Black holes have been found to expel a substantial fraction of material consumed by them, creating a powerful cosmic digestive system. This discovery challenges previous assumptions that black holes are efficient eaters.
The DDD Benchmark provides an independent, real-world measure of how a model performs in drug discovery. It comprises two evaluation suites: Drug Discovery Foundations and Drug Candidate Essentials.
Two university-led projects receive $2.96 million to develop next-generation instruments for mid-sized ground-based optical and near-infrared telescopes. The grants aim to improve sensitivity and expand access to key wavelengths, enabling observations of extremely faint astronomical objects.
Researchers developed a new treatment strategy using the cancer medicine Teclistamab to reduce antibodies against potential transplants, improving transplant prospects for patients with unfavorable immunological profiles. The study successfully performed a kidney transplant in a patient who had been on the waiting list for over a decade.
Researchers developed an infrared spectroscopy system that can rapidly detect chemical aerosols from a distance using common surfaces like traffic signs and tree trunks. The method eliminates the need for mirrors, making it practical for real-world applications.
Researchers at École Polytechnique have achieved a breakthrough by creating an all-optical photonic time crystal, allowing for the modulation of light's optical properties on picosecond timescales. This discovery paves the way for ultrafast optical computing and new telecommunication systems.
Illinois researchers have discovered a new type of quantum light emitter in diamonds that could help overcome challenges facing quantum technologies. The newly identified IL1 center emits bright and narrowband quantum light while remaining insensitive to crystal vibrations, which is a significant obstacle for existing quantum systems.
Mexico served as a long-term evolutionary hub where North American species adapted and diversified for millions of years before migrating to South America during the Great American Biotic Interchange. The findings suggest that prolonged diversification in Mexico contributed to the eventual prevalence of North American mammals in South ...
Researchers have developed a new biological treatment that targets inflammation-driven scarring after a heart attack, aiming to reduce the risk of heart failure. The treatment uses donated human bone marrow-produced exosomes to dampen inflammation and promote healing.
A study by Bar-Ilan University researchers found that learning is driven primarily by changes in the strength of existing neural connections. The models became significantly better at learning as the amount of training data increased, but the proportion of lost connections remained roughly the same.
A multidisciplinary team of Penn researchers has developed a platform that delivers a combination of cancer-fighting therapies to treat oral squamous cell carcinoma. The findings show that the platform significantly reduces tumor burden and extends survival in aggressive, p53-therapy-resistant cancer models.
Researchers developed an open-source tool RIME-X to generate regional climate and impact projections while capturing uncertainties. The new method combines simple climate models with regional information from multi-model climate and impact model ensembles, producing scenario- and time-dependent probability distributions.
Recurrent mutations in chromatin remodeling genes, such as PBRM1, BAP1, and SETD2, are associated with impaired DNA damage repair and altered tumor immune microenvironments. These genetic alterations can lead to synthetic lethality and influence treatment response.
A new study found that fructose increases the spread of aggressive ovarian cancer by suppressing cholesterol production in neighboring cells. This discovery raises the possibility that simple dietary changes could influence cancer progression and potentially lead to new treatment strategies.
Biochar researchers explore how changing reactor atmospheres can tailor materials for carbon storage, pollution control, and industrial applications. Alternative gases like CO2, steam, and ammonia can shape the production process and resulting materials.
Scientists at NYU have identified a key regulator controlling nitrogen use in plants, which can be harnessed to develop 'gluttonous' plant varieties that absorb more nitrogen from the soil. This discovery could lead to reduced fertilizer application and lower greenhouse gas emissions.
Researchers found that bees' habits don't match current organic certification guidelines, which require a 6.4 kilometer buffer zone for foraging. The study suggests that revised standards could allow US producers to meet USDA organic certification requirements with pesticide contamination levels comparable to imported honeys.
Researchers have discovered that tumor-educated pericytes drive alternative angiogenic pathways, bypassing VEGF inhibition and making them a major contributor to drug resistance. A novel therapeutic strategy targeting both endothelial cells and pericytes has shown superior anti-angiogenic effects in multiple cancer models.
A study at USC discovers a common genetic variant in Indigenous American populations that silences the microprotein MENTSH, restoring it improves insulin signaling and blocks diet-induced weight gain. MENTSH-based therapies could offer a precision-medicine approach to Type 2 diabetes.
The University of Cologne has been awarded €1 million in EU funding to support six EUniWell study programmes in their efforts to meet the criteria for the Joint European Degree Label. The project, PATH_ED, will focus on making necessary adjustments to curricula and governance structures.
Researchers developed a framework to optimize energy management in recirculating aquaculture systems (RAS) by coordinating equipment operation with renewable generation. The study demonstrated substantial reductions in electricity consumption and CO₂ emissions while maintaining fish safety, using dissolved oxygen as a key process state.
Researchers have identified a new type of brain plaque, called mitochondrial plaques, that may emerge at the earliest stages of Alzheimer's disease. These plaques contain high levels of amyloid precursor protein and can directly affect neurons, making them a potential target for new treatments.
Wearable sensors can track dynamic changes in uric acid levels, providing valuable information for assessing healing progress and adjusting treatment plans. Researchers have improved the accuracy and reliability of these sensors using new materials and technologies.
Researchers connected visible stress responses to genetic and physiological changes in plants, identifying a conserved stress signaling mechanism. A protein called DUS2 was found to regulate photosynthesis under stress by modifying RNA transcripts.
A pilot clinical trial of psilocybin-assisted therapy in veterans with severe PTSD found that 75% of participants were in remission one month after treatment, with no serious adverse events reported. The results suggest the protocol may be a game-changer for those struggling with treatment-resistant PTSD.
Researchers at University of Witwatersrand have discovered that quantum information can be kept intact even when transmitted through turbulent environments. This breakthrough enables the use of twisted light to create high-capacity communication networks and ultra-resilient quantum computers.
Scientists discovered a 100-million-year-old beetle fossil that reveals early evolution of firefly sensory and signaling systems. The fossil preserves elaborate antennae and light-emitting organs, suggesting that lampyroid beetles relied heavily on pheromonal cues for mate searching.
Researchers at University of Oxford have invented a novel potassium fluoride-based Appel fluorination method that converts alcohols into alkyl halides, including fluorides. The new technology uses simple and inexpensive fluoride sources, minimizes waste, and recycles catalysts and by-products.
The vascular system plays a critical role in mediating muscle-bone interactions, influencing both their development and health. Therapeutic strategies targeting the vascular-musculoskeletal axis hold promise for preventing and treating sarcopenia and osteoporosis.
Researchers developed a theoretical framework explaining unusual conduction behavior in magnetic materials. Quantum fluctuations affect electron transport in chiral magnets, leading to logarithmic temperature dependence at low temperatures.
Researchers at IISc have demonstrated a new way of switching materials between two fundamentally different magnetic states using an electric current. This discovery could pave the way for compact, energy-efficient electronic devices that store information and perform logic operations, with potential applications in quantum computing.
New research from Hokkaido University shows that team success or failure strongly influences how individuals learn from their mistakes. When an individual makes an error, they are less likely to correct it if their team succeeds, but more likely to adjust their behavior when the team fails.
A study analyzing 1.6 million ICE arrests found that only 34% of those arrested had a criminal conviction, with the majority having no record. Increased enforcement did not translate to more arrests of previously convicted criminals.
Researchers at Gladstone Institutes have made significant progress in understanding the causes of long COVID, focusing on changes in virus-specific immune cells. Specifically, they found that people with long COVID have distinctive changes in CD8 T cells, which are specialized to protect against specific viruses.
A new study by researchers at Johns Hopkins University highlights a significant disconnect between those who use AI health tools and those who create and fund them. The study reveals that key stakeholders have fundamentally different definitions of value, usability, and cost, creating systemic barriers to technology adoption.
A cross-sectional study examines trends in US FDA-approved cancer medicines for adult solid tumors between 2006 and 2025. The analysis reveals significant increases in approvals, particularly for original indication approvals.
New research from Memorial Sloan Kettering Cancer Center sheds light on leukemia resistance to promising new drugs and the role of bone hardness in the immune battle against metastasis. A telehealth tobacco treatment program also shows promise in helping cancer patients quit smoking.
Researchers have identified a natural protective protein called BMP3 that helps maintain healthy lung blood vessels. Increasing BMP3 levels in preclinical models of pulmonary arterial hypertension reversed key features of the disease, including damaged blood vessels and impaired heart function.
Researchers introduce a new metric W² to complement traditional measures of predictive accuracy, revealing hidden patterns of systematic bias in AI models. By combining Q² with a penalty for angular difference from the ideal line, W² provides a more comprehensive evaluation of model reliability.
Research reveals Golgi complex is involved in DNA repair control, regulating protein recruitment and localization to the nucleus. The study suggests a global process of DNA repair coordinated across the cell, with organelles like the Golgi controlling it.
A team of researchers at Rice University has created an electrochemical ion pumping platform that can desalinate wastewater while selectively recovering dissolved metals. The approach uses electrode potential as a programmable control parameter, allowing ions to move continuously through the system.
Scientists used chemical clues in microscopic fossils to find evidence that ocean acidification caused one of the largest extinction events in planktic foraminifera history. The study suggests that volcanic eruptions and rising CO2 levels led to a decrease in shell-building ability, ultimately contributing to the extinction.
A review highlights the role of culturally rooted practices in oral squamous cell carcinoma (OSCC) risk across global populations. Culturally sensitive prevention strategies combining education, harm reduction, and community engagement are crucial in reducing OSCC incidence and disparities. Dermatologists can play a key role in early c...
Pusan National University researchers have successfully developed a hybrid quantum network with indistinguishable quantum sources. The team demonstrated two-photon interference between a warm atomic ensemble and quantum dots, achieving high-visibility two-photon interference without needing spectral or temporal modifications.
Researchers discover that a two-gene supergene and gravity work together to create butterfly lily's unique left- and right-handed flowers. This coordinated arrangement promotes pollen transfer between opposite handedness flowers, maintaining the species' reproductive characteristics.
A study published in Communications Medicine found that early vitrectomy surgery can be more beneficial for patients' vision than the current antibiotic-first approach. After six months, patients who received this treatment showed a median improvement of 40 additional letters they could read compared to those receiving antibiotics.
A team of researchers has discovered a supergene controlling the development of mirror-image flowers in South African butterfly lilies. The study found that two tightly linked genes work together to ensure precise positioning of reproductive organs, promoting genetic diversity and adaptation.
The study argues that managing wildfires requires integrated risk governance systems spanning prevention, preparedness, response, and recovery. CMCC researchers identify the need for cooperation and coordination across sectors and governance levels to build resilience to climate-driven wildfire risk in Europe.
The FLEX Toolkit is a new ADHD toolkit designed specifically for use in UK primary schools. It provides teachers with strategies and regulation tools to support children with ADHD, helping to shift the narrative and promote success and celebration of individual strengths.
Neuroimaging studies reveal that systemic diseases profoundly affect brain structure and function, while brain disorders can influence peripheral organ systems. Cardiovascular diseases, metabolic disorders, autoimmune diseases, and infectious diseases are all associated with characteristic patterns of brain changes.
Traveling patients from restrictive states experience mistrust of online sources, legal concerns, and knowledge gaps regarding remote services. Health policies should address these issues to improve understanding and trust in safe, reliable options.
A nationwide real-world study investigated the incidence of HBV reactivation in Chinese IBD patients receiving infliximab, identifying key risk factors and characterizing outcomes. The study recommends universal HBV screening before biologic therapy initiation and tailored management strategies based on HBV serology and disease activity.
A study of ancient DNA from over 500 mammoth bones found that Ice Age humans selectively targeted female woolly mammoths, unlike the sex ratio among naturally occurring remains. The research sheds light on how ancient humans and mammoths interacted across the Late Pleistocene.
Recent progress in lanthanide carriers is mapped to improve biomedical imaging and diagnosis, combining optical, X-ray, and magnetic resonance imaging techniques. These carriers enable high-resolution imaging with tunability for different applications, reducing tissue damage and enhancing image clarity.
Liquid biopsy targeting viral ctDNA holds promise as a diagnostic and surveillance tool for head and neck cancer. The study aims to monitor treatment response and assess minimal residual disease (MRD) to adapt treatment via precision oncology.
A new report proposes a complementary strategy of increasing potassium intake to reduce blood pressure, alongside reducing sodium intake. The authors conclude that dietary sodium reduction is a foundational strategy, but with new evidence supporting equal emphasis on increasing potassium intake.
Researchers have developed a new technique that pinpoints areas of human DNA inherited from two unknown, ancient ancestors. The study reveals that modern humans interbred with these 'ghost' ancestors and Denisovans in Eurasia around 1.8 million years ago.
Researchers have discovered that oscillatory pressure accelerates densification and inhibits grain growth in Al2O3/TiCp composites, resulting in improved mechanical properties and near-full density. The study integrates sintering kinetics with metal hysteresis theory to elucidate the promoting mechanism of dynamic pressure.
A new wearable sticker system has been developed to simplify diagnostic sweat testing for cystic fibrosis, a genetic disorder affecting digestion and breathing. The innovative technology is reliably accurate and makes the test more accessible beyond specialized centers.
Chandrasekaran, an assistant professor at Boston University School of Medicine, has been recognized with a Faculty Early Career Development Program (CAREER) award. He will receive $400,000 over five years to support his research on multisensory integration and its applications in understanding brain function.