The partnership aims to co-develop and evaluate next-generation self-amplifying RNA (saRNA) vaccines targeting seasonal and pandemic influenza. Apriori's Octavia platform will be combined with A*STAR IDL's saRNA delivery technology to develop improved H5 influenza vaccines that anticipate infection in humans.
Research reveals that miR-378 acts as a metabolic-state-dependent switch controlling liver autophagy and lipid balance. Under short-term fasting, miR-378 promotes lipid clearance by suppressing its target gene MAFG, while during prolonged fasting or high-fat feeding, it increases bile acid synthesis leading to fat accumulation.
Researchers found that Sirt6 mimics the effects of calorie restriction by fine-tuning H2S production, boosting it when needed but preventing overproduction. This precise control helps maintain the body's natural balance during healthy aging.
The study presents a comprehensive approach to next-generation icephobic technologies, achieving real-time anti-icing on horizontal substrates under sunlight. The self-draining slippery surface (SDSS) converts sunlight into heat and electrostatic repulsion, eliminating external energy input and reducing re-freezing risk.
A mouse study by University of California, Riverside scientists suggests microplastic exposure may accelerate the development of atherosclerosis in males. The study found microplastics dramatically worsened plaque buildup in male mice, but not females.
A Mayo Clinic study found that nearly 90% of people with the inherited condition familial hypercholesterolemia would not have been flagged for standard genetic testing. This condition can cause dangerously high cholesterol and early heart disease, making it highly treatable yet often undiagnosed.
The initiative aims to decipher the basic function of human genomic sequences, enabling personalized diagnosis and therapy. The partnership will analyze genomic regions to identify underlying mechanisms that contribute to disease and uncover potential therapeutic targets.
Hospital accreditation in Brazil has a positive impact on patient safety culture, with accredited hospitals showing stronger openness to communication and incident reporting. However, non-punitive responses to errors and underreporting of incidents remain significant challenges.
Researchers from SK Specialty developed a machine learning framework to predict the GWP of potential alternative materials for etching and cleaning semiconductors. The technique identified key patterns in molecular features related to radiative efficiency and atmospheric lifetime, enabling the prediction of GWP with high accuracy.
A new fabrication method has been developed to create wafer-scale energy storage capacitors with astonishing heating and cooling rates of up to 1,000 °C per second. This 'flash annealing' technique enables the synthesis of high-performance relaxor antiferroelectric films on silicon wafers in just one second.
Studies reveal neurobiological changes in both mothers and fathers that support caregiving. Hormonal shifts and neural adaptations occur to prepare the brain for parenting, yielding insights into clinical practice, perinatal care, and policies supporting parental well-being.
A new AI-based tool proves effective in assessing individual risk in severe cases of community-acquired pneumonia in Intensive Care Units (ICUs), enabling ICU performance evaluation adjusted for patient severity. The Standardized Length of Stay Ratio (SLOSR) shows strong explanatory power with low prediction errors.
Researchers identified miR-21 as a key regulator of bladder cancer growth and spread, highlighting its potential as a therapeutic target and diagnostic biomarker. By inhibiting miR-21, tumor cells lose their ability to multiply and invade tissues, slowing down tumor growth.
A KAIST research team has developed a highly efficient technique to characterize complex multimode quantum operations, which is essential for scalable optical quantum computing and quantum communication technologies. The new 'Multimode Quantum Process Tomography' technique can analyze large-scale operations with less data, representing...
A low-fat vegan diet is associated with a significant reduction in greenhouse gas emissions and cumulative energy demand, mainly due to reduced meat consumption. The study found a 51% reduction in GHGE and CED, equivalent to driving a gas-powered vehicle about 4.3 miles daily.
A new study has discovered that cancer cells use different strategies to move through tight tissue gaps, with fibrosarcoma cells being more flexible and deformable. This flexibility allows them to squeeze through narrow gaps more efficiently, but does not affect the direction of their movement.
Four industry luminaries will discuss the use of AI-driven network architectures, advances in optical technologies for hyperscale datacenters, and laser-based communications between satellites. The talks highlight innovations in hardware solutions to meet increasing performance demands necessary for AI, datacenters and networks.
A new study led by Prof. Maayan Salton and Dr. Tal Schiller found that gestational diabetes alters the placenta's genetic messages, causing hundreds of errors in protein synthesis. The key protein SRSF10 appears to contribute to this process, suggesting a potential therapeutic target for mitigating its effects.
Researchers found that bifidobacterium can boost cancer treatment by regulating the immune system, reducing inflammation, and supporting anti-tumor responses. The probiotic also helps detoxify carcinogens and convert food-based substances into cancer-fighting agents, offering a promising natural ally for cancer prevention and treatment.
A recent study found that weight loss in midlife can aggravate inflammation in the hypothalamus, a brain region regulating appetite and energy balance. This neuroinflammation persists for several weeks before subsiding, raising concerns about its impact on cognitive decline and neurodegenerative diseases.
A nationwide telehealth clinical trial is now open at Ohio State University Wexner Medical Center for adults with advanced or metastatic pancreatic cancer with specific mutations in the fibroblast growth factor receptor (FGFR) gene. The study will test pemigatinib, a smart drug targeting these genetic mutations.
Researchers demonstrated a method to enhance biosynthetic capacity in Saccharomyces cerevisiae by extending cellular lifespan, resulting in increased sclareol production. The strategy combines lifespan engineering with metabolic pathway optimization, showing improved product synthesis and robustness.
Engineers from the University of Rochester's Department of Biomedical Engineering are studying how cells interact mechanically with the extracellular matrix to build tissues and organs. The study aims to shed light on developmental diseases, such as cancer and failed wound healing, which involve distorted principles during development.
Studies reveal potential signs of early disease in the brain, including excitation-inhibition imbalance and impact on suprachiasmatic nucleus connectivity. Experts emphasize the importance of lifestyle choices and tools for protecting brain health and reducing Alzheimer's risk.
The American Society for Radiation Oncology (ASTRO) has published its first clinical guideline on radiation therapy for gastric cancer. The guidelines provide evidence-based recommendations for the role of radiation therapy in multidisciplinary care, including patient selection, integration with systemic therapy and treatment delivery.
The GSK/Fleming Initiative is launching six new research programs to tackle antimicrobial resistance (AMR) using advanced AI. The programs focus on discovering new antibiotics and vaccines for Gram-negative bacteria and fungal infections, with the goal of accelerating development of effective treatments.
Researchers at MIT used CT scans to study 5,000-year-old slag waste from an ancient site in Iran, revealing fine details about structures within the pieces. The technique complements traditional methods of studying ancient artifacts, shedding light on materials used and technological sophistication of early metallurgists.
Scientists used four analytical techniques to assess the composition and likely age of lead in the Jordan codices, finding some pages contaminated by environmental interactions. The study suggests that while some parts may be modern, others show characteristics of older lead.
Dr. Tara O. Henderson is the recipient of the 2026 Norman J. Siegel New Member Outstanding Science Award, recognizing her groundbreaking research and dedication to improving outcomes for children with cancer. She has established a distinguished record as a mentor and educator, shaping the careers of numerous physicians and scientists i...
AI is revolutionizing neuroscience by quickly analyzing vast datasets to identify patterns and mechanisms invisible before. Researchers are now simulating brain functions using AI, enabling faster insights and diagnosis options.
A Japanese research team studied beryllium-7 concentrations in the surface air over Antarctic regions of the Southern Ocean. Their findings showed that variations in beryllium-7 were connected to synoptic-scale disturbances, which also deposit other stratospheric materials onto the Antarctic ice sheet.
Concordia researchers propose a new model for urban development combining key strategies to ensure an environmentally friendly future. By integrating energy, mobility, land use, and social functions, the 15-minute city principle can be applied to create sustainable neighborhoods with reduced carbon emissions.
New research on GLP-1 agonists reveals their impact on brain circuits involved in nausea, thirst, and pleasurable behaviors. The findings suggest potential benefits for treating chronic diseases with overlapping neural mechanisms, including binge eating disorders and addictive disorders.
Simple items like hay feeders and giant rubber activity balls can improve horse behavior and reduce health issues such as ulcers and fragile leg bones. Researchers found that stabled horses displayed increased movement and reduced frustration behaviors when provided with enrichment tools.
A machine learning framework, LifeTracer, has been developed to analyze mass spectrometry data and identify patterns distinguishing abiotic from biotic origins. The framework achieved over 87% accuracy in classifying meteoritic and terrestrial samples, with key predictive features including polycyclic aromatic hydrocarbons.
The University of Liverpool has announced an ambitious plan to establish the UK's flagship AI-driven materials discovery centre, AIM-HI. The centre will focus on areas such as catalysis, materials for net-zero, soft matter, and product formulation, driving innovation in sectors crucial to the UK economy.
A new study found that individuals with a history of major depression showed higher MRI markers associated with neuroinflammation in the VTA, suggesting increased extracellular inflammatory processes. Current depressive symptom severity was associated with distinct microstructural changes indicating different underlying pathophysiologi...
SourceElsevier·JournalBiological Psychiatry Cognitive Neuroscience and Neuroimaging·TypeImaging analysis·DateNov 18, 2025
Scientists are investigating how the brain processes sensory information, develops sensory capabilities, and responds to sensory dysfunctions. New findings include characterizing tickle responses, decoding Mcgurk perception, and showing neural prioritization of speech over music in children.
Researchers at Waseda University have demonstrated a transformative approach for realizing skyrmion logic based on fluidic principles, utilizing the flow behavior of many skyrmions to simplify device operations. This breakthrough enables the development of nanofluidic logic gates with reduced complexity and improved stability.
Researchers at UC Davis have discovered that Cabernet Sauvignon retains molecular marks from its ancestors after 400 years of clonal propagation. The study used advanced genome sequencing to assess the stability of epigenetic modifications, which can influence traits like fruit quality and stress tolerance.
Zap Energy's FuZE-3 device has reached electron pressures of up to 830 MPa, or 1.6 GPa total, in a sheared-flow-stabilized Z pinch, a major milestone on the path to scientific energy gain. The device achieves this high pressure through independent control of plasma acceleration and compression.
Researchers discovered unicellular organisms have more intricate DNA methylation systems than multicellular organisms. This finding opens new possibilities for targeting parasites and developing new drugs against diseases caused by protists.
Researchers at SwRI discovered a security vulnerability in the Signal Level Attenuation Characterization (SLAC) protocol used in electric vehicle-to-grid communications. The team successfully modeled and replicated a machine-in-the-middle attack that could manipulate or halt EV charging processes.
Chronic subdural hematoma (CSDH) is projected to rise significantly due to aging population and increased anticoagulant use, with surgical interventions including twist-drill craniostomy, burr-hole craniostomy, and middle meningeal artery embolization. Emerging strategies like MMAE aim to reduce recurrence rates.
Bairitone Health's anatomic polysomnogram platform uses AI analysis to transform routine sleep studies into a dynamic map of airway behavior. Nidra, authorized by the FDA, treats restless legs syndrome with patented Tonic Motor Activation technology.
The algorithm identifies the minimum set of locations where field studies would guarantee finding the least expensive route, considering problem structure and uncertainty. This method can be applied to broad classes of structured decision-making problems under uncertainty.
A new paper argues that modern life has outpaced human evolution, leading to chronic stress and health issues. The researchers suggest that societies need to rethink their relationship with nature and design healthier environments to mitigate these effects.
MIT engineers have developed an ultrasonic device that vibrates at high frequency to shake out water molecules from a material, recovering clean drinking water in minutes. This design is 45 times more efficient than existing heat-based systems, which can take hours or days.
A state-level incentive program aimed at improving diet in SNAP participants showed no significant increase in fruit and vegetable intake. However, the study found benefits among existing high-fruit-and-vegetable consumers. Enhanced implementation strategies may be needed to maximize public health outcomes.
Research highlights CNDP enzymes as key regulators of metabolic disorders and oncogenic pathways. Genetic polymorphisms and molecular mechanisms revealed, linking CNDP function to energy balance and obesity management. Future studies focus on developing targeted therapies and diagnostic tools.
A recent study published in Obesity found a direct relationship between obesity severity and the likelihood of disease burden in the US population. The researchers discovered that higher BMI levels were associated with increased odds for various cardiometabolic conditions, including diabetes, hypertension, and kidney disease.
A new study has identified three existing medications that could potentially prevent or treat Alzheimer's disease. The shingles vaccine is the most promising candidate, showing a strong safety record and reducing dementia risk by 16%. Repurposing medicines from other conditions offers a quicker and safer route to potential new treatments.
The Duke-NUS Health Innovator Programme (DHIP) will be strengthened by industry partners, guiding teams through innovation pipeline from idea to prototypes. Industry mentors will provide guidance and networking opportunities to cultivate future MedTech talent.
Researchers are developing precision brain imaging to create individualized maps of brain structure and function, which could lead to new insights into treating psychiatric disorders. The findings show that precision mapping can reveal highly interdigitated network patches with conserved motifs in the lateral prefrontal cortex.
A new tool called LEVA allows researchers to precisely arrange and track tiny biological packages called surface-bound extracellular vesicles and particles (EVPs). By studying EVPs' messages, scientists can gain insights into various biological processes, including wound healing, infection, regeneration, and cancer spread.
A study finds that relationships with lower-profile, unelected officials often have a bigger impact on corporations' success in winning government contracts. The research highlights the importance of visibility and transparency in public procurement processes.
A new peer-reviewed study finds that generic environmental information significantly increases participation in take-back programs, while mentioning profit motives decreases it. Convenient return options also play a crucial role in improving program effectiveness.
A new heart monitoring system featuring dry 3D-printed electrodes and AI software can diagnose up to 10 types of arrhythmias, reducing testing time and medical waste. The system's reusable design improves patient comfort and compliance during long-term monitoring.
Researchers at Martin Luther University Halle-Wittenberg develop PROTAC molecule MA203, specifically binding to tumor protein CHK1, leading to its breakdown in cancer cells. This triggers a chain reaction destroying other tumor proteins, ultimately killing the cancer cells.
Researchers studied fungal communities on highbush blueberry plants from buds to ripe fruits, revealing a core microbiome with beneficial and pathogenic members. The study highlights the importance of understanding plant development's impact on phyllosphere microbiomes for improving disease management and reducing fungicide reliance.