Articles tagged with Neurodegenerative Diseases
A new approach enables researchers to generate antibodies against transitory protein targets, providing insights into disease mechanisms and potential therapeutic targets for Alzheimer's and Parkinson's.
Marcel P. Goldschen-Ohm wins the 2024 Paper of the Year-Early Career Investigator Award for his study on GABA receptor subunit linkers and their role in pore gating and diazepam modulation, challenging conventional views on receptor function.
Researchers have discovered Mitofusin 2's unexpected function in maintaining protein quality within cells, interacting with the proteasome and chaperones to prevent toxic aggregates. This novel connection has far-reaching implications for treating CMT and other neurodegenerative diseases.
A fungal infection has been shown to trigger a fruit fly's own immune system to destroy brain cells leading to signs of neurodegeneration. The fungus makes the fly's innate immune system release Sarm, which suppresses the immune response and kills brain cells.
Researchers at WashU Medicine found that new Alzheimer's therapies can add up to 10 months of independent living with lecanemab and 8 months with donanemab. The study provides a more meaningful measure of treatment benefits, focusing on day-to-day impacts on patients' lives.
Dr. Mikael Simons is being recognized for his pioneering research on myelin biology, glial cell biology, and neuroinflammation that continues to inform MS research. His work has helped identify a promising therapeutic target with potential to benefit people with MS.
A team of scientists at Linköping University has developed a method to anchor conductive polymers to individual living cell membranes without affecting the cell's functions. This innovation opens up new possibilities for treating neurological diseases with high precision.
Researchers investigate how repetitive blows to the head impact brain health, potentially leading to neurodegenerative diseases. The study aims to detect and mitigate acute effects of exposure to repetitive head hits using objective measures.
A study led by Toho University and Maastricht University revealed that loss of VCP gene function during neural development causes FTLD. This finding offers fundamental insights for developing new treatments for the disease.
Researchers have found that microglia function differently in adult male versus female mice when given an enzyme inhibitor, with potential broad implications for how neurological diseases are studied. This discovery highlights the necessity of gender-specific research and may lead to new disease-modifying therapies targeting microglia.
Intrinsically disordered proteins make up 30% of all proteins and are linked to various diseases. By combining two methods in a single sample, researchers have improved the accuracy of measuring protein size and its impact on disease development.
This study investigated the performance of plasma neurodegenerative biomarkers (NfL, GFAP, tau, and UCHL1) in diagnosing minimal hepatic encephalopathy (MHE) and predicting overt hepatic encephalopathy (OHE) in Chinese patients with hepatic cirrhosis. The results showed that a combination of NfL, GFAP, tau, and UCHL1 was effective in d...
The Aligning Science Across Parkinson’s initiative is launching a new funding opportunity to support collaborative research teams focused on understanding Parkinson’s disease heterogeneity across six focus areas. The grants will provide up to $3 million per year over three years.
Batten disease, a neurodegenerative disorder, affects the bowel wall's enteric nervous system, causing degeneration and bowel symptoms. Gene therapy has been shown to slow symptoms and extend lifespan in mice by preventing enteric neuron degeneration.
The Cognitive Neuroscience Society conference will feature keynote addresses, award lectures, and symposia on various topics in cognitive neuroscience. Researchers will present the latest findings on sleep, emotional experiences, brain connectivity, and more.
Researchers at the University of Bergen have made a groundbreaking discovery in understanding the structure of protein clumps associated with Huntington's disease. The study provides new insights into the disease's mechanisms and paves the way for the development of diagnostic tools and treatments.
A study by Tufts University researchers found that head trauma can activate dormant viruses in the brain, triggering neurodegenerative diseases like Alzheimer's. The discovery suggests antiviral drugs could be used as early preventive treatments after head injuries.
Researchers have discovered a nucleolar complex that plays a pivotal role in maintaining cellular health through protein homeostasis, allowing for the dramatic reduction of toxic effects of Alzheimer's-causing proteins. This breakthrough offers hope for new therapies to slow or prevent neurodegenerative diseases, promoting healthy aging.
Researchers have unveiled a critical mechanism linking cellular stress in the brain to Alzheimer's disease progression, highlighting microglia as central players in both protective and harmful responses. The study reveals that blocking a specific stress pathway reverses symptoms of Alzheimer's disease in preclinical models.
A recent study suggests that tiny antenna-like structures on cells called primary cilia could be a potential therapeutic target for Amyotrophic Lateral Sclerosis (ALS). Researchers have identified mutations in the C21orf2 gene, which impair primary cilia formation and structure, leading to motor neuron death.
Researchers found that neuroinflammation in the hippocampus significantly alters motivation and behaviour in mice, particularly in females. This study suggests that treatments targeting hippocampal neuroinflammation could help reduce cognitive and behavioural symptoms in diseases such as Alzheimer's and Depression.
A team of researchers has discovered a hitherto unrecognized role of mitochondria in maintaining cellular NAD levels. Decreased NAD levels are involved in ageing processes and various pathologies, but the study reveals that cells can generally tolerate reduced NAD levels without fatal consequences.
The InteReg project aims to create interactive biomaterials that instruct cells to regenerate after brain or spinal cord injuries, potentially treating MS and other neurological disorders. The project, funded by the Carl Zeiss Foundation, brings together experts in biology, chemistry, medicine, and polymer research.
The Pew Charitable Trusts has funded eight teams of researchers to conduct interdisciplinary biomedical research projects. These partnerships aim to advance scientific discovery and improve human health by combining expertise in cell biology, immunology, neuroscience, and genetics.
The study reveals that electrical signals enhance calcium entry into cells, amplifying localized signals and extending their influence to neighboring cells through E-Ca coupling. This creates a synchronized system that adjusts blood flow both locally and across wider distances.
The partnership integrates Answer ALS’s Neuromine Data Portal with the AD Data Initiative's AD Workbench, providing a unified platform for data sharing and analysis. This collaboration enables integrative analysis of ALS and Alzheimer’s data, streamlining efforts and enhancing research impact.
A new study reveals that glyphosate exposure in mice can cause lasting brain inflammation and accelerate Alzheimer's disease-like pathology, even after a significant pause from exposure. The herbicide's byproducts have been found to accumulate in brain tissue, raising serious concerns about its safety for human populations.
Researchers use cryo-electron microscopy to study Microprocessor's interactions with primary microRNAs. The protein can process multiple pri-miRNAs due to its flexibility and 'tentacle-like' properties.
A new study aims to uncover genetic and phenotypic factors affecting maternal health, including Alzheimer's disease. The research may lead to preventive or therapeutic strategies for women's health worldwide.
Scientists at Purdue University have identified new molecular markers for neurodegenerative diseases by analyzing protein behavior with age. The study sheds light on how phosphorylation causes protein aggregation, a hallmark of these diseases.
University Hospitals Brain Health & Memory Center is now treating patients with KISUNLA, a medication approved by the FDA to treat Alzheimer's disease. The treatment has shown promise in clinical trials and may be an option for patients with mild cognitive impairment and mild dementia.
A new Israeli study explores physician attitudes toward emerging anti-amyloid treatments for Alzheimer's disease. Key findings highlight the need for multidisciplinary collaboration to address financial and logistical barriers, emphasizing education, cost-benefit analysis, and improved insurance coverage.
Researchers identified a protein that inhibits human defense mechanisms and allows fungal growth. The study suggests that the lack of this enzyme makes the fungus more prone to elimination by the immune system.
Researchers at the University of Tokyo have developed a new CRISPR-based system to label small extracellular vesicles (sEVs) with RNA barcodes, enabling comprehensive analysis of their biogenesis and release regulators. This system allows for the simultaneous study of thousands of genes and estimation of sEV release from host cells.
Researchers from Salk Institute found that specific dietary fats are incorporated into sphingolipids to drive the development of atherosclerotic cardiovascular disease. The team discovered that trans fats are preferentially metabolized by an enzyme, leading to increased lipoprotein secretion and plaque formation.
A team of researchers has identified 30 patients with previously undiagnosed conditions, linking them to rare mutations in the FLVCR1 gene. The study reveals a range of severe developmental disorders, including anemia and bone malformations, which share similarities with mice lacking the Flvcr1 gene and Diamond-Blackfan anemia.
A team of researchers at the University of California San Diego has identified a key pathway leading to neurodegeneration in early stages of ALS. The study suggests that targeting this pathway may prevent or slow disease progression, offering new hope for therapies.
The F.M. Kirby Research Center has driven critical breakthroughs in understanding the human brain in health and disease, aiding discoveries of effective diagnoses and interventions for various conditions.
Researchers develop transcranial ultrasound stimulation (TUS) as a non-invasive therapy for brain-related issues, with potential for personalized treatments. A 'search and rescue tool' for the brain, TUS enables precise targeting of specific areas before treatment.
Scientists have successfully imaged superspreader fibrils in the brain tissue of Alzheimer's patients, shedding light on their role in spreading the disease. The study, published in Science Advances, uses advanced imaging techniques to visualize the fibrils' formation and spread.
A new study in mice shows a unique mRNA delivery method can successfully edit faulty genes in fetal brain cells. The technology has the potential to stop progression of genetic-based neurodevelopmental conditions like Angelman syndrome and Rett syndrome before birth.
Researchers have unveiled a complex interplay between liver X and thyroid hormone receptors that regulates critical brain functions and protects against neurodegeneration. LXRs play a crucial role in regulating thyroid hormone function in the brain, while both receptors are essential for normal brain development and maintenance.
A new study has identified two neuron types in the brainstem that induce REM sleep, revealing a potential cause of Parkinson's disease. The discovery provides insight into the neural circuitry underlying REM sleep and its relationship to neurodegenerative diseases.
Mayo Clinic scientists created mini brain models in a dish that closely match key features seen in the brains of patients with Lewy body dementia. The team identified four potential drug compounds that may offer approaches to treating the disease.
Researchers at UC San Diego developed a fluorescent biosensor to observe PKC activity in real time and 3D space. The study revealed designated signaling territories where different types of PKC are active, shedding light on their critical role in human disease.
Researchers create Lewy bodies in living dopaminergic neurons using human stem cells and find that immune challenge is crucial for their formation. The study identifies a previously unknown link between the immune system and neurological disease, suggesting that genetic predisposition may not be necessary for Parkinson's development.
University of Rochester researchers have refined a noninvasive method called BL-OG that harnesses light to activate neurons in the brain. The technique has the potential to transform invasive procedures used to treat Parkinson's disease and other neurological conditions by providing a safer, less invasive alternative.
Researchers have developed a peptide inhibitor called RI-AG03 that effectively prevents Tau protein aggregation in lab and fruit fly studies. The breakthrough targets both major aggregation-promoting 'hotspots' of the Tau protein, potentially paving the way for more effective treatments for neurodegenerative diseases.
Researchers identify a homozygous SPAG9 gene mutation associated with intellectual disability, progressive cognitive decline, and heterogeneous brain abnormalities. The study provides a unique model for understanding disruptions in cellular transport mechanisms leading to neurodevelopmental and degenerative brain conditions.
Researchers have identified eight novel genetic mutations in patients with CSF1R-Related Disorder worldwide, highlighting the prevalence of the disease and paving the way for future individualized treatment. The discovery also suggests that genetic and environmental factors may influence the disease.
A Pitt study found that protein STING plays a protective role in cellular stress clearance and cell survival, increasing autophagy and lysosome production. The findings suggest targeting inflammation pathway downstream of STING may be a better approach to develop therapeutics for age-related diseases.
New research reveals that downregulating the enzyme EGLN2 can protect motor neurons and mitigate ALS symptoms in animal models. This discovery brings hope to understanding how to slow or prevent this devastating disease.
Researchers at the UAB Institut de Neurociències found that daily cannabidiol administration extends lifespan and improves symptoms in animal models of Leigh syndrome. CBD also improves cellular function, neuropathology, and breathing abnormalities, with a promising treatment option for this severe disease.
The study compares nerve fiber orientation captured with specialized MRI and OCT approaches, laying groundwork for combining these imaging techniques. The findings show strong potential for PS-OCT to validate dMRI data, providing valuable insights about the microstructural organization of nerve fibers.
Researchers have developed an integrated optical sensor capable of detecting dopamine directly from unprocessed blood samples. This breakthrough enables low-cost and efficient screening tools for various neurological conditions and cancers.
A new study reveals that more than half of strokes causing ataxia are located outside the cerebellum but affect a specific brain network. This discovery changes our understanding of ataxia's neural mechanisms and may lead to safer treatments for patients.
A study published in The EMBO Journal reveals that PQBP3 plays a crucial role in stabilizing the nuclear membrane, which is destabilized in senescent cells and contributes to neurodegenerative disorders. PQBP3's dysfunction may lead to the degradation of Lamin B1, a protein essential for maintaining the nuclear membrane.
A cross-sectional study of 170 former football players found a strong association between repeated head impacts and increased perivascular space volume, as well as worse cognitive test performance. The findings suggest that PVS volume may contribute to the link between RHI exposure and neurodegeneration.
Researchers have identified two proteins, PARP1 and histone H1.2, that interact with an ALS-causing mutant FUS protein, leading to pathological changes. Inhibiting these proteins may be a possible therapeutic target for familial ALS cases caused by mutations in the FUS gene.
Scientists at IOCB Prague have developed a new compound that suppresses appetite and protects the brain against Alzheimer's disease. The modified molecule, derived from the neuropeptide CART, is effective in reducing pathology associated with Alzheimer's.