Researchers in Lund have presented a new model for cooperation that will shorten lead times and reduce costs. The Cell and Gene Therapy Navigator tool helps identify imbalances and future bottlenecks in projects.
The journal explores the convergence of computational biology, artificial intelligence, and healthcare innovation, with a focus on precision medicine and enhanced patient care. Submissions are accepted from researchers, clinicians, and technologists on topics such as AI in medicine, computational genomics, and drug discovery.
SeaCast consistently outperforms the Copernicus operational model over a 10-day forecast horizon and extends predictions to 15 days, generating forecasts in just 20 seconds using a single GPU. This advancement enables rapid 'what-if' scenario testing and probabilistic ensemble forecasts.
A study by University of Texas at Dallas bioengineers found that both cancerous and noncancerous colon tissue from young patients with colorectal cancer was mechanically stiffer than in older patients. This stiffness may promote the development of early-onset colorectal cancer, a condition rising over the past 30 years.
The Ecological Society of America has named 20 graduate students who will receive policy, communication and career training in Washington, D.C., followed by meetings with lawmakers on Capitol Hill.
Researchers developed antibody–drug conjugates that combine CD4 mimic and neutralizing antibodies to target HIV entry, showing seven times better efficacy than existing approaches. The strategy aims to block HIV before it enters the host cell, offering a more targeted therapeutic profile and potentially reducing adverse effects.
A new study uses AI to predict which ulcerative colitis patients with low-grade dysplasia are at high risk of developing colorectal cancer. The model integrates risk factors from narrative clinical notes, enabling more accurate and timely surveillance and potentially reducing treatment delays.
Researchers developed a new computational approach to predict chemotherapy response in triple-negative breast cancer, outperforming current methods. The TmS biomarker accurately sorts patients into those with favorable or poor prognosis, highlighting its potential as an effective starting point for patient stratification.
Researchers used satellite imagery and machine learning to estimate HDI scores for 61,530 municipalities and counties. The results show that over half the global population lives in areas with different development tiers than their national level, highlighting the need for finer-grained data to inform policy decisions.
The Brain Trauma Foundation has updated its guidelines for the care of patients with penetrating traumatic brain injury (pTBI) with new evidence-based recommendations and treatment algorithms. The guidelines aim to balance complexity with convenience for use during emergencies, providing practical flowcharts for clinicians.
The University of California San Diego School of Medicine and UC San Diego Health are now part of the NICHD Maternal-Fetal Care Network, expanding access to research on pregnancy and newborn health. Clinical trials will focus on maternal mortality, prematurity birth rates, and infant mortality rates.
60Nd, a UC3M spin-off, develops NeoMag to study tumor behavior, traumatic brain injuries, and wound healing processes. The technology enables researchers to replicate physical disease behaviors and identify new therapeutic targets.
Researchers found that ultrasounds performed too early during hospitalization were more likely to produce false positives, leading to additional invasive testing. Waiting until a fever resolved and closer to discharge did not prolong the hospital stay, but reduced unnecessary tests and added stress for families.
A systematic review found that musicians experience substantially higher rates of tinnitus, hearing loss, and hyperacusis compared to non-musicians. The study, which pooled data from 67 studies, revealed that 42.6% of musicians reported tinnitus, while 25.7% experienced hearing loss.
Research reveals that podocytes in aged rats adapt by increasing volume and forming atypical junctions to compensate for loss, while exporting unnecessary cellular components into the extracellular space. The study employed array tomography to elucidate age-related structural changes, shedding light on the mechanisms of aging glomeruli.
A new AI-powered algorithm, M-PACT, uses liquid biopsy to classify pediatric brain tumors based on DNA methylation patterns. The technology has been shown to achieve a high sensitivity rate of 92% in identifying brain tumors.
Researchers used mitochondrial DNA from 13 Jomon skeletons to examine population changes over time, finding a significant increase in eastern Japan between 13,000 and 8,000 years ago. This study suggests regional factors, such as climate and food resources, played a role in shaping the Jomon population history.
POST-PURPLE aims to convert urban wastewater and organic waste into valuable resources through innovative bio-based technologies. The project will demonstrate practical pathways toward cleaner, more circular urban biorefineries and reduce diffuse emissions.
A new study from Houston Methodist Research Institute finds that brain swelling during Alzheimer's treatment may indicate a stronger treatment response. Brain regions that swell have larger drops in brain plaques than areas that never swelled.
Researchers found that enhanced rock weathering can remove significant amounts of carbon from the atmosphere, with potential co-benefits for farmers. The method could remove up to 0.7-1.1 gigatons of carbon by 2100, depending on adoption rates.
A recent study at the University of Helsinki found that short periods of REM sleep impair horses' perseverance and performance in demanding learning tasks. Horses with longer REM sleep duration performed better in a reverse learning test, suggesting that REM sleep is associated with motivation and perseverance.
A psychology study found that social and emotional skills training benefits both younger and older adults equally. The study showed that participants in their twenties and those between 60-80 years old demonstrated similar improvements in emotional stability and extraversion after an eight-week personality intervention program.
A new study from Aarhus University finds that early puberty is associated with an increased risk of general psychological distress, psychiatric diagnoses, and the use of psychiatric medication. Girls who enter puberty early may have twice the risk of receiving psychiatric medication for mental health conditions compared to their peers.
A study found that forest conversion harm dung beetles by increasing temperatures and drying out the ground, making it hostile for them. The key species, Anoplotrupes stercorosus, is particularly affected, with its population declining as temperatures rise.
The JAX-NYSCF Collaborative and GSK are working together to develop human cellular models of neurodegenerative diseases. This collaboration aims to generate disease-relevant cellular models that can help scientists understand the underlying biology of neurodegenerative conditions like Alzheimer's disease.
Researchers analyzed downward climbing behaviors in 21 small-to-medium-sized arboreal mammal species to understand early primate evolution. They found primates used tail-first and side postures more often than non-primates, suggesting upright postures evolved to adapt to tree environments.
The collaboration aims to uncover actionable targets and biological pathways that may lead to personalized therapeutic options and improved outcomes for patients. Insilico's PandaOmics platform integrates clinical datasets with AI models to systematically prioritize druggable targets.
A Phase 2a trial of SPL026 demonstrated statistically significant and clinically meaningful reductions in depressive symptoms at two weeks, with effects lasting up to six months. The treatment was generally well-tolerated, and the findings provide clinical proof-of-concept for short-acting serotonergic modulation.
A new study by researchers from the University of Southern Denmark has found no evidence of naturally occurring DMT in the adult rat brain, even when its breakdown was inhibited. The study used highly sensitive methods to detect trace substances and examined whether administered DMT could be stored in serotonin neurons.
A new UCLA study found that adding immunotherapy to standard chemotherapy before surgery is safe and shows promise for some patients with borderline-resectable pancreatic cancer. The combination treatment helped patients live long enough to reach surgery, shrank tumors, and produced encouraging survival outcomes.
A new framework, BPR-LTC, integrates scientific research and bioethics into architectural planning for long-term care spaces. This approach aims to improve the health and well-being of residents by systematically incorporating evidence-based design principles.
A new study reveals that the tempo of repetitive movements during bonobo sex is remarkably high, averaging seven movements per second. Facial mimicry plays a crucial role in this behavior, but its impact on the tempo of movements is limited, with a sharp drop in tempo after facial mimicry ceases.
Researchers developed a process to convert phytate into bioavailable phosphate using a biocatalyst, improving phosphorus recycling efficiency. The method uses engineered yeast cells displaying the enzyme phytase, which can efficiently and stably convert organic phosphorus into usable phosphate.
Despite AI tool limitations, generative AI projects continue due to various justifications that make them hard to stop. The study highlights nine conceptions of the common good that drive innovation momentum. Effective boundary work and reframing failure as a learning process also sustain innovation.
Researchers review the molecular mechanisms of mitophagy in breast cancer, highlighting its potential as a biomarker and therapeutic target. The study suggests that strategic modulation of mitophagy can enhance personalized treatment approaches for BC.
A new study published in Information Systems Research finds that when businesses can't silence reviews, consumers tell the truth more honestly and in greater detail. The law increased negative reviews, longer review content, and more detailed criticisms.
Researchers at Tampere University found that humanoid robots perceived as having eyes exhibit greater agency and experience, evoking emotional responses and increasing empathy. This suggests that the presence of eyes shapes human perception of a robot's mind, with implications for design and ethics.
A new study reveals that C-reactive protein is associated with ventricular arrhythmias in stable coronary disease, while its relationship with heart rhythms is different in patients with cirrhosis. In cirrhosis, only high white blood cell count shows a trend for linking to unstable rhythms.
Research reveals major gaps in studying the relationship between AI and journalism, including environmental impact and Global South deployment. Most studies are conducted from Europe, leaving scarce attention to the Middle East, Latin America, and sub-Saharan Africa.
The study found that people's everyday experiences with technology play a crucial role in shaping trust around the world. Human-centred approaches to AI design and governance are essential for building trust, as simply improving technical performance is insufficient if people feel disconnected or powerless.
The conference aims to improve genetic studies, clinical best practices and community interventions to combat the increasing cancer incidence rates. It will bring together top cancer-focused minds to promote precision medicine and stimulate multidisciplinary collaborations for cancer solutions.
MIT researchers used a large language model to optimize the genetic sequences of proteins manufactured by yeast, reducing production costs. The new model predicted which codons would work best for manufacturing six different proteins, including human growth hormone and a monoclonal antibody, with successful results.
Enrollment among eligible individuals increased by 27.5% after subsidy expansion, with gains seen among children 18 and under, Black and Hispanic individuals, part-time workers, and rural residents. The study found that 7.8 million enrollees retained marketplace coverage over the 2021-2022 period
Researchers identified 95 facilitators for increasing physical activity participation among autistic children, including predictable routines, family involvement, and sensory-friendly spaces. The study suggests that a strengths-based approach can help build confidence, enjoyment, and social connection in autistic youth.
A University of Minnesota study investigated a 2023/2024 Legionnaires' disease outbreak in Grand Rapids, Minn. and found that introducing disinfection to untreated groundwater stopped the spread of the disease. The city implemented chloramine disinfection, which dropped Legionella levels so low they could no longer be detected, resulti...
Researchers at KIT have achieved a significant milestone in compressorless hydrogen gas turbine technology, extending runtime to over five minutes. The innovation saves energy and increases efficiency by utilizing pressure-gain combustion, making it an attractive option for fossil-free energy systems.
Researchers at NICT successfully demonstrated simultaneous communications with 10 devices using a hybrid signal processing method combining quantum annealing and classical computing. This breakthrough addresses the massive connectivity requirements of 6G networks, enabling real-time detection for up to 60,000 possible signal combinations.
New research from the University of Copenhagen suggests that volcanic eruptions during the Ice Age may have disrupted the AMOC, threatening Denmark's climate. The study shows that extreme volcanic eruptions can throw the climate system out of balance and push the AMOC into a weakened or collapsed state.
Astronomers from the University of Waterloo have observed a distant jellyfish galaxy, providing rare insight into how galaxies were transformed in the early universe. The discovery challenges previous beliefs about galaxy clusters and their impact on galaxy properties.
A new study analyzing three decades of research found that animals respond more consistently to lethal humans than non-lethal ones, altering behavior in foraging, vigilance, and movement. Non-lethal human structures can even function as perceived refuges, reducing animal vigilance.
The collaboration aims to accelerate the discovery and development of next-generation antimalarial drugs, with a focus on global access and affordability. Calibr-Skaggs and Kainomyx will jointly advance promising hits through the drug discovery pipeline, with a shared commitment to open publication.
Researchers from the University of Tokyo used CT scans to study Triceratops' nasal anatomy, revealing a specialized structure called a respiratory turbinate. This unique feature helped regulate temperature and moisture levels in the dinosaur's large skull.
Researchers from UPF and 3D-Shaper Medical developed a new computational system to predict and prevent the risk of hip fracture among people with osteoporosis. The system, which simulates the functioning of hip bone tissue using 3D images and finite elements modeling, has been shown to be a robust alternative to current clinical methods.
Rice bioengineer Jerzy Szablowski has been awarded a Sloan Research Fellowship for his innovative work on noninvasive methods to communicate with the brain. He aims to develop versatile platform technologies to obtain new types of research data and treat multiple diseases.
Researchers on M217/1 expedition study upwelling system and extreme events off southwest African coast, focusing on Coastal Kelvin waves and Benguela Niños. Key findings include the seasonal upwelling without wind off Angola and the causes of marine heatwaves that disrupt marine ecosystems.
Researchers found that fungi can extract valuable metal palladium and platinum group elements from meteorite material in microgravity. The study suggests that microbial biomining could have terrestrial benefits for efficient resource extraction and create sustainable biotechnologies.
A new framework proposes a 'three-strata' model to classify gastrointestinal tract cancers, guiding more precise and effective strategies. The review advocates for chemotherapy-free approaches in highly immunogenic tumors and explores optimized combinations with chemotherapy for intermediate-sensitive tumors.
A record-breaking sediment core 700 km from Antarctica's nearest stations provides direct evidence of how the West Antarctic Ice Sheet and Ross Ice Shelf responded to warmer temperatures. The core, measuring 228 meters in length, contains layers of mud and rock documenting environmental conditions during earlier warm periods.
The Mayo Clinic has installed the first magnetic nanoparticle-mediated hyperthermia machine for cancer research in the US. This innovative technology uses heat to damage and kill cancer cells, offering a new angle in cancer treatment and potentially improving outcomes for patients with resistant tumors.
Southwest Research Institute's Metering Research Facility has received ISO/IEC 17025 accreditation, confirming compliance with international testing and calibration standards. The facility offers highly specialized calibration services to energy sector clients using its recirculating natural gas flow lab.