Articles tagged with Parkinsons Disease
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Over a 40-year period, Antarctic sea ice coverage increased gradually until 2014 before declining sharply between 2014 and 2017. This trend is more pronounced than observed in the Arctic over the same time frame, with implications for climate modeling and understanding.
Parkinson's UK is partnering with NRG Therapeutics to develop a potential drug that could safeguard dopamine cells and slow down the progression of Parkinson's. The partnership will support the identification of novel molecules to protect mitochondria within dopamine-producing cells.
Researchers at Johns Hopkins Medicine found evidence that Parkinson's disease originates in the gut and travels up the brain's neurons. The study used mice with misfolded alpha-synuclein protein, which causes nerve cell death, to demonstrate the connection.
A team of researchers refutes the long-held common thesis that Parkinson's disease is caused by deposits of insoluble fibrils consisting of alpha-synculein. Instead, they found that Lewy bodies contain mainly membrane fragments, lipids, and other cellular material.
Researchers developed a mouse model that recapitulates Parkinson's disease's progression, showing how misfolded protein α-synuclein spreads from the gut to the brain. The study supports Braak's hypothesis and suggests potential therapeutic targets.
Researchers have found an enzyme in the body that metabolizes compounds from tobacco smoke, alcohol, and certain foods into chemicals that trigger Parkinson's disease. Mitochondrial CYP2D6 is a promising new target for treating idiopathic Parkinson's disease.
Researchers at King's College London have identified the earliest signs of Parkinson's disease in the brain, many years before symptoms appear. The study found changes to the serotonin system as a key early warning signal for the disease.
Researchers investigated mirror activity in healthy humans and found that amplitude grows with repetition, while latency decreases. This inverse relation may be linked to fatigue-induced inhibitory mechanisms failure.
Researchers developed a novel technique using transcranial ultrasound and microbubbles to open the blood-brain barrier, enabling drugs to penetrate the brain and restore dopaminergic pathways. The method has been approved by FDA for clinical trials in Alzheimer's patients and shows promise for treating Parkinson's disease at early stages.
A research team from Osaka University has developed a novel gene therapy approach that targets α-synuclein, a protein associated with Parkinson's disease. By using amido-bridged nucleic acid-modified antisense oligonucleotides, the treatment effectively decreases α-synuclein production and reduces disease severity in mice models.
Researchers track early stages of alpha-synuclein protein aggregation in Parkinson's disease, which can lead to significant delay in disease progression. The study's novel method using super-resolution microscopy and advanced analysis has the potential to detect disease progression before symptoms appear.
Researchers have found that anle138b can reduce alpha-synuclein clumps, restore dopamine levels and stop the progression of Parkinson's. Early treatment may be crucial in stopping the condition in its tracks.
The National Institutes of Health has awarded a $3 million grant to the Cleveland Clinic to conduct a multi-site clinical trial investigating the long-term effects of aerobic exercise on slowing Parkinson's disease progression. The CYCLE trial aims to determine if high-intensity aerobic exercise can slow disease advancement.
Parkinson's disease can spread throughout the brain via tiny channels, where harmful protein aggregates bind and 'hitch a lift' with channel-forming proteins. This process involves specific proteins called connexins, which create small channels between cells.
A national Taiwanese health database study found people with bipolar disorder were nearly seven times as likely to develop Parkinson's disease as those without the condition. The risk was higher for those hospitalized more frequently, developing the disease at a younger age.
Parkin's activity depends on recruitment and activation by proteins such as PINK1 and MITOL. The discovery of MITOL's role in tagging damaged mitochondria could lead to improved therapies for Parkinson's disease.
Researchers discovered a novel noninvasive electrophysiological biomarker for Parkinson's disease using scalp electrodes and electroencephalography (EEG). The approach showed promise for developing wearable technology to monitor disease-related brain activity at home.
A study from the University of Oregon suggests that specific angles and sharpness of brain waves in unfiltered EEG data may indicate Parkinson's disease. Researchers used raw, unfiltered beta waves to distinguish between patients on and off medication, providing a potentially new approach for diagnosis and treatment.
Researchers have identified two cell populations in the substantia nigra that control distinct phases of locomotion. The study reveals a critical role for these populations in maintaining correct movement, and their dysfunction may contribute to Parkinson's disease symptoms.
Researchers found a clear association between appendix removal and development of Parkinson's disease, with patients being over three times more likely to develop the condition. The study analyzed over 62 million patient records and found similar risk levels across all age groups.
Researchers at Osaka University developed a fully automated tool to assess α-synuclein aggregation in cerebrospinal fluid using ultrasonication. The HANABI device can accurately detect patients with Parkinson's disease and has potential for early diagnosis and treatment assessment.
A phase 3 study involving 336 participants found that isradipine did not slow the progression of Parkinson's symptoms over three years. Researchers will continue to work on finding a treatment for the disease despite negative results.
A new study suggests that older adults with poor sense of smell may be at a 46% higher risk for death at 10 years and 30% at 13 years compared to those with good smell. Poor sense of smell is linked to higher mortality in both healthy and unhealthy individuals, with most of the risk remaining unexplained.
A commonly used blood pressure medication has shown potential in slowing the progression of neurodegenerative diseases such as Parkinson's and dementia. The study, published in Nature Communications, found that felodipine induced autophagy in mice with Huntington's disease and zebrafish models of dementia.
A new study reveals that neurofeedback can strengthen neural connections and communication among brain areas in under 1 hour, paving the way for optimizing therapeutic approaches against stroke and Parkinson's. The technique showed increased integrity of the corpus callosum and strengthened neural networks controlling body movements.
The €50 million MOBILISE-D project aims to develop a system using small sensors to monitor mobility and assess health. It will enable personalized healthcare, predictive diagnosis, and improved treatment for conditions like COPD, Parkinson's disease, and multiple sclerosis.
A new service in the UK uses wearable technology to monitor Parkinson's symptoms, enabling patients and specialists to identify and implement changes to therapy remotely. The project aims to reduce healthcare burden and improve quality of life for people with Parkinson's.
Researchers developed a virtual reality training system to aid people with Parkinson's disease in improving their balance and avoiding obstacles. The six-week program showed significant improvements in obstacle negotiation, balance, and range of motion.
Researchers suggest that bi-directional electrodes can both stimulate and record from deep brain structures, enabling closed-loop DBS for movement and psychiatric disorders. This technology could expand treatment possibilities beyond Parkinson's disease.
Researchers at University of the Basque Country have discovered that vitamin B12 inhibits the LRRK2 enzyme, a key target for developing treatments for hereditary Parkinson's. The study shows promise for a new class of neuroprotective therapies.
Researchers identified specific variations in human leukocyte antigen (HLA) genes associated with increased or decreased risk of Parkinson's disease. A history of cigarette smoking modified these associations, suggesting a possible explanation for the apparent protective effect of smoking on PD.
A team of researchers discovered the chemicals responsible for the distinctive smell of Parkinson's disease using a 'super smeller'. The finding could lead to an early diagnosis and monitoring of the condition. Hippuric acid, eicosane, and octadecanal were identified as biomarkers in sebum samples from patients with Parkinson's.
Researchers are seeking to recruit 10,000 participants over 60 without Parkinson's for an annual online questionnaire and tests to develop a predictive algorithm. Early detection could lead to treatments that slow or prevent the condition's progression.
A new study from Iowa State University researchers explores the biological processes by which exposure to metals can contribute to Parkinson's-like symptoms. The study found that manganese combines with a protein called alpha-synuclein, leading to misfolded proteins and a neurodegenerative response.
A €7 million Parkinson's research project, PD-MitoQUANT, will be coordinated by RCSI to deepen understanding of the disease and develop new treatments. The project aims to increase knowledge of how cells in the brain become damaged in Parkinson's, with a focus on mitochondria.
A new study suggests that deep brain stimulation boosts the number and strength of mitochondria in brain cells, which may help reduce Parkinson's symptoms. The treatment, used for late-stage Parkinson's disease, involves surgically implanting thin wires into the brain to deliver small electric pulses.
Researchers found that nilotinib increases dopamine levels by reducing toxic alpha-synuclein protein, allowing normal dopamine release. The study also showed a significant reduction in alpha-synuclein levels and increased TREM-2 activity, indicating an elevated immune response against misfolded proteins.
Researchers have successfully pharmacologically activated Nurr1, a key molecule implicated in Parkinson's disease, offering a potential new treatment strategy. The breakthrough discovery provides valuable leads for developing drugs to restore proper dopamine balance and slow the progression of the disease.
Researchers at Wake Forest Baptist Health will investigate deep brain stimulation as a potential therapeutic approach for Alzheimer's disease, building on previous studies that showed significant improvements in cognitive function in young nonhuman primates. The five-year study aims to determine if DBS can improve memory and counteract...
A Michigan State University researcher is investigating the role of pesticides in olfactory impairment and their relevance to neurodegenerative diseases such as Alzheimer's and Parkinson's. Researchers will assess over 2,200 farmers using a standard smell test and conduct home visits to evaluate cognitive function and motor symptoms.
A device called VibeForward reduces symptoms of freezing of gait in patients with Parkinson's disease by providing vibration therapy through a portable, non-invasive shoe. The technology has shown early evidence to help improve daily life for those with the condition.
Researchers tested an experimental treatment boosting Glial Cell Line Derived Neurotrophic Factor (GDNF) to regenerate dopamine brain cells in patients with Parkinson's. After nine months, the group receiving GDNF showed a 100% improvement in affected brain areas, offering hope for a potential reversal of the condition.
A lab study found that a substance called Emapunil alleviated motor disorders in mice, potentially slowing down Parkinson's disease progression. The compound targets microglia and TSPO, a molecular receptor involved in neurodegeneration.
A pioneering clinical trial has shown promising effects on restoring brain cells damaged in Parkinson's. While the treatment did not significantly impact symptoms, it demonstrated significant improvements in brain scans, suggesting long-term beneficial effects may be possible.
A new study finds that Parkinson's disease patients treated with Deep Brain Stimulation (DBS) do not exhibit increased impulsive decision-making when faced with immediate or delayed rewards. The research challenges existing notions about the technique's impact on behavior and cognitive processes.
Using a mouse model of Parkinson's disease, researchers identified unusual patterns of brain activity that appear to underlie its signature symptoms. The striatal neurons' normal pattern of activity warps when dopamine levels are low, leading to synchronized cell firing and repetitive movements.
Scientists at the University of Virginia Health System identified a potential explanation for the death of specific brain cells seen in Alzheimer's and Parkinson's diseases. The discovery suggests that naturally occurring gene variation, called 'somatic mosaicism,' may be responsible for this selective vulnerability.
Researchers at the Buck Institute have identified a novel molecular mechanism that orchestrates harmful inflammatory signaling in glial cells, contributing to Parkinson's disease pathology. Blocking Furin 1, a catalytic protein, in dopaminergic neurons reduces toxic cross-talk and protects neurons from degeneration.
Recent advances in understanding Parkinson's disease have identified promising developments to slow or stop its progression. Researchers explore new therapeutic targets, targeting non-motor features of the disease, and repurposing drugs for their potential disease-modifying properties.
Researchers at Osaka University developed a neurofeedback system allowing Parkinson's patients to control β waves in their deep brain. The system enables voluntary control of beta wave activity, which is associated with symptoms of the disorder.
A new study is analyzing blood samples from over 2,500 participants to identify biomarkers of Parkinson's disease. The researchers aim to find molecular indicators in DNA that can aid in early diagnosis and treatment.
Researchers review novel research hypotheses and approaches to understand the role of environment in Parkinson's disease, particularly before diagnosis. The study suggests targeting specific environmental factors via the nose or gut may help prevent or modify the disease's progression.
Researchers found that gut microbiota can convert levodopa into dopamine, reducing its effectiveness in treating Parkinson's disease. The study suggests that the presence of bacterial tyrosine decarboxylase enzyme contributes to this effect.
Researchers discovered manganese's role in disrupting protein transport, leading to parkinsonian symptoms. Manganese accumulates in cellular vesicles, disturbing nerve cell function and affecting Parkinson's disease-like symptoms.
A study suggests defective astrocytes contribute to α-synuclein accumulation, leading to neuronal degeneration. Researchers discovered that healthy astrocytes can prevent α-synuclein buildup and restore neuronal function when cultured with Parkinson's disease neurons.
The FDA has approved focused ultrasound treatment for reducing medication-resistant Parkinson's disease tremors, allowing doctors to perform brain surgery without cutting into the skull. Researchers are now exploring its potential for treating other conditions, including breast cancer and epilepsy.
Researchers at Clemson University discover Mojave rattlesnakes have a wider distribution of life-threatening venom types than expected. The study reveals a peculiar variability in the species, with local optima favoring different venom types depending on location.
Researchers at Michigan State University have developed a gene therapy that could reduce and possibly eliminate dyskinesia, a frustrating side effect of levodopa treatment in Parkinson's patients. The study focuses on brain cells and has shown promising results in preventing the development of dyskinesia over extended periods.
Researchers found defective astrocytes cause accumulation of toxic alpha-synuclein, leading to neuronal death and degeneration. Healthy astrocytes protect neurons from cell death through restored cellular degradation processes.
A new mouse model has revealed the crucial role of PARL in maintaining mitochondrial respiratory chain function and structural integrity. The study found that mice lacking PARL display symptoms reminiscent of Leigh syndrome, highlighting the importance of understanding the protein's mechanisms in neurodegenerative diseases.