A new study by UNC Charlotte scientists has discovered a self-clustering mechanism in the Polycomb protein CBX2 that is essential for initiating gene-repressive condensates and guiding stem cells toward their proper fates. The researchers found that CBX2 clusters recruit two Polycomb repressive complexes, creating multicomponent repres...
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Researchers used a single-molecule platform to watch individual mammalian transcription complexes, revealing the molecular engine's acceleration, pauses, and gear shifts. The study found key regulatory proteins govern Pol II movement, with P-TEFb as a master switch and PAF1C as the main accelerator.
A team of researchers has revealed the molecular mechanisms underlying the binding of small extracellular vesicles to host cells, which could lead to the development of more effective cancer treatments. The study found that EVs primarily bind to laminin via CD151-associated integrin heterodimers and GM1, eliciting responses in recipien...
Researchers discovered a new process by which cancer cells use small extracellular vesicles to spread to healthy tissue. The study found that these vesicles are primarily internalized by clathrin-independent endocytosis via galectin-3, which is facilitated by an increase in intracellular calcium concentration.
Researchers have developed a method to stretch and immobilize single DNA molecules, enabling detailed analysis. By controlling the shear force applied through liquid pressure flow and bonding the molecule to a substrate, scientists can distinguish between tiny biomolecular features with higher precision.
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Scientists have captured 3D snapshots of individual RNA nanoparticles in motion, showcasing the dynamic and intricate folding process. This breakthrough uses advanced electron microscopy to study RNA's flexibility, enabling new insights into its structure and potential applications in molecular medicine.
Researchers at St. Jude Children's Research Hospital have developed a way to mitigate long-lived triplet dark states in smFRET, significantly increasing the method's resolution for molecular imaging. This advancement enables direct visualization of biomolecules' functions and dynamics, crucial for understanding biological processes and...
Researchers have published novel spatial omics algorithms and tools in GigaScience and GigaByte journals to analyze biological data-based spatial information. These new methods enable the discovery of spatial domains, improvement of data quality, and better clustering of cells.
Researchers provide new insights into STING's function in innate immunity, revealing its role as a scaffold that activates TBK1. They also found that cholesterol plays a crucial role in STING clustering and activation, offering a potential target for treating diseases associated with STING inflammation.
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Researchers at Purdue University developed a novel AI engine to control and optimize optical microscopes, enabling 3D ultrastructure visualization of the brain circuitry with nanometer resolution. This technology has the potential to shed light on human development and disease, particularly autism and Alzheimer's disease.
A new deblurring algorithm has been developed to improve the resolution of microscopy images without amplifying noise. This breakthrough technique, called 'deblurring by pixel reassignment,' uses local gradients to sharpen images while preserving larger structures.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A study published in Communications Biology reveals that a large portion of an insulin dose may not be effective, providing a tool for developing more precise medications. The discovery could lead to improved treatment outcomes for millions of people worldwide.
The study uses 3D electron microscopy and live cell imaging to observe molecular tethers between organelles. These dynamic structures are constantly binding and unbinding, altering contact site configuration in response to cellular changes.
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Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers at Penn Medicine have developed an imaging agent that detects cancer cells in real-time during biopsies, offering promise for earlier and more accurate diagnoses. The technology, known as NIR-nCLE, uses a combination of near-infrared tracers and confocal laser endomicroscopy to identify microscopic cancer cells.
Researchers at Arizona State University have developed a new technique called evanescent scattering microscopy (ESM), which allows for the visualization of proteins and other vital biomolecules with unparalleled clarity. This label-free imaging method reduces light-induced heating and requires no fluorescent dye or gold coating, making...
Researchers developed a vortex microscope that captures detailed motion and rotation of molecules in liquid. The technique provides unprecedented insight into molecular dynamics, enabling the study of diseases like Alzheimer's.
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Using advanced microscopy techniques, researchers recorded the breaking of a single chemical bond between a carbon atom and an iron atom on different molecules. The team measured the mechanical forces applied at the moment of breakage, revealing insights into the nature of these bonds and their implications for catalysis.
Researchers at Oak Ridge National Laboratory are advancing various technologies to minimize oil leaks, enable 3D printing in space, and increase fuel efficiency from ethanol. They have developed a quantum sensing system to detect pipeline leaks more quickly, built a thermal protection shield for a capsule launched into space, and creat...
Researchers at USTC achieved sub-molecular resolution in single-molecule Raman spectroscopy imaging and photoluminescence imaging. They demonstrated the effects of local plasmon-exciton interaction on fluorescence intensity, peak position and peak width on the sub-nanometer scale.
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Researchers developed a new spectroscopic nanoscopy technique that improves spatial imaging resolution and spectral precision. The approach enables full use of photons for both spatial and spectral analyses, leading to significant improvements in image quality.
A Japanese research team has uncovered more about how proteins move using high-speed imaging to track dynein's movement along a microtubule. They found dynein moves erratically with frequent backward steps and side steps, challenging the conventional understanding of molecular motor tasks.
Researchers developed imaging technology to visualize and understand frameshifting mechanisms at single molecule level, revealing bursts of activity and subsets of RNAs involved. This discovery promises new depth to understanding viral replication and could inform future antiviral therapeutics.
A team of researchers has developed a photostable fluorescent labeling agent for single molecule, multicolor, and 3D deep imaging in the near infrared region. The new dye, PREX 710, allows for long-term bioimaging of blood vessels in mice brains.
A new research provides a mechanism to detect and correct systematic errors in data and image analysis used in many areas of science and engineering. The single-pixel interior filling function (SPIFF) method can improve the accuracy of imaging systems for tracking objects on scales ranging from nanometers to astrophysical scales.
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Researchers at University of Missouri have developed a new, low-cost imaging platform that enables single molecule imaging with ordinary microscopes. The patented method uses surface plasmon resonance to achieve super-resolution imaging down to 65 nanometers.
Researchers at Berkeley Lab have discovered new rules for creating ultra-bright light-emitting crystals less than 10 nanometers in diameter, which should be a big asset for biological imaging. The discovery shows that factors known to increase brightness in bulk experiments lose importance at higher excitation powers.
Researchers developed a detector that can chemically identify single molecules using terahertz radiation, enabling 'molecular imaging' at scales similar to airport screenings. The technology, featured in Nano Letters, has the potential for fundamental studies and practical applications.
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Researchers at UT Dallas have developed a new low-light imaging method that can significantly improve the accuracy of microscopic images. By minimizing camera noise and distortion, this method enables scientists to extract precise quantities from acquired images, such as object location, size, and orientation.
The symposium explores the leading edge of interdisciplinary collaboration in microscopy, featuring experts who are developing new techniques to visualize life processes at unprecedented spatial and temporal resolution. The goal is to advance the visualization of life from the scale of a single molecule to the whole organism., Research...
Researchers developed a novel 3D cell imaging method using multifocal plane microscopy to track single molecules in live cells for extended periods. This technique overcomes previous limitations and enables the study of complex spatial-temporal dynamics of protein transport.
Researchers at Rice University have successfully created nanocars that can move and operate at room temperature using fluorescent imaging. The breakthrough, led by Stephan Link, allows for the possibility of adapting these tiny machines to various applications beyond their original heated requirements.
A team of researchers led by University of Notre Dame physicist Bolizsár Jankó presents an overview of research into quantum jumps and fluorescence intermittency. The phenomenon, known as 'blinking,' reveals unexpected deviations from Bohr's predictions in various systems.
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