A team of physicists identified the dominant mechanism responsible for energy release in molybdenum-93m using high-precision experiments. Inelastic nuclear scattering is confirmed to be the primary driver of isomer depletion under experimental conditions, contradicting previous hypotheses about nuclear excitation by electron capture.
Inhaled polystyrene nanoparticles induce lung injury by disrupting redox balance and triggering inflammation. Oxidative stress leads to mitochondrial dysfunction, respiration impairment, and apoptosis in lung cells.
Graphene and diamond hybrids show promising performance in electronic devices, sensors, and machining tests. However, major challenges remain, including producing large-area hybrids with consistent quality and understanding fundamental properties.
Researchers at Harbin Institute of Technology in China report a method to fabricate transparent conductive films on curved surfaces. The technique, using multi-angle co-velocity fitting deposition model, produces smooth and continuous films with high transparency and low electrical resistance.
Researchers develop a probabilistic framework to predict turbulence onset in flow systems, enabling better forecasting of extreme weather events and understanding climate tipping points. This approach has potential implications for atmospheric science, aviation, and meteorology.
Researchers have created a process to produce clean hydrogen from freshwater and seawater using liquid metals powered by sunlight. The method avoids many obstacles in current hydrogen production methods, including the need for purified water and high costs. The team is working to improve efficiency for commercialization.
The English listening section of the Common Test for University Admissions featured land-based aquaculture using 'the new type of water', a mixture of seawater and freshwater minerals. This innovative method enhances fish growth rates, disease resistance, and reduces salt content, addressing global food shortages.
Researchers developed an AI-based method to create binaural audio from monaural recordings, using visual information from the video to guide spatialization. The system accurately preserves a sense of direction and space, even in complex environments.
Pentachlorophenol exposure triggers inflammatory responses and oxidative stress, leading to liver damage and compromised immune function. The study identified the Toll-like receptor signaling pathway as a key mechanism of PCP-induced immunotoxicity.
A research team at Tohoku University has made a groundbreaking discovery about the anatomy of lymph nodes, revealing new structures that challenge traditional ideas about immune system function. The findings have significant implications for understanding and treating conditions like lymphedema and cancer.
Fusarium cugenangense has been identified as a novel causal agent of wilt disease on Pyrus pyrifolia in China. The fungus was isolated and characterized through morphological and molecular analysis, revealing its ability to cause systemic infection in pear plants.
A new study finds that ESG rating providers play a crucial role in building and repairing trust in sustainable finance. By comparing EU and UK regulatory approaches, researchers show that 'enhanced self-regulation' combining public oversight with industry-led rules can support a credible market-led green transition.
A new study finds that cognitive reappraisal, a mental reframing strategy, significantly reduces burnout in teachers during times of crisis. By promoting this skill through targeted workshops, educators can maintain their mental health and efficacy.
Researchers developed a novel proton exchange strategy to enhance manganese-based oxide performance, offering a promising path toward affordable, platinum-free electrocatalysts. The modified catalyst demonstrated superior stability and durability, with improved half-wave potential and retention of current.
Researchers investigated e-beam propagation through ionospheric plasma using particle-in-cell simulations. Nonrelativistic e-beams exhibit laminar-to-turbulent transition with beam compression factor quantified for the first time.
Research suggests that deaths from synthetic opioids like nitazenes have been underreported, with some studies suggesting a 33% excess in drug-related deaths. The team believes that the non-detection of degraded nitazene breakdown products is to blame for the undercounting.
Psychotherapist Lynn Somerfield emphasizes the importance of setting boundaries in relationships, work, and personal beliefs to promote emotional well-being. She advises that healthy boundaries strengthen connections with others while preserving individual identity and energy.
A team of scientists from Tokyo Metropolitan University discovered how fertilized rice seeds begin to divide and establish their body axis. They found that the process involves radical steps different from Arabidopsis, with cells acting collectively to allow axis development despite apparent randomness.
Researchers developed a new strategy to engineer biochar with enhanced sunlight-driven chemical activity, boosting its ability to drive light-powered reduction reactions. The findings suggest that biochar can dynamically transform under sunlight, participating in complex photochemical reactions that affect pollutant behavior and metal ...
Researchers discovered potent and selective SARS-CoV-2 PLpro and RIPK1 inhibitors, SHY1643 and QY1892, that demonstrate synergistic effects in reducing viral loads and cytokine release syndromes in mice. These findings establish a proof-of-concept combination therapy strategy for treating severe COVID-19.
A new global review emphasizes that tackling climate change requires coordinated integration of financial systems, technological solutions, and governance reforms. The study presents a comprehensive framework designed to help countries implement effective and equitable climate strategies.
Researchers designed macrocyclic TRPC5 inhibitors exhibiting exceptional potency and selectivity, overcoming lipid-binding site challenges. JDIC-127 demonstrated unprecedented potency and specificity, aligning with preclinical evidence supporting its potential in treating neuropsychiatric disorders.
This study reveals that palmitoylation of Tfr1 enhances platelet ferroptosis, leading to liver injury in heat stroke. Inhibiting Tfr1-mediated ferroptosis mitigates thrombocytopenia and improves liver function.
DHL-11, a novel prieurianin-type limonoid isolated from Munronia henryi, targets IMPDH2 to inhibit triple-negative breast cancer cell proliferation and migration. It induces G2/M cell cycle arrest and apoptosis, and increases ROS levels and cellular DNA damage.
This study introduces Chinese medicine and intermittent fasting integration therapy, which synergistically enhances calcium-phosphorus homeostasis regulation and vascular repair, demonstrating significantly greater efficacy than traditional therapies. The miR21-5p/Tpm1 axis mediates the anti-calcification effect, promoting VSMC overpro...
Researchers developed a data-driven classification-generation cascade model to discover new chemotype antitumor drugs. WJ0976 and WJ0909, two tetrahydrocarbazole derivatives, displayed potent broad-spectrum antitumor activity against multidrug-resistant cancer cells.
Researchers developed a self-assembling peptide-based vaccine to create a localized immune niche, demonstrating its remarkable efficacy in inducing durable and potent immunity. The vaccine served as a reservoir for antigens and adjuvants, recruiting antigen-presenting dendritic cells to accumulate within the scaffold.
Developed by Compuscript Ltd, the innovative mRNA-LNP microneedle vaccine induces effective innate immune responses and robust systemic humoral responses in the spleen. It also elicits multifunctional cellular immunity, providing some protection against lung invasion by SARS-CoV-2 pseudovirus.
A new study reveals cyanobacteria as major carriers of antibiotic resistance genes in estuarine ecosystems. The researchers found strong connections between microbial carbon and nitrogen cycling and the presence of resistance genes.
A new study found that tuberculosis is a major cause of deadly sepsis among people living with HIV, particularly in Africa. Early treatment of TB has been shown to significantly reduce sepsis deaths, with a 23% reduction in mortality rate.
Acta Pharmaceutica Sinica B Volume 16, Issue 1 publishes original articles on various pharmaceutical sciences topics. The journal covers pharmacology, pharmaceutics, medicinal chemistry, natural products, and more. Recent studies explore the use of neg-entropy as a drug target for chronic diseases and psoriasis treatment.
The new S-PTP MN patch improves psoriasis therapy by facilitating deep drug penetration and sustained release of triamcinolone acetonide. It achieves superior therapeutic efficacy compared to conventional topical treatments, reducing epidermal thickness and inflammatory cytokine levels.
This guideline standardizes therapeutic drug monitoring of biologics in IBD to improve patient outcomes. It addresses five key questions, including the indicators to be monitored and the therapeutic drug trough concentration thresholds.
Researchers propose neg-entropy as key strategy for discovering new drugs targeting 'head goose molecules', which restore order from disorder in the human body. Clinically proven effective drugs that target these molecules illustrate the concept and offer hope for treating chronic diseases.
A new cross-cultural study suggests that children's behavior in situations involving fairness, trust, forgiveness, and honesty is shaped by local cultural norms. As children enter middle childhood, their behavior aligns with community values, refining their understanding of social norms and cooperation.
A Phase III clinical trial found that neuroprotective medication loberamisal improved brain cell recovery in stroke patients treated within 48 hours. The study, conducted at 32 centers in China, compared loberamisal to a placebo and showed significant benefits.
The University of Tennessee Center for Dairy Advancement and Sustainability has received an additional $3.45 million in funding for the Southeast Dairy Business Innovation Initiative, a nationwide network to facilitate regional efforts to support dairy businesses.
Children across the globe exhibit similar cooperative behaviors, such as fairness and trustworthiness, that align with adult norms over age. As children get older, their behavior reflects local norms, but younger children tend to be self-interested.
Researchers at Washington University in St. Louis have found ways to stabilize ubiquitous iron components for use in fuel cells, replacing expensive platinum metals. This innovation aims to lower costs for fuel-cell vehicles and other niche applications, enabling widespread adoption of hydrogen fuel-cell technology.
A University of Phoenix study found that integrating AI tasks into coursework improves key learning outcomes and prepares students for AI-enabled roles. The research team redesigned a course with industry advisory councils to focus on real-world needs, yielding positive results in student gains on AI skills and career competencies.
A new study from National Jewish Health reveals that exposure to burn pit smoke and desert dust can damage the lungs of military service members. The research found that particles linked to burn pit exposure cause stronger inflammation and stress in lung immune cells, leading to chronic breathing problems.
Researchers developed a novel CRISPR-based technology called pPro-MobV that can remove antibiotic-resistant elements from bacterial populations. The new tool uses gene-drive thinking and has the potential to combat antibiotic resistance in healthcare settings, environmental remediation, and microbiome engineering.
A new hybrid optical system noninvasively tracks tissue water dynamics during hemodialysis, identifying early signs of patient instability. The system uses near-infrared spectroscopy to gather data on tissue water content and other physiological signals, providing a high-resolution portrait of the optical properties of tissue.
A new treatment combining restricted arm use with intensive physical therapy improved function and skills on the weak side in infants with perinatal arterial ischemic stroke. While results were promising, differences in responses among children highlight the need for further research.
Ovarian cancer cells recruit protective mesothelial cells in abdominal fluid to form hybrid cell clusters that resist chemotherapy. These clusters use spike-like structures called invadopodia to invade surrounding tissue. The discovery opens new treatment possibilities and could help doctors monitor disease progression.
Researchers found that many birds don't strictly follow their supposed temperature adaptations, instead moving to efficiently acquire and use energy. This 'energy efficiency' hypothesis suggests that altitudinal migration is a behavioral mechanism allowing birds to optimize their energy budgets in the face of seasonality and competition.
Five Ochsner Health hospitals have been named among Newsweek's America's Best-in-State Hospitals 2026, exceling in clinical excellence, patient experience, and innovation. These hospitals were recognized from over 6,000 nationwide for their dedication to providing excellent care.
A new treatment developed by EMBRAPA uses modulated UV-C light to combat anthracnose in guavas. The technique increases the fruit's natural resistance to microorganisms, preserving quality and shelf life.
A new study from CU Anschutz researchers found that regular physical activity can significantly lower post-ablation atrial fibrillation recurrence risk. Adults who engaged in moderate exercise for 30 minutes three times a week had markedly lower rates of AF recurrence compared to those who were less active.
A new study suggests some early life forms evolved to use oxygen hundreds of millions of years before the Great Oxidation Event, potentially delaying oxygen's accumulation in the atmosphere. This discovery adds to our understanding of aerobic respiration and its evolution on Earth.
Researchers developed a new method to measure ecosystem resilience and predict glacier surges, enabling early warnings for natural hazards. The study applies the approach to the Amazon rainforest and mountain glaciers in Alaska and Asia.
The 2026 iEnergy Frontier Forum on Power and Energy and Editorial Board Meeting was held in Hong Kong, featuring presentations by renowned experts on materials science, artificial intelligence, and low-carbon energy systems. The meeting aimed to strengthen the journal's academic quality and global influence.
A team of researchers uses CRISPR gene editing to eliminate cells with amplified oncogenes, reducing tumour growth and increasing animal survival. The study offers a promising approach for precision therapies in resistant cancers.
The URBANK database aggregates and analyzes urban data to overcome fragmentation and variability in archaeological record. It offers a multidisciplinary platform for studying cities as dynamic networks of connected elements.
Halle Zhang joins Insilico Medicine to lead global clinical development strategy for the company's oncology portfolio. She brings over 20 years of experience in oncology clinical development and a track record of advancing therapies through registrational trials.
The USF Health Institute for Voice and Hearing Innovation is a state-of-the-art facility that combines clinical research and comprehensive patient care for voice, hearing and swallowing disorders. Every patient becomes a research partner, driving innovations from lab to real-world clinical practice.
Researchers at Tohoku University successfully synthesized π-electron compounds with a pentagonal silicon framework, 'pentasilacyclopentadienide', and elucidated their molecular structures. The new compound has delocalized π-electrons and aromaticity similar to carbon-based cyclopentadienide.
Researchers from Rutgers Health examine how educators approach student wellness and find that emotional and social dimensions are prioritized. The study suggests an 'Eight Dimensions of Wellness' activity can serve as a professional development tool to enhance educator wellness while strengthening protective factors for students.
Researchers developed the Meat 3G system to predict beef eating quality, combining animal characteristics, rearing conditions, and consumer expectations. The system generates €0.10-€0.55/kg of added value for farmers, improving remuneration and competitiveness.
Blautia luti produces formic acid as an electron taxi, bypassing the energetically costly production of hydrogen. The bacterium detoxifies formic acid via a special metabolic pathway, linked to sugar breakdown and acetic acid production.