The research team will test a combination of new technologies that release antibacterial agents in response to acid presence, promising longer service life and improved dental applications. The novel materials aim to inhibit oral biofilm formation and have excellent physical and mechanical properties.
Researchers applied bioinformatics to develop and evaluate boron-containing compounds for treating cancer and infectious diseases. Computational approaches facilitate pharmacochemical analysis, revealing essential parameters of the boron atom and its effects on biological systems.
Researchers have identified a new combination therapy that may improve survival for women with ovarian cancer by eradicating chemotherapy-resistant tumors. The treatment, involving carboplatin and birinapant, showed promise in mice and human tumor models, with 50% of samples responding to the therapy.
Research reveals that strong feelings about immigrants are controlled by the immune system, particularly in people with a hypersensitive behavioral immune system. This leads to misconceptions about infection risks and a reluctance to interact with immigrants, blocking integration paths.
A study found that paying users to write product reviews suppresses the number of reviews on social platforms, especially among those who are socially well-connected. The authors argue that this approach undermines the intrinsic motivation for honest reviews and increases the likelihood of fake reviews.
Karl Deisseroth received the inaugural Distinguished Redelsheimer Award for his transformative work on optogenetics and CLARITY, revolutionizing brain manipulation and visualization. His laboratory's advancements have significantly contributed to understanding how brain circuitry contributes to behavior in neuropsychiatric diseases.
Scientists have demonstrated the effectiveness of gene editing in rhesus monkey embryos, paving the way for new therapies and treatments. The breakthrough opens up possibilities for human disease research, including neurological and reproductive conditions.
Researchers will study Chinese haze events and their sources using oxygen-isotopic compositions of sulfate and nitrate aerosols. The findings will aid development of air quality mitigation strategies in China.
A new study published in the Journal of the American College of Surgeons found that pancreatic cancer patients who travel to academic medical centers for surgery have longer overall survival rates and better quality care. For thyroid cancer patients, traveling also results in more adherence to evidence-based treatment guidelines.
According to research by Cornell's Food and Brand Lab director Brian Wansink, retailers can increase healthy food sales through small, low-cost in-store changes. A health predisposition pyramid suggests that different marketing interventions are more successful with various shopper groups.
Researchers developed an automated drill that can make complex cranial surgeries 50 times faster than standard procedures, reducing time and increasing safety. The drill uses software to set safe cutting paths and has an automatic emergency shut-off switch.
A new study reveals that 90% of global health development assistance funds target individuals under the age of 60, while those aged 70 and older receive less than half as much. The majority of this funding goes to children under the age of 5, highlighting a significant gap in support for older adults.
Researchers find that members of the DUX family of proteins, specifically DUX4, trigger gene expression program in human embryos. DUX4 stimulates expression of genes induced during zygotic genome activation by binding to their regulatory regions.
Researchers created a new tool that analyzes RNA sequencing data using topology, providing insights into cellular differentiation and development. The approach identifies connections between cellular states and genes active during development, offering potential discoveries in understanding cell identity and guiding cellular development.
After two high-profile mass shootings, California's handgun sales spiked by 53% and 85% in the following weeks. The study found that these spikes were driven by increased concern over personal security, with many individuals motivated to acquire firearms for self-protection.
A new study published in Journal of Consumer Research found that individuals with larger working memory capacities tend to feel like they've had an experience more often, leading to faster satiation. This could have implications for marketers and consumers seeking to manage cravings for unhealthy foods.
Researchers at the University of Texas MD Anderson Cancer Center used TACC's advanced computers to discover a potential new cancer drug, mebendazole, which can selectively inhibit TNIK enzyme activity. Virtual screening and molecular modeling approaches identified this compound as a strong candidate for further exploration.
Stephanie Solso received the award for her paper on diffusion tensor imaging and axonal overconnectivity in autism spectrum disorder toddlers. The study revealed abnormal brain development and age-related changes in brain regions involved in social, language, and behavioral control functions.
The National Institutes of Health is finding solutions to improve the health of nearly 25 million Americans with asthma. Research funded by NIEHS, NHLBI, and NIAID has demonstrated the importance of healthy school environments and explored the complex role of the immune system in asthma.
A noninvasive PET imaging method measuring granzyme B can distinguish responders from nonresponders to immune checkpoint inhibitors. The method accurately predicted treatment outcomes in both mice and human melanoma samples.
Pregnant women are vulnerable to orthopaedic traumas due to car crashes or domestic violence, with bodily changes affecting treatment processes. A team of specialists is essential for optimal patient outcomes, prioritizing the mother's health and minimizing fetal harm.
Researchers at MIT have developed a new CRISPR-based model for colon cancer that enables rapid simulation of the disease's progression and testing of new treatments. The model uses genetic mutations with CRISPR to recreate human-like tumors in mice, providing a valuable tool for scientists studying colon cancer.
Following mass shootings, there are sharp increases in handgun acquisitions in California, with significant spikes seen among white and Hispanic persons. Researchers suggest this may lead to substantial increases in firearm ownership.
A new study published in CMAJ found that many common antibiotics increase the risk of miscarriage, with a 60% to two-fold increased risk. Erythromycin and nitrofurantoin were not associated with an increased risk.
A new study found that childhood and adolescent cardiovascular risk factors are associated with worse midlife cognition, regardless of adulthood exposure. High blood pressure and high cholesterol in childhood, adolescence, and young adulthood, as well as smoking in adolescence and young adulthood, were linked to impaired cognitive perf...
Researchers found that two species of triggerfish control pencil urchin populations, reducing their consumption of algae. This mid-level predator has a strong impact on the coastal ecosystems' vitality.
A study by RIKEN Brain Science Institute found that remembering goal locations in virtual reality requires the same brain parts as in real life, using a mouse model. The researchers used virtual reality to test how mice learned spatial routes, finding that mice with a protein deficiency performed poorly.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has published appropriate use criteria for ventilation/perfusion imaging in pulmonary embolism. The guidelines aim to promote cost-effective and appropriate utilization of advanced diagnostic imaging services, affecting approximately 300,000 Americans each year.
A new discovery at the University of Alberta found that chronic ischemia after spinal cord injury disrupts blood flow, leading to poor oxygenation and motor dysfunction. Elevating oxygen levels improved blood flow and restored function in rat models.
A Rutgers-led team has invented a promising technology for killing microbes using paper-based sanitizers, which can eliminate more than 99 percent of bacteria cells. The devices consist of paper with thin layers of aluminum and hexagon/honeycomb patterns that produce plasma to kill microorganisms.
Researchers developed a novel strategy using cytokines TGF-β and IL-10 to promote tolerance in high-risk corneal transplant patients. Treating donor tissue with this combination improved graft survival rates by 68.7%, offering a promising approach for reducing rejection.
Researchers found that LGBT individuals living in smoke-free communities are more likely to want to quit smoking than those in non-smoke-free areas. The study, published in Nicotine and Tobacco Research, also reveals a higher prevalence of smoking among the LGBT population compared to heterosexual adults.
A national study found that phone calls to suicidal patients following ED discharge led to a significant reduction in future suicide attempts. The year-long trial, involving 1,376 patients nationwide, provided specialized screening, safety planning guidance and follow-up telephone calls.
A new discovery in chemistry could lead to more specific and desired forms of drugs, with the creation of chiral molecular sieves that can sort and create left- and right-handed molecules. This breakthrough has broad implications for pharmaceutical companies and may improve medications such as ibuprofen.
Cornell researchers find that state databases tracking opioid prescriptions lead to a decline in abuse among Medicare recipients. Doctor shopping and excessive prescription refills also decrease in states with stricter laws.
Researchers have identified 'silent seizures' in the brains of patients with Alzheimer's disease, a discovery that could lead to new treatments. The findings suggest that these non-convulsive hippocampal seizures may contribute to or accelerate the degenerative process underlying the disease.
Researchers at CIFAR have successfully bred Schrödinger cat states in optics, amplifying classical states of light beyond microscopic limits. This breakthrough could lead to applications in quantum communication, teleportation, and cryptography.
A new study from the Santa Fe Institute proposes a quantitative index to measure sustainable development in cities, revealing systematic correlations between urbanization and poverty reduction. The research also highlights persistent inequalities in access to housing and services across neighborhoods.
A new study found that cervical cancer incidence rates among women without a hysterectomy increase with age until 70 and do not begin to decline until 85. Many women over 65 have inadequate screening history, highlighting the need for continued surveillance.
The Society of Biological Psychiatry honored Dr. Stephen Strakowski with the 2017 George N. Thompson Award for his leadership and service to the organization. Dr. Strakowski, Inaugural Chair of Psychiatry at the University of Texas at Austin, was recognized for his contributions to promoting the welfare of SOBP.
Investigators at MUSC have identified a critical regulatory mechanism for nitric oxide production in liver endothelial cells following liver injury. The study reveals that inhibition of CAV1 or GRK2 phosphorylation compromises complex formation and reduces eNOS activity, leading to increased portal pressure.
A new study in mice reveals how the protein Brd4 boosts the inflammatory response, with both beneficial and harmful effects. The findings suggest that Brd4 can protect the body from infection but also contribute to chronic inflammatory diseases.
A new study suggests that adjusting psychiatric medication can reduce the risk of falls among older adults. The research found an association between depressive symptoms and falls, with moderate increases in depressive symptoms linked to a 30% higher risk of experiencing a fall over two years.
Researchers developed a polarimetric radar time-series simulator to study tornadic debris, improving tornado warning accuracy and damage estimation. The simulator explains the relationship between debris characteristics and tornado dynamics.
A study by University of Missouri researchers found that restaurant servers rely on first impressions and stereotypes to determine which customers will leave better tips. Well-dressed customers, regardless of race or gender, were perceived as more likely to leave good tips.
Kyle Williams, a UH doctoral student in applied mathematics, has been selected for the DOE's Graduate Student Research Program. He will work at Sandia National Lab to further his research on computational fluid dynamics and Navier-Stokes equations.
Trevor Robbins is honored with the 2017 Gold Medal Award for his fundamental contributions to understanding cortico-striatal function and its role in psychiatric disorders. He has made significant advancements in bridging mechanisms of pathology to new treatments, including developing the CANTAB computerized neuropsychological assessment.
A UCL-led study found that the brain responds weaker to money gained through immoral actions compared to those earned morally. The research identified a neural process that dampens the appeal of profiting at others' expense.
A study published in The Journal of the American Osteopathic Association finds that vitamin D deficiency is widespread due to sunscreen use and inadequate sun exposure. Chronic diseases like Type 2 Diabetes and malabsorption disorders can inhibit vitamin D metabolism, leading to symptoms such as muscle weakness and bone fractures.
International scientists have discovered a short-lived community of organisms that may hold clues to forces shaping our planet today. The community, which included microbial mats, trace fossils, bivalves, and echinoids, was found in a moderately deep-water setting near Shangsi in China's Sichuan Province.
A study found that a decrease in circulating tumor cells with increased ALK gene copies is associated with longer progression-free survival in patients with non-small cell lung cancer treated with crizotinib. This biomarker may help predict treatment response and tailor therapies for individual patients.
Dr. Carolyn Rodriguez, a neuroscientist and clinical psychiatrist, received the award for her discovery of ketamine's rapid therapeutic effects on OCD symptoms, while Dr. Todd Gould was recognized for his work on ketamine's antidepressant effects in treating depression. The prestigious awards come with a $5,000 cash prize.
Research suggests that apologizing for a past crime is the most effective strategy in reducing concerns about trustworthiness. Justifying or making excuses can lead to negative hiring decisions. Apologizing shows remorse and reduces deviant behaviors at work.
Researchers have observed a complex process in plant cell wall growth using nanoscale imaging. The findings suggest that microfibrils' movements under stretching regimes reveal a different pattern of motion than previously thought.
Researchers at Harvard John A. Paulson School of Engineering and Applied Sciences used mathematical models to determine the best way to throw an object at a target. They found that underhand throws are best for close, high targets and overhand throws are more accurate for targets below the shoulder.