Articles tagged with Hippocampal Neurons
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists classify neurons into three classes based on their response to heartbeat-induced brain motion, revealing differences in firing properties and coordination with cognitive waves. This work aims to bridge scales between microscopic cell behavior and macroscopic cognition.
Research found that high fat diets limit newborn and developing neurons in adult female mice, but not males, potentially linking metabolic disorders to brain disorders like Alzheimer's disease. The study may inspire metabolism-based preventions and treatments.
Increasing 40Hz gamma rhythm power in the brain has been shown to strengthen neural connections and improve symptoms in Alzheimer's disease models. The study used light flickering or sound buzzing at 40Hz to achieve this effect, which was found to decline pathological amyloid and tau protein buildups and protect neurons from degeneration.
Researchers have successfully reproduced electrical properties of biological neurons onto semiconductor chips, enabling medical devices to cure chronic diseases. The artificial neurons require only 140 nanoWatts of power, making them ideal for bio-electronic implants.
Researchers at Kyoto University developed a machine learning model that reconstructs neuronal circuitry by analyzing brain signal spikes, estimating the strength of nerve connections with high accuracy. The findings, published in Nature Communications, have the potential to elucidate how different brain regions process information.
Researchers identified the GRIK1 gene as a cause of spatial orientation problems in people with Down syndrome. Normalizing the dose of this gene in mouse models reversed the imbalance and eliminated spatial memory issues.
Research in mouse neurons reveals that misfolded tau protein can quickly spread between neurons without being immediately harmful. Early therapeutic intervention targeting the initial accumulation of tau may halt Alzheimer's disease progression.
Research finds that delta waves during sleep selectively activate specific neuron assemblies involved in long-term memory formation. These assemblies code information and send crucial signals between the hippocampus and cortex, allowing memories to stabilize.
A new study from OIST and RIKEN has developed a computational model that demonstrates the importance of inhibitory circuits in brain function. The model shows that inhibitory neurons play a key role in associative memory, allowing patterns to be stored in memory for longer periods.
A WVU researcher recorded single neurons in epilepsy patients to study the pre-supplementary motor area's role in visual search tasks. The study found that 40% of neurons signaled target detection, regardless of task format or cue.
A study suggests that REM sleep may prevent information overload by actively forgetting new, possibly unimportant information. Researchers found that MCH neurons in the brain play a role in controlling memory consolidation and preventing dream content from being stored.
The study found that neuronal activation leaves lasting epigenetic changes, creating a genomic memory of past experiences. These changes can be detected days after initial activation and may contribute to the formation of memories.
Researchers found that Id4 controls whether stem cells remain in a state of rest or enter cell division, with increasing age leading to hyperactive signaling pathway inhibiting cell division.
Researchers at Caltech have discovered that strong memories are formed when multiple neurons fire in sync, providing redundancy for long-term retention. This finding has implications for understanding memory loss due to brain damage or aging.
Researchers found that a drug used for Alzheimer's reversed brain inflammation and neuron damage in rats exposed to alcohol during adolescence. The study suggests that adolescent binge drinking can lead to subtle deficits in brain function, anxiety, and social behaviors.
Researchers successfully recorded hippocampal ripples in humans, demonstrating their role in new memory engraving and recall. The findings suggest that synchronized neural activity is crucial for free recall.
Researchers at McGill University discovered how a specific mutant form of the SLC9A6 encoding gene affects neurons' ability to form connections. The study provides clues for new treatments, potentially benefiting patients with Christianson Syndrome and other neurodegenerative disorders.
Researchers found that most amygdala neurons mature rapidly during adolescence, suggesting a key role in emotional development. However, some neurons remain immature throughout life, offering new insights into how the brain maintains emotional responses flexibility.
Researchers found that new neurons continue to form well into old age, including in people with cognitive impairment and Alzheimer's disease. The study provides evidence that neurogenesis may moderate the effects of brain pathology, suggesting potential therapeutic possibilities.
Researchers investigating the link between aging fat cells and Alzheimer's disease have found that fat cells play a crucial role in supporting neuronal growth and survival. The study suggests targeting a specific receptor, PPAR-γ2, could lead to a new treatment for Alzheimer's.
Researchers have discovered that graphene flakes can selectively and reversibly affect specific neurons in the brain, offering a promising approach for treating conditions like epilepsy. The study's findings suggest that the particles' size is key to their selectivity, with effects observed only at specific synapse sites.
Researchers created an algorithm that generated images to super-stimulate monkey neurons, showing the brain builds preferred images from scratch. The study reveals insights into how the brain learns to abstract statistically relevant features of its world.
Researchers at Harvard University have developed a new tool that records and controls neural activity in real-time using genetically encoded voltage indicators. This breakthrough enables the study of complex behaviors and neural interactions with unprecedented clarity.
Scientists at UCSF have discovered a type of neuron called VIP interneurons that play a crucial role in anxiety-driven decision-making. By shutting off signals from these cells, researchers found they can reduce anxious behavior, offering potential insights into treating brain disorders.
A new study reveals that hippocampal neurons provide pointers to complete memories by firing strongly during recall. This process, called reinstatement, helps the brain reconstruct associated objects from memory, similar to initial learning. The discovery has implications for understanding memory deficits and potential treatments.
Research in mice reveals the existence of brain cells called hD2R neurons that curb an animal's impulse to eat. These cells play a role in regulating memory and are part of a larger brain circuit that promotes balanced eating.
Researchers from the University of Pennsylvania have found that a single population of stem cells generates new neurons throughout life in the hippocampus. This process is crucial for healthy learning, memory, and mood adjustment.
The study reveals that the rapidity with which neurons fire off affects information processing in the brain. Neurons in the hippocampus use spike-timing-dependent plasticity (STDP) to learn and form memories, with precise timing determining the strength of connections between neurons.
Neurons in both males and females produce estrogen, which is essential for synaptic plasticity and memory. Research shows that mice lacking estrogen have impaired spatial reference memory and recognition memory.
Researchers developed a powerful new tool to investigate brain development, memory, and learning, and the role of gene regulation in neuropsychiatric diseases. The tool selectively and robustly turns on genes in neurons, allowing for controlled expression of individual or multiple genes.
Researchers at Harvard University have developed a novel brain implant that mimics the appearance, size, and flexibility of real neurons, allowing for stable monitoring of neural signals and potential treatment of neurological disorders. The implants inspire negligible immune response and may even encourage tissue regeneration.
A study at Cedars-Sinai Medical Center found that transplanting young bone marrow into old mice preserved their memory and learning abilities. The research suggests that specific properties of youthful blood cells may be responsible for this effect.
Research at University of Queensland suggests a connection between vitamin D levels and brain structure, finding that low levels disrupt perineuronal nets in the hippocampus. This disruption leads to reduced cognitive function and potentially contributes to disorders like depression and schizophrenia.
University of British Columbia professor Jason Snyder reviews the conflicting reports on adult neurogenesis in humans, pointing to methodological differences as a major issue. He argues that there is evidence for low rates of neurogenesis in specific brain regions, particularly the hippocampus.
Researchers identified 13,000 epigenetic regions with varying activity levels in different brain regions. These changes were found to co-locate with genetic signals contributing to addictive behavior, schizophrenia, and neuroses.
New research published in JNeurosci finds that stroke generates dysfunctional brain cells that fail to develop properly, leading to memory impairments. Intervening in the production of these cells may help mitigate stroke-induced memory loss.
Researchers discovered a novel function of nestin in regulating neurogenesis through Notch signaling from astrocytes to neural stem cells. Adult mice deficient in nestin show increased newly born neurons and impaired long-term memory, highlighting the complex role of astrocytes in brain plasticity.
Researchers at Texas A&M University have made a breakthrough in treating epilepsy by using stem cell-derived neurons to stop seizures and improve cognitive function. The study showed that transplanted human GABAergic neurons formed synapses with host excitatory neurons and were directly involved in controlling seizures.
A team of researchers at Baylor College of Medicine identified novel cellular targets and genetic pathways involved in wiring adult-born neurons into existing brain circuits. They found that the brain consists of unique subtypes of cells, many of which are currently uncharacterized.
Scientists at UNC School of Medicine discovered that replacing the faulty UBE3A gene in children's brains can prevent seizures, but not in adults. The study suggests a window of opportunity for prevention between early childhood and adulthood.
Researchers have developed an optoelectronic interface that uses fiber-optic channels to transmit signals from artificial neurons to live ones, providing galvanic isolation and adaptive stimulation capabilities. This system has been demonstrated effective in stimulating electrophysiological activity of neurons in a surviving section of...
Researchers at USC have created a new map of the mouse hippocampus, revealing its internal circuitry and nerve connections in vivid detail. The study aims to provide a resource for scientists to better understand the brain's memory bank and develop strategies to target neurons for treatment.
Scientists at VIB and KU Leuven identify a new protein interaction that regulates the formation of specific synapses between pyramidal neurons and mossy fibers in the hippocampus. This discovery sheds light on the mechanisms that govern unique interactions in neuronal networks.
Researchers from Boston University School of Medicine shed light on mechanisms underlying prion disease progression and identified a potential target for treatment. Inhibiting p38 MAPKα enzyme prevents nerve connection damage and promotes recovery.
Researchers at the University of Bonn have found that CCL17 influences signal transmission in the brain and may be linked to autism. The chemokine is mainly produced by neurons in the hippocampus, a structure involved in tasks such as orientation and memory formation.
Chronic inflammation caused by failed sensor mechanism can lead to brain cells' loss in old age. The study suggests that CB1 receptors on neurons control microglial cell activity.
Newborn granule cells in the dentate gyrus become less excitable after three weeks, a crucial step for mature functioning. The researchers found that functional GIRK channels start to appear at this stage, controlled by G protein signaling, and contribute to lowering excitability of mature dentate granule cells.
Researchers found reduced complexity of adult-born neurons in mice with ApoE4 compared to ApoE3-expressing mice. The study suggests that the Apolipoprotein E risk gene contributes to memory impairment by impairing new neuron development.
Researchers at UNC School of Medicine found that mossy cells regulate adult neural stem cells to control neurogenesis, which is disrupted in many common brain disorders. Targeting these cells may offer a new treatment strategy for conditions like Alzheimer's disease and depression.
Researchers discovered a molecular code that determines synapse formation and function in the brain. Three adhesion molecules precisely define how connections between neurons are made, shedding light on autism and schizophrenia. This finding could lead to better understanding of brain disorders and potential new therapies.
Researchers at IRB Barcelona have identified the NEK7 protein as a crucial regulator of neuron formation in the hippocampus, a region associated with memory. The study found that NEK7 is essential for dendrite growth and branching, and its deficiency leads to complex phenotypes in mice, suggesting broader roles for this protein.
Researchers identified a new mechanism involved in age-related memory loss, where specific changes in brain circuit signaling lead to abnormal neuron responses. The study found that an adenosine receptor, A2A, is concentrated in neurons and its overactivation leads to increased glutamate release.
New study reveals that protein molecules in brain cells are broken down and replaced at different rates, depending on their location. The study found that proteins near the surface of the cell have shorter lifespans, while those involved in energy metabolism have longer lifespans.
Researchers have discovered that neurons use the duration of silence between electrical pulses to encode information. This breakthrough, known as Neural Self-Information Theory, suggests that groups of neurons work together to enable real-time thinking and action despite ongoing variability in their responses.
Researchers found that overproduction of ephrin-B1 in astrocytes weakens memory retention in mice. In contrast, decreased ephrin-B1 levels lead to more synapses and better learning. The study suggests that glial cells play a crucial role in regulating learning and memory.
Researchers discovered that rewriting long-term traumatic memories involves the activity of specific neurons in the brain's dentate gyrus. This finding supports the use of exposure-based therapy as a effective treatment for PTSD and other trauma-related disorders.
Researchers found that frequent nerve signals strengthen dendritic spines in adult-born neurons, allowing them to connect with the existing neural network. This process is crucial for learning and memory formation in the hippocampus.
A team of researchers at the University of Freiburg has created a new model to explain how the brain stores memories of tangible events. The model is based on an experiment with mice, where they used a virtual environment and recorded the activity of their nerve cells.
A novel therapy inhibits complement activation in affected brain tissue to preserve neurons and reduce inflammation after stroke. This treatment shows promise in preventing chronic inflammation and improving neurological deficits.
Researchers found changes in hippocampal neurons early after alpha-synuclein aggregates appear, suggesting potential therapeutic treatments to halt or reverse cognitive impairments. The study suggests defects in pre- and post-synaptic functions, indicating plasticity in the neurons.