Articles tagged with Innate Immunity
A new study reveals that macrophages, a key immune cell type, age differently across tissues and between sexes. The researchers found that aging macrophages become more focused on responding to stress and cellular damage, but lose some molecular programs involved in maintaining healthy tissue structure.
Scientists from the University of Osaka have identified a previously unknown molecular mechanism linking mitochondrial morphology to innate immune activation. Abnormally long mitochondria can trigger the release of mitochondrial RNA into the cytosol, activating RNA-sensing proteins and leading to anti-tumor immunity.
A comprehensive map of human STING reveals how different regions regulate immune signaling and how small genetic changes can alter its behavior. The study identifies both known and previously unknown regulatory sites, providing new insight into how immune signaling is regulated.
A study reveals that TREM2+ macrophages directly recognize candidalysin, a toxin secreted by Candida albicans, to initiate an immune response. This recognition leads to the activation of key immune cells and the production of pro-inflammatory cytokines, ultimately protecting against fungal infection.
A new COVID-19 vaccine adjuvant has been developed that can extend vaccine protection for up to two years, reducing the need for repeated boosters. The adjuvant, known as mannadjuvant, was created from a fungal component and showed a more pronounced response against omicron viral components than the vaccine alone.
Researchers found that Rhein reduces pancreatic and intestinal damage, restores intestinal barrier integrity, and promotes repair macrophage responses. PPARγ is identified as the central mediator of Rhein's effects.
Researchers discover enzyme ANKIB1 crucial for innate immune signalling, driving type I and type III interferon induction. This finding solves a long-standing puzzle in innate immunity and provides opportunities for new therapies for devastating diseases.
Researchers summarize itaconate biology highlighting its chemical reactivity and therapeutic potential in treating infectious diseases, sepsis, autoimmunity, neurodegenerative disorders. Itaconate exerts biological effects through post-translational modifications, altering protein activity and signaling pathways
A new study from the Medical University of South Carolina suggests that the complement system, a part of the body's innate immune system, plays a major role in brain damage after repeated concussions. The research found that reducing complement activation can help protect the brain and reduce cognitive impairments.
Researchers at CU Anschutz discovered a genetic program within lymphatic endothelial cells that enables storage and archival of antigens, helping the immune system remember infections. This understanding could lead to improved vaccines and therapies by fine-tuning immune memory.
Researchers found that immature neutrophils migrate into inflamed tissues upon stimulation by interferon-γ, suppressing inflammation and reducing tissue damage. In humans, these cells also produce interleukin-10, which increases in the blood of COVID-19 patients.
Researchers discovered a key molecular sensor detecting changes in intracellular pH that regulates immune defense against bacterial infections and influences inflammatory diseases and cancer. The findings may lead to innovative strategies for disease prevention and treatment by altering how the internal environment shapes immune function.
Researchers have discovered that blocking NK cell checkpoints could significantly enhance cancer immunotherapy, providing new avenues for treating solid tumors and blood cancers. Emerging precision approaches using gene editing and engineered cell therapies promise specific recognition of cancer cells with potentially fewer side effects.
The BNT162b2 vaccine not only targets the COVID-19 virus but also helps reduce and control innate inflammation to other bacterial and fungal pathogens. By reprogramming innate immune cells, the vaccine reduces pro-inflammatory mediators, providing potential benefits beyond its primary target.
Researchers found that mRNA-based COVID-19 vaccines cause persistent epigenetic changes in monocyte-derived macrophages, enabling a sustained immune response. These changes were preserved for six months after vaccination and required multiple doses to maintain long-term immunity.
Researchers found that training the innate immune system can exacerbate inflammatory bone loss in models of chronic diseases like periodontitis and arthritis. The study suggests that a previously thought beneficial effect of trained immunity may actually contribute to harm in certain contexts.
A synthetic retinoic acid-inducible gene I (RIG-I) agonist RNA has been shown to induce innate immune signaling and death of hepatocellular carcinoma cells in vitro. The addition of recombinant interferon-b potentiated this cell death, suggesting a potential new mechanism for treating patients with liver cancer.
A study on six serodiscordant couples found that women who were immune to SARS-CoV-2 had elevated expression of the gene IFIT3 compared to their male partners. This suggests that overexpression of IFIT3 may offer protection against COVID-19 by inhibiting viral replication and preventing cell invasion.
Gut bacteria that cross a weakened intestinal barrier induce epigenetic changes in bone marrow, generating trained immune cells primed to respond more efficiently to infections. However, this amplified immune response also contributes to the development of inflammatory diseases such as cardiovascular and neurodegenerative conditions.
A new longitudinal study has provided unprecedented insights into human papillomavirus (HPV) infection dynamics. The study found that non-persistent infections exhibit a plateau in viral load before rapidly declining, while chronic infections show a strong correlation between immune cells and virus production. This research could infor...
Researchers developed a new experimental infection model using Drosophila flies to test drugs for infectious diseases, reducing the use of vertebrate animals. The model assesses innate immunity against infections by Candida albicans and allows for the design of new therapeutic approaches targeting uncontrolled immune responses.
Researchers found higher levels of CD47 expression linked to more aggressive tumors, immune cells, and oncogenic signaling. Targeting CD47 could lead to improved outcomes with immunotherapy drugs, especially in cases where existing treatments are ineffective.
A recent study published in Stem Cell Reports has found that brief exposure to certain 'danger signals' can prime the body's innate immune system, leading to a long-term hyperreactive and inflammatory state. This mechanism can help fight infections but also increases the risk of cardiovascular disease.
Natural Killer (NK) cell-based therapies have shown promise in preclinical and clinical studies for treating Acute Myeloid Leukemia (AML), offering a potential cure with minimal prior antigen sensitization. However, the dysfunction of NK cells in AML patients poses a significant challenge that must be overcome to unlock their full ther...
Research reveals T cells regulate trained immunity, a process previously thought to be independent of the innate immune system. This discovery offers potential for new treatments in autoimmune disorders, cancer, and cardiovascular diseases.
Researchers describe redundant innate immune pathways triggered by AAV vectors, including sensing of viral genome and cytoplasmic DNA sensors. The study highlights the need to understand complex biologic mechanisms underlying adverse reactions to AAV vectors in human gene therapy trials.
Non-flowering bryophytes, including mosses, have sophisticated immune receptor repertoires that can be transferred between flowering and non-flowering plants. This discovery offers a new source of resistance genes against pathogens for major crops facing climate change threats.
Researchers found that frequent respiratory infections in children may have elevated their innate immune activity, protecting them from severe COVID-19 symptoms. The study suggests that childhood exposure to common cold viruses and bacteria boosted the kids' immune systems, allowing them to better fight off SARS-CoV-2.
Scientists at Brigham and Women's Hospital have identified a metabolic switch in the gut that helps regulate immune tolerance and protect against harmful intestinal inflammation. This discovery could lead to new strategies for promoting remission in patients with inflammatory bowel disease.
Researchers identified gartisertib as a potent ATR inhibitor that enhances cell death in patient-derived glioblastoma cell lines. The study also showed synergy between gartisertib and TMZ+RT treatment, with higher sensitivity to gartisertib observed in MGMT promoter unmethylated cells.
A team of researchers discovered a multiprotein complex involving NLRP3, AIM2, NLRC4, and Pyrin that drives PANoptosis, a type of programmed inflammatory cell death. The findings have implications for understanding inflammasome biology and identifying potential therapeutic targets.
Researchers found SARS-CoV-2 viruses persisting in lung cells for up to 18 months post-infection, despite undetectable upper respiratory tract presence. The study suggests a link between innate immunity failure and virus persistence.
A recent study reveals that NK cells can memorize viral antigens and differentiate into immune memory NK cells with considerable killing ability. Themis2, a cytoplasmic protein, plays a crucial role in regulating this process.
Researchers have created an 'immune cell map' that reveals the origin of neutrophils' subcellular response to microbes. The study found that a specific type of glycoprotein is responsible for the restricted subcellular origin, and this discovery may lead to refined personalized immune responses.
Researchers found that Dectin-1 stimulation induced a unique immune signature in HIV-positive older adults, characterized by increased levels of IL-12, TNF-α, and IFN-α. This signature may contribute to the pro-inflammatory environment associated with HIV and aging.
Researchers at the University of Illinois Chicago have discovered that trained immune cells can remove cellular debris and reduce inflammation in the lungs. This 'memory' or training allows these cells to respond better to subsequent infections, potentially leading to a cell therapy to prevent acute lung injury.
A recent study found that the cGAS/STING molecular signaling pathway plays a critical role in driving chronic inflammation and functional decline during aging. By blocking STING, researchers were able to suppress inflammatory responses and improve tissue function, leading to enhancements in spatial and associative memory.
Researchers have identified a novel gene WTS that confers broad-spectrum resistance to clubroot disease in Brassica crops. The WTS protein complex functions as an endoplasmic reticulum-localized calcium release channel, increasing cytosolic calcium ions and activating plant defenses.
SMART researchers have discovered a novel combination therapy using rifaximin and clarithromycin to treat antibiotic-resistant Mycobacterium abscessus infections. The study found that rifaximin potentiates clarithromycin against M. abscessus, increasing its sensitivity and effectiveness in killing the bacteria.
Researchers from St. Jude Children's Research Hospital discovered NLRP12 to be the key molecule responsible for inducing inflammatory cell death and pathology in response to heme combined with other cellular damage or infection. This finding provides a new potential drug target to prevent morbidity in certain illnesses.
Researchers have developed a new immunotherapy targeting tumour macrophages, which are immunosuppressive cells that weaken the immune system. The treatment, RImAb, reduces tumour growth and modifies the tumour microenvironment, offering potential for a new line of treatment for lung cancer patients.
Researchers at Monash University have discovered a key mechanism to control the inflammatory response to infection. The study found that the termination of STING responses is mediated via ESCRT-dependent degradation.
Researchers found that agricultural antimicrobial peptide use can generate broad cross-resistance to the human innate immune response. This has major implications for the design and use of therapeutic antimicrobial peptides.
A research team led by Dr Gary Ying Wai Chan reveals the function of enzyme ANKLE1 in cutting chromatin bridges, preventing DNA damages and autoimmunity. This discovery has significant implications for understanding immune responses and developing new strategies to prevent diseases such as cancer and autoinflammatory disorders.
A new study identifies several cytokine markers associated with poor prognosis in New-Onset Refractory Status Epilepticus (NORSE) patients. The researchers found that the concentration of these inflammatory proteins was higher in NORSE patients than controls, and their increase was correlated with short-term and long-term neurological ...
Researchers discovered that lipid deposition on medical implant surfaces can signal to the immune system whether to attack or ignore the implant. This knowledge could help develop biomaterials that deflect host immune aggression, reducing malfunction rates for devices like pacemakers and surgical mesh.
Researchers have uncovered the ancient roots of a gene in wheat that provides resistance to the devastating Wheat Yellow Mosaic Virus, which causes significant economic losses. The discovery could lead to more resistant wheat cultivars, increased crop yields, and reduced use of harmful fungicides.
Researchers used AgRenSeq genomic discovery method to identify two genes protecting experimental wheat plants against wheat blast. The study highlights the power of heritage wheat varieties and wild grass relatives in providing disease-fighting diversity.
A study by North Carolina State University found that PFAS chemical GenX and another chemical, PFHxA, can suppress the neutrophil respiratory burst, a method used by white blood cells to kill invading pathogens. The research highlights the potential toxic effects of PFAS on the human immune system.
A new subset of B lymphocytes has been found to play a crucial role in promoting the clearance of microbes by enhancing the production of innate immune cells. The discovery highlights the importance of adaptive immune cells in responding to infections and could lead to new strategies for combating serious diseases.
Researchers found that the F-box gene FBXC-58 is a novel mediator of dietary restriction effects on extending the health span of Caenorhabditis elegans. FBXC-58 prevents muscle aging and extends longevity through an S6 kinase-dependent pathway.
A new study uses serial femtosecond X-ray crystallography to reveal the structure of NendoU protein at room temperature. The resulting high-resolution image shows that the protein's flexibility plays a crucial role in its functional mechanism, which is essential for designing antiviral drugs against SARS-CoV-2.
Researchers discovered a previously unknown property of certain immune cells called Th17 cells, which produce the pro-inflammatory cytokine IL-1α. This finding sheds light on autoimmune diseases like rheumatoid arthritis in children and provides new insights into the defense against fungal infections.
Research reveals mitochondria play crucial role in NF-κB signaling pathway regulation. Mitochondria assemble signaling platform at outer membrane, amplifying signal through large surface area.
Researchers investigated Aicardi-Goutières syndrome and found that viral RNA recognition drives uncontrolled interferon production. The immune system mistakenly attacks healthy cells due to the failure of safety mechanisms to distinguish between viral and host genetic material.
Researchers discovered that a ketogenic diet high in saturated fats can reprogram the mouse immune system, making it better at fighting off infections but more susceptible to systemic inflammatory conditions. The study also found that another type of fat, oleic acid, may be able to counteract the harmful effects of palmitic acid.
Researchers from Trinity College Dublin have identified an enhanced type I interferon response in women who resisted infection after exposure to hepatitis C. This finding has significant implications for understanding viral resistance and designing therapies to treat infected individuals.
Researchers at the University of Bonn have identified a new signaling pathway that triggers inflammatory responses in the skin after UV damage. This pathway involves the activation of p38 molecularly modifying NLRP1, a critical switch for inflammation, and initiates the assembly of inflammasomes.
Researchers at La Jolla Institute for Immunology discovered how Zika virus forces dendritic cells to churn out lipid molecules, allowing the virus to build copies of itself. This study provides a major step forward in developing antiviral therapies against multiple flavivirus infections.
Researchers discovered a novel role for an E. coli enzyme in reducing the toxic effects of hypothiocyanite, a key antimicrobial released by the human immune system. This finding has implications for diseases like cystic fibrosis and inflammatory bowel disease, as it suggests that various bacteria can evade this powerful oxidant.