A new review highlights the cytokine storm's key role in lung injury and multi-organ dysfunction in acute respiratory distress syndrome (ARDS). The review emphasizes biological heterogeneity, subphenotypes, and the need for biomarker-guided patient stratification.
The updated guidelines provide evidence-based recommendations to standardize catheter use, improve infection prevention, and enhance outcomes for critically ill patients. The guidelines emphasize the importance of daily clinical reassessment, routine blood sampling, and proper antimicrobial use.
A cohort study of patients with chronic kidney disease found that more advanced stages of the condition are associated with a higher incidence of cognitive impairment. The study underscores CKD severity as a key risk factor for cognitive decline across the entire spectrum of CKD.
A study of six pooled cohorts found that moderate to vigorous physical activity after a cancer diagnosis is associated with reduced risk of cancer mortality. Higher levels of physical activity were linked to longer survival rates and overall health benefits for cancer survivors.
Researchers discovered that pairing familiar plant-derived compounds can suppress inflammatory signals more effectively than using each compound independently. The study found that certain combinations increased the anti-inflammatory effect several hundred-fold compared to single ingredients alone.
Scientists create a porous silica microrod material that can form dense dispersions in nematic liquid crystals, overcoming the challenge of strong surface anchoring. This enables the reconfigurable self-assembly of micrometer-sized particles, opening up new possibilities for optical and biomedical applications.
Chemical Insights scientists received awards for their research on vaping-associated exposures and health risks, as well as other papers that integrate molecular biology or systems biology to toxicology research. The institute's efforts aim to safeguard public health by advancing scientific understanding of chemical risks.
Neotropical otter study reveals 40 years of field data showing that otters aggregate environmental signals across time and space. The study highlights the critical Tropical Knowledge Gap in otter research, with 70% focusing on temperate species.
Studies presented at the inaugural Multidisciplinary Radiopharmaceutical Therapy Symposium highlight the growing potential of RPTs to improve cancer outcomes. A meta-analysis shows Lu-177 PSMA-617 consistently prolongs progression-free survival without adding severe side effects for patients with advanced prostate cancer.
Researchers at Fred Hutchinson Cancer Center developed new genetically human monoclonal antibodies that prevent EBV from infecting immune cells. The study highlights one of the antibodies that successfully blocked infection in mice with human immune systems.
Researchers at UCSF and Wayne State University found that generative AI tools can perform orders of magnitude faster than human teams in analyzing health data. Junior researchers paired with AI generated viable prediction models in minutes, outperforming experienced programmers in hours or days.
Researchers develop porous liquids to trap methane, creating a supplemental domestic energy source. The technology can be integrated into existing infrastructure and has shown significant gas absorption capacity.
The National Comprehensive Cancer Network has published new guidelines for Pediatric Soft Tissue Sarcomas, highlighting the unique characteristics of this childhood cancer. The guidelines focus on rhabdomyosarcoma (RMS), a subtype with varying genetic changes that influence treatment outcomes.
Researchers used computer simulations to study the behavior of exhaust particles in tokamaks. They found that the toroidal rotation of plasma plays a key role in determining where particles land in the machine's exhaust system. This discovery could help engineers design divertors better equipped to handle intense heat.
A recent study from Norwegian University of Science and Technology suggests that optimizing production in fertile areas while allowing less productive areas to lie fallow can cut greenhouse gas emissions. By doing so, food production can be maintained while reducing pressure on biodiversity by up to 20%.
A new study proposes that myopia is driven by how we use our eyes indoors, with prolonged close-up focus in low-light environments limiting retinal illumination. This mechanism could lead to a paradigm shift in understanding and controlling myopia progression and control.
Four NYU faculty members have been awarded Sloan Research Fellowships for their groundbreaking work in brain injury, organic chemistry, computing, and software. Since 1955, 102 NYU faculty members have been selected as recipients, including this year's 126 fellows.
A new study suggests that short periods of extreme heat and drought during flowering could become a major threat to global wheat production. This could lead to yield losses of up to three-quarters by 2090, highlighting the need for farmers to develop more heat-tolerant varieties.
Researchers found that participants initially overestimated the awkwardness of their gait but improved as they practiced using the prosthetic device. Despite significant performance gains, participants remained inaccurate in assessing their own body movement, focusing on torso position rather than prosthetic behavior.
A Stanford University study reveals that brain activity can forecast which wildlife images inspire people to engage online and donate to conservation causes. Socioemotional features, such as visible faces or cues encouraging emotional connections, play a key role in driving engagement.
Harlequin ichthyosis is caused by ABCA12 mutations leading to defective lipid transport and loss of skin barrier function. Management includes neonatal care, systemic retinoids, daily emollients, and keratolytics, with improved survival rates and quality of life.
A study using brain imaging identified the social and emotional features of wildlife photos that predict engagement on social media. The analysis found that animal faces and evolutionarily similar species in images boosted engagement and predicted actual likes on Instagram.
Researchers found Chinese chatbots more likely to refuse or provide inaccurate responses to sensitive questions about politics, while non-Chinese models offered longer, more accurate answers. The study suggests the source of this issue cannot be explained solely by training data or model development choices.
Researchers studied participants' ambulatory body image while learning to walk with a robotic leg. They found that participants initially underestimated and later overestimated their walking quality before incorporating the device into their body image.
Scientists at the National Air and Space Museum's Center for Earth and Planetary Studies have created a comprehensive map of small mare ridges (SMRs) on the Moon. The research, published in The Planetary Science Journal, reveals that SMRs are geologically young and widespread across the lunar maria.
Wiley is launching eight new Advanced journals in life, health and social sciences disciplines by the end of 2026. The expansion aims to empower scientists with a streamlined publishing approach, reflecting Wiley's commitment to accelerating science that addresses humanity's most pressing challenges.
A yeast enzyme, Sc URA, has been found to sustain nucleotide synthesis independently of mitochondrial respiration in human cells. This discovery opens up new possibilities for treating mitochondrial diseases with no cure, and could provide a valuable experimental tool for understanding rare diseases and cancer.
A new study estimates that each hectare of tropical forest generates 2.4 million litres of rain annually, enough to fill an Olympic-sized swimming pool. This process is known as evapotranspiration, where the sun's energy is used to transfer moisture from the leaves into the atmosphere.
A new method allows for precise visualization of modern polymer binders in negative lithium-ion battery electrodes. The study found that small changes in binder distribution can significantly affect charging efficiency and battery lifespan.
Researchers discovered a 5,000-year-old bacterial strain in an underground ice cave that shows resistance to multiple modern antibiotics. The Psychrobacter SC65A.3 strain has over 100 resistance-related genes and can inhibit the growth of several major antibiotic-resistant superbugs.
Hospital admissions for child maltreatment declined by 31% during the initial lockdown of the COVID-19 pandemic but rebounded to pre-pandemic levels after restrictions were lifted. However, rates of admission to intensive care units (ICUs) increased by 80% after the 16-week period of restricted healthcare access.
Kobe University scientists have engineered bacteria to produce a group of compounds with promising pharmacological activities. The breakthrough uses a rational design strategy to create a platform for industrial production of drug candidates.
The review outlines how vascular-immune crosstalk affects various diseases, revealing novel therapeutic opportunities. It highlights the shared embryonic origin of blood vessel cells and immune cells, as well as coordinated immune cell trafficking mechanisms.
The study found that living with HIV leads to a decline in labor market outcomes, including a 4% decrease in employment rates, a 5% reduction in work hours, and an 9% drop in annual earnings. The impact is most pronounced for individuals diagnosed with late-stage HIV.
Generative AI can play seven distinct roles in combating misinformation, including informer, guardian, persuader, and collaborator. However, its use also poses risks such as hallucinations and deliberate manipulation. To effectively combat misinformation, clear policies on the permissible use of AI are needed.
Researchers have explored how human mesenchymal stem cells can help repair brain injury in children born preterm. The PREMSTEM project has investigated the use of h-MSCs to address brain injury caused by early-life birth, with promising results showing a positive impact on brain damage and inflammation.
New research suggests that inhaled microplastics can cause inflammation and damage to the lungs, potentially increasing the risk of respiratory diseases such as asthma and COPD. Microplastics can also trigger inflammatory responses and deliver toxins directly into the lungs, highlighting a growing concern for lung health.
Researchers at Tohoku University have developed a new technology that uses thioguanosine to achieve highly efficient and controllable interstrand crosslinking of DNA. This breakthrough enables reversible DNA modification with high stability and reversibility, opening opportunities for next-generation bionanomaterials.
A research team led by Universitat Autonoma de Barcelona has discovered the molecular mechanism regulating bacterial cell division. The MraZ protein binds to the dcw gene cluster, enabling coordinated action of proteins necessary for cell division and bacterial wall formation.
Researchers identified 255 insect species in perennial grasses, but few in annual grasses, highlighting the importance of unmown refuges for biodiversity
Epicurrents is an open-source web browser application that enables users to view various clinical neurophysiology recordings directly in a web browser. It supports easy, secure, and cost-effective remote teaching and can be used for both educational purposes and scientific research.
Researchers at the University of Bergen have discovered that thermal convection, a slow churning movement inside the ice driven by vertical differences in temperature, is responsible for the giant plumes. This finding could help reduce uncertainties in models of future ice sheet mass balance and sea-level rise.
The Olympic Games' substantial carbon footprint highlights the need for a profound overhaul to comply with the Paris Agreement. Researchers recommend scaling down events, reducing air travel and increasing use of renewable energy to achieve ambitious emission reduction targets.
A new study externally validates the NOFI model, which uses three clinical variables to predict feeding intolerance and stratify patients by 28-day mortality risk. The analysis found that patients in the high-risk group experienced substantially higher 28-day mortality compared with those in lower-risk groups.
A recent clinical trial led by Oregon State University scientists found that the composition of a dog's microbiome is linked to its cancer survival rate. The study identified 11 specific types of bacteria that were associated with longer or shorter survival, suggesting potential biomarkers for predicting treatment response and improvin...
Global study finds that nitrogen pollution causes forests to follow two distinct patterns in response to added nutrients, with some experiencing a boost and others collapsing. The findings highlight the importance of reducing nitrogen levels to stabilize forest soil carbon pools and maintain natural respiration rhythms.
Research reveals that nuclear speckles are essential for processing and exporting viral messenger RNAs from the nucleus, highlighting their critical role in viral infections. The study suggests that understanding how viruses interact with host cells can lead to new ways to treat and prevent viral diseases.
Satellite images from Sentinel-2 show Doñana Marshland losing surface water and vegetation cover, with a predicted loss of up to 15% since 2010. Researchers suggest implementing strategies such as closing illegal wells and adopting sustainable agricultural models to mitigate the impact.
Research from the University of Bath reveals that childhood adversity can alter the expression of genes associated with educational attainment, leading to differences in risk tolerance and patience. Individuals from disadvantaged backgrounds may prioritize short-term needs over long-term gains, creating hidden barriers to social mobility.
Researchers found that about 40% of West Antarctica's ice may be lost already, while East Antarctica could lose more with 2-3°C warming. The study highlights the need to monitor and mitigate greenhouse gas emissions to prevent destabilization of Antarctic ice basins.
Researchers isolated native SOD1 monomers using coordination cages, revealing the dimer interface and enabling targeted ligand binding. This approach provides a promising new strategy for finding drugs that inhibit disease-causing protein aggregation.
A new study suggests that energy-efficient 5G network features can significantly cut indirect carbon emissions across the UK economy. By optimizing energy use in base stations and user devices, industries such as finance and IT can benefit from reduced emissions.
A new study published in JAMA Oncology found that salvage focal therapy is as effective as radical prostatectomy in treating recurrent prostate cancer after radiotherapy, but with much fewer complications. The treatment targets only the cancerous area of the prostate, resulting in less impact on quality of life.
A study using the James Webb Space Telescope found that supermassive black holes can suppress star growth not only in their host galaxy but also in neighboring galaxies within a million-light-year radius. This discovery reveals a larger impact of quasars on galaxy evolution, contradicting previous assumptions.
A new position statement from CSANZ and ACRA highlights telehealth as a critical tool for increasing access to quality cardiovascular care. The guidance provides best practice guidance for safe use by clinicians while emphasizing patient-centered, culturally inclusive multidisciplinary care.
Researchers have identified astrocytes as a promising cellular target for Alzheimer's therapy. Senescent astrocytes, which lose functional capacity, are found in Alzheimer's patients' brains, leading to neuronal damage and inflammation. The study opens an avenue for therapeutic strategies like senolytic drugs.
Researchers from Edith Cowan University found that seagrasses vary in their thermal tolerance, with some species more resilient to elevated water temperatures. The study's findings highlight the need for a one-size-fits-all approach in seagrass management and restoration.
Researchers have genetically engineered therapeutic CAR T cells that can destroy solid tumors, overcoming a major obstacle in cancer treatment. By silencing prostaglandin E2 signalling, these new cells can recognize and attack cancer cells without suppressing their own immune function.
A recent study reveals that hydration and terminal chemistry of poly(ethylene) glycol (PEG) polymers influence immune recognition, providing insights into why some PEGylated drug coatings fail to evade the immune system. The findings pave the way for novel drug coatings with improved performance.
The INSOIL project develops three families of fully bio-based plastic products for agriculture, reducing microplastic release by 5,820 tonnes and agrochemical use by 4,000 tonnes. These products aim to contribute to more sustainable agricultural production and support European reduction targets.