Dr. Candida Rebello's five-year NIH grant will explore lifestyle strategies to reduce excess body fat and declining muscle mass in older adults with obesity. The study aims to protect skeletal muscle health, independence, and quality of life for this rapidly growing population.
A new Phase II trial will examine whether giving chemotherapy or chemotherapy combined with immunotherapy before surgery can improve survival compared to surgery alone. The trial aims to identify a treatment that will help patients live longer without the cancer returning.
Researchers found 'dark energy' in protein structures, indicating energetic frustration between form and function. This 'dark energy' varies by site, revealing the cost of specific functions like binding.
Virginia Tech researchers identified a malformed area in the corpus callosum and pattern of bad connections that may help doctors diagnose Leigh syndrome earlier. The study found that developmental defects can be seen before symptoms appear, suggesting potential for earlier intervention.
A recent study by a UCLA-led team reveals that leftover COVID-19 viral fragments can selectively accumulate on and penetrate star-shaped surfaces of dendritic cells and T cells, killing these immune cells. In contrast, the omicron variant's smaller fragments have little effect on these cells.
Graduate students at MUSC are earning digital badges in science communications, highlighting their ability to explain complex scientific concepts to the public. This program is part of a larger shift towards providing graduate students with valuable skills that apply to multiple career paths in science.
Animal studies reveal complex dynamics of sex, fidelity, and monogamy in various species like wolves, dolphins, and swans. The intimate animal explores the evolutionary roots of human attachment and love.
A Simon Fraser University study reveals Canada's cycling infrastructure expanded by 3,596 km between 2022 and 2024. However, areas with more children and older adults saw less growth in cycling infrastructure, highlighting the need for more inclusive transportation planning.
A UC San Diego study found that older women with a history of depression and anxiety had a 78% higher risk of developing long COVID. The researchers analyzed data from the Women's Health Initiative and hope to inform preventative measures for public health officials and policymakers.
Researchers have found a way to harness the electrical energy generated by protein condensates, constantly shifting membrane-less organelles that govern cell function. This discovery could lead to bioelectrochemical devices for cleaning pollutants and fighting infection.
Researchers at Oregon State University developed a new nanomaterial that generates both hydroxyl radicals and singlet oxygen to kill cancer cells. The material showed potent toxicity in multiple cancer cell lines with negligible harm to non-cancerous cells.
The center will develop cutting-edge computational methods, including AI algorithms, to tackle fundamental geophysical problems. By studying weather and climate on Earth and other planets, the hub aims to shed light on many events that have historically been difficult to forecast.
Researchers at the University of British Columbia have developed a topical CRISPR-based therapy that can correct faulty genes in human skin, potentially treating genetic skin conditions like ARCI and eczema. The treatment, using lipid nanoparticle technology, restores up to 30% of normal skin function.
The ISSCR is hosting a summit on access and affordability in cell and gene therapies to explore pricing, manufacturing, regulation, and reimbursement strategies. Experts will examine key barriers and emerging solutions across the access landscape.
Drivers who participated in a program based on their driving habits showed reduced speeding, hard braking, and rapid acceleration by up to 25%. They continued these safe habits even after the program ended. The programs were equally effective in improving safety scores.
Overactive valosin-containing protein (VCP) disrupts the nuclear pore complex, leading to abnormal TDP-43 trafficking and neuronal damage in neurodegenerative diseases. Inhibiting VCP activity may offer new therapeutic strategies for treating these conditions.
A UH psychologist's study finds that anxiety sensitivity and pain-related anxiety are linked to mental health problems and clinically significant alcohol use among survivors of traumatic sexual assault. The investigation highlights the importance of addressing both types of anxiety in reducing the risk of lifelong challenges.
A study from Florida International University finds that claiming a business page on review platforms like Yelp can lead to a significant drop in average ratings, with a 10% decrease in five-star reviews and a 9.5% rise in one-star reviews. The study also reveals that these lowest-rated reviews become substantially longer and more crit...
A recent study from Penn State College of Medicine researchers found that helper T cells, typically involved in fighting infections, become overly activated in failing human hearts, causing damage. The activation of these T cells highlights the impact of inflammation and immune dysfunction in heart failure.
A new research project aims to develop an eye drop that can detect the fluorescent signal of a protein associated with Alzheimer's disease. If successful, this low-cost and accessible screening tool could help identify patients in their earliest stages of the disease, enabling them to receive early treatment.
A Mount Sinai study found that antibody-producing immune cells called IgG1 plasma cells help patients respond to PD-1 immune checkpoint inhibitors, which have transformed cancer care. The researchers identified IgG1 plasma cells as a critical factor in determining clinical outcomes.
A new study found that nudging both patients and providers with reminders increased flu vaccine numbers by almost 3,000 more people than expected. The researchers believe this could lead to strategies to boost annual flu vaccination rates.
Research suggests that blocking growth factor receptor signaling using cancer drugs may overcome two challenges: managing oral cancer pain and preventing opioid tolerance. This approach could control cancer while addressing pain through a non-opioid, biologically rational approach.
A team of University of Toledo physicists predicts significant growth for cadmium telluride photovoltaics in the US, with a target manufacturing capacity of 100 gigawatts by 2030. The technology offers advantages over silicon photovoltaics, including improved performance in hot and humid climates, and supports national energy security.
Researchers at Salk Institute debut an epigenetic catalog that shows genetic inheritance and life experiences have distinct effects on various types of immune cells, shedding light on individual differences in immune responses and potential new personalized therapeutics.
The four-year grant will provide educators with professional development training, create enduring resources, and develop virtual learning pathways for K-12 students. Over 1,000 teachers and 42,000 students in Nevada will benefit from the curriculum, materials, and resources.
The American College of Medical Genetics and Genomics announces Medical Genetics Awareness Week 2026, celebrating the power of collaboration in medical genetics. The week aims to bridge awareness gaps about the field and its professionals.
A Purdue University team led by Kyle Cottrell has discovered a new therapeutic target for triple-negative breast cancer, a deadly form of breast cancer lacking targeted therapies. The researchers identified dsRNA-binding proteins, specifically PACT, which suppress another protein called RNA-activated protein kinase (PKR).
A study by UC Riverside scientists reveals that the cysts of Toxoplasma gondii contain multiple distinct subtypes of parasites, each with different biological roles. This discovery offers new insights into how the parasite causes disease and why it has been difficult to treat.
A research team has developed a way to produce corticospinal-like neurons that centrally degenerate in motor neuron disease and are damaged in spinal cord injury. The study uses a multi-component gene-expression system called NVOF to precisely fine tune regulatory signals, resulting in mature neurons with distinct characteristics.
A newly excavated archaeological site in central China has uncovered evidence of advanced stone tool technologies, dating back 160,000-72,000 years ago, challenging long-held assumptions about early hominin behaviour in Eastern Asia. The findings suggest that hominins in this region were more inventive and adaptable than previously bel...
A new study in Geology suggests that massive undersea volcanism triggered at least four Triassic extinctions. Marine large igneous provinces were found to be a key driver of these events, accounting for half of the extinctions with an identifiable geological trigger.
A cohort study found that Medicaid expansion under the Affordable Care Act was associated with lower overall mortality among women with breast cancer aged 40-64. The benefits of expanded coverage were uneven, highlighting persistent disparities in healthcare access for certain populations.
Researchers have captured the first radio waves from a rare type of exploding star, revealing the star's final years. The discovery provides an unprecedented look at a massive star's behavior before its death in a supernova explosion.
The book sheds light on the often-ignored contributions of women in economics, highlighting their role as economic agents throughout history. Heggeness shares robust data and anecdotes about women who have thrived economically, from Taylor Swift to unsung heroes like Francis Perkins.
Researchers are developing next-generation adaptive insulin delivery systems using machine learning algorithms and ultra-rapid-acting U-500 insulin to personalize glucose control without manual intervention. The project aims to give people with Type 1 Diabetes their time, attention, and peace of mind back.
A nationwide survey found that 61% of Americans are unaware of non-statin medications to lower cholesterol, while 73% have never heard of lipoprotein(a) or coronary artery calcium score testing. Non-statin options include Ezetimibe, PCSK9 Inhibitors, and Bempedoic Acid, which can help patients at risk for heart disease.
The VERIFHE project aims to develop an open-source library for verifiable homomorphic encryption, enabling private and reliable inference. The ERC Proof of Concept grant will support the development of practical tools for machine learning services.
A new study discovered two previously unidentified fat distribution types associated with extensive gray matter atrophy and accelerated brain aging in men and women. Individuals with 'pancreatic-predominant' and 'skinny fat' profiles showed increased risk of neurological diseases, cognitive decline, and brain health issues.
The University of Virginia has launched a cross-Grounds initiative to advance health and healthcare through data and artificial intelligence. The Collaboratory aims to accelerate discovery, share expertise, and lower collaboration barriers across disciplines.
The MLEDGE project has successfully combined federated learning with cloud and edge computing to develop more secure, efficient, and personalized AI solutions. The project's applications include real-time COVID risk maps and energy consumption optimization in industry.
A large multinational clinical trial found that giving healthcare providers access to patient-reported outcome (PRO) data significantly improves the consistency of how treatment-related side effects are assessed in patients with cancer. This study highlights the importance of integrating the patient's voice into routine clinical evalua...
Researchers developed a high-resolution 3D ultrasonic imaging system for concrete that automatically adapts to different materials, improving contrast between defects and background material. The system uses a wide range of frequencies and can handle diverse materials without manual tuning.
Researchers at the University of Kansas have developed a tornado-forecast system called Warn-on-Forecast System (WoFS) that can predict tornado formation up to an hour before it occurs. The system uses high-resolution simulations and gauges uncertainties, providing guidance on severe weather threats.
Researchers developed miniature 3D tumor organoid models that closely mimic the human brain, revealing how glioblastoma interacts with surrounding brain cells and immune system. The models identified PTPRZ1 as a key regulator of tumor behavior, which helps determine its aggressiveness.
Researchers provide radiation oncologists with practical guidance to identify and protect female sexual organs during pelvic cancer treatment. The study establishes a shared, standardized approach to identifying the bulboclitoris, enabling clinicians to measure radiation dose to these tissues.
The Xigou site in central China has yielded evidence of sophisticated stone tool technologies dating back 160,000 to 72,000 years, revealing that hominins in the region were more innovative and adaptable than previously thought. The discovery challenges long-held views on early human technology in East Asia.
A hospital-based program supporting gun and knife violence victims can halve the likelihood of future harm, according to a Boston University study. Regular engagement with the Violence Intervention Advocacy Program reduced the risk of being revictimized or committing violence by 50 percent two to three years after discharge.
Rutgers University has developed a self-sustaining fund that reinvests revenue from commercialized technologies to support next-wave innovations. The model has generated an estimated 2.5-3.5 times more investment in follow-on funding.
Researchers used MRI analysis to measure glymphatic system activity, finding changes related to IIH stage and pressure levels. The findings suggest a noninvasive test could diagnose IIH more reliably, improving treatment options for patients with symptoms including headaches and vision loss.
A new computational modeling framework uses Type-3 Fuzzy Logic and neural networks to simulate tumor-immune dynamics under uncertainty and chaos. The model generates 'bands of uncertainty' and provides interpretable results, enabling physicians to understand the 'why' behind predictions.
Climate-risk scores are being used in infrastructure design, housing markets, and public policy, but the devil is in the details. Only 4% of highly cited studies shared their data and code, highlighting a structural barrier to cumulative progress.
Chronic wounds heal slowly due to healing disorders, affecting 800,000 people in Germany. Current treatment options lack evidence-based recommendations and patient-reported outcomes are underconsidered.
Researchers have uncovered a new understanding of how cardiac events are interconnected with the brain and nervous/immune systems. They found that sensory neurons in the vagus nerve detect injury and transfer signals to dedicated brain structures, leading to activation of the immune system.
Researchers led by Michael Wasserman are studying pesticide exposure in farming communities in Uganda, using household diaries and silicone wristbands to track human exposure. The study aims to inform communities about safe levels of exposure and suggest ways to reduce it.
Researchers have discovered a way to host graphene's electronic properties in a three-dimensional material, potentially removing hurdles for its use at scale in green computing. The discovery offers opportunities for designing materials with advanced low-energy electronic behaviour.
George Newman, a professor at the University of Toronto's Rotman School of Management, has been identified as an up-and-coming thinker whose ideas are predicted to make a significant impact on management thinking. His research focuses on creativity, identity, and meaning construction, with his work widely featured in prominent outlets.
Shorter-duration antibiotic therapy shows comparable success to longer-duration treatment in children with community-acquired pneumonia. However, more studies are needed for other age groups and diseases like acute otitis media.
A new study published in JAMA Network Open found that acupuncture is effective in reducing migraine without aura pain and improving functionality. The research identified specific brain network connections that predict treatment outcomes, enabling a personalized approach to pain management.
Researchers uncover a hypoxia–m⁶A–Gal-1 regulatory axis that fuels HCC progression by stabilizing Galectin-1 (Gal-1) mRNA, promoting malignant phenotypes. Functional experiments confirmed Gal-1's role in enhancing HCC cell proliferation, migration, invasion, and EMT-driven phenotypic plasticity.