Articles tagged with Gene Regulation
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers identified four previously unknown genetic conditions within schizophrenia, each with distinct symptoms and disease features. The study provides a framework for finding influential genes across complex genetic diseases, enabling more precise treatment design.
A study by UCLA life scientists found that fructose damages brain genes, leading to diseases such as diabetes and cardiovascular disease. However, a diet rich in DHA reversed the harmful effects of fructose, suggesting a potential treatment for these conditions.
A team of scientists has identified a gene, HMGA2, that explains variation in beak size among Darwin's finches. The gene contributed to a rapid shift in beak size following a severe drought, enabling the medium ground finch to adapt and survive.
A study found that a gene variation linked to obesity also affects food intake regulation by altering the expression of nearby genes. Reduced expression of these genes led to increased food intake and weight gain in mice.
Researchers have identified two novel molecular players necessary to regulate plasmodesmata in plants under biotic and abiotic stress conditions. These enzymes help control the flow of nutrients, minerals, and cellular signals between cells by altering callose levels at the plasmodesmata channel.
Researchers have discovered regulatory sequences in zebrafish that can turn on genes involved in regeneration, which also exist in humans. These 'tissue regeneration enhancer elements' or TREEs may hold the key to improving human regenerative capabilities through genome editing technologies.
Researchers develop approach to understand chromatin regulators, which modify DNA to alter gene expression. They found that regulators control the probability of gene expression in a population, not just individual cells.
A study found that IGF2BP3 promotes B cell proliferation in B-cell acute lymphoblastic leukemia by regulating oncogenes like MYC. The RNA binding protein is reactivated in some cancer cells, making it an attractive target for cancer-fighting drugs.
The article highlights regional differences in demographics, disease prevalence, and cultural attitudes towards donated tissues and organs. Regulatory approaches vary across countries, necessitating a tailored approach to balance risk and benefit.
Scientists at Université de Genève found a novel regulatory mechanism in the HigBA toxin-antitoxin system that can selectively kill bacteria when they suffer from DNA damage. This discovery could lead to new treatments for bacterial infections by forcing bacteria to turn their weapons against themselves.
Researchers review gene drive systems, analyzing pros and cons, applications, and regulatory issues. They highlight the potential benefits of controlling insect-borne diseases, removing invasive species, and reversing pesticide resistance. Gene drives combine CRISPR technology to enable environmentally friendly solutions.
Researchers at the University of Chicago and Tel Aviv University have discovered a new chemical modification that can boost gene conversion to proteins. The study enriches the epitranscriptome, a critical new dimension in molecular biology, suggesting an even larger cellular control panel.
A study in yeast reveals that nutrients can affect gene expression, suggesting a complex interplay between metabolism and genetics. The findings have implications for understanding how cells respond to certain drugs and may explain why some individuals fail to respond to treatment.
A new 'Ouija Board' protein in Drosophila melanogaster flies plays a crucial role in regulating the expression of a single gene required for biosynthesis of insect steroid hormones. This study provides new insights into animal steroid hormone biosynthesis and its evolution.
Researchers have found age-dependent alterations in metabolism and gene regulation in middle-aged fruitflies, linked to a reduction in lifespan. The study identified a common process of protein acetylation as a key factor in the aging process.
A study exploring GABPa gene regulator reveals its influence as a master switch in energy metabolism and human brain evolution. Key findings include enrichment of GABPa sites at genes important for unique human functions and associations with diseases like Alzheimer's, Parkinson's, and breast cancer.
Scientists have discovered a mechanism by which the immune system retains a 'memory' of past infections, allowing for a quick and successful response upon future encounters. The study found that T cells leave behind imprints on chromosomes, enabling the immune system to rapidly respond to recurrent infections.
Researchers at Helmholtz Zentrum München developed a method to analyze protein modifications, including the phosphorylation of RNA polymerase II. This helps regulate gene expression by controlling enzyme activity at precise sites.
Researchers at Whitehead Institute created a 3D map of the human genome's DNA loops that regulate gene expression in human embryonic stem cells and adult cells. This new understanding will help scientists predict relationships between mutated elements and their target genes, leading to improved disease development insights.
Scientists at Rockefeller University identified a new regulator of RNA polymerase II, a critical process for gene expression. The discovery could lead to more specific cancer therapies by targeting this form of gene regulation.
The African cheetah's genome sequence has revealed a lack of genetic variation and unique adaptations that contribute to its incredible speed. The study has shed light on the cheetah's past and its struggles with reproductive impairments, providing valuable lessons for conservation efforts.
MicroRNAs, specifically miR-125a, control endothelial cell proliferation and are increased in lung tissue of hypoxia-exposed animals. Inhibition of miR-125a increases expression of tumor suppressor genes, reducing cell proliferation.
A recent study published in Nature Communications reveals that TET protein loss of function leads to rapid development of malignant cancer. The research found that mice lacking both Tet2 and Tet3 developed aggressive myeloid leukemia, highlighting the importance of TET proteins in maintaining genome stability and preventing cancer.
A recent study published in Nature Genetics reveals that Short Tandem Repeats (STRs) regulate gene expression and modulate disease traits. STRs, previously thought to be neutral or 'junk' DNA, were found to act like springs or knobs that fine-tune nearby gene expression.
Cells use kinetic proofreading to regulate gene expression with increased specificity but at the cost of more energy investment. The authors propose an alternative out-of-equilibrium, proofreading-based transcriptional regulation to mitigate crosstalk in multicellular organisms.
A recent study from Karolinska Institutet shows that the human genome's 'grammar' is more complex than even intricate spoken languages. The findings contribute to understanding how genetic differences affect disease risk and pave the way for cracking the genetic code controlling gene expression.
Researchers at LSU have identified a new gene regulation pathway that prevents inflammation and speeds up the skin's healing process. A nanoparticle-carried small interference RNA blocks the Nax sodium sensor, enabling faster healing.
Researchers have discovered a single gene regulating salmon age at maturity, which also influences human puberty timing. The VGLL3 gene affects body fat accumulation and balances out sex-specific traits to maintain population stability.
Scientists have generated genome-scale sequence information for the fathead minnow, a commonly used model organism in environmental toxicology studies. The new data will enhance the understanding of complex traits and biological pathways affected by environmental toxins.
A new study finds that cells activate and deactivate proteins in a series of unpredictable pulses, allowing them to control gene expression. The timing of these pulses may play an important role in cellular processes such as information processing and stress response.
Researchers uncovered molecular mechanisms behind caste differentiation in insects, revealing subtle gene networks and lack of DNA methylation. The study used two species, dinosaur ants and red paper wasps, to gain insights into social evolution.
A study on dinosaur ants and red paper wasps found subtle, non-random arrangements of gene networks distinguish queens from workers, suggesting no single master gene regulates caste differentiation. The research also suggests that epigenetic modifications play a limited role in regulating these differences.
A study at Mount Sinai found that inhibiting a family of epigenetic brain proteins, known as BETs, can induce an autism-like syndrome in mice. This links environmental factors to gene transcription and may provide insights into the disease's pathology.
A genetic variant near the KLF14 gene regulates fat storage in women, affecting their risk of developing Type 2 diabetes. The variant influences hip circumference, with women carrying one allele tending to have larger hips than those with the other allele.
Researchers found that chromatin marks are irrelevant for regulating genes expressed in specific tissues during development. The study challenges current beliefs about epigenetics and offers new insights into gene expression.
Researchers have created a new method for controlling gene activation, allowing for precise regulation of gene expression in cells. The method employs CRISPR technology combined with chemical compounds to activate specific genes without altering the genome.
Researchers at Harvard and MIT have developed a new approach that allows for both genome editing and gene regulation to be achieved using the same Cas9 protein, opening up possibilities for understanding diseases and designing synthetic gene circuits. The method uses engineered guide RNAs to control gene expression.
Scientists from Karolinska Institutet have identified 32 genes that are switched on within two days of fertilization, marking a significant breakthrough in understanding early embryonic development. The study's findings also reveal the importance of 'junk DNA' in regulating gene expression.
A new policy analysis warns that current regulations are stifling the use of genetically engineered trees to combat catastrophic forest threats. The authors argue for a shift in regulatory approaches that focus on product rather than process, considering need, urgency, and genetic similarity.
Researchers have developed a strategy for genome-wide annotation of primary miRNA transcripts, providing extensive new annotations in human and mouse. This study sheds light on the mechanisms of regulation of microRNA gene expression, including novel regulatory mechanisms and alternative promoters.
Scientists at VIB and KU Leuven discovered polyglutamine repeats play a key role in functional development of cells. Excessive repeats cause neurodegenerative disorders, but moderate expansions may enable dynamic changes in cell physiology.
A new method, PrediXcan, uses transcriptome data to estimate gene expression levels and integrate with genome-wide association study (GWAS) data. This improves the detection of genes linked to complex diseases and biological traits.
Scientists at MD Anderson Cancer Center discovered the critical role of fumarase enzyme in DNA repair, revealing a key mechanism for reversing genetic damage leading to cancer and therapy resistance. The study's findings have potential implications for developing new cancer treatments by inhibiting DNA-PKs and fumarase.
Researchers have discovered that RNA-binding protein ROQUIN regulates the stability of thousands of mRNA molecules, including those involved in cellular inflammation and stress responses. By binding to these mRNAs, ROQUIN influences the activity of the key mediator NF-kappaB, which is essential for regulating gene expression.
The Genetics Society of America has awarded prizes to undergraduate and graduate students who presented research on Caenorhabditis elegans at the recent meeting. The awards recognized innovative work in various fields, including cell biology, development and evolution, gene regulation and genomics, neurobiology, and physiology.
Researchers have developed a novel control system to regulate therapeutic transgene expression by targeting the passenger strand of a specific microRNA. This approach achieves safe and specific regulation while sparing endogenous gene expression, offering potential for new gene therapy applications.
The study provides a powerful tool for guiding strain design and protocol optimization, facilitating the development of next-generation biofuels. It elucidates the complex system-level orchestration of metabolic reactions, gene regulation, and environmental cues during clostridial ABE fermentation.
Researchers developed a novel live-imaging system to study gene transcription and nuclear position, enabling simultaneous measurements of these processes. The technique shows high specificity and has potential applications in studying higher-order gene regulation and cell-to-cell heterogeneity.
Researchers at EMBL-EBI developed a new method and algorithm that enables fast and efficient genetic analysis of large cohorts. The mSet algorithm allows for the simultaneous analysis of many genetic variants and traits, improving statistical power and enabling the study of up to half a million individuals.
The study found almost double the number of differentially expressed heart and liver genes in translation compared to transcription. This discovery sheds light on the genes and regulatory pathways underlying disease, offering new avenues for research.
Researchers at Hiroshima University found that long noncoding RNA CCDC26 controls receptor tyrosine kinase KIT expression in leukemia cells. This discovery provides new insights into leukemia recurrence and may help develop new therapies.
A study found that a common mutation in the SCARB1 gene is associated with an increased risk of heart disease, especially among men and African Americans. The mutation was linked to a 49% higher risk of heart disease in African American males compared to white males.
A genome analysis of ten bee species reveals that eusociality evolves differently each time, but shares common trends in gene regulation and complexity. Natural selection relaxes for key genes after complex social forms emerge, as seen in honeybees.
A recent study by the University of Helsinki found that early exposure to alcohol changes the way genes function in the brains of mice, influencing brain structure. The timing of the exposure corresponds to human gestational weeks 3-6, and similar changes were observed in other tissues of the infant mice.
Scientists from the University of Chicago identified a newly-evolved gene, panish, which determines head-to-tail polarity in midge fly embryos. This discovery suggests that genetic changes to fundamental biological processes occur more often than previously thought, and opens new research avenues.
A new technique called Promoter Capture Hi-C was used to connect regulatory elements in the mouse and human genomes, providing insight into how genes are regulated. The analysis identified long-range interactions between promoters and enhancers, shedding light on the genetic basis of disease.
The bumblebee genome has been mapped, revealing a relatively small fraction of genes involved in the immune response compared to flies and mosquitoes. Despite its weak social organization, the bumblebee has just as few immune genes as the honeybee, suggesting that diet may play a role in shaping its immune system.
A new technique identifies how genes are controlled and pinpoints source of disease-causing mutations in enhancers. Researchers found that genes are regulated by multiple enhancers, allowing precise control during development and maintaining normal brain function.
Researchers at MD Anderson Cancer Center have uncovered a novel mechanism by which the tumor suppressor gene p53 regulates PD-L1, allowing non-small cell lung cancer to grow. MicroRNA delivery with existing treatments may represent a new therapeutic approach for lung cancer.
Researchers at the University of Pennsylvania School of Medicine have discovered how early cells make decisions to turn on one genetic program and exclude others. By understanding this process, scientists can create new cells at will for transplantation and tissue repair in diseases such as liver or heart disease.