A family of mutations in the BAF complex is found in 20% of human cancers, driving malignancy by altering gene accessibility to CTCF. CTCF's role in reshaping DNA is confirmed in multiple cancer types, suggesting potential therapeutic targets for BAF-mutant cancers.
A UBC-led global review found that relocating amphibians and reptiles to make way for development rarely leads to long-term conservation success. Conservation-focused relocations showed population growth or potential for survival over the long term, with only 6% of development-related relocations achieving population growth.
NVision's breakthrough molecular qubit enables practical path to quantum computing at scale using photonic connectivity, tolerating up to 70% photon loss for reliable operation. The company's Photonic Integrated Quantum Circuits (PIQC) platform establishes a new architecture for scalable quantum hardware.
A study published in Nature reveals that abnormal neurons with multiple copy number variants are surprisingly widespread in the developing brain, but are selectively eliminated by a quality control mechanism. This mechanism may provide insight into autism and other neurodevelopmental disorders.
A cosmic explosion revealed a powerful stellar jet lurking out of sight, with the team discovering the telltale signatures of the jet pointing away from Earth. The study found that the jet's shape and composition were complex, with the early afterglow radiation coming from the broader wings of the jet.
A recent brain study questions the notion that the prefrontal cortex is responsible for regulating emotions, suggesting that individual differences in emotional regulation may be more complex. The study found that participants' brain activity during reappraisal did not reliably indicate their ability to regulate emotions.
Researchers developed an AI model using retinal images to diagnose diabetic nephropathy and predict progression, avoiding kidney biopsies. The model achieved high accuracy and robust performance, showing great clinical value in kidney disease diagnosis and management.
Researchers have sequenced the genome of the trapdoor spider Aptostichus stephencolberti, finding it to be roughly 50% larger than the human genome, with 52 chromosomes and 77% repetitive sequences. The discovery may broaden our understanding of spider genome composition and its evolution across the animal Tree of Life.
A randomized clinical trial led by Mount Sinai researchers found that Mindfulness-Oriented Recovery Enhancement (MORE) can change brain responses to drug cues in people with opioid use disorder, reducing cravings and supporting recovery. The treatment, combined with medication, aims to reduce the influence of drug-related cues while st...
Researchers found a new way to interpret Einstein's equations, revealing a process called gravitational reconnection, where gravitational field structures break and reconnect, releasing energy into matter. This process could help physicists better understand extreme events like black hole collisions.
A Boston University-led study estimates that 75% of former NFL players who died between 2008-2023 had CTE neuropathology. The study analyzed brain donors and death certificates to estimate the prevalence of CTE among deceased NFL players.
Researchers analyzed 2,362 former NFL players and found 74.5% had CTE neuropathology at death after adjusting for selection bias. The study suggests that selection bias inflates donor-based estimates but does not fully explain the high burden of CTE among deceased NFL players.
Researchers at PolyU have uncovered a novel cross-domain cyberattack that can redirect electric vehicles to the same charging station, concentrating demand and potentially triggering power outages. The attack can originate outside the distribution network and propagate through EV charging behavior, threatening the grid's secure operation.
Research led by Nagoya University found evidence that ultra-relativistic electrons were accelerated locally within Earth's barrier, not infiltrating from outer radiation belts. Chorus waves, natural low-frequency electromagnetic waves, played a key role in this process.
Researchers at Kyushu University found that an ultrathin layer of iridium manganese improves spin transfer, enabling ultra-low-power devices for computing and energy harvesting. The findings could lead to the development of spin-based technology to convert heat into electricity.
Japan's newly enacted law regulates human genome-edited embryos and germ cells, prohibiting reproductive use but allowing basic research under ministerial oversight. The law imposes penalties for violations and sets a global ethics challenge, highlighting the need for international coordination to prevent circumvention of regulations.
Researchers at Kyushu University and Sumitomo Chemical have demonstrated high optical modulation efficiency and ultrafast operation at 180 Gbaud using KNN thin-film wafers in optical modulators. This breakthrough has significant implications for photonics-electronics convergence and next-generation data processing.
JMIRx journals have joined the Publish, Review, Curate (PRC) Alliance as a founding member to help advance more open and transparent approaches to scholarly publishing. This move reflects the commitment of JMIRx journals to the PRC approach, which prioritizes openness, equity, interoperability, and stakeholder governance.
Researchers at Tohoku University propose 'interfacial intelligence' framework to design polymer brushes with improved predictability and reliability. The approach combines polymer physics, machine learning, and simulations to understand how polymer brushes interact with their surroundings.
Researchers studied catalysts that use sunlight to produce ammonia, finding that a triangle of iron atoms can produce ammonia due to its magnetic properties, but a triangle of chromium atoms cannot. The difference lies in the magnetic orientation of the atoms, which affects the material's ability to bind nitrogen.
Macromolecular crowding stabilized synthetic DNA droplets and induced the formation of complex self-organized patterns, supporting the development of programmable artificial cell systems. The findings reveal that crowding promotes droplet formation, stability, and organization, enabling control over interactions and structure.
A study found nearly 90% of retracted brain tumor papers continued to receive citations, raising concerns about evidence-based patient care. The study analyzed 582 retracted publications and identified the most common reasons for retraction, including research misconduct and paper mill involvement.
The Research Ideas and Outcomes journal has joined the Publish, Review, Curate Alliance as a founding member, adopting an open-science model that promotes timely publication and open peer review. This transition aims to increase the visibility and discoverability of research outputs, aligning with the Alliance's goals.
A new study shows that global stroke burden is increasing, despite falling stroke rates, mainly due to metabolic risk factors and climate change. Population growth and aging contribute to the rise, but not all of it, with 52% of strokes now happening in people of working age.
Researchers developed an admission-based score to identify pancreatitis patients at risk of thrombosis, which showed moderate separation between patients with and without detected thrombosis. The score was associated with lower mortality rates among patients with thrombosis, suggesting potential benefits in early detection and treatment.
Research from Florida Atlantic University reveals that translucent windows in flower petals alter light and heat entry, changing internal temperature and influencing microbes. Warmer flowers generally harbor fewer microbes, and IR transmission increases floral temperature.
A new open-source energy-economy modeling framework, C-NEMS, aims to provide modular and transparent modeling code and data to advance energy systems analysis. The project, initiated by former US energy officials, is supported by Arnold Ventures and the William + Flora Hewlett Foundation.
A new study found that Cyclospora outbreaks lead to a 3.89% decline in weekly bagged salad purchases, resulting in an estimated $374 million in retail losses. The study suggests that retailers did not restrict supply during outbreaks, indicating that food safety concerns drove the decline in sales.
A recent study reveals the Antarctic Intermediate Water has reversed its long-term trends in salinity and density, driven by reduced freshwater input from melting sea ice. This change could impact global ocean currents, carbon storage, and climate stability, with potential cascading effects on weather patterns and atmospheric circulation.
A team of researchers at Kyoto University identified endophytes, fungi that symbiotically inhabit plant tissue, as key species shaping forest root microbiomes. These hidden masterminds significantly influence the landscape structure of fungal communities, with implications for ecosystem management.
A new study challenges the theory that comets delivered molecular building blocks for life on Earth, finding it highly unlikely due to comets' speed and angle of impact. Mars may be a more promising candidate for cometary delivery of prebiotic molecules, but it's still a rare occurrence.
Researchers at Washington State University have discovered a feed supplement that increases honey bee colony size, addressing blueberry pollination declines. The supplement, called Nano-B-Feed, is a powdered mixture of minerals and organic compounds that bees consume to boost their population.
A team of Oxford chemists used machine learning simulations to trace the atomic-scale processes that give hard carbon its disordered structure. The study reveals how removal of hydrogen and chlorine atoms generates reactive carbon sites that form new bonds, connecting the polymer chains into an extended network.
Researchers developed a long-acting protein-based therapeutic by fusing human erythropoietin to engineered albumin, showing a 5.7-day plasma half-life and improved mucosal barrier crossing. The fusion protein maintained therapeutic function and increased red blood cell production.
The study identified a thermodynamic boundary for photocurrent generation and found that more rigid donor molecules were associated with lower radiative voltage losses. This energy relationship could help maintain photocurrent while minimizing voltage losses, providing design guidelines for more efficient organic solar cells.
Researchers have developed a new process that captures CO₂ and produces itaconic acid, a valuable bio-based chemical, using a combination of electrochemical and microbial processes. The process uses CO₂ instead of sugar as a starting material, eliminating the need to transport intermediate products.
Experts from 14 countries discussed evidence-based medicine, TCM clinical research, and international cooperation, exploring how reliable evidence supports high-quality TCM development and serves clinical practice and public health. The forum also addressed artificial intelligence and translation of evidence into clinical practice guid...
A 99-million-year-old fossil community discovered in Myanmar reveals a remarkable connection between Australia's geological past and Southeast Asia's tropical plant diversity. The ancient plant community, preserved in exceptional detail, provides a rare glimpse into the region's evolutionary roots.
Researchers found that a weak La Niña combined with South Indian Ocean warmth drove record-low Arctic sea ice in 2025. The study suggests that these two signals are largely independent but can produce a stronger anticyclonic anomaly over the Sea of Okhotsk, accelerating local sea ice melt.
Glaciers in High Mountain Asia have lost an average of 12.8 billion cubic meters of water equivalent per year between 1975 and 2000, increasing to 19.7 billion cubic meters per year between 2000 and 2013. The study's findings highlight regional variations in glacier mass loss, influenced by temperature and precipitation patterns.
The study, led by Prof. JIANG Ling and Assoc. Prof. LI Gang, identified three lowest-energy structural models, with the endohedral cage being dominant. The findings provide experimental evidence for the smallest endohedral water cage, shedding light on liquid water, hydrophobic solvation, and ice nucleation.
Researchers developed a plasma-ultrasound catalytic process to synthesize nitroaromatic compounds from air, achieving an overall yield of 8.1% and 92.5% selectivity in one hour. The process controls the activation of air and phenol, avoiding over-oxidation and promoting selective C–N and N–O coupling.
Researchers at the University of Toronto have developed a flexible foot pad for the 'Hopcopter', a one-legged hopping robot, significantly enhancing its performance on challenging terrain. The new design enables the robot to traverse sand, ice, and other difficult surfaces with improved efficiency and accuracy.
A research team found that donor-derived NK cells accelerate hematopoietic recovery and improve clinical outcomes in patients undergoing myeloablative conditioning. The study also showed that NK cells promote the differentiation of hematopoietic stem cells towards granulocytic and megakaryocytic lineages.
The study reveals that breastmilk vesicles from mothers with postnatal depression contain specific miRNAs that affect offspring brain development, leading to cognitive impairment and behavioral abnormalities. These changes are mediated by the suppression of mGluR8 expression in the offspring brain.
Studies found that mechanical forces and extracellular matrix organization influence where muscle cells fuse and grow. The findings provide a physical framework for understanding how local cellular interactions shape large-scale muscle organization.
A new study by Edith Cowan University found that travellers consider GenAI for travel planning based on reliability, accountability, trustworthiness, fairness, and transparency. Excessive transparency can reduce willingness to use AI, highlighting the importance of balancing information with trust.
A new study has found that combining medications dobutamine and norepinephrine during septic shock surgery can significantly lower the risk of acute kidney injury. The trial, which tracked 584 adult patients, showed that the drug combination cut the risk of severe kidney damage in half, reducing moderate to severe kidney injuries.
Researchers capture radical positions and motion on 100-picosecond timescale using time-resolved X-rays, revealing radical behavior varies by neighboring molecule. The findings provide new insights into reaction selectivity and could lead to more precise production of effective new drugs and high-performance materials.
Delft researchers have successfully controlled the magnetism in the nucleus of a single atom using radio waves. This discovery raises new questions about the mechanism driving the nuclear spin and provides new opportunities for storing and reading quantum information.
The Lancet Countdown report finds that climate change health impacts are growing faster than climate action, with record-high heat deaths and economic losses. The authors call for climate change to be recognized as a global health emergency, with health at the center of climate decision-making.
A UK-wide analysis of bowel screening for patients with IBD has identified opportunities to improve early cancer detection. Regular experience, more time, and use of dye are associated with finding polyps, which may become cancer. The study provides a starting point for measuring and improving care for those with IBD.
Researchers developed a synthetic system to control gibberellin hormone signaling, revealing coordinated root growth across distinct cell layers. Activating GA signaling in specific layers promotes root elongation, with simultaneous activation in both endodermis and epidermis resulting in stronger growth.
Researchers develop linker-editing strategy to create ordered hydrogen-bond networks in COFs, accelerating proton-coupled electron transfer and improving solar-to-chemical efficiency. The urea-COF delivers high photocatalytic H2O2 generation rates and retains 90% activity after six recycling cycles.
Research reveals cancer diagnosis can lead to discrimination in work, finances, healthcare, and social networks, affecting quality of life and health
A Cochrane review found that ergonomic interventions have no significant impact on pain, function, or sick leave for workers with work-related arm, neck, or shoulder complaints. The review of 20 trials involving 2,478 people found little to no difference between ergonomic interventions and no treatment in short-term pain relief.
Researchers have created a portable device for detecting PFAS in water using inexpensive electrodes combined with synthetic antibodies. The device can detect trace levels of PFAS in water, opening a promising route to portable environmental monitoring. The platform is compact, low-cost, and designed for easy manufacturing.
A switching-dependent prescribed performance adaptive control scheme is proposed for switched nonlinear systems, ensuring practical finite-time stability with an explicit settling-time upper bound. The approach constructs mode-specific performance bounds and a dedicated error transformation to resolve switching-induced discontinuities.
GradientScreen, a 'lab-on-a-chip,' measures how a patient's leukemia cells respond to various drug combinations before treatment starts. This technology helps clinicians identify which patients are likely to be unresponsive to standard treatment and personalize treatment approaches.
A promising AI-based approach has been developed to detect early signs of suicide-related behavior in emergency room patients, reducing clinician workload. The model uses routine patient intake data and light-weight computing to estimate risk, and is intended to assist ER staff rather than replace them.