A new study reveals that a high-sugar and high-fat diet can disrupt the natural adaptation of the digestive system by accelerating the division and differentiation of intestinal stem cells. This can lead to an increased risk of obesity, type 2 diabetes, and gastrointestinal cancer.
By introducing defects, researchers created chemically active hBN that can hold precious metal atoms, enabling cost-effective catalysts and potential applications in energy storage and sensors. This breakthrough challenges the long-held assumption that inert materials cannot be activated.
Researchers at OHSU have discovered a unique neural cell assembly that enables complex learning in songbirds, similar to those found in the human primary motor cortex. This finding has implications for understanding fine motor control and may lead to new avenues for treating disorders such as ALS.
Researchers have developed efficient catalysts for ammonia synthesis under mild conditions using ternary ruthenium complex hydrides. The unique configuration and function mechanism of these complexes enables non-dissociative activation of nitrogen, leading to superior kinetics and favored ammonia production.
Scientists at the University of Nottingham found a plant-based antiviral treatment to be effective in blocking the highly infectious SARS-CoV-2 Delta variant. The novel natural antiviral drug, thapsigargin, was shown to trigger a broad-spectrum host-centred antiviral innate immune response against all variants of the virus.
Researchers used a machine-learning algorithm to identify differences in how the brain responds to various chemicals, including salt and benzaldehyde. The study provides insight into how brains process information and may help understand sensory processing disorders.
Researchers at the University of California, Davis, have discovered a mechanism to eliminate half the genome in plants, making it easier to breed crops with desirable traits like disease resistance. This breakthrough could shorten breeding times by several generations.
Researchers at the University of Helsinki and Aalto University have developed a gel-grown mini-breast cancer model that can effectively treat hormone-dependent breast cancers. The discovery opens new avenues for hormonal therapies, individual drug responses, and drug resistance mechanisms.
Researchers developed a framework to evaluate urbanization's impact on food and land use biodiversity. Urban areas can provide a range of approaches to increasing food diversity, including peri-urban agriculture and small farms. Strengthening food biodiversity among the urban poor can improve nutrition and security.
A recent study by Weill Cornell Medicine found that nursing homes acquired by private equity companies have lower quality of care and higher Medicare costs. Residents at these facilities were 11% more likely to have emergency room visits and hospitalizations, resulting in $1,080 higher annual Medicare costs.
Researchers from Louisiana State University discovered the molecular architecture of fungal cell walls and how they respond to stresses, paving the way for new antifungal compounds. The study's findings reveal the structural role of each major carbohydrate in the cell wall and provide a revised model of fungal cell wall organization.
Researchers developed a nickel-cobalt metal dimer on nitrogen-doped carbon that can catalyze electrolysis under both acidic and basic conditions. The new system exhibits comparable overvoltage to commercial Pt-based catalysts and shows significant activity enhancements compared to individual single-atom catalysts.
Researchers found that higher lymphoma volume at diagnosis was associated with increased risk of recurrence. This could lead to improved patient outcomes by selecting the most appropriate treatment. The study also explored PET-based measures of initial disease burden, which may help predict patients' risk of recurrence.
A new UNLV research study found that remote work technology exacerbated stress and mental health issues among working mothers with children. The study suggests that asynchronous communication methods like email may be more effective in alleviating stress, while synchronous forms like video chats and texting can hinder multitasking.
Researchers identified a subset of dendritic cells that can cloak themselves in tumor proteins and trigger a strong T cell response. Stimulating these dendritic cells may enhance the effectiveness of cancer immunotherapy by slowing the growth of melanoma and colon tumors.
A new study published in Frontiers in Psychology has identified specific facial features that can be used to distinguish children's faces from adult faces. These features include the shape of the nose and eyebrows for adult faces and the eye, jawline, and nasal bone for child faces.
Researchers at KAIST discovered a single amino acid change in the PTEN protein that improves health status while retaining longevity. The study, published in Nature Communications, highlights the potential for targeting this protein to develop therapies for promoting healthy longevity.
Researchers found high rates of SARS-COV-2 infections in Mali but low evidence of severe disease, hospitalization, or deaths. In contrast, COVID-19 patients with high levels of previous malaria infections showed lower risks of severe outcomes in Uganda.
A new framework assesses flood risk by integrating climate model outputs and hydrologic models to predict uncertainty. The study found that climate uncertainty dominates overall uncertainty, and areas prone to flooding in the future will be mostly the same as current ones.
A recent study by La Jolla Institute for Immunology has identified a trio of proteins - TWEAK, TNF, and IL-17 - that control inflammation in psoriasis patients. Targeting this protein complex may lead to more effective treatments for the disease.
A study led by Children's Hospital of Philadelphia researchers used stem cells to implicate several genes involved in bodily functions associated with the hypothalamus. The findings could help clinicians identify potential causes of dysfunction for traits regulated by the hypothalamus, such as sleep and stress.
A recent study of 9,900 US nursing homes found that private equity acquisition was associated with higher Medicare costs and increased emergency department visits and hospitalizations for preventable conditions. The study highlights concerns about the impact of corporate ownership on nursing home quality and cost.
A mathematical model suggests that SARS-CoV-2 Delta-like variants, which combine enhanced transmissibility and partial immune escape, will cause more severe pandemics than variants with either trait alone. Vaccination is predicted to be highly beneficial in these cases, preventing more infections and breakthroughs.
A Dartmouth study uses mobile sensing to predict individual job performance based on commute data, revealing the link between work commute and job quality. The research also shows how data from personal tech devices can help improve employee productivity and satisfaction.
A new study warns that California's Central Valley groundwater may be unable to recover from past and future droughts, with less than a third recovered after the 2012-2016 drought. The researchers found that groundwater recovery times can be halved with modest caps on pumping in drought and post-drought years.
A study published in PLOS Computational Biology found that rodents have a greater diversity and accelerated rate of evolution in the ACE2 receptors used by SARS viruses. This suggests that some rodent species may be asymptomatic carriers of SARS-like coronaviruses, potentially leading to new pathogen transmission to humans.
SourcePLOS·JournalPLOS Computational Biology·TypeComputational simulation/modeling·DateNov 18, 2021
A study by Technical University of Munich found that major tech companies significantly underreported CO2 emissions from their value chain, with 50% of emissions omitted in 2019. The researchers developed a method to identify reporting gaps and estimated the omitted emissions at 751 megatons carbon dioxide equivalents.
Researchers at Stowers Institute for Medical Research discovered that Hox genes, known to orchestrate early development, continue to be expressed in adult tissues and are required for asexual reproduction in flatworms. The study suggests new roles of these genes in adulthood.
Researchers from the University of Tsukuba found that lifestyle factors such as smoking, alcohol consumption, and sedentary behavior significantly increase the risk of developing metabolic syndrome in non-obese individuals. Similar risk factors were identified for both obese and lean individuals, highlighting the importance of healthy ...
A recent study has found that while US suicide rates fell during the COVID-19 pandemic, a significant socio-economic gap persists, with vulnerable populations disproportionately affected. The researchers highlight the need for further research and social cohesion measures to mitigate pandemic-induced suicide risk in these communities.
A new study argues that the Justinianic Plague had a devastating impact on the Mediterranean world, and its effects were felt in England. Genetic discoveries suggest that bubonic plague may have reached England before its first recorded case in the Mediterranean, via a currently unknown route.
Researchers developed a simpler, greener method for producing Grignard reagents using environment-friendly paste-based technology. This new process drastically cuts down on the use of hazardous organic solvents and could lead to reduced production costs and environmental benefits.
Researchers warn of a potential long-term economic slowdown in developed democracies, driven by factors such as aging populations, shifts to services, and debt. The team proposes a 'guided civic revival' approach to address this challenge, combining grassroots forces with government participation to promote social solidarity and unity.
Researchers from UC Davis MIND Institute develop a home-based language testing method using telehealth, allowing Spanish-speaking parents to assess their children's language abilities. The study found the parent-led test to be feasible, reliable, and effective in both English and Spanish-speaking groups.
A recent study found that using consumer-grade wearable devices to track a child's heart rate and physical activity after surgery can help clinicians decide if at-home recovery is going as expected. The data from the wearables, coupled with parent reports, aids clinicians' decision-making and potentially prevents unnecessary ED visits.
Mass treatment with Ivermectin has halted the spread of river blindness in two Nigerian states, Plateau and Nasarawa, marking a major milestone in disease elimination efforts. Separate studies also show the potential for Ivermectin to reduce West Nile Virus transmission by mixing it into bird feed.
Gastric cancer is the sixth most common cancer worldwide, with 1.09 million new cases in 2020. Recent research offers hope for improved treatment options, making it a critical area of focus for medical oncologists like Dr. Mohamad Sonbol.
Researchers from SMART and TLL have developed a rapid Raman spectroscopy-based method to detect and quantify early bacterial infection in crops. This method enables non-invasive early diagnosis, which is crucial for plant disease management and agricultural productivity.
Scientists from Japan and Denmark discovered disordered one-dimensional chains in indium telluride, which exhibit ultralow thermal conductivity. This finding confirms the chemical and physical basis of low thermal conduction in thallium selenide-type materials, advancing thermoelectric power technologies.
Extreme heat events are associated with a greater risk of death from ischemic heart disease, stroke, and heart failure. Preventive strategies aim to reduce hyperthermia and dehydration to minimize cardiovascular risk during extreme heat events.
Research team discovered mRNA vaccines induce antibodies recognizing Spike and N protein fragments, potentially leading to misclassified breakthrough infections. The study suggests using multiple viral antigens for accurate detection of vaccine effectiveness.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
A recent study found that earthquakes and extreme rainfall lead to a significant increase in landslide rates in Nepal during the monsoon season. The research, published in Nature Communications, reveals that landscape damage caused by the April 2015 Gorkha earthquake increased landslide risk by six times.
A team of researchers from Hefei Institutes of Physical Science and University of Science and Technology developed a highly efficient magneto-tunable monochromatic THz generator. The new source utilizes a 2D ferromagnetic Cr2Ge2Te6 crystal, exhibiting advantages such as zero threshold, high quality factor, and radiation efficiency.
A new study published in Ecology Letters reveals a global decline in the resilience of vertebrate populations, with accelerating loss of ecological functions and services. The research found that cumulative effects of anthropogenic threats such as climate change, invasive species, habitat loss, and pollution are driving this loss.
Researchers have developed an assay that uses specific immune-biomarkers to monitor patient survival chances and effectiveness of ovarian cancer treatments. The 'sFIS' assay will enable targeted therapy for each patient, improving treatment outcomes.
SourceKU Leuven·JournalJournal for ImmunoTherapy of Cancer·TypeRandomized controlled/clinical trial·DateNov 18, 2021
A study found that many IVF embryos with chromosomal abnormalities have the potential to lead to successful pregnancies. Embryos with low-grade mosaicism had similar live birth rates and miscarriage rates as euploid embryos.
SourceCell Press·JournalThe American Journal of Human Genetics·TypeRandomized controlled/clinical trial·DateNov 18, 2021
A new imaging method measures individual photons, greatly reducing interference and improving spatial resolution by three times. The technology could also reduce radiation exposure during x-ray imaging, making it ideal for medical applications.
Researchers developed a model showing that microbes with complementary preferences can coexist in communities. The study found that assembled communities consist almost exclusively of microbes that grow the fastest on their top choice nutrient.
Scientists at the University of Groningen have developed a nanopore-based method for protein identification and sequencing. They constructed a proteosome-nanopore system that can recognize proteins from peptide spectra and sequence entire proteins directly.
Researchers at Karolinska Institutet found that CRISPR gene-editing causes DNA damage, activating the p53 protein, which can lead to an accumulation of mutated cancer cells. The study identified a network of linked genes with similar mutations and suggests transient inhibition of p53 as a potential strategy to prevent their enrichment.
Researchers discovered that chemotherapy drugs can affect protein synthesis in muscle cells, even at low doses. This finding has significant implications for cancer treatment and exercise rehabilitation programs, suggesting that even non-oxidative stress effects of chemotherapy should be considered.
A recent study found that low-, middle-, and high-income countries hosting COVID-19 vaccine trials received proportionately more doses of vaccines. High-income countries were able to fully vaccinate their populations due to the higher dose allocation, raising concerns about unequal access to life-saving vaccines.
Researchers found that humour emerges as early as 1 month, with different types of humour developing at various ages. By 11 months, half the children were producing humour, often within a few hours. The study identified 21 types of humour in young children, shedding light on their cognitive, social, and mental health development.
A study found that 'surgery selfies' taken by patients and assessed by clinicians can diagnose wound infections early, reducing GP visits and improving access to care. The practice could manage surgical patient care while reducing pressure on the NHS.
A group of deaf and hard-of-hearing scientists argue that providing basic standards of support can increase diversity in fields of science and medicine. The authors propose five pillars to promote inclusion, including peer mentorship, captioning at conferences, and opportunities for leadership roles.
A plant-based diet rich in dark green leafy vegetables may help alleviate chronic migraine symptoms, according to doctors. The LIFE diet, which includes dark green veggies and limits animal protein, reduced the patient's migraines from 18 days a month to just one day a month.
A research team led by Barbara Mazzolai has created a soft, biodegradable, and soluble velcro that mimics the micro-hook structure of leaves on the 'catchweed' plant, enabling devices for environmental monitoring and precision farming. The technology reduces pesticide use and promotes sustainable agriculture practices.
Researchers developed a method to directly grow high-quality graphene on wafer-scale insulators without transfer, achieving improved electrical performance and carrier mobility. The approach utilizes copper acetate to supply copper clusters, enhancing precursor decomposition and resulting in robust graphene films.
A new study in mice reveals that the insular cortex plays a crucial role in balancing fear responses, integrating sensory and bodily signals to maintain an adaptive range. The InsCtx function depends on bodily feedback signals, dampening excessive fear-evoked activity and promoting healthy fear regulation.