Research on muscle biology and repair. Covers tissue maintenance, Parkinson's protection, repair-cell preservation, and muscle strength with age.
A new study by Cincinnati Children's Hospital Medical Center suggests that the drug bortezomib may help re-balance disrupted muscle growth and prevent muscle contractures in children with brachial plexus injury or cerebral palsy. The treatment shows promise in preventing loss of elbow and shoulder motion and disrupting skeletal growth.
Research from Trinity College Dublin shows that vitamin D deficiency is associated with poor skeletal muscle function in adults aged 60 years and over. Regular physical activity was found to be protective against impaired muscle strength and performance.
A team of Tufts University-led researchers found that adding the iron-carrying protein myoglobin improves the growth, texture and color of bovine muscle grown from cells in culture. Myoglobin was also shown to promote cell proliferation and differentiation, leading to a rich meat-like color.
A clinical trial by University of Kentucky researchers found that metformin did not enhance muscle mass gains in older adults undergoing rigorous resistance exercise training. Progressive resistance training was shown to retain or build muscle mass in older adults.
Researchers have discovered a tiny, fully functional extra finger in the aye-aye's hand, which is believed to aid in gripping and mobility. The pseudothumb is composed of both bone and cartilage and has three distinct muscles that enable movement and force.
A six-week study found that exercising before breakfast increased fat burn by 100% compared to after breakfast. This shift allowed for better insulin control, potentially lowering diabetes and heart disease risk.
A McMaster University study found that statin drugs cause muscle pain by releasing glutamate, a potent activator of pain receptors. Administering antioxidants like Vitamin E can help reduce glutamate release.
A clinical trial found that testosterone significantly increases young women's running capacity, with a notable impact on anaerobic performance and lean body mass. The study suggests that allowing female athletes with high testosterone levels to compete without hormone reduction could be fair.
Researchers discovered that natural loss of foot muscles in rodents shares similarities with skeletal muscle atrophy, a condition typically associated with injury or disease. The study found that cells in the foot muscles disassemble proteins responsible for contraction and increase gene expression degrading these proteins.
A study published in Medicine & Science in Sports & Exercise found no significant difference between non-BFR exercise and BFR exercise on the trunk extensor muscles, contradicting previous positive conclusions.
Researchers at U.S. Army Research Laboratory have made significant breakthroughs in developing artificial nanomotors inspired by biological molecules, which can harness Brownian motion for efficient energy production. These advancements aim to create faster, more versatile robots with improved autonomy and stealth capabilities.
Aric Rogers' research on cellular and molecular mechanisms governing aging aims to develop new therapies for sarcopenia and age-related diseases. The grant will support further research on the genetic pathways that regulate dietary restriction, which has shown to extend healthy lifespan in various organisms.
Researchers found that older adults experience physical weakness due to impairments in brain and nerve function, rather than muscle changes. The study suggests that addressing the nervous system's role could improve quality of life for older adults with age-related strength loss.
Researchers at the University of Arizona have shown that Aliskiren, a FDA-approved drug, can delay the progression of congestive heart failure and lengthen survival rates in properly identified patients. The study used non-invasive technology to evaluate changes in muscle mass and fluid retention over time.
Researchers at the German Sport University explored the effects of full-body exergaming in VR on cardiovascular system and strength endurance. Results showed that VR-based training had little to no cardiovascular benefit but created incentives for increased physical activity, motivating users to take up exercise.
A Penn Medicine study shows delivering a 'distant cousin' of a key protein prevents muscle damage and maintains muscle function in both small and large animal models. The synthetic substitute, utrophin, proved to be an effective and safe alternative to dystrophin, with significant implications for gene therapy.
A team of evolutionary biologists discovered that atavistic limb muscles, lost in adult humans, are formed during early human development and then disappear. These muscles are present in many limbed animals but are absent in adults. The study uses high-quality 3D images to analyze the development of human arm and leg muscles.
Researchers found that protein GAS1 suppresses muscle stem cells' ability to build new muscles and regenerate after injury. Reversing GAS1's effect by using GDNF restores muscle stem cell function and regeneration.
Researchers at the University of Alberta are developing a new treatment that could help almost half of patients with Duchenne muscular dystrophy by restoring dystrophin protein production. The experimental cocktail of DNA-like molecules has shown dramatic regrowth of dystrophin, which acts as a support beam to keep muscles strong.
A recent study has identified FHL1 protein as a crucial cellular factor for the replication and pathogenesis of chikungunya virus. The researchers found that FHL1 interacts with viral protein nsP3 to facilitate viral infection, making it a promising target for antiviral development.
A randomized clinical trial found that combining behavioral and physical therapy before and after midurethral sling surgery improved symptoms of mixed urinary incontinence. However, the small difference may not be clinically significant due to a lack of established thresholds for minimal clinically important differences.
Researchers identified differences in gut microbiome composition between physically high-functioning and low-functioning older adults. The study suggests that the gut microbiome plays a role in maintaining muscle strength in older adults, with mice colonized with fecal samples from high-functioning individuals showing increased grip st...
Researchers have successfully corrected the genetic mutation responsible for Duchenne muscular dystrophy using CRISPR gene editing in muscle stem cells. The edited cells regenerated and produced dystrophin, suggesting a potential method for lifelong correction of the disorder.
Researchers at the University of Illinois developed soft robotic devices driven by neuromuscular tissue stimulated by light, enabling biobots to swim and walk autonomously. The new generation of two-tailed bots uses skeletal muscle tissue and optogenetic neurons for propulsion.
A new study reveals that bat wing muscles are uniquely adapted to operate at low temperatures during flight, a phenomenon with implications for human exercise in extreme conditions. By understanding this adaptation, scientists hope to develop strategies to improve human performance and safety in cold weather.
Researchers discovered a sensorimotor function integration mechanism in expert pianists that enables skillful fingering. This neuroplastic adaptation enhances speed and precision of finger movements, revealing new insights into the brain's role in motor control.
Research found that mice with gut microbes had stronger skeletal muscles and improved energy production compared to germ-free mice. Transplanting gut microbes partially restored muscle function in germline mice, opening new avenues for interventions targeting age-related skeletal muscle loss.
A study by the University of Granada recommends spending more time standing to increase energy expenditure and reduce negative health effects of a sedentary lifestyle. Standing burns approximately 45 kilocalories more per six-hour period than sitting or lying down, making it an effective way to combat excess weight and obesity.
Researchers found that European whitefish muscle omega-3 fatty acid concentration declined by 60% from growing to spawning seasons. Local people traditionally fish for winter supplies during the main growing season when nutritional quality is optimal, reflecting an understanding of the fish's energy-demanding spawning process.
Researchers found that older men who never exercised before could build muscle at a similar rate as master athletes, highlighting the benefits of starting exercise later in life. The study suggests that regular physical activity can help delay age-related decline and improve overall health.
Biofeedback has shown promise as a treatment for various conditions, including headache pain reduction, improved urinary and fecal incontinence, and aid in stroke recovery. The review highlights the benefits of biofeedback for several conditions, while also identifying areas where further research is needed.
Research suggests that statins cause spontaneous calcium leaks in muscle cells, leading to pain and weakness in susceptible individuals. Moderate exercise may prevent this leak and mitigate symptoms, according to the study.
Researchers from KAIST have created an ultrathin artificial muscle that expands, contracts, and rotates using electricity, opening doors for applications in wearable electronics and advanced prosthetics. The actuator is flexible, durable, and highly responsive, with a durability of over five hours.
A novel robotic neck brace has been developed to assist ALS patients in holding their heads and supporting range of motion. The device incorporates sensors and actuators to restore approximately 70% of the active range of motion, allowing for improved eye contact and computer control.
Scientists discovered a protein called LIN-53 that controls muscle integrity, lifespan and levels of an essential sugar. The protein is an epigenetic factor that affects gene expression and heritable traits.
A new study suggests that oral appliances can be an effective alternative to CPAP for treating moderate to severe obstructive sleep apnea. Patients with mild collapsibility and weaker reflex responses tend to benefit more from oral appliances, which move the lower jaw forward to prevent airflow obstruction.
Focusing on movement during weightlifting may improve performance by reducing mechanical inefficiency and increasing automatic control processes. This contradicts the traditional mind-muscle connection theory, which suggests focusing on individual muscles enhances activation and development.
A study of individuals over 65 years old found that low appendicular muscle mass significantly increased all-cause mortality risk nearly 63-fold in women and 11.4-fold in men. The researchers used DXA body composition analysis to determine the correlation between body composition factors and mortality risk.
A new position statement suggests resistance training is crucial for improving the health and longevity of older adults. It provides evidence-based recommendations for successful resistance training programs, highlighting practical applications and functional benefits.
In a study published in Scientific Reports, researchers found that changing gravity levels altered the bone mass of mice's forefoot and boosted their leg muscles. The findings suggest new avenues for developing treatments for skeletal diseases like osteoporosis and sarcopenia.
A study published in Nature Communications reveals that the activation of mTORC1 must be tightly balanced to maintain the neuromuscular junction after nerve injury. This balance is crucial for proper muscle response and preventing age-related muscle atrophy.
Research found that strength training reduces endurance muscle fiber number by producing brain-derived neurotrophic factor (BDNF), which remodels neuromuscular synapses. This results in a decline in endurance muscles and an increase in strength muscles.
The University of Alabama at Birmingham will organize and implement an international, multi-site study to learn more about AFM incidence and progression. The study aims to better understand how the disease develops in children and identify potential risk factors.
Researchers at Beth Israel Deaconess Medical Center found that resveratrol supplementation preserved muscle function and mitigated muscle atrophy under Martian gravity. The study suggests that resveratrol could be a key dietary supplement to maintain musculoskeletal health on long-term Mars missions.
A Harvard study suggests that resveratrol can preserve muscle mass and strength in rats exposed to simulated Mars gravity, with almost complete rescue of front and rear paw grip. The compound's anti-inflammatory and antioxidant effects may help conserve muscle and bone in astronauts on long missions to Mars.
Researchers at UMN Medical School found that estrogen deficiency leads to a 30-60% drop in muscle stem cells and severe difficulty reproducing new muscle after injury. Estrogen replacement therapy may help maintain muscle health, but risks cancer due to its effects on tissues.
Researchers have discovered how a fungus controls zombie ants by invading their mandibular muscles, breaking open membrane covering muscle fibres and causing the muscle to contract forcefully, resulting in the ant's death grip.
A small study suggests that treating pelvic floor muscle spasm with botulinum toxin may relieve pain and improve quality of life in women with endometriosis. The treatment showed long-lasting benefits, with many patients reporting pain relief lasting at least six months.
Researchers have developed a new type of artificial muscle called sheath-run artificial muscles (SRAMs), which use a polymer coating to twist yarns and create powerful contraction. SRAMs outperform human muscle power density, with some yarns producing contractile powers up to 40 times that of human muscle.
Researchers developed new fiber-based designs for artificial muscles that can be activated by heat, electricity, and chemistry, offering potential uses in miniaturized medical devices and smart textiles. The resulting materials show impressive contractile powers, including 40 times that of human muscle.
The team of researchers from RIKEN BDR and Tokyo Denki University have developed a bio-MEMS that is driven by real muscle, which could be useful in surgical implants. The new study successfully demonstrates an on-chip muscle-driven valve that can open and close without any external power source.
Researchers suggest that strengthening muscles, rather than losing fat, may be a better way to protect against weight-related health risks like diabetes and cardiovascular disease. Muscle health is linked to metabolic function, insulin sensitivity, and glucose uptake, making it a potential indicator of overall health.
A novel surgical technique connects functioning nerves with injured nerves to restore power in paralyzed muscles, enabling participants to perform everyday tasks independently. The study suggests that nerve transfers can achieve similar functional improvements to traditional tendon transfers, with the benefit of smaller incisions and s...
A study by the University of Exeter found that mycoprotein stimulates post-exercise muscle growth more effectively than milk protein. This breakthrough could have significant implications for those seeking to reduce their meat intake while maintaining optimal muscle mass.
Researchers found that combining aerobic exercise and resistance training preserves muscle mass in obese older adults. The study showed increased muscle protein synthesis and improved muscle quality compared to control groups.
Researchers found a significant jump in medically unnecessary ambulance rides for minor injuries like abrasions and muscle sprains after the ACA expansion. In New York City, these dispatches increased by 37%, equivalent to 2,868 additional rides per year.
A recent study published in the Journal of Cachexia, Sarcopenia and Muscle found that vitamin D signaling is crucial for maintaining normal muscle size and strength. Researchers discovered that mice lacking vitamin D receptors in their muscle cells had smaller muscles and reduced physical performance.
A KIST research team has successfully taught a robot to trap a dropped ball like a soccer player using surface electromyograms (sEMG) of muscles. The technology enables robots with flexible joints to mimic human movements, advancing the study of interactions between humans and robots.
Scientists at Linköping University have created artificial muscles that harness energy from glucose and oxygen, mimicking biological muscle movement. The innovation uses enzymes to convert chemical energy into electrical energy, enabling the creation of implantable and autonomous microrobots.
Researchers found that dogs have developed a muscle above the eyes to intensively raise their inner eyebrow, making them appear larger and more infant-like. This movement, known as AU101, triggers a caregiving response in humans, potentially leading to enhanced social interaction.