Articles tagged with Hippocampal Neurons
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A novel brain cell type, named theta off-ripples on (TORO), has been discovered in the hippocampus, playing a key role in the formation of memories. TORO neurons are activated during sharp wave ripples and inhibit other brain areas, propagating SWR information broadly in the brain.
The study found that the fragile X protein regulates the opening and closing of the GABA-A receptor in neurons from the brain's memory center, influencing how such neurons process information. This nuanced understanding may hold the key to developing effective therapies for fragile X syndrome.
Researchers at UNC School of Medicine used optogenetic techniques to stimulate specific brain cells, increasing production of neural stem cells and neurons relevant to memory and emotion processing. This promoted neurogenesis, altering anxiety-like behaviors in mice.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers found that somatic mutations accumulated at a faster rate in Alzheimer's disease patients' brain cells, leading to DNA damage and dysfunction. This discovery provides a window into the molecular events of AD pathogenesis, potentially leading to novel treatments targeting these pathways.
Researchers found high levels of an enzyme called HDAC9 in healthy neurons, which decline with age and more drastically with Alzheimer's. The study suggests adjusting the enzyme's level may be a potential treatment for both conditions.
Researchers discovered newborn neurons and immature astroglia in patients with epilepsy, which could lead to new anti-seizure medications. The study suggests that targeting immature astroglia may be an effective approach to controlling seizures without aggressive brain surgery.
A study found that intact astrocyte networks are essential for neural homeostasis, synaptic plasticity, and spatial cognitive abilities in adult mice. Disrupting these networks impairs spatial learning and memory due to altered neuronal excitability and compromised synaptic transmission.
Researchers have identified a specific location in the hippocampus called the dentate gyrus where schizophrenia may originate. Studying rats with damaged SAP97, they found changes in activity in this region, directly linking alterations to the development of schizophrenia.
A recent study at Rockefeller University reveals that the FMRP protein plays a dual role in regulating synaptic connections between neurons. It controls protein production in dendrites to strengthen connections, while also regulating gene expression in cell bodies to maintain overall neuron state.
Researchers discovered increased activity in the hippocampus during anesthesia and sleep, preceding Alzheimer's symptoms by years. This abnormality may enable early diagnosis and treatment of the disease.
Researchers discovered that old neurons can block neurogenesis in mice, highlighting excessive senescence as a driving factor behind aging. By destroying senescent cells, the study showed enhanced hippocampal neurogenesis and cognitive function in middle-aged mice.
Researchers at Göttingen University have developed a new X-ray imaging method to detect changes in neuronal cell nuclei, indicating altered activity of neurons. This technique enabled the identification of changes in neurons in Alzheimer's disease.
University of Michigan scientists found that RNAs associated with an understudied cell compartment in hippocampal neurons vary greatly between sleeping and sleep-deprived mice after learning. These changes are present almost exclusively on ribosomes associated with neuronal cell membranes, suggesting a novel mechanism for memory storage.
Researchers have found that stimulating the anterior thalamus can increase memory-related brain activity and restore memory function in rats with MTT lesions. The study suggests that therapies targeting this region could help recover memory in patients with brain injury, challenging previous notions of memory recovery.
Researchers at Virginia Tech explore mitochondrial differences in CA2 neurons, which encode social memories in the hippocampus. They found unique mitochondrial characteristics in individual neurons, influencing plasticity and behavior.
Researchers uncover how sensory inputs and cognitive processes interact in the brain to create our perception of the world. The study explores the neural basis of perceptual phenomena, shedding light on disorders like ADHD, autism, and Alzheimer's disease.
Scientists studied rats in a virtual reality maze to gain a deeper understanding of the hippocampus' circuit-level functions. They discovered that hippocampal neurons encoded multiple aspects of an animal's location, including distance traveled and body direction.
Scientists at the University of California San Diego have discovered that planar cell polarity is a widely used mechanism for forming and maintaining glutamatergic synapses. The study found that Prickle protein plays a crucial role in stabilizing these synapses, which are essential for neuronal communication.
Scientists discovered beige fat cells mediate subcutaneous fat's brain protection and provide anti-inflammatory effects. Beige fat transplantation restored cognitive function in obese mice with dementia-like behavior.
A new study found that memory formation causes neurons to break their DNA, leading to changes in gene expression and potentially undermining brain health with age. The study also discovered that glia play a significant role in establishing memories from fear conditioning.
A recent study published in PNAS found that gut microbes that metabolize tryptophan secrete indoles, which stimulate the development of new brain cells in adults. This discovery highlights the importance of lifestyle factors and diet in supporting brain health.
Researchers found no protection against Parkinson's and Lewy body dementias when reducing tau protein in brain neurons. Instead, the study highlights distinct roles of tau in these diseases compared to Alzheimer's, where reducing endogenous tau levels is protective.
A study using protein mapping reveals that abnormal glutamate levels in the brains of schizophrenic patients can lead to oxidative stress and apoptosis in neurons, while oligodendrocytes display different responses. This knowledge may contribute to the development of more targeted treatments for schizophrenia.
A study led by Genevieve Konopka and Bradley C. Lega found significant differences in gene activity between the anterior and posterior portions of the hippocampus, with genes associated with mood disorders active in the anterior portion and cognitive disorders in the posterior portion.
Researchers have updated one of the world's largest databases on neuronal types, Hippocampome.org, with a comprehensive mapping between neural activity and identified neuron types. This may enable biologically meaningful computer modeling of the full neuronal circuit of the hippocampus.
A new $2.3 million grant will support a five-year research project at UC Riverside, led by Viji Santhakumar, exploring the relationship between inflammation and abnormal neuron connections after brain injury. The study aims to identify potential early therapies to prevent epilepsy and memory issues following traumatic brain injury.
Research led by Ulrike Müller found that APP protein plays a crucial role in normal brain development, learning, memory formation, and social communication. The absence of APP during brain development led to malformations in critical brain regions and impaired behavior tests, including autistic-like behavior.
Researchers developed a novel drug that increases LAMP2A receptors, revitalizing chaperone-mediated autophagy and removing toxic protein aggregates. In mouse models of Alzheimer's, the drug reversed key symptoms, suggesting potential for human treatment.
A new study published in Cell Stem Cell reveals that neural stem cells in the nervous system age rapidly, leading to a decrease in their ability to divide and replicate. The researchers found that certain genes, including Abl1, play a key role in this process, which may contribute to cognitive decline and dementia.
Researchers at Tokyo Medical and Dental University have developed an mRNA delivery system that effectively produces BDNF protein in rat brain to protect neurons from ischemia. The system, known as an mRNA nanomicelle, increases the survival of hippocampal neurons and shows long-term therapeutic benefits.
A mouse study suggests that intense behavioral training before symptoms develop can delay the onset of Rett syndrome, a devastating neurological disorder. The training improved memory loss and motor control decline in mice with the genetic disorder.
The study reveals how neural circuits balance excitation and inhibition, crucial for normal functionality of our brain. The results provide a clearer picture of how this balance is preserved and where it fails in living neural networks.
Researchers at the University of Oregon have discovered a fractal network of connecting neurons in the brain, which balances energy costs to facilitate communication between neurons. The study's findings have implications for designing implants to treat macular degeneration and other retinal diseases.
A study by University of Zurich researchers reveals that increasing lamin B1 levels in aging mice stem cell division improves, leading to increased new neurons. The findings offer hope for future therapies targeting neurogenesis in older individuals or those with degenerative diseases like Alzheimer's.
Researchers from Skoltech have developed biodegradable microcapsules that deliver nerve growth factor to guide neuronal development. The microcapsules demonstrate significant boosting of neuronal growth and formation of functional synapses.
New research reveals that prenatal alcohol exposure impairs adult hippocampal neurogenesis in mice, while adult-generated neurons may contribute to recovery from alcohol dependence. The study suggests that targeting adult neurogenesis could lead to more effective treatment of alcohol use disorders.
A novel molecular voltage sensor allows researchers to observe the propagation of electrical signals in living nerve cells with high precision. This enables investigations into completely new questions about brain function and could lead to a better understanding of neurological diseases.
Neuroscientists at Harvard Medical School have identified a critical gene, Fos, that allows neurons to rewire inputs from other neurons, enabling networks of disparate neurons to coordinate activity. This mechanism is thought to be essential for memory consolidation and recall.
Researchers discover that reactive oxygen molecules control cellular processes important for brain adaptation in mice. Free radicals are necessary for healthy aging and neuroplasticity, contradicting previous harmful views.
A new fluorescent imaging technique allows scientists to observe up to five different molecule types at a time, enabling them to study complex signaling networks and their relationships. By identifying two populations of neurons with distinct calcium signaling dynamics, researchers hope to understand how they encode long-term memories.
A new study by University of Leicester neuroscientists argues that the way humans store memories is key to our superior intelligence. Contrary to long-held beliefs, the same group of neurons stores all memories, enabling abstract thinking and cognitive abilities unique to humans.
A McGill-led research team found that protein synthesis in inhibitory cells plays a crucial role in controlling long-term memory. The study identified two distinct processes taking place in excitatory and inhibitory networks, with each neuronal system capable of selective manipulation for memory control.
Researchers at RIKEN Center for Brain Science discovered a brain region called the SuM that detects new social experiences and segregates them from unfamiliar places. This finding can help understand normal memory and conditions where recognizing new information is impaired.
Research at the University of Bristol discovers a new mechanism for learning in the brain that stabilises memories and reduces interference. This breakthrough provides insight into how humans form expectations and make accurate predictions about future events.
Researchers used RNA editing to correct a genetic error causing Rett Syndrome, repairing half of the normal protein in three types of neurons. The approach shows promise for treating the disorder, which affects 350,000 individuals worldwide.
A study published in Science identifies neurons in the frontal lobe that help retrieve memories and make decisions based on those memories. The researchers used implanted electrodes to record neuron activity in patients undergoing brain surgery for epilepsy treatment.
Researchers found that adult-born neurons in rats continue to grow and develop for a longer period than those born during infancy. The study suggests that these mature neurons may have distinct functions, contributing to brain flexibility and plasticity. Adult neurogenesis can occur even after the decline of this process in adulthood.
Researchers from Lobachevsky University and international colleagues have developed a model that demonstrates the existence of concept cells in the brain, which can process and learn abstract concepts. The study suggests that individual neurons, rather than large neuronal complexes, are responsible for complex tasks performed by humans.
Research published in Neuron found that adult-born neurons are essential for synaptic structural remodeling and memory consolidation during rapid eye movement sleep in mice. The study used optogenetics to manipulate ABN activity during REM sleep and showed that reactivation of ABNs during sleep consolidates memory.
Researchers found that when hippocampal neurons are already firing at high rates before seeing a word, participants are more successful in encoding and remembering the word later. This suggests that the hippocampus may have a specific mode for facilitating memory formation.
Scientists at Columbia's Zuckerman Institute mapped the brain's complex calculations to link distinct events separated in time, shedding light on anxiety and trauma-related disorders. The hippocampus uses bursts of activity to form associations, saving energy by encoding information in synapses rather than constant electrical activity.
Giorgio Ascoli is working to enhance the NeuroMorpho.org repository by doubling its reconstructions and adding search functionality. He aims to link morphological, physiological, and molecular properties to create a spiking neural network model.
Researchers found that astrocytes lacking the NFIA gene had defective shapes, altered functions, and impaired ability to detect neurotransmitters. This led to defects in learning and memory, providing evidence that astrocytes control neuronal circuits mediating these processes.
Researchers at University of California San Diego School of Medicine found that adult brain cells revert to an embryonic state after injury, allowing them to regenerate new connections. The study identifies the essential genetic pathway involved in this process, which sustains regeneration by a gene known as Huntingtin.
A research team led by Dr. Kea Joo Lee found that MAP2 plays a crucial role in inducing long-term potentiation, a cellular mechanism underlying learning and memory. The study's discovery provides key insights into synaptic plasticity mechanisms and potential therapeutic strategies for memory-related diseases.
A study by the University of Bonn has identified an autoantibody that triggers epilepsy in some patients. The autoantibody targets the protein Drebrin, disrupting nerve cell transmission and leading to inflammation and seizures.
Researchers discovered that Epo increases nerve cell production and connections in the brain, leading to improved cognitive performance. Cognitive challenges trigger oxygen deficits, stimulating Epo production, which drives neuroplasticity and neurogenesis.
The NCAM2 protein is essential for the formation of structures for cognitive learning and brain development. A deficit in NCAM2 causes incorrect neuron migration, altered morphology, and cytoskeleton changes, leading to neuronal polarization issues.
A new preclinical study reveals that a lack of BIN1 leads to defective neurotransmitter transmission, impairing brain cell communication and memory consolidation. The study suggests that BIN1 plays a crucial role in regulating synaptic transmission and may be involved in the progression of Alzheimer's disease.