Articles tagged with Cognitive Disorders
A study of 11,000 children found that maternal tobacco use during pregnancy is associated with enduring deficits in childhood neurocognition. Continued research on the link between maternal tobacco use and cognitive performance is needed.
A team at Texas A&M University's School of Public Health has received funding to design a mobile app to help older Chinese American and Korean American adults prevent dementia. The app will focus on cognitive function and quality of life, with culturally appropriate content and multiple language options.
A systematic review and meta-analysis of 104 studies with 341,000 participants found that physical activity was associated with better late-life cognition, although the association was weak. The findings suggest that even a weak link between physical activity and cognitive decline is still important from a population health perspective.
Researchers at Buck Institute for Research on Aging propose an alternate strategy for reversing memory problems in Alzheimer's disease by targeting the KIBRA protein. The findings suggest that KIBRA can rescue mechanisms that promote synapse resilience, potentially leading to improved memory function.
A new study found that 50% of youth aged 11-24 with mental health issues exhibit Psychosis Spectrum Symptoms, highlighting the need for early intervention. The study aims to identify predictors of psychosis spectrum disorder and improve mental health outcomes for this population.
A new study published by experts at the University of Exeter found that playing a musical instrument is associated with improved memory and executive function in older adults. Continuing to play into later life provides even greater benefit, suggesting that music could be a way to harness cognitive reserve.
Researchers at UTA developed a novel learning-based framework to predict Alzheimer’s disease progression. The DETree strategy can pinpoint clinical status within the disease spectrum, allowing for more accurate planning and potential applications in other diseases with multiple stages of development.
Researchers at UC Davis found that men with FMR1 premutation who experienced reduced executive function were at higher likelihood of developing fragile X-associated tremor/ataxia syndrome. Executive function challenges, particularly working memory and organization issues, were strongly associated with the development of FXTAS.
A recent study of over 7,900 participants found that pet ownership was associated with slower rates of verbal memory and fluency decline among older adults living alone. This suggests that pet ownership may offset the negative effects of social isolation on cognitive health.
A prognostic study of 1,000 very preterm infants found predictive modeling can identify those at risk for cognitive impairment. This allows for targeted interventions to be implemented early, potentially improving outcomes.
A study of 8,000 participants found that negative wealth shock was associated with accelerated cognitive decline and elevated risks of dementia among middle-aged and older U.S. adults. The findings suggest a potential link between financial hardship and cognitive aging.
Researchers at the University of Cincinnati's Lindner Center of HOPE have developed a novel approach to treating depression using spinal cord stimulation. The study found that electrical stimulation of the spinal cord decreased depressive symptoms and showed therapeutic potential.
A new study finds that exposure and response prevention (EX/RP) therapy for OCD improves cognitive control by strengthening connections between brain networks. This breakthrough sheds light on the mechanisms underlying EX/RP's effectiveness in treating OCD, paving the way for targeted therapies.
A study from the University of Ottawa found that sleep deprivation significantly impacts decision-making processes, reducing neural responses to winning and losing outcomes. This can lead to diminished positive emotions in response to winning and negative emotions when faced with losses.
A new study from Johns Hopkins Medicine finds that excess thyroid hormone levels are associated with a higher risk of cognitive disorders in older adults. The research suggests that clinicians should avoid overtreatment when prescribing thyroid hormone therapy to prevent potential negative consequences.
Researchers developed a new diagnostic tool to identify and treat Hikikomori, a condition characterized by prolonged physical isolation or social withdrawal. The Hikikomori Diagnostic Evaluation (HiDE) assesses the severity of social withdrawal, providing a practical guide for clinicians.
Researchers found CBT reduced fatigue and physical limitations in nearly 1300 patients with ME/CFS, regardless of symptoms or diagnosis. Younger, less impaired patients benefited most from CBT.
Greater PTSD symptoms were associated with higher carotid atherosclerosis and brain small vessel disease among midlife women. Women carrying the APOEɛ4 gene showed poorer cognitive performance in response to PTSD.
Researchers investigate centro-cingulate network changes and cholinergic innervation deficits in Parkinson disease and normal aging. Studies reveal significant correlations between centro-cingulate changes and cognitive impairments, motor symptoms, and age.
Researchers found that hierarchical cortical organization is impaired in people with schizophrenia, leading to disruptions in processing stimuli from the external world. This disruption affects secondary processing of sensorimotor-visual gradients, explaining behavioral and clinical symptoms of the disease.
A study of 15,000 dogs found that body size significantly impacts aging patterns, with smaller dogs living longer and experiencing slower decline rates. Larger dogs show an earlier onset of age-related decline but maintain cognitive health longer.
A study using virtual reality led by UCL researchers found people with early Alzheimer's consistently overestimated turns and showed increased variability in sense of direction. These specific impairments were not observed in healthy older participants or those with mild cognitive impairment.
Researchers at Mount Sinai Hospital developed an algorithm called HistoAge that predicts age at death based on human brain tissue specimens using artificial intelligence, revealing insights into aging mechanisms and neurodegenerative diseases like Alzheimer's disease.
Previous studies suggest that psychedelics can induce an altered state of consciousness leading to new thought patterns, which is promising in treating OCD. Research analyzing the experience of past users found dissipation of obsessive thoughts, reduced anxiety, and increased acceptance of OCD symptoms.
Researchers found dementia prevalence among people with ID to be 6.44%, with modifiable risk factors identified as hypertension, depression, stroke, age, severity of ID, duration of education, and traumatic brain injury. These findings can inform better screening and support for individuals with intellectual disabilities.
A behavioral experiment involving 644 older adults found that many are susceptible to government impersonation scams, including those without cognitive impairment. The study highlights the need for awareness and education among this demographic to prevent such scams.
Researchers developed A-CensNet, a fusion model predicting cognitive scores from movie-watching fMRI and eye-tracking data. The model outperforms individual modalities and leading techniques, suggesting synergy between brain functionality and behavior.
A new study uses brain imaging to explore the neural underpinnings of uncertainty processing in OCD, finding that patients struggle with certainty and decision-making, particularly when outcomes are more certain. This understanding may offer new hope for developing therapies targeting uncertainty processing in OCD.
A pioneering study published in Cancer Cell finds that brain metastasis alters the brain's chemistry and disrupts neuronal communication. Researchers discovered a molecule, EGR1, that may play a role in this process, paving the way for potential drug development to alleviate neurocognitive effects.
The study found a significant decline in the prevalence of serious later-life cognitive impairments among Black Americans, narrowing racial disparities. However, racial disparities persisted in activities of daily living and functional limitations. Improved air quality may have contributed to the narrowing of disparities in cognitive i...
Researchers found that wildfire smoke triggers chronic brain inflammation affecting learning and memory regions, lasting up to 28 days. The study's findings are concerning given the frequent exposure of people to wildfire smoke.
A new study found that children's mental health and wellbeing gradually worsened over the past six years, with measures of life satisfaction, optimism, and emotional regulation declining consistently since 2020. The COVID-19 pandemic has had a profound impact on young Australians, particularly those in higher year levels and from lower...
A new special issue of the Journal of Huntington’s Disease highlights the critical impact of sleep dysfunction on HD patients. Disrupted sleep can alter metabolism, increase vulnerability to infection, and exacerbate disease outcomes.
Researchers found that endogenous retroviruses, naturally present in the human genome, can influence the spread of tau aggregates between cells. This suggests that viral proteins could be potential targets for therapies to stop or slow neurodegeneration.
Researchers highlight concerns among healthcare providers about patients with cognitive decline living alone, who are vulnerable to missing medical appointments and failing to respond to follow-up phone calls. The study emphasizes the need for improved support systems to prevent untreated medical conditions, self-neglect, and falls.
A new study found that cumulative exposure to extreme heat can worsen cognitive health, particularly among Black older adults and residents of disadvantaged neighborhoods. Researchers analyzed data from nearly 9,500 U.S. adults ages 52 and older, finding a link between high heat exposure and faster cognitive decline in these groups.
Researchers found that participants with MCI performed significantly worse on a test of four types of decision-making abilities compared to those without. The study's findings have broad implications for choices about finances, health care, and other daily decisions.
A new study published in The New England Journal of Medicine found that the MIND diet had a significant improvement in cognition during the first two years, but no significant difference in three-year changes. The study enrolled 604 people with suboptimal diets and family history of Alzheimer's disease.
The MIND diet, which combines Mediterranean and DASH principles, was positively linked with attentional inhibition in school-aged children. The diet's emphasis on brain-healthy foods like leafy greens, berries, and legumes may help improve cognitive development.
A three-month mild exercise program improved executive function in middle-aged and older adults by increasing neural efficiency in the prefrontal cortex. The benefits were particularly pronounced in the older adult group, suggesting a positive impact on cognitive function and brain function with minimal physical exertion.
Repetitive heading in professional soccer increases cognitive impairment risk in later life, according to a new study. The study suggests that establishing an upper threshold for heading frequency could help mitigate this risk.
Researchers at Texas A&M University found that substance use impairs cognitive flexibility by inhibiting specific neurons. Chronic cocaine or alcohol use alters the local inhibitory brain circuit, leading to decreased cognitive flexibility and increased risk of academic deficits and lower quality of life.
A recent meta-analysis of 29 studies found that intranasal insulin treatment can boost cognition in individuals with mild cognitive impairment or Alzheimer's Disease. The analysis suggests potential benefits for this treatment approach, which may be worth further investigation.
A group of educators is urging caution when using artificial intelligence (AI) in special education, highlighting its potential to benefit students with disabilities. The authors emphasize the need for careful consideration of AI's uses and limitations, including information literacy, consent, and critical thinking.
The study used transcranial photobiomodulation (tPBM) to stimulate the prefrontal cortex, a region involved in cognitive function. The results showed that tPBM modulated hemodynamic and metabolic activities in a wavelength- and site-specific manner.
Researchers identified mRNAs and long non-coding RNAs targeted by stress granule proteins, which accumulate AD-associated gene transcripts in these structures. SGs may play a key role in regulating AD development through the impairment of protein neurohomeostasis.
Late-onset cognitive impairment emerged in adult childhood cancer survivors decades after diagnosis and treatment. Modifiable health behaviors and chronic health conditions significantly increase this risk.
A new study in a mouse model of Alzheimer's disease examines the effects of environmental enrichment on AD symptom progression and pathology. The researchers found that living in an enriched environment improved several measures of metabolism and reduced individual behaviors, which became more similar and rigid as the disease progressed.
A case study published in the Journal of Alzheimer's Disease reveals that lecanemab can lead to therapy-induced Aβ phagocytosis and multifocal intracerebral hemorrhage, highlighting a potential risk of brain damage and death. The study suggests that better biomarkers are needed to assess the extent of cerebral amyloid angiopathy.
Researchers used AI to analyze speech patterns of patients with Parkinson's disease, finding they spoke in shorter sentences with more verbs and fewer common nouns. The study suggests potential early detection methods for the condition through conversational analysis.
Glioblastoma steals cognitive faculties as it spreads, but its insidious ability to infiltrate neighboring networks may be its undoing. Researchers found neural activity can restructure connections in surrounding tissue, causing decline. The drug gabapentin blocks this growth-causing activity in mice with glioblastoma.
A study by University of California, Riverside found that older adults are less likely to ignore distractors in their surroundings while engaging in a cognitive task and an effortful physical task. This decline is greater when simultaneously performing a physical task, such as driving or carrying grocery bags.
Patients with SARS-CoV-2 infection report cognitive deficits that are associated with post-COVID-19 condition (long COVID) symptoms. Researchers suggest a potential affective component in some patients, highlighting the need for further exploration of underlying reasons.
Researchers found that GlyNAC supplementation corrected brain glutathione deficiency, improved glucose transporters, reversed mitochondrial dysfunction, and improved cognition in old mice. The study also showed reductions in oxidative stress, inflammation, and genomic damage, as well as improvements in neurotrophic factors.
A new study by St. Jude Children's Research Hospital found that children with supportive environments fared better than those living in neighborhoods with economic hardship. Higher EHI scores were associated with lower cognitive abilities and greater decline after treatment, especially in math skills.
A new study reveals an association between poor air quality in India and impaired cognition in infants under two. The study found that air quality was poorer in homes that used solid cooking materials like cow dung cake, and that reducing cooking emissions could have benefits to infants' emerging cognitive abilities.
Research by Professor Mila Vulchanova reveals associations between language development and cognitive skills in children. Non-verbal tests show that severity of language difficulties can be predicted based on cognitive markers, supporting the importance of measuring both verbal and non-verbal skills.
Researchers found that enhancing NMDAR function via increased serine racemase expression improved attention and cognitive flexibility in middle-aged rats. Upregulating serine racemase in the medial prefrontal cortex also increased glutamatergic synaptic transmission, including NMDAR activity.
A study found that practicing music and active listening can alter cognitive decline in healthy seniors by promoting brain plasticity. The researchers discovered an increase in grey matter volume in four brain regions involved in high-level cognitive functioning.
Researchers at Salk Institute discover that dysfunctional mitochondria at synapses fail to meet energetic demand, supplying either too much or too little power and potentially causing working memory impairment with age. Adherence to the ultrastructural size principle is essential for avoiding cognitive decline in aging brains.