Researchers identified four distinct subtypes of leukemia stem cells, each responding differently to treatments. The study provides new avenues to overcome venetoclax resistance and develop personalized treatment strategies for AML patients.
A comprehensive systematic review and meta-analysis found seductive details have a significant but small negative impact on academic performance, particularly memory and comprehension. The study provides empirical support for Cognitive Load Theory and offers guidance for multimedia instructional design.
Two studies reveal substantial losses of plant diversity, identifying priority species and limits of conservation strategies. Using data from the EDGE2 index and computational modeling, researchers identified species that are both evolutionarily unique and at risk of extinction.
Research on the 2025 Myanmar earthquake reveals that small differences in fault movement over time can build uneven stress, influencing where quakes start and spread. This study challenges the seismic gap hypothesis and suggests a broader shift in understanding earthquake hazard, enabling better quake risk estimates for major faults.
A new Northwestern University study details how NIH built the field of genomics through coordinated scientific efforts, supported workforces, and developed shared research infrastructure. The analysis of NIH's digital archive shows leadership played a crucial role in resolving technical challenges and guiding scientific communities.
A new study finds that early-career scientists are more likely to drive transformative breakthroughs in science, while seasoned researchers focus on integrating and extending existing knowledge. This shift has significant implications for policies governing funding, tenure, collaboration, and scientific talent.
A study by University of Bristol researchers found that forming social connections online boosts networking performance, while reducing engagement with content. Individuals with sharper cognitive abilities are more likely to prioritize social connections over knowledge gathering.
Researchers at Paul Scherrer Institute used high-speed cameras to document the physical processes inside a system on the scale of a nuclear power plant. They found that gases separate in the lower section, and condensation is determined by diffusion, not larger currents. The cooling process is highly dependent on local conditions.
A large-scale study found that forest fuel treatments can prevent significant wildfires by reducing fire severity and spread. Every dollar spent on prevention saves about $3.75, with treatments estimated to have prevented $2.8 billion in damages.
Researchers at Stanford University have successfully combined five metals to form a single, uniform nanocrystal. The discovery could have significant implications for the future of hydrogen fuel and opens a new chapter in the preparation of nanomaterials.
Assistant Professor Gianmarco Mengaldo has been appointed to the Joint Advisory Group on Artificial Intelligence at the World Meteorological Organization. He will guide how AI is integrated into global meteorological and hydrological systems, improving forecasting capabilities and early warning systems.
A real-world cohort study investigates the association between HBV DNA levels and clinical outcomes in patients with cirrhosis. Patients achieving a sustained virological response had lower rates of hepatocellular carcinoma, liver-related death, and progression to decompensation.
A research team has identified two distinct genetic lineages corresponding to low- and high-altitude habitats in Capsella bursa-pastoris. Genome-wide scans detected 54 candidate genes under positive selection, highlighting temperature seasonality and precipitation as key drivers of adaptive divergence.
Researchers developed microneedles containing collagen, hyaluronic acid, and a photo-crosslinkable polymer to improve transdermal delivery. The microneedles' mechanical strength and skin permeation behavior can be modulated with light and temperature.
Researchers explore two popular metaphors for describing climate-related issues: the ocean conveyor belt and tipping point metaphors. While they have scientific origins and helped foster interdisciplinary communications, oversimplification can lead to misunderstanding. Dr. Gerrit Lohmann suggests integrating communication research with...
This study explores the effects of 1,5-anhydroglucitol on acute liver failure and reveals its role in inhibiting the PPARα signaling pathway, leading to increased hepatocyte apoptosis. Empagliflozin treatment alleviates liver injury by reducing 1,5AG levels and promoting the PPARα pathway.
A new study analyzes three scenarios for green hydrogen production and trade, highlighting the need for policymakers and businesses to address uncertainties in global supply chains. The Fuel Switch scenario assumes stable alliances, but may misdirect investment; Industrial Relocation shifts production to low-cost regions with abundant ...
The Muon g-2 collaboration has made a significant contribution to the measurement of the muon's anomalous magnetic moment, achieving a precision of 127 parts per billion. The team's international collaboration and innovative methods have enabled them to explore subtle wobbles in the subatomic particle.
Researchers found that mid-Holocene soil cooling reduced thermally suitable zones for millet cultivation, contributing to a southward displacement of farming. Soil temperatures recovered after around 6,000 years ago, facilitating millet expansion and late Neolithic development.
New research from the University of Surrey found that Brexit-related events significantly increased volatility spillovers between European markets. The analysis shows that large financial markets tend to transmit volatility to smaller ones, with France emerging as the most persistent transmitter of volatility across the EU.
Researchers develop novel inverse phase enhancement strategy for fabricating graphene paper composites, achieving record-high thermal conductivity of 802 W/m·K. The minimal polymer loading enhances tensile strength by 117% while preserving the highly ordered crystalline structure necessary for efficient heat transfer.
A national UK study found that nearly half of untested breast and ovarian cancer patients carry a heritable genetic variant increasing cancer risk. The study reveals the potential benefits of efficient genetic testing to identify at-risk individuals and inform targeted follow-up care.
Nerve-sparing surgery aims to preserve the neurovascular bundles responsible for erectile function and urinary continence. The review discusses three primary fascial dissection planes, antegrade and retrograde dissection strategies, and innovative techniques such as Veil of Aphrodite and biological membrane wraps.
Researchers developed a novel ratiometric SERS platform using dual bioprobes for stable detection of circulating tumor cells (CTCs). The platform achieved a low limit of detection, minimal relative standard deviation, and high cell viability, offering a new strategy for sensitive CTC detection.
Researchers describe how oral nanomaterial formulations overcome conventional drug limitations in gastrointestinal disease treatment. Non-metallic nanomaterials, such as selenium nanoparticles, show better biocompatibility and tunable biodegradability.
A new study warns that climate change is creating serious risks for millions of pilgrims performing Hajj, with extreme heat and humidity pushing human physiological limits. The researchers suggest that urgent adaptation and global climate mitigation are essential to reduce the danger, but not eliminate it.
A Canadian study found that seasonal COVID-19 vaccination significantly reduced the risk of illness in 2025/26, with vaccine protection extending beyond its target strain. The vaccine was particularly beneficial for people aged 65 or older, offering 53% effectiveness against severe COVID-19.
Researchers identify genetic syndrome where unusually long telomeres predispose individuals to lymphoma and other cancers. Inherited loss-of-function mutations in the POT1 gene disrupt normal aging of lymphocytes, allowing cancer-associated changes to accumulate over time.
Researchers developed an AI model that learns from real-world match data to optimize attacking play against compact defensive structures. The framework models each attacking player as an individual decision-maker while capturing how players interact as a coordinated unit.
The study found that personalized virtual try-on significantly enhances product imagination, making consumers feel more confident about their choices. However, the effects were stronger among consumers with lower spatial processing perception, highlighting a key moderating factor.
An international team, led by Göttingen University, investigates how molecular crowding influences enzyme working efficiencies and signalling pathways within cells. The project aims to understand the role of cytoplasm's physical properties in controlling chemical reaction rates.
Researchers found that DNA helicase HELQ promotes replication fork reversal to protect cells from toxic DNA crosslinks. This process enables stalled replication forks to reverse and stabilize, minimizing mutations and cell death. The study identifies HELQ as a critical regulator of genome integrity under replication stress.
A new type of concrete made from sugarcane waste shows improved mechanical performance and reduced carbon emissions. The study finds that replacing fly ash with sugarcane bagasse ash improves compressive strength by 41% and reduces CO2 emissions by 25-30%.
The study identified a critical boron transporter gene, BnaC3.BOR1, which regulates boron distribution and tissue-level homeostasis in Brassica napus L. Null mutants exhibited heightened sensitivity to boron deprivation, leading to stunted growth and yield loss.
Researchers from South China University of Technology reconstructed the path and intensity of a devastating EF3-level tornado that occurred in Guangzhou, China on April 27, 2024. The study used a combination of UAV remote sensing, ground-based surveys, and mesoscale numerical simulation to analyze the tornado's damage mechanisms.
A new study found that 9% of individuals who survived an opioid overdose in Ontario, Canada died within a year, with the highest risks occurring within seven and thirty days after discharge. People with prior overdose experiences were at increased risk of death.
Researchers mapped over 1.25 million cells to reveal sex-specific differences in the human immune system. Female immune cells exhibit higher levels of B cells and regulatory T cells, but also a greater predisposition to autoimmune diseases like lupus due to their highly reactive profile.
A major international study has identified a genetic contributor to juvenile glaucoma, which can affect people before the age of 40. The study found that individuals with a specific genetic duplication have an increased risk of developing the condition, and may benefit from routine testing.
Researchers at the University of Manchester demonstrate that electrons can travel ballistically over micrometre distances in graphene while maintaining spin coherence. By using transverse magnetic focusing (TMF), they were able to bend electron trajectories like light rays and show that curved paths carry a clear spin signature.
A new study published in Stroke found that muscle loss, weak grip, and slow walking pace are associated with a higher risk of stroke. People with low muscle strength had a 30% higher risk of any type of stroke compared to those with high muscle strength.
A study reveals that S-1-propenyl-L-cysteine, a bioactive compound found in aged garlic extract, promotes inter-organ communication between fat tissue and the brain, enhancing muscle strength. Long-term administration of S1PC reduced frailty scores and increased skeletal muscle force in aged mice.
A study published in JAMA Oncology reveals that nearly half of patients with metastatic non-small-cell lung cancer never receive treatment, highlighting a significant gap in care. The research emphasizes the importance of referring patients promptly to an oncologist and improving access to life-saving treatments.
Researchers have designed copper cold plates with optimized fins that deliver up to 32% better cooling performance, reducing pressure drop by up to 68%. This technology could lead to significant energy savings in data centers, where it is estimated to contribute only around 1.1% of total energy usage.
JAYseq, a whole-genome sequencing assay, provides detailed information on genetic changes and cell surface proteins to guide personalized treatment strategies. The test enables the identification of high-risk markers and assesses the presence of specific cell surface proteins targeted by advanced immunotherapies.
A randomized clinical trial suggests psilocybin is safe and efficacious for treating cocaine use disorder. The study found psilocybin to be effective in reducing substance use and improving mental health outcomes.
A recent study found a one-year mortality rate of 8.6% among opioid overdose survivors, significantly higher than previous estimates. The study also revealed that 21.2% of individuals experienced repeat overdoses within the same year.
Researchers developed chiral luminescent radicals that emit circularly polarized light with high photoluminescence efficiency and improved stability. These compounds have potential applications in lasers, bioimaging, and quantum technologies.
A study by Frontiers analyzed three papermill detection tools on over 37,000 manuscript submissions, finding that the tools flag different proportions of manuscripts and have low manuscript-level overlap, highlighting a detection gap. The tools emphasize different types of signals, contributing to the divergence in flagging rates.
Scientists at La Jolla Institute for Immunology have characterized human antibodies capable of neutralizing measles virus. The new panel of human antibodies may form the basis for future medical therapies against measles infection, with a study showing a 500-fold lower viral load in a rodent model.
Researchers at Flinders University found that methamphetamine contamination on car surfaces can persist despite ventilation, with textile or soft surfaces still at risk. The study highlights the complexity of managing meth contamination in contained spaces and emphasizes the need for public health safeguards when buying or using vehicles.
MARGO integrates machine learning-based predictive models with overlap weights to address covariate imbalance in clinical trials. The framework demonstrates superior performance over conventional methods, allocating more patients to the effective treatment while maintaining statistical power.
Researchers at UCLA Health have discovered that transcranial magnetic stimulation (TMS) selectively targets specific brain cells to restore communication channels in the brains of stressed mice. The study found that TMS repairs damaged dendritic spines, leading to enhanced activity and rapid improvements in stress-related behaviors.
The BHARAT study, led by the Indian Institute of Science, is a groundbreaking initiative that integrates clinical, molecular, lifestyle, and environmental data from diverse demographic groups in India. The study aims to develop population-specific biological aging signatures and predictive models tailored to Indian populations.
A global validation study led by NYU Langone Health confirms the accuracy of the American Heart Association's PREVENT tool in predicting cardiovascular disease (CVD) risk for diverse populations. The tool, which considers kidney health and albuminuria levels, was found to be highly effective in identifying patients at high CVD risk.
The new device mimics an octopus's multimodal grasping strategy, achieving the fastest stiffness-switching performance reported to date. It delivers stunning speed, softening in 1.3 seconds and rigidifying in 0.8 seconds, while maintaining cooperative grasping forces exceeding 4 newtons.
Researchers found that increases in macrophage cell volume reprogram gene expression and induce inflammation. Cell swelling also triggers an enhanced antiviral response in infected cells.
A team of researchers has developed a wearable fabric electrotactile system that provides more precise and localized tactile feedback in virtual reality. The system uses a novel 'stimulation-inhibition' design to cancel lateral current spread, resulting in improved recognition accuracy and reaction times for users.
A study by the University of Gothenburg reveals that changes in gut bacteria composition after bariatric surgery are strongly associated with improved glucose metabolism and insulin release. Patients with type 2 diabetes who achieved improved glycemic control exhibited greater microbial gene richness and enhanced fermentation processes.
A new study by TU Graz finds that women have a 60 per cent higher injury risk in car accidents compared to men. Women suffer noticeably more severe injuries even at lower collision speeds, with the risk of serious injury or death being twice as high. The study highlights the need for more realistic tests and intelligent safety systems.
A study of over 31,000 patients found that pneumonia occurred more often after breathing tubes were removed than during ventilation, with most cases developing within a 1–2 week window after surgery. Early assessment and intervention focusing on swallowing function are crucial for prevention and improved outcomes.