Researchers discuss diverse BRAF alterations found in human cancers and strategies to inhibit them. Class I BRAF inhibitors represent a landmark achievement in precision oncology, with FDA-approved dabrafenib/trametinib for metastatic BRAF p.V600E-mutant solid tumors.
A new study found that mTORC1 activity correlates with classical biometrics, such as height and macrocephaly, as well as specific neuropsychiatric diseases like anxiety and autism. The research suggests that human variability of mTORC1 gain of function may predict medication response.
Researchers discuss how PROM2 is a predictive biomarker of distant metastases and shorter survival among patients with stage III melanomas. They also demonstrate that runaway metastasis is closely linked to PROM2 overexpression, through increased epithelial-to-mesenchymal transition marker expression and ferroptosis resistance.
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Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at TU Darmstadt have successfully demonstrated a quantum-processing architecture with over 1,000 individually controllable atomic qubits. This breakthrough enables the development of highly beneficial applications in fields such as drug development and traffic optimization.
Laura Feetham-Walker has won the 2024 APE Award for Innovation in Scholarly Communication for her work on peer review training and certification. Her approach extends the pool of reviewers by enfranchising early career researchers, increasing capacity and quality.
A study published in the Journal of Nursing Administration found that Transcendental Meditation significantly reduced PTSD, anxiety, and burnout in frontline nurses during the COVID-19 pandemic. The technique improved flourishing by 15% and decreased symptoms by more than half over a 3-month period.
The MIT Press is expanding its shift+OPEN initiative with a $275,000 NSF grant to flip two high-impact subscription-based journals to diamond OA. The program aims to accelerate STEM and HSS research by providing barrier-free access to scholarly works.
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The guidance paper outlines reliable methods and research practices for improving evidence syntheses. It emphasizes the need for proper education in methodology and cautions against relying solely on appraisal tools and software programs.
A team led by Laurie Schintler is conducting a study to compare perceptions of peer review decisions made by humans versus algorithms. The research aims to measure the legitimacy of both human and algorithmic decision-making processes in scientific publishing and funding outcomes.
The traditional rating approach has limitations, including relying solely on reviewer ratings and summary statistics to establish funding priorities. Researchers propose adding rankings to improve this process.
The initiative aims to improve data collection methods on researchers' racial and ethnic dimensions. It seeks to overcome obstacles, including sensitive data that may be leaked, to promote structural changes and impact in the research ecosystem.
A new study from City University London suggests that the Research Excellence Framework (REF) has led to significant increases in high-quality published research, but not active academics. The study highlights areas of improvement needed in the assessment framework, including greater collaboration between domestic competitors.
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A meta-analysis of 55 studies on grant awards found women received an average of $342,000 compared to $659,000 for men. Women were also less likely to receive second grants and faced 'discounting of women's science' despite similar funding requests.
The COVID-19 pandemic had a substantial and diverse impact on cancer care, with changes to screening, diagnosis, and treatment reported. However, the available evidence on how this affected cancer prognosis is limited.
Impact Journals will participate as an exhibitor at the AACR Annual Meeting 2023, showcasing Aging's growth in impact factor to 5.955. The meeting theme focuses on Advancing the Frontiers of Cancer Science and Medicine.
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DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
A new study using ChatGPT highlights the challenges of AI in academia, including concerns over academic dishonesty. However, researchers believe that AI can also be leveraged to improve education by automating administrative tasks and adapting assessments.
A University of Cambridge analysis identified 98% of reports from trials evaluating new school-based physical exercise programs as lacking key details about teacher training. The study urged journal editors to update their submission guidelines to encourage better reporting, with seven journals already altered their guidance.
A new study found that most people don't understand the difference between preprints and published academic journal articles. Researchers suggest that frequent reporting of scientific preprints could lead to public distrust in science, as findings may change after peer review.
Pediatric hospitalizations for cannabis poisonings increased significantly in provinces with legal edible cannabis sales compared to those without. The study highlights the need for regulatory measures to mitigate risks associated with recreational cannabis legalization.
The American Roentgen Ray Society (ARRS) named Dr. Sarah Kamel of Thomas Jefferson University Hospital and Dr. Ankur Goyal of the All India Institute of Medical Sciences as Melvin Figley and Lee Rogers Fellows in Radiology Journalism, respectively. They will receive expert instruction in scientific writing and communication through the...
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The study suggests that marketing research should start with real-world problems and observations, developing valid insights through empirical analysis. The authors propose a three-stage approach: Identify Opportunity, Explore Terrain, and Advance Understanding.
eLife is ending its practice of making accept/reject decisions following peer review, instead publishing every paper it reviews as a Reviewed Preprint. This new model restores control to authors, promoting the assessment of scientists based on their research output rather than publication venue.
A new report found that 90% of COVID-19 preprint data points remained unchanged after peer review, with only minor changes in estimates. This suggests that preprint studies can be reliable and trustworthy, especially for infectious-disease research.
This volume of Oncotarget features groundbreaking research on various cancers, including breast, lung, colorectal, and neuroblastoma, as well as novel drug targets for bladder cancer. The studies also delve into the role of BRCA in breast and colorectal cancers.
A novel contract proposed by UTD researchers could help alleviate key sources of conflict between restaurants and food-delivery platforms. The study found that standard contractual relationships have two key issues: simple revenue sharing and strain on restaurant operations.
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Dr. Valentin Fuster is receiving the inaugural 'Valentin Fuster Award for Innovation in Science' at the ACC's 71st Annual Scientific Session. The award honors his contributions to cardiovascular medicine and scientific research.
A systematic review found that mobile apps based on ecological momentary intervention (EMI) may be a useful tool for managing patients at risk of suicide. EMI interventions can provide 'low-cost, 24/7 support' and are particularly promising for adolescents and young adults who are comfortable with digital technologies.
A new peer-reviewed study confirms MiSight 1 day contact lenses slow eye growth and halt myopia progression in 90% of children, with no loss of effectiveness over time. The longest-running soft contact lens study among children demonstrates sustained efficacy for nearly all children, regardless of age or initial refractive error.
A survey of Minority-Serving Institutions (MSIs) found that only 45% of respondents participated in grant review, compared to 76% at traditionally White institutions. Despite this, 76% of MSI scientists reported an interest in taking part in grant review.
Researchers compared preprints to their final publications and found that over 83% of COVID-19 and 93% of non-COVID related life sciences articles do not change from their preprint to final published versions. A machine learning tool also recommends potential journals for linguistically similar articles.
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Samuel Galgano and Pankaj Gupta have been named the 2022 Melvin M. Figley Fellow in Radiology Journalism and the 2022 Lee F. Rogers International Fellow in Radiology Journalism, respectively. They will attend the 2022 ARRS Annual Meeting and participate in the Editor’s Forum.
A survey of scientists from minority-serving institutions found that only 45% participated in grant peer review, despite 76% expressing interest. The study highlights the need for more inclusive grant review recruiting and training to break the cycle of exclusion faced by underrepresented minority scientists.
A University of Guam professor emeritus has discovered a new species of diatom, Licmophora complanata, that produces an estimated one-fifth of the oxygen in the air we breathe. The discovery was made using advanced microscopy techniques and builds on previous finds by UOG students.
A recent study published in PLOS Biology found evidence of editorial bias and nepotism in some biomedical journals, where a few authors, often on the editorial board, dominate publications and receive preferential treatment.
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A study of 5 million authors found that the pandemic exacerbated existing gender inequalities in academia, with women submitting fewer manuscripts than men across various fields. The research highlights the need for addressing these disparities to prevent long-term effects on career success and deepen gender inequality.
A study of 2,329 academic journals found a significant gender gap in manuscript submissions during the first COVID-19 wave, with women submitting fewer papers than men, especially in health and medicine.
A systematic review and meta-analysis found that universal and selective interventions targeting young people can reduce the risk of most mental disorders. These interventions, such as psychoeducation and therapy, showed promise in preventing symptoms like ADHD, anxiety, and interpersonal violence.
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The ACS Quality Verification Program utilizes data surveillance, standardized processes, and systems to identify quality improvement issues and improve surgical patient care. The program's 12 standards provide a framework for hospitals to implement robust surgical quality improvement initiatives.
The new PRISMA 2020 guideline provides a 27-item reporting checklist to ensure transparent, complete, and accurate accounts of systematic reviews. This updated version aims to combat incompletely reported reviews that lead to low-value healthcare.
Research on opioid use among Black people is scarce due to historical exclusion and underrepresentation. The review identifies key disparities in overdose risk, treatment access, and prescription opioid use, emphasizing the importance of culturally informed care.
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The new journal features short contributions and rapid turnarounds, covering all disciplines of biophysics with an emphasis on methods and techniques. The inaugural Editor-in-Chief, Jörg Enderlein, expects significant potential for the journal to offer transparent and rapid editorial decisions.
A study of 145 scholarly journals found that peer review itself is unlikely to explain gender disparities in publication rates. Despite improvements in female representation in certain fields, a persistent gap remains between male and female authors.
A systematic review and meta-analysis found associations between exposure to high temperatures in pregnancy and increased risk of preterm birth, low birth weight, and stillbirth. The study analyzed data from 70 studies across 27 countries and found that the odds of preterm birth rose by 5% per 1°C increase in temperature.
A new study published in PLOS Medicine suggests that true asymptomatic cases of SARS-CoV-2 comprise a minority of infections. The researchers estimated that 20% (95% CI 17-25) of COVID-19 infections remained asymptomatic during follow-up.
Researchers say AI and machine learning can help improve the peer review process by detecting discrepancies in research papers. With many COVID-19 studies published without thorough review, AI-powered tools may be able to analyze large amounts of data and identify patterns that human reviewers might miss.
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The rapid expansion of COVID-19 research has led to an infodemic in scientific literature, underscoring the need for more accessible and transparent research publication. Experts propose combining human expertise with AI to summarize and collect research, while curating findings to ensure relevant and reliable information.
Recent peer reviews from the MIT Press journal RAPID REVIEWS COVID-19 offer valuable insights into various aspects of COVID-19 research. The analyses suggest that new prognostic scores can guide clinical decision-making and hospital admissions, while estrogen levels have been found to be associated with a reduced risk of severe complic...
A study published by University of Huddersfield researchers found that dexamethasone significantly reduced COVID-19 patient deaths by 41% compared to those without corticosteroids. The research highlights the importance of evidence-based practice and the need for further investment in scientific research.
A panel of experts recommends using remdesivir in patients with severe COVID-19 to potentially reduce recovery time. However, the evidence is uncertain due to limited trials and study limitations, making it a costly treatment option.
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A new study finds that preliminary criterion scores do not mitigate racial disparities in NIH grant awards, with black investigators receiving worse scores on all five criteria. The study reveals substantial funding gaps between black and white applicants, with black PIs award probability only 55% of their white counterparts.
The review found that low-dose aspirin significantly lowers cardiovascular disease risk by 17% and increases the risk of gastrointestinal bleeding and intracranial bleeding. The benefits should be weighted against the risks in formal decision analyses to guide aspirin use.
Pensoft has launched a pilot phase with its open-access journal Biodiversity Data Journal, certifying reviewers' contributions via ReviewerCredits. Reviewers can now record their peer reviews and earn virtual credits redeemable for benefits, including discounted APCs.
Neurotrauma Reports is a peer-reviewed open access journal publishing research on traumatic brain and spinal cord injury. The journal aims to provide a dedicated forum for the neurotrauma field, including original papers, review articles, and studies on regional scope or patient populations.
A team of researchers has developed a new system to evaluate proposed scientific research projects that distributes the workload among proposers and uses machine learning to match reviewers with proposals. The system also includes a feedback mechanism to improve the review process.
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A Dartmouth research team analyzed the Minister's gait in Monty Python's 'The Ministry of Silly Walks.' The study found that his walk was 6.7 times more variable than normal, sparking a comparison to peer review inefficiencies in academic research. Researchers propose streamlining grant applications and awarding grants more quickly to ...
Research by Arizona State University's Tess Neal found that psychological tests used in courts are not always scientifically valid and are rarely challenged. The study examined 364 commonly used psychological assessment tools and found that only about 40% have generally favorable reviews of their psychometric properties.
Review Commons, launched by ASAPbio and EMBO Press, enables high-quality pre-journal peer review of manuscripts from the life sciences. This platform empowers authors to make informed decisions on paper submission and expedites submission to affiliate journals without restarting reviews.
A collaboration between Elsevier and Wageningen University uses analytical methods to detect and prevent citation stacking and pushing in scientific research. The study found that 0.8% of reviewers were associated with suspicious citation patterns, highlighting the importance of quality control in publishing.
The Journal of Development Economics introduces Pre-results Review, a peer review process that evaluates empirical research before results are known. This approach helps improve methodological quality and provides earlier recognition for authors. The practice is gaining traction among journals in various disciplines.
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A review in the Harvard Review of Psychiatry suggests that wisdom is a complex concept that contributes to mental health and happiness. The authors propose that wisdom can be defined as a complex human trait with several specific components, including social decision making, emotion regulation, and self-reflection.