Researchers found that FDA decisions were based on safety considerations, with limited instances of political intervention. The agency acted cautiously, incrementally, and with a commitment to well-grounded scientific evidence.
A new study by the University of Tennessee shows that virus infection of cyanobacteria releases nutrients, fueling microbial growth and contributing to enhanced oxygen levels in the ocean. The findings suggest a direct link between viral activity and ecosystem functioning below the surface.
Researchers from The University of Osaka discovered that loss of heterochromatin can trigger genetic changes leading to chromosomal rearrangements and diseases like cancer. Accumulation of R-loops at pericentromeric repeats was found to be a key mechanism in this process.
Mars plays a measurable role in shaping Earth's long-term climate patterns, including ice ages, through its gravitational influence and orbital cycles. The study suggests that Mars' presence is necessary for the existence of major climate cycles, which have driven evolutionary changes on Earth.
A large-scale field trial in Ethiopia found no significant difference between fluorometholone and placebo treatments in reducing postoperative trachomatous trichiasis recurrence. The study, which involved over 2,400 participants, suggests that anti-inflammatory therapy may not be beneficial for improving TT surgery outcomes.
Researchers have found that El Niño and La Niña are driving total water storage extremes globally, with a synchronizing effect on water storage across continents. The study uses gravity data from NASA's GRACE and GRACE Follow-On satellites to track water extremes and their connections.
Researchers describe chemical journey of YCT-529, a non-hormonal male birth control pill, and its promising molecular science behind it. The compound effectively suppresses sperm counts, showing promise as a durable and reversible contraceptive option.
A new long-term prediction tool estimates the risk of dying from prostate cancer by combining PSA levels with factors like family history, race, age, and other health conditions. The tool showed higher accuracy in predicting prostate cancer death over decades compared to existing models.
A study of over 1.1 million people in England found that most COVID-19 vaccine hesitancy is addressable and can be reduced over time. Among those who initially expressed hesitation, 65% went on to get vaccinated at least once, highlighting the potential for targeted messaging and information to improve vaccine uptake.
A new Stanford-led analysis found that companies undercount emissions from their supply chains by billions of tons due to the use of single-region U.S. models. This can lead to missed opportunities to reduce emissions and associated costs by sourcing goods from countries with cleaner grids.
A new protocol models alcoholism in mice and shows that stimulating the FGF21-oxytocin-dopamine system with rare sugars can reduce alcohol consumption. The researchers believe that this system may play a role in regulating subconscious information processing, leading to effective dietary therapy for reducing over-drinking.
A new global study finds that nearly half of livestock production occurs in areas with destocking, a process that poses new ecological and land management challenges. Destocking can increase wildfire risk and biodiversity decline, but also enables ecosystems to capture more atmospheric carbon dioxide.
Researchers at Georgia State University found that segmented filamentous bacteria (SFB) provide marked protection against post-influenza bacterial pneumonia in mice. SFB reprograms alveolar macrophages to resist influenza virus-induced dysfunction, maintaining their defense against respiratory bacterial pathogens.
A study published in PNAS found that over 60% of pairs of damaging genetic variants can restore enzyme activity when combined, challenging long-held assumptions about genetics. This phenomenon, known as intragenic complementation, has implications for rare disease diagnosis and treatment.
Researchers use AI-driven target discovery platform to identify PRPF19 and MAPK9 as promising targets that suppress tumor cell proliferation while reducing senescence-associated signaling. The study suggests these dual-purpose targets may address both hepatocellular carcinoma progression and cellular senescence.
Researchers at UC San Diego have discovered a previously unrecognized treatment target for triple-negative breast cancer (TNBC). Disrupting the activity of PUF60 causes widespread errors in gene processing, resulting in DNA damage and tumor cell death.
New research simulates 10,000 years of seismic activity to show how underground temperature and sediment patterns control where earthquakes start, spread, and stop. This study provides a more accurate picture of the Main Marmara Fault's behavior, essential for building codes, emergency planning, and infrastructure decisions.
Ruth Harris has made outstanding contributions to the Seismological Society of America through her drive to create student presentation awards and support open access options. Her active participation in numerous committees has benefited nearly every SSA committee.
A new study found that silky sharks spent less than half their time within the Galapagos Marine Reserve despite its designation as a haven. The species' tendency to migrate towards unprotected waters poses a significant threat to their survival, emphasizing the need for expanded MPAs and improved fisheries management.
The Paulson Family Foundation has donated an additional $19 million to Hebrew University, bringing the total support to $46 million. The donation will be used for a state-of-the-art research and teaching complex supporting STEM disciplines critical to Israel's high-tech future.
A new framework, called Humane Intelligence, aims to make AI in older-adult mental health care safer and more human. The framework has four pillars and a Moral Grid Operational Index to guide clinicians and health systems. It emphasizes relational intelligence, transparency, reciprocity, and ethical governance.
A new study reveals that people with an unexpectedly high metabolic BMI have up to a five times higher risk level for diseases such as diabetes and fatty liver. Metabolic BMI is based on advanced metabolomic analyses and identifies obesity-linked changes in metabolism that can be present even at normal weight.
From 2022 to 2025, US counties saw a population-level decline in child poverty rates overall. However, Black and Hispanic children continued to experience disproportionately higher poverty rates compared to white children.
A new study reveals a significant association between police-related stress and physical markers of cardiovascular health risk in Black women. Women who expressed concern for their children's potential interactions with police had thicker carotid artery walls, indicating increased cardiovascular risk.
Researchers identified altered gene expression in smokers with periodontitis, leading to weakened gum epithelial integrity and excessive inflammation. A new target molecule, CXCL12, was found to drive immune-cell recruitment and inflammation, making it a potential therapeutic approach.
The EU-funded Trees4Adapt project aims to strengthen Europe's adaptation and resilience to climate change through tree-based solutions. By combining cutting-edge research with practical applications, the project will help policymakers make informed choices and inform EU policies.
The FDA's regulation of mifepristone involves characterizing its decision-making process and rationale for key components. The agency's approach has evolved over time, with notable changes to its regulatory framework.
A new study reveals that childhood exposure to indoor air pollution from solid fuels may impair brain health and cognitive abilities throughout life. The research analysed data from over 7,000 Chinese adults aged 45 and above, showing a significant association between early-life exposure and poorer cognitive performance in adulthood.
Research found that extreme summer heat can overwhelm honey bees' cooling systems, causing significant colony population declines. Larger colonies with more stable internal temperatures were less affected, highlighting the need for effective management strategies to mitigate impacts of high temperatures and maintain colony stability.
The Arabian Gulf's mangroves are vulnerable to development, pollution, and climate change, with a projected 45% decline in coverage over the next 50 years. Conservation efforts have shown promise, but more needs to be done to preserve these salt-tolerant coastal forests.
Research finds that nearly one in four Medicare beneficiaries with dementia are prescribed potentially harmful medications linked to falls, confusion, and hospitalization. Despite declines in prescribing rates, high levels of inappropriate prescribing persist among older adults with cognitive impairment.
Kevin Milner, a research geophysicist at the USGS Geologic Hazards Science Center, has been awarded the Seismological Society of America's Charles F. Richter Early Career Award for his innovative work in seismic hazard analysis modeling and earthquake forecasting.
A new study by CNIO has identified two genes in the complement system that increase the risk of pancreatic ductal adenocarcinoma. These genes, FCN1 and PLAT, may serve as biomarkers for screening high-risk populations.
Scientists create designer enzymes in yeast cells, enabling sustainable production of industrially important fatty acids. The new method reduces environmental issues associated with palm oil extraction.
Adolescents bullied or engaging in bullying face lasting mental, physical and social challenges. The study identified socioeconomic disadvantages, race, physical differences, and pre-existing health conditions as risk factors for bullying.
Researchers discovered a previously unknown interplay between wheat's resistance genes and fungal disease factors. The study found that powdery mildew fungus overcomes resistance by modifying recognized effectors, but a new approach could slow down its development by combining targeted resistance genes.
A cohort study of students in grades 4-12 found that social media use varied by age and sex, with heavy use linked to poorer well-being. The study's findings suggest that abstinence from social media may not always be beneficial for adolescents.
A comprehensive study reveals that urbanization significantly amplifies lake warming, threatening freshwater ecosystems. The research highlights the role of urban heat island effect and altered hydrological processes in driving accelerated warming.
New research from Aalto University clarifies the link between autonomy and well-being, finding it universally important but stronger in wealthier, more individualistic nations. The study suggests that policy-makers should focus on boosting autonomy in richer countries to improve overall well-being.
Researchers at The Lundquist Institute have identified PTRH2 as a critical gene that protects the maternal heart during pregnancy, shedding light on the causes of peripartum cardiomyopathy. Loss of this gene leads to severe postpartum heart failure, highlighting the urgent need for better treatments.
Scientists reveal that slow orbital wobbles, known as precession cycles, generate abrupt millennial-scale climate fluctuations even under ice-free conditions. The study provides a new clue for understanding rapid climate swings and offers insights for future warming scenarios.
A Mass General Brigham study identifies new mutations that emerge in tumor cells following treatment, driving resistance in patients with different types of cancer. The researchers found two main categories of mutations: those impairing p53 function and others disrupting drug binding, highlighting a path forward for overcoming resistance.
Researchers at Cornell University have developed a new technique to create digital images of cloth that more accurately captures the texture of textiles. The method models how light interacts with yarns, both as it passes through and reflects off the fabric, enabling more realistic renderings for the gaming and animation industry.
A joint study by Bar-Ilan University and Sheba Medical Center found that symptoms of post-traumatic stress, anxiety, and depression remain common among childhood cancer survivors and their parents more than a year after treatment completion. The study highlights the need for long-term follow-up care that includes assessment of psycholo...
Researchers analyzed national data and found Black children were more likely to be investigated and placed out-of-home than white children, even when economic profiles were similar. The study suggests racial bias, specifically anti-Black racism, is a key factor driving these outcomes.
Researchers tested large-scale roofing assemblies with mounted PV solar panels, exposing the leading edge to flame and crosswind to understand fire hazards. The study aims to update building codes and fire mitigation protocols for commercial and industrial solar panel installations.
A new consensus classifier for pancreatic cancer has been developed, enabling accurate determination of tumor subtypes and informing treatment choices. The tool also identifies risk factors for the disease, including smoking, which may be more significant in certain subtypes.
Researchers have uncovered the critical function of occludin in regulating cell barriers, particularly in diabetic retinopathy. The study revealed that occludin's alternative splicing produces a form of occludin that controls leaky blood vessels and excessive vessel growth.
Researchers developed a lab-grown model of the prostate gland to study bacterial infections. They found that E. coli targets specific cells and uses a 'lock and key' principle to invade. A sugar molecule called D-mannose blocks this interaction, offering a potential new strategy to prevent and treat prostate infections.
A machine-learning-based approach has been developed to map real-time tumor metabolism in brain cancer patients, helping doctors discover effective treatment strategies. The digital twin uses patient data to calculate metabolic flux, predicting which treatments are likely to work for individual cases of glioma.
Scientists have created a novel form of water that exhibits structural diversity similar to solid ice, revealing new properties under extreme conditions. The discovery provides valuable constraints for improved models of ice giants and their interiors.
Sandia's economic impact reached a record high of $5.2 billion in 2025, more than doubling its economic impact from 12 years ago. The laboratory's workforce of 16,000 people drove this growth through pay raises and high-paying jobs.
Aggressive triple-negative breast cancer fine-tunes its protein production through a previously unknown mechanism discovered by Umea University researchers. The study reveals that fibrillarin collaborates with RPS28 to create specialized ribosomes, leading to imbalance in protein production and driving cancer development.
Researchers discovered genes that regulate fibroblast growth, which builds the scaffolding between cells. Adjusting these factors reversed age-related changes and improved health outcomes in mice. The study offers new opportunities to understand and reverse aging-related diseases.
Researchers have discovered that feline infectious peritonitis virus infects a broader range of immune cells, including B lymphocytes and T lymphocytes. The findings suggest that the virus can persist in these cells even after treatment, potentially leading to long-term immune problems.
Researchers at KAIST developed a new near-planar light outcoupling structure and OLED design method to significantly reduce light loss in OLED devices. This enables brighter displays with the same power consumption, extending battery life and reducing heat generation in mobile devices.
Game theorists propose revising Grand Slam rules to give greater weight to games won, resolving rare but striking fairness problems. In a study of over 50,000 matches, researchers found that game-set discrepancies occur between 3-5% of the time, affecting high-level competition.
A new study demonstrates the effectiveness of a widely-used eye injection in managing hypotony, a rare condition characterized by abnormally low eye pressure. The treatment, which involves injecting HPMC gel, has shown promising results in restoring vision and increasing eye pressure.
University of Florida researchers have identified a new potential target for treating methamphetamine addiction by modulating the immune system. Using immune-modulating medicines, they were able to mitigate the effects of TNF and dopamine release in mouse brain specimens.
Scientists have developed a refined X-ray diffraction technique that allows for the simultaneous analysis of materials on scales from nanometres to millimetres, enabling detailed studies of complex tissue and bone diseases. This method has been successfully applied to reveal the alignment of collagen fibres in a human ossicle, providin...