring and integration of these genes into breeding programs to combat evolving pathogens.
SourceUniversity of Sydney·JournalNature Plants·DateAug 27, 2018
Researchers at UT Southwestern Medical Center have identified the body's microreactors for innate immunity, which could lead to novel treatments for infections and autoimmune diseases. The discovery involves a DNA-sensing enzyme that forms droplets that act as tiny bioreactors creating molecules to stimulate the immune system.
SourceUT Southwestern Medical Center·JournalScience·DateJul 6, 2018
A new study shows that innate immune pathways in the intestine fine-tune body metabolism to diet and conditions in response to
SourceBoston Children's Hospital·JournalCell Metabolism·DateJun 21, 2018
A study has isolated colistin-resistant E. coli from commercial poultry farms in China and hospital patients, revealing the coexistence of mcr-1 and mcr-3 resistance genes on a single plasmid. This finding poses a significant threat to public health due to the spread of antibiotic resistance genes.
SourceAmerican Society for Microbiology·JournalAntimicrobial Agents and Chemotherapy·DateMay 14, 2018
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Dr. Giorgio Trinchieri is recognized for his pioneering contributions to cytokine biology, including the discovery of interleukin-12 and its role in inflammation and immunity. His work has led to significant breakthroughs in understanding and treating cancer, inflammatory diseases, and autoimmune disorders.
SourceInternational Cytokine & Interferon Society·DateMay 9, 2018
Thirumala-Devi Kanneganti and Luke O'Neill were awarded the 2018 Seymour & Vivian Milstein Award for their major advances in understanding how our bodies recognize and respond to pathogens, leading to profound clinical benefits in treating diseases. The award recognizes outstanding contributions to cytokine and interferon research.
SourceInternational Cytokine & Interferon Society·DateMay 8, 2018
A deficiency of TRIF, a key innate immune adaptor, significantly shortens the survival time of ALS mice by allowing the accumulation of toxic reactive oxygens. This study reveals a new role for innate immunity in ALS pathomechanism and provides a clue to develop a therapeutic approach for protecting motor neurons.
SourceNagoya University·JournalCell Death and Differentiation·DateApr 15, 2018
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Research reveals that vampire bats in areas with high livestock abundance have different immune profiles, investing more in adaptive immunity to fight infections. The study's findings also suggest a higher risk of virus transmission to humans through cross-species contact, highlighting the importance of sustainable farming practices.
SourceUniversity of Georgia·JournalPhilosophical Transactions of the Royal Society of London (B )·DateMar 26, 2018
Scientists discover that training precursor cells in the bone marrow with beta-glucan leads to a sustained positive response of the hematopoietic system. This effect could help accelerate the formation of new white blood cells, which are vital during chemotherapy.
SourceTechnische Universität Dresden·JournalCell·DateJan 16, 2018
A recent study by the University of Bonn found that fast food can make the immune system more aggressive in the long term. Even after switching to a healthy diet, inflammation remains higher, potentially leading to diseases like arteriosclerosis and diabetes.
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A 3D stem cell-derived intestine model has been developed that closely mimics the natural human response to gut infection. The model displayed key small intestine characteristics and exhibited an antibacterial response upon E. coli infection.
Research reveals a connection between genetic innate immunity deficiencies and high-risk children for dental caries. Children with defective salivary proteins are more susceptible to caries, even without bad eating habits or oral hygiene routines.
Researchers at Chalmers University of Technology and the University of Gothenburg have discovered 76 new types of antibiotic resistance genes. These genes can provide bacteria with the ability to degrade carbapenems, a powerful class of antibiotics.
SourceChalmers University of Technology·JournalMicrobiome·DateOct 16, 2017
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers successfully built a gene drive to reduce female fertility in malaria-spreading mosquitoes, but mutations soon arose that blocked the spread of new genes. This study documents the emergence of resistance and will help improve future gene drives.
Researchers have discovered a new mobile colistin resistance gene, mcr-3, in Escherichia coli of pig origin, which may already be widely disseminated. The prevalence of mcr-3 is likely underestimated due to potential transfer between bacterial species.
SourceAmerican Society for Microbiology·JournalmBio·DateJun 27, 2017
Researchers at Technical University of Denmark discover that resistance genes originate from the same group as antibiotics, Actinobacteria. The study reveals a new mechanism called 'carry back', where pathogens acquire genes through a primitive form of bacterial sex.
SourceTechnical University of Denmark·JournalNature Communications·DateJun 16, 2017
Researchers found that administering certain drugs to make cells more negatively charged strengthens tadpoles' innate immune response to E. coli infection. Removing tail buds also increases survival rate.
SourceTufts University·Journalnpj Regenerative Medicine·DateMay 26, 2017
Researchers have discovered a new variant of the mcr-1 gene in a healthy individual carrying Salmonella, highlighting the potential for spread of antimicrobial resistance. The finding raises concerns about food safety and the need for increased monitoring of this gene and its variants.
SourceAmerican Society for Microbiology·JournalAntimicrobial Agents and Chemotherapy·DateMar 6, 2017
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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A new method called poreFUME can rapidly detect resistance genes in gut bacteria, leading to improved treatment outcomes. The study found the method to be 97% accurate and significantly cheaper than current methods.
SourceTechnical University of Denmark·JournalNucleic Acids Research·DateFeb 10, 2017