Articles tagged with Brain Tumors
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A Phase 0 clinical trial shows ribociclib effectively targets glioblastoma cells and breaks the blood-brain barrier, offering a new treatment hope. The study identifies a potential mechanism of drug resistance, paving the way for a combined-drug regimen to overcome resistance.
A study by St. Jude Children's Research Hospital and Massachusetts General Hospital has revealed the cells of origin for four known subtypes of medulloblastoma, a malignant pediatric brain tumor. The researchers used single-cell RNA sequencing to shed light on the relationship between the subtypes and provided new insights into Group 4...
Researchers discovered that a repurposed heart drug can overcome chemotherapy resistance in over a third of ependymoma patients. The study found that the presence of ABCB1, a protein pumping out chemotherapy drugs, is associated with poorer outcomes and lower survival rates.
Research studies using liquid biopsy and ddPCR technology found that mutant BRAF ctDNA levels can predict treatment efficacy in advanced melanoma patients, while ctDNA may not reliably detect brain metastases. Meanwhile, chimeric cell-free DNA tracked tumor recurrence in hepatocellular carcinoma patients.
A study identified Glycerol-3-phosphate dehydrogenase 1 (GPD1) as a molecular marker specific to dormant glioma stem cells. GPD1-producing cells are resistant to chemotherapy and radiation, and their activation leads to tumor relapse.
Researchers used advanced imaging techniques to visualize macrophages in living mice with brain tumors, finding clear morphological and behavioral differences between blood-derived and brain-resident macrophages. Blocking macrophage infiltration improved survival in treated mice.
Research by Georgia State University found that women undergoing radiation therapy for pediatric brain tumors are more likely to experience long-term cognitive issues. Female survivors were more negatively affected in activities of daily living and higher-order skills compared to male counterparts.
A study published in CANCER journal found that childhood brain tumor survivors who received radiotherapy at a young age experience cognitive and socioeconomic burdens decades after treatment. Interventions like cognitive therapies may be needed to mitigate these effects.
Researchers found that administering anti-inflammatory treatments before surgery can eliminate the spread of cancer cells and promote prolonged survival in animal models. These findings suggest a potential paradigm shift in cancer treatment approaches, particularly for patients undergoing resectable cancers.
A new artificial nose technology helps neurosurgeons identify cancerous tissue during brain tumor surgery by analyzing surgical smoke. The system achieved an accuracy of 83% in classifying samples from brain tumors, with improved performance for low-malignancy tumours.
Researchers discovered a molecular mechanism that allows cancer cells to regenerate and evade therapy, but found treatments that can target these cells. The study provides a new logic for identifying therapies that can kill hard-to-kill cancer cells.
Researchers found that immune cells recruited by tumor cells drive faster growth, suggesting targeting immune system cells could slow brain tumor growth in people with neurofibromatosis type 1 (NF1). The study suggests reprogramming T cells to shut down tumors, a promising new strategy for treating NF1.
Researchers from Johns Hopkins Medicine found a distinct subtype of primary central nervous system lymphoma suitable for surgical removal, offering improved outcomes and potential cure rates. The study suggests a shift in treatment approach, moving away from traditional biopsy, radiotherapy, and high-dose chemotherapy.
A study published in PLOS Medicine found that a computer-assisted diagnostic procedure can detect the growth of low-grade brain tumors earlier and at smaller volumes than current clinical methods. This could lead to reduced delays in detecting tumor growth and potentially improve patient outcomes.
A novel imaging technique using scorpion venom-derived protein BLZ-100 has shown promise in detecting and removing brain tumors. The agent binds to tumor cells and glows under near-infrared laser stimulation, enhancing surgical visualization. Clinical trials demonstrate the imaging system's safety and effectiveness.
Researchers use optical coherence tomography to analyze tissue samples and identify differences between malignant and healthy cells, simplifying tumor removal operations. The technology offers higher resolution than ultrasound or MRI, allowing for more accurate diagnoses and improved patient outcomes.
Young cancer survivors with severe hearing loss experience significant declines in reading skills due to processing speed and phonological difficulties. Interventions focusing on neurocognitive and language-based skills can help improve reading mastery before tackling more complex tasks.
Researchers have identified normal cells that can transform into cancerous cells in the brain, leading to a better understanding of childhood brain tumors. The study used single-cell sequencing technology and mouse models to pinpoint these cells, which were observed much earlier in fetal development than expected.
A new study presents evidence that pencil beam scanning proton therapy offers the best hope of preserving cognitive functions in children with brain tumors. The treatment delivers low doses of radiation to critical areas of the brain, including the temporal lobes and hippocampus.
Researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter called N-acetyl-aspartyl-glutamate (NAAG) in the spread of aggressive cancers. NAAG is found to be more abundant in higher-grade cancers, making it a potential marker for tumor progression or regression during cancer therapy.
Researchers discovered multiple potential targets for glioblastoma by systematically profiling patient-derived brain tumour cells. They found that adult glioblastoma cells rely on genes important for brain development in infancy, highlighting the need for new research to understand the developing human brain.
Researchers developed a method to distinguish tumor margins from healthy tissues using bright spot analysis in confocal microscopy. The technique showed promise in differentiating glioblastoma tumors from surrounding brain tissue and has potential applications for tumors without 5-ALA-derived red fluorescence.
A team of researchers developed an AI method for automated image analysis of brain tumors, which outperforms traditional radiological methods. The new approach enables more reliable and precise assessment of therapy response, improving overall survival predictions.
A phase I clinical trial has found a new combination therapy to be well-tolerated in patients with recurrent high-grade gliomas, a disease historically under-funded. The treatment combines ADI-PEG20, pemetrexed and cisplatin, showing encouraging efficacy and paving the way for further research.
Researchers at Sanford Burnham Prebys have created a mouse model of choroid plexus carcinoma (CPC), a challenging type of brain cancer that affects young children. The study identified three promising drug compounds with biological activity, including dinaciclib and flavopiridol.
Researchers found that low-dose radiation increases the uptake of therapeutic nanoparticles by glioblastomas, allowing for targeted siRNA delivery and improved survival in mouse models. The therapy also activates the immune response at the tumor site, decreasing PD-L1 expression and increasing CD8 T cell recruitment.
Patients often downplay minor symptoms, fearing a waste of doctor's time, and may struggle to revisit their GP after reassurance, highlighting the need for increased awareness and timely investigation.
Researchers identified three key genetic drivers of glioblastoma development, including the activation of telomerase. Early tumors exhibit concurrent genetic alterations, but recurrent tumors display distinct mutation patterns. This study highlights the need for new treatments to effectively target resistant subclones.
Researchers found that combining carboplatin and everolimus increased DNA damage and cell death in laboratory models, slowing tumor growth. The treatment showed promise in killing tumor cells and reducing tumor size, especially in tumors with high mTOR expression.
A study using high-resolution MRI scans found that protein content in glioma tumors is associated with treatment response and patient survival. The research suggests that assessing tumor protein levels could help choose the best possible treatment strategy for patients.
Researchers found that brain metastases from melanoma are equipped to thwart immunotherapies and targeted therapies due to their reliance on oxidative phosphorylation metabolism. This metabolic pathway presents a potentially new therapeutic against these lethal tumors.
A preclinical study has identified a potential treatment strategy for low-grade gliomas, a common and lethal form of brain tumor. The researchers found that certain mutations in genes IDH1, TP53, and ATRX make glioma cells less aggressive and resistant to radiation therapy.
Researchers at the University of Bonn have reported significant progress in treating aggressive brain tumors like glioblastoma. Combination chemotherapy with CCNU and temozolomide significantly prolongs patients' survival time, with a notable benefit for those with methylated MGMT promoter.
A genetic mutation in glioma tumors makes them resistant to radiation treatment, but a new study suggests that currently available drugs can restore sensitivity. This breakthrough could lead to extended survival and improved treatment options for patients with low-grade gliomas.
A FSU research team discovered medulloblastoma's heterogeneity makes it challenging to treat. By pinpointing specific driver gene mutations, they hope to develop individualized treatments using advanced bioinformatics tools.
Researchers identified a translocation between chromosomes 4 and 9 in acinic cell carcinomas, leading to the activation of oncogenic genes. This discovery sheds light on the molecular causes of salivary gland cancer, enabling easier diagnosis and potentially new treatment options.
A study by MGH researchers reveals that brain tumors use existing blood vessels to resist anti-angiogenic drugs, leading to compression and stimulation of angiogenesis. The study suggests targeting vessel co-option before using anti-angiogenic drugs could be an effective strategy for glioblastoma treatment.
The foundation awarded over $4.7 million in grants to support innovative projects and breakthrough discoveries in cancer research. Young scientists will receive funding to pursue careers in cancer research and develop novel therapies.
Researchers at MD Anderson Cancer Center have discovered a link between FGL2 protein and glioblastoma progression. FGL2, known for suppressing the immune system, is highly expressed in GBM and can be eliminated by knocking it out, eliminating tumor progression in mice with intact immune systems.
A targeted therapy that blocks the protein LSD1 has been shown to shrink tumors in mice with a form of pediatric brain cancer known as medulloblastoma. The treatment, which is currently being tested in clinical trials for other cancers, may offer new hope for children with this devastating disease.
Researchers have engineered immune cells to target different types of pediatric solid tumors, including brain tumors, with promising results. The treatment uses a surface marker called B7-H3, which is expressed on most pediatric cancer cells, and has been shown to eradicate tumors in mice.
A new study describes a novel approach to suppressing chemotherapy-induced tumor growth and recurrence in ovarian cancer. Researchers developed an anti-inflammatory drug called PTUPB that blocks the release of tumor-promoting chemicals by macrophages.
A £1.5 million grant from Barts Charity will support brain tumour researchers at Queen Mary University of London in extending their lab-based research to clinical trials with patients. The funding aims to increase experimental treatments available to brain tumour patients and bring hope to those diagnosed with this devastating disease.
Research demonstrates how solid stress from brain tumors impacts surrounding tissue, leading to neurological dysfunction and neuronal cell death. Lithium treatment is identified as a promising strategy for preserving function in compressed brain tissue.
Recent research by Children's Tumor Foundation advances understanding of brain tumors affecting neurofibromatosis patients. Two large-scale studies have identified genetic, epigenetic, and metabolic alterations in NF1 gliomas, paving the way for targeted therapies.
Researchers found that many slow-growing NF1 gliomas contain few macrophages and produce proteins that can trigger an immune system attack, making them good candidates for treatment with immunotherapy. Clinical trials are now being planned for these high-immune tumors.
The new robotic system uses a thin probe inserted into the brain through a small hole drilled in the skull to deliver high-intensity ultrasound energy lethal to tumors while minimizing damage to surrounding brain tissue. Real-time MRI-based thermal imaging provides feedback on dose delivery, ensuring precise control and safety.
UCSF scientists create new animal model of glioma that captures the clinical lifecycle of brain tumors, allowing them to test strategies to prevent radiation-associated cognitive decline. They discover that temporarily suppressing a key immune system component can prevent this problem.
Researchers found that failing DNA repair systems lead to chromosome fragmentation and defective assembly in cancer cells. This can be treated with PARP inhibitors, which block another critical DNA repair enzyme, causing genetic damage that kills the cell.
Researchers discovered MiR-584-5p, a tiny molecule, can kill medulloblastoma and sensitizes cancer to chemotherapy and radiation. This could lead to treating the tumor with one-tenth the current required dose.
Researchers have successfully detected brain tumor DNA in cerebrospinal fluid (CSF) using a cheap and widely available technique, opening up new possibilities for monitoring and treating brain tumors. The test has the potential to increase detection rates and provide more tailored treatment approaches for patients with brain tumors.
Researchers used a compound to highlight fast-growing cancer cells, allowing surgeons to distinguish between high-grade and low-grade glioma cells. This technique improves the accuracy of diagnosing high-grade glioma during surgery, potentially increasing patient survival.
Hong Kong University of Science and Technology researchers identified a new mutation, METex14, in 14% of sGBM patients, leading to more aggressive tumor growth. A promising MET kinase inhibitor, PLB-1001, has been shown to target these tumors with remarkable potency.
Scientists at Newcastle University have made a significant discovery in treating childhood brain cancer, identifying a chromosome signature that can predict patient outcomes and tailor treatment to individual needs. This breakthrough aims to reduce toxicity and side effects while maintaining cure rates.
Research by Norwegian University of Science and Technology found that individuals with larger brains are more likely to develop brain tumors. The study, which analyzed data from over 1,000 participants, revealed a statistically significant association between brain size and increased cancer risk.
Researchers have developed a new tool to study genetic switches in glioblastoma tumors, which drive cancer growth and survival. The new technique uses ChRO-seq data to classify tumors into subtypes based on active switches, with potential applications in predicting patient outcomes and developing new therapies.
A new blood test offers a safer approach than surgical biopsies and allows doctors to monitor treatment effectiveness even before changes are identified on scans. The study found that circulating tumor DNA in the blood or cerebrospinal fluid can reveal a driver mutation in 42 of 48 patients, indicating the tumor's genetic signature.
A global update on medically significant scorpions reveals over 100 species across dozens of countries, with key clusters in Asia, Africa, and South America. The study also highlights the need for improved communication between clinicians and scientists to combat misinformation and enhance research.
A specific protein called TEAD1 has been identified as a key regulator of tumor migration in glioblastoma, a devastating form of brain cancer. By deactivating this protein, researchers may be able to stop tumor cells from migrating away from the main tumor mass, increasing the success rate and overall survival time for patients.
Researchers genetically engineered olfactory ensheathing cells to carry an anticancer drug, reducing tumor growth and improving survival in a mouse model. The treatment delivered the medication directly to glioblastoma cells while sparing healthy tissue, leading to a significant reduction in tumor size and prolonged survival.