Articles tagged with Parkinsons Disease
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A new neurostimulator, WAND, can stimulate and record electric current in the brain simultaneously, potentially delivering fine-tuned treatments to patients with diseases like epilepsy and Parkinson's. This closed-loop system allows for real-time adjustments, enabling improved outcomes and accessibility.
Researchers have discovered that protein clumps, particularly pα-syn*, recruit enzymes and tau to damage brain cells, leading to mitochondrial destruction. This study provides insight into the molecular mechanisms of Parkinson's disease, shedding light on potential treatment targets.
Researchers have discovered how a protein called Parkin protects neurons in the brain by repairing internal damage that may otherwise kill them. The study found that Parkin 'buys time' for cells to respond to damage and triggers cell death, potentially leading to neuronal loss in Parkinson's disease.
Scientists at the University of Edinburgh have created stem cells that can transform into brain cells and produce dopamine, a key neurotransmitter lost in Parkinson's. The gene-edited cells resisted developing Lewy bodies, a hallmark of Parkinson's disease.
Researchers developed a method to translate brain activity into visual representations, enabling patients to increase or decrease beta waves associated with symptoms. Although no improvement in symptoms was observed, the study demonstrates a new approach toward managing disease-related brain activity that could inform new treatments.
Researchers at Rutgers University discovered that a fatty acid derivative of serotonin in coffee beans' waxy coating, EHT, combined with caffeine can protect against brain degeneration. This combination boosts the activity of a catalyst that prevents protein accumulation associated with Parkinson's disease and Lewy body dementia.
The company's discovery engine identified a series of compounds that shielded cells against alpha-synuclein-induced toxicity by inhibiting stearoyl-CoA desaturase. This finding suggests that inhibition of fatty acid desaturation could be a potential therapeutic approach for treating Parkinson's disease and other synuclein-based disorders.
Researchers found that combining low doses of paraquat herbicide with sugar-binding proteins called lectins triggered Parkinsonism-like symptoms in rats. The study suggests that the toxin travels from the stomach to the brain, forming a misfolded protein alpha-synuclein that causes the disease.
Research reveals that coffee compounds eicosanoyl-5-hydroxytryptamide and caffeine work together to maintain enzyme PP2A activity, dephosphorylating pathogenic α-synuclein proteins. This synergy prevents neurodegeneration and neuroinflammation in Parkinson's disease models.
A Finnish study of 68,800 patients found that hip fracture surgery is associated with a significant risk of surgical complications. Patients with osteoarthritis, Parkinson's disease, and rheumatic diseases are particularly at risk, with 4.6% experiencing complications within three months of surgery.
Scientists have discovered that an emerging Parkinson's gene therapy called AAV2-GAD creates new brain circuits associated with improved motor movement. The therapy has shown therapeutic effects for patients by forming new neural pathways in the brain, connecting the subthalamic nucleus to other motor regions.
Research found that more Oregonians filled out POLST forms between 2015-16, with a 45% increase compared to 2010-11. The study also showed changes in how people use the form, including increased use by middle-aged individuals and those with Alzheimer's and Parkinson's diseases.
A new series of studies assesses death and disability from neurological disorders between 1990 and 2016, finding one in four people worldwide suffered from headaches in 2016. Parkinson's disease has more than doubled since 1990, with motor neuron diseases causing severe disability and high fatality rates.
Researchers at UC Berkeley found that humans rely on two distinct neural networks to predict the future in tasks like music and sports. The basal ganglia system is sensitive to rhythmic cues, while the cerebellum relies on interval timing based on past experiences.
A team of neurologists at Georgetown University Medical Center found that inhibiting the USP13 protein eliminates Lewy bodies and stops their buildup in mouse models of Parkinson's disease. The study suggests targeting USP13 as a therapeutic target for treating Parkinson's and other neurodegenerative diseases.
A new study found that focused ultrasound thalamotomy improves quality of life in people with medication-resistant Parkinson's disease. The procedure showed significant and sustained benefits in functional disability and overall well-being.
Researchers found that singing reduced physiological indicators of stress, improved mood, and enhanced motor symptoms in people with Parkinson's disease. The therapy showed promise as a non-pharmacological approach to manage the condition.
A molecular pathway previously studied in laboratory conditions has been verified to be disrupted in Parkinson's disease patients. The study identifies a key enzyme switch that plays a pivotal role in protecting the brain against stress.
Aryn Gittis, a Carnegie Mellon University neuroscientist, has been recognized for her creativity and originality in research. She discovered a class of neurons that restored movement in a mouse model for Parkinson's disease when targeted with optogenetics.
A recent study suggests that drinking coffee may protect against both Alzheimer's and Parkinson's diseases. The research found that phenylindanes, compounds present in dark roasted coffee, inhibit the formation of beta amyloid and tau protein fragments, which are common in these diseases.
New research presents promising results from preclinical studies using gene therapy to treat amyotrophic lateral sclerosis, Parkinson's disease, and other neurological disorders. Gene therapy has been successfully used to slow disease progression and improve symptoms in mouse models.
A study published in Science identifies Parthanatos as a key driver of nerve cell degradation in Parkinson's disease. The researchers found that blocking a protein called PARP1 can rescue cells from death, suggesting new targets for drugs to interrupt the disease progression.
A recent study published in Neurology suggests that when Parkinson's disease does not affect thinking skills early on, life span is not affected. The study found people with problems with memory and thinking skills were more likely to die during the study.
A study published in Science Translational Medicine found that removing the appendix early in life can lower the risk of developing Parkinson's disease. The appendix acts as a reservoir for disease-associated proteins, and appendectomy delays disease progression by an average of 3.6 years.
Researchers at The University of Queensland have developed a promising new therapy using the small molecule MCC950, which blocks NLRP3 activation and prevents brain cell loss in Parkinson's patients. The therapy shows marked improvement in motor function and may offer an alternative approach to current treatments.
Researchers have developed a novel strategy to measure material properties of the cell nucleus and its components using naturally occurring cellular dynamics. The study shows that human nucleoli behave like liquid droplets, which can influence disease progression, such as Alzheimer's and Parkinson's disease.
Researchers at Lehigh University identify fruit fly protein Scarlet as a key to preventing age-dependent loss of dopaminergic neurons in Parkinson's disease. The study found that Scarlet has a neuroprotective role in a model of the disease, suggesting potential for future treatments.
A team of Canadian scientists discovered a French-Canadian founder mutation gene linked to synucleinopathies, a group of neurodegenerative diseases including Parkinson's disease and dementia. The GBA mutation increases the risk of developing these diseases, particularly in people with other mutations.
Researchers tracked over 12,000 participants to estimate the lifetime risk of dementia, Parkinson's disease, and stroke. Preventive strategies could delay onset and reduce lifetime risk by 20-50% in theory, particularly for those aged 85+.
Researchers evaluated the safety of pimavanserin for treating Parkinson's disease psychosis, finding a lower mortality risk compared to quetiapine or combination therapy. The study provides reassurance for clinicians and families but highlights the need for further research on disease severity and cause of death.
A team of scientists has identified a molecule called SynuClean-D that can inhibit the aggregation of alpha-synuclein protein, a key contributor to Parkinson's disease. By administering SynuClean-D to Caenorhabditis elegans worms, researchers were able to reduce alpha-synuclein aggregations and prevent neural degeneration.
Researchers created a way to measure different types of fear of falling (FOF) in Parkinson's patients, highlighting the importance of cognitive function. The study aims to improve treatment and quality of life for patients with FOF.
Researchers advocate for a systems biology approach to better understand Parkinson's disease, emphasizing the need for modern, human-based technologies to improve treatment outcomes.
A comprehensive study has cataloged over 70,000 novel noncoding RNAs active in dopamine neurons, implicating them in conditions like Parkinson's disease and schizophrenia. The findings suggest that genetic risk variants may affect gene switches in these specialized cells.
Computer simulation models how toxic proteins spread through the brain to reproduce patterns of atrophy associated with Alzheimer's disease, Parkinson's disease, and other neurodegenerative diseases. The model reveals that biochemistry and connectivity play key roles in mediating disease progression.
MIT neuroscientists have developed tiny probes that can measure dopamine levels in the brain for more than a year. The sensors were implanted in animals and found to produce accurate readings for up to 393 days, opening up new possibilities for understanding dopamine's role in diseases such as Parkinson's.
Researchers found ADHD patients had a higher risk of developing Parkinson's and Parkinson-like diseases than non-ADHD individuals, especially those prescribed stimulant medications. The study suggests that the long-term health effects of ADHD and its treatment remain understudied.
A high-throughput screening study has identified six potent small-molecule inhibitors of α-synuclein aggregation, which could potentially halt Parkinson's disease development. The compounds target the monomeric state of αSN and share a common core structure.
A new €10 million Parkinson's study will implement an integrated care model designed specifically for people with Parkinson's disease across two health hubs in Bath, UK and Nijmegen, Netherlands. The project aims to bridge the gap between fragmented care providers and deliver proactive and integrated care to patients.
Researchers tracked marmosets with Fitbit-like devices to study sleep disturbances, circadian rhythm changes, and cognitive impairment, mirroring Parkinson's non-motor symptoms. The findings provide a valuable animal model for understanding the neuro-circuitry responsible for these complex aspects of the disease.
Researchers developed a modified Nurr1 protein that can enter cells from the outside, showing promise in treating Parkinson's disease. The protein increased tyrosine hydroxylase production, a key enzyme in dopamine synthesis, and protected against neurotoxin-induced cell death.
Researchers found that deep brain stimulation affects different neural pathways for motor and cognitive functions. The treatment shows improved effects on motor control and fewer adverse cognitive effects.
A novel brain network has been discovered that links chronic pain in Parkinson's disease to a specific region of the brain, including the subthalamic nucleus. This research provides new insights into pain processing and suggests a potential target for pain relief in PD and other neurological diseases.
A study of 2.5 million Swedes found that high job demands and low control were associated with increased Parkinson's disease risk. High education level was a moderating factor for men, while low education level exacerbated the risk among women.
A new study has found that the thinning of the retina is linked to the loss of brain cells that produce dopamine, a substance that helps control movement. This discovery may lead to a simple eye scan being used to detect Parkinson's disease in its earliest stages.
Guidelines for discovering Parkinson's biomarkers aim to develop new treatments, focusing on biomarkers within the disease itself. The research emphasizes collaboration and access to biobanks containing thousands of biological samples.
Scientists at Michigan State University have discovered a navigational gene in glass catfish that responds to magnetic waves, which may one day be used to treat Parkinson's and epilepsy. The gene, called the electromagnetic-perceptive gene, can be activated using magnets and has shown promise in controlling movement in mice.
New research reveals that coral-algal partnerships date back to the Jurassic Period, approximately 160 million years ago. This finding challenges previous assumptions and provides evidence for a more diverse range of algal species worldwide.
A team of scientists found that coral-algal partnerships are older and more diverse than previously thought, with a history dating back to the 'age of dinosaurs.' This relationship has enabled corals to adapt to environmental changes over millions of years.
A new study from Rice University links biological markers for cancer-related exhaustion to fatigue in Parkinson's disease, highlighting potential targets for treatment. Researchers found elevated levels of inflammatory biomarkers in patients with Parkinson's who experienced fatigue, similar to those seen in cancer patients.
Researchers at the University of Basel have identified a factor that could support the early detection of neurodegenerative diseases such as Alzheimer's or Parkinson's. FGF21 is induced by cellular stress reactions after disturbances in mitochondria and can be detected prior to neuronal cell death.
A study published in eNeuro found a common neural signature of balance maintenance in the healthy brain, which could be used to assess balance in patients with movement disorders. The researchers used EEG and EMG to record electrical activity from the brain and muscles while participants walked or stood on a narrow beam.
Aryn Gittis' research establishes new therapeutic targets for Parkinson's therapies, using optogenetics to identify a subset of neurons in the globus pallidus that play a critical role in restoring movement. Her findings suggest targeting these cells could repair neural circuit dysfunction in diseases like Parkinson's.
Nir Grossman's temporal interference (TI) approach stimulates deep brain regions without surgery, offering a new treatment option for brain disorders. TI uses multiple electric fields to target specific brain areas, improving spatial resolution and non-invasiveness.
A post hoc analysis of the exenatide-PD trial results showed that patients on exenatide treatment experienced improvements in severity of depression, independent of motor function improvement. Additionally, self-reported apathy and cognition also improved with exenatide.
Ceria nanoparticles selectively remove reactive oxygen species from mitochondria, intracellular and extracellular spaces, improving Parkinson's disease symptoms in mice. Lowering oxidative stress in these compartments is crucial for treating the disease.
A new study finds contact sports associated with an increased risk of Lewy Body Disease (LBD), which can cause Parkinson's disease and dementia. LBD was linked to problems with movement, cognition, depression, sleep, and visual hallucinations, independent of CTE pathology.
Disrupted transportation routes in nerve cells cause Parkinson's disease by destroying synapses and leading to cell death. Researchers identified alpha-synuclein protein as the trigger for these traffic jams.
Researchers have discovered a new link between gene LLRK2 and Parkinson's disease, suggesting that therapies currently being developed for a small group of patients may benefit everyone with the disease. The study also found that LRRK2 plays a key role in clearing excess alpha-synuclein, a protein associated with Parkinson's.
Researchers developed a sensor to detect early-stage Parkinson's disease from patient breath, achieving 79% sensitivity and 84% specificity. The device detected differences in the exhaled breath of newly diagnosed patients, outperforming diagnostic smell tests and ultrasound scans.