A global assessment found that only 63.3% of lakes worldwide meet good water quality standards, exposing nearly half of the world's population to potential health risks associated with freshwater security. Strong regional disparities were observed, with Europe and North America faring better than Asia, South America, and Africa.
Researchers propose a four-stage pathway to evaluate AI for intracranial aneurysm detection, including lesion-level testing, reader performance evaluation, and surveillance after deployment. The framework aims to assess the tool's net clinical benefit in specific care settings.
Researchers have discovered that Leishmania parasites do not move through their hosts' bodies on their own, but instead embed themselves in phagocytes and manipulate immune cell migration. This manipulation is species-specific and depends on variations in individual genes.
Researchers found that molecules in tiny gaps between gold nanoparticles can synchronize their behavior even with light escaping quickly. The study could lead to new ways to build synchronized states of matter like superfluids and potentially advance sensing, photonics, and quantum devices.
A new set of recommendations provides clinicians with evidence-based guidance on discussing smoking cessation, including the use of nicotine e-cigarettes as a treatment option. The authors emphasize that the best approach will vary from person to person and should be tailored to each patient's goals, preferences, and medical needs.
A phase 2 clinical trial found that combining two immunotherapies with standard chemotherapy prior to surgery improved pathologic complete response rates in high-risk, early-stage HER2-negative breast cancer patients. The regimen demonstrated strong activity among patients with ImPrint-positive tumors, including high pCR rates.
The American Meteorological Society recognizes individuals and organizations making a positive difference in the world through fundamental research, public engagement, teaching, and informed decision-making. This year's honorees include Rong Fu, Paola Cessi, Sharon Nicholson, Renhe Zhang, Christian Kummerow, and David Thompson.
Two studies led by Montserrat Anguera investigate the process of X chromosome inactivation in immune cells and link impaired XCI maintenance to lupus-like disease. Impaired X chromosome inactivation in B cells has been linked to lupus, offering a novel pathogenic mechanism that accounts for the strong female sex bias of SLE.
A new Perspective in Nature Sustainability proposes industry-specific net-zero blueprints to ensure corporate climate action is grounded in science. The plan aims to provide a common scientific foundation for companies to set targets and track progress, reducing the reliance on carbon credit markets and planetary limits.
A large-scale study found that even when people are exposed to less social media misinformation, their political beliefs don't change much. Researchers tested what happened when participants saw far less content from untrustworthy sources and found no measurable changes in attitudes.
Binghamton University researchers have uncovered a novel mechanism that enables the creation of two chemical changes in a single step. This breakthrough could significantly shorten the route to target molecules for pharmaceutical research.
A study found that ALS rates are higher among men who served in the US Air Force compared to Army veterans. Marine veterans had lower rates of ALS, while officers experienced more psychosocial stress, which may contribute to the increased risk.
A collaborative research group has developed an atom-holography microscope that can directly visualize three-dimensional atomic arrangements in nanoscale regions using electron-beam excitation. This breakthrough enables element-specific analysis of three-dimensional atomic structures without the need for synchrotron radiation.
Researchers found that attention networks play a crucial role in communication difficulties in children with autism, affecting verbal and non-verbal communication. Weaker connections in the Dorsal Attention Network and Salience Network led to greater difficulties with understanding gestures, facial expressions, and social signals.
Researchers identify a previously unknown mechanism linking dysfunctional mitochondria and epigenetic machinery to chronic inflammation in aging cells. The discovery reveals how senescent cells drive inflammation by switching on inflammatory genes through metabolic signals from mitochondria.
A survey of over 6,000 women aged 50+ found they value quality of life over adding extra years to their lives. Men, on the other hand, are more likely to prioritize living longer and leaving healthcare decisions to medical professionals.
The Cornell researchers have created a 'microwave brain' microchip capable of encoding information into its own language, which enables fast and secure communication. The device uses microwave token embeddings to compress data, reducing bandwidth and energy consumption.
A new holistic scoring system for dietary protein evaluates environmental impact, health, affordability, and availability. The analysis found plant-based foods dominate the highest-scoring quintile while animal-based products are in the lowest-scoring group.
Kessler Foundation has been named one of the 2026 Best Places to Work for Women, highlighting its commitment to fostering an inclusive environment where women can grow professionally and thrive as leaders. The organization's mission-driven culture values diversity and invests in the success of all employees.
Researchers at DGIST identified a novel molecular mechanism regulating the N-type voltage-gated calcium channel, which plays a critical role in neural signal transmission. This discovery provides an important clue for developing therapeutics for brain disorders such as neuropathic pain, epilepsy, and Alzheimer's disease.
A UMBC researcher is exploring the effects of two key HIV prevention drugs in colon tissue, seeking to understand why they work better for some people than others. The study aims to provide knowledge that could lead to better dosing strategies and improved formulations, making PrEP more effective.
Rice University professor develops inexpensive process for thiophosphate synthesis, reducing the cost of phosphorylation by up to 90%. This breakthrough opens new avenues for drug design and could lead to more efficient production of genetically targeted therapies.
A recent study found that a higher body fat percentage is linked to lower sperm counts and changes in male reproductive hormones. Men with high body fat percentages had lower semen volume, sperm concentration, and testosterone levels compared to those with normal body fat percentages.
Researchers found specific combinations of blood proteins from western diamondback rattlesnakes provided unprecedented neutralizing power against multiple dangerous snake species. Combining several FETUA proteins dramatically increased ability to neutralize venom's damaging effects.
Ectopic pregnancy hospital admissions have been increasing in England since 2021, with significant disparities between deprived and non-deprived areas. The study highlights the need for an equity-focused approach to address preventable inequalities in health and access to care.
A study published in the Journal of Clinical Oncology found that combining atezolizumab with modified FOLFOX6 chemotherapy and bevacizumab improved progression-free survival by 58% for patients with metastatic dMMR colorectal cancer. The combination also showed higher response rates and reduced primary disease progression.
Researchers at Penn State will use the funding to develop new tools for investigating the genetics underpinning relationships between mosquitoes and various microbes. The projects aim to improve scientific understanding of mosquito-borne pathogens and eventually enable new discoveries that could help inhibit disease spread.
Chika C. Okafor, a University of Tennessee Veterinary Public Health faculty member, has been named president-elect of the American College of Veterinary Preventive Medicine (ACVPM) Epidemiology Specialty. He will help lead the national specialty in Veterinary Epidemiology before assuming the presidency in 2027.
A new review published in Addiction found that controlled breathing interventions can reduce cravings in people who use substances, including alcohol and tobacco. The strongest evidence showed small but statistically significant reductions in craving.
Researchers have created microscopic oil droplets in water that can change shape in complex ways and engulf their surroundings. The droplets' behavior mimics morphogenesis, a process by which cells reshape themselves, without relying on genes or cellular machinery.
Researchers at the University of Queensland have developed ultra-wideband radar sensors to measure muscle forces in a non-invasive way. This technology has the potential to improve rehabilitation, injury prevention, and recovery for people with motor neuron disease or aging. The goal is to eventually use real-time sensor data to assist...
Researchers discovered a new mechanism by which leiomodin builds actin filaments in muscles, challenging a long-standing paradigm. This breakthrough may lead to therapies for dilated cardiomyopathy and other muscle diseases.
An international clinical trial has shown that a once-weekly oral treatment for HIV is non-inferior to one of today's leading daily therapies. The Phase 3 ISLEND-1 trial evaluated a tablet combining islatravir and lenacapavir in adults with well-controlled HIV, demonstrating over 93% viral suppression in both groups.
The University of Phoenix survey found that 60% of working learners who use AI in the workplace report improved knowledge of accessibility standards, with nearly 1 in 5 experiencing significant improvement. The survey also highlights the need for clearer organizational guidance on accessibility, with 45% of respondents unsure if it is ...
Research suggests that an overactive immune response in the brain may play a role in Dravet Syndrome, leading to frequent seizures and developmental challenges. Blocking an inflammatory pathway called cGAS-STING-interferon signaling could lead to new therapeutic strategies for epilepsy disorders.
Researchers at Hebrew University of Jerusalem identify previously unknown law of geometry that explains why growing surfaces suddenly develop complex patterns. The discovery could reshape understanding of natural structures and guide design of shape-changing materials.
A Phase III clinical trial has demonstrated that a new cell therapy called deramiocel can slow the weakening of skeletal muscles by 54% and preserve heart function, slowing progression of cardiomyopathy. The therapy, based on Marbán's discoveries, takes a different approach from other treatments for Duchenne muscular dystrophy.
A systematic review of 47 randomized trials found that oral antihistamines do not improve eczema symptoms and may cause harm. Alternative treatments like moisturizers, topical anti-inflammatory treatments, and whole-body treatments like phototherapy and biologics are recommended.
Researchers found that nanosecond laser-driven proton FLASH radiotherapy effectively kills cancer cells while minimizing damage to normal cells. The study showed that this new irradiation method preserves mitochondrial structure and function, reducing ferroptosis and stress responses in healthy tissues.
A new study published in The Journal of Archaeological Science: Reports sheds light on longstanding relationships between humans and sea turtles in the Southern Caribbean. The research reveals details of interactions between humans and turtles dating back 1,000-years and provides information needed to protect populations going forward.
Researchers developed a low-noise magnetic sensor that improves weak-field detection, leveraging spin-texture dynamics to break the sensitivity–noise limitation. The anomalous Hall magnetic sensor achieved a magnetic-field detectivity of 15.7 nT/√Hz at 1 Hz, nearly one order of magnitude better than conventional ferromagnetic materials.
Researchers found that Bofutsushosan reduced fibrosis in fat tissue and liver of mice with obesity, and identified herbal components with anti-fibrotic activity. The study suggests that Bofutsushosan may have benefits beyond weight control, providing a scientific basis for studying Kampo medicines.
Alison Derbenwick Miller brings extensive executive leadership experience to ACM, with a focus on research, education, and global partnerships. As CEO, she aims to strengthen ACM's role in advancing computing, promoting technical excellence, and supporting member growth.
The research team created 'OpenABE' base editors, which precisely edit both nuclear and mitochondrial genes while reducing off-target effects. This breakthrough enables safer treatment of genetic diseases.
Researchers discovered a signaling pathway activated by acidic tumor environments that drives resistance to PARP inhibitors. Blocking the pathway resensitizes tumors, suggesting a potential new therapeutic strategy for overcoming acquired resistance.
A new database maps building-level landslide risk for the entire US, revealing that 6.5 million people live in landslide-prone regions. The analysis shows an urban-rural divide in landslide susceptibility, with rural areas facing greater economic constraints and limited resources.
Researchers developed a highly crystalline three-dimensional graphitic carbon tube grid that improves filtering supercapacitor performance, offering potential for compact and efficient electronic devices. The new material shows faster coupled electron and ion transport and strong high mass loading capabilities.
The US has launched a new national center to help strengthen its cement and concrete supply chain at a time of rising demand and increasing imports. The ACCENT Center will accelerate the development of advanced materials and manufacturing processes, closing critical gaps between laboratory research and field performance.
A review of 47 trials involving 6,230 children and adults found that adding oral antihistamines to existing treatments showed small but clinically unimportant reductions in eczema severity. First-generation antihistamines may also increase cognitive impairment and the risk of stopping treatment due to side effects.
Researchers developed CAMI-2DNet, an AI system that measures a child's ability to imitate simple body movements using ordinary video recordings. This technology brings scalable and objective methods for evaluating motor imitation, a key behavioral marker associated with autism.
A study of over 64,000 people found that those born before and during World War II sugar rationing had a lower risk of developing dementia. Those with lower sugar levels in early life also experienced a delay in dementia development, on average by 2.6 years.
Researchers developed a quantum machine learning framework to predict which tumor mutations will trigger an immune response. The Q-CHIPP model outperformed classical computing methods and achieved a significant technical milestone by scaling to full-length peptide modeling on quantum hardware.
Three academic papers from Sage journals published in 2015 have demonstrated enduring influence over the decade, according to the 10-Year Impact Awards. The awards recognize the most-cited articles alongside policy citation data, highlighting research's broader impact on debates and decision-making.
Researchers develop SenMayo gene set to identify senescent cells across different tissues and experimental models. Several studies evaluate approaches to reduce the burden or harmful effects of senescent cells in preclinical models.
A new study reveals that avocado trees alternate between male and female flowers based on a single gene that evolved about 42 million years ago. This genetic mechanism helps prevent self-pollination and inbreeding, allowing avocado breeders to sort seedlings more efficiently.
A new study reveals that global crop models are less sensitive to heat extremes than real-world observations, particularly in the reproductive stages of rice. This discrepancy highlights the need for adaptation measures such as developing heat-tolerant varieties and adjusting planting dates to protect crops from extreme heat.
Researchers found that problematic Internet usage is associated with worse mood, more stress, and longer internet use times. The study suggests that temptation is the main driver for continued internet use, with feelings of pleasure and relief emerging as reinforcing factors.
A team of international researchers has uncovered a unique fossil from China that preserves the digestive system of an ancient marine reptile. The study provides insight into the early adaptations of long-necked marine reptiles to life in the oceans, contradicting previous assumptions about their limited aquatic capabilities.
Players who prefer cooperative, strategic, and story-driven video games are at a higher risk of extreme social withdrawal known as hikikomori. The study suggests that game-based mental health interventions may be beneficial for this population.
Elephants released from human care successfully reintegrate into the wild, exhibiting behaviors comparable to those of their wild neighbors. While some individuals show age- and sex-related differences, overall, rewilded elephants adapt well, with most stress levels within normal ranges.