A new phase 1 trial shows that preexisting immunity can boost viral counts and worsen symptoms in secondary dengue infections. Researchers found that individuals with high levels of anti-dengue antibodies against the nonstructural protein 1 had more balanced immune responses and lower viral counts.
Researchers found the urban plume was enriched in lead, chlorine, and bromine, with 7 million people exposed to 24-hour lead concentrations 80 times higher than typical values. The study characterizes the air breathed by residents during urban fires and informs models for emergency response.
A new study by the Helmholtz Centre for Environmental Research - UFZ reveals that climate change increases flood hazards more than expected from extreme precipitation alone. The researchers used hydrological models to analyze flood peaks during Storm Boris and found that flood peaks increased considerably more than precipitation.
A novel antibody therapy empowers the immune system's tumor-fighting capabilities by targeting immune-suppressing T cells with greater precision. The therapy, which combines targeting CCR8 and activating CD3, promotes antitumor immunity in mice and nonhuman primates.
Historical sources reveal the 'Little Ice Age' in Transylvania had far-reaching environmental impacts, including colder temperatures and altered ecosystems. The study also highlights the social implications of these climate extremes, including changes in agriculture and human migration patterns.
Researchers have identified CHI3L2 as a key regulator of skin inflammation in psoriasis, found to boost keratinocyte proliferation and promote an inflammatory state. Targeting CHI3L2 with neutralizing antibodies calmed skin inflammation in mouse models, offering previously unrecognized therapeutic avenues for psoriasis treatment.
Early Paxlovid treatment was associated with modestly lower risks of Long COVID, post-acute hospitalization, and death among high-risk, nonhospitalized patients with COVID-19. No clear reduction in Long COVID risk was observed among low-risk patients.
A new study analyzing 194 countries and 7 years of data found that universal health coverage is more strongly linked to income levels than world regions. The study reveals significant income-group disparities in health coverage, with low-income countries having 21% lower UHC coverage compared to high-income countries.
SourcePLOS·JournalPLOS Global Public Health·TypeObservational study·DateOct 28, 2026
Researchers have engineered CAR-T cells that target brain tissue, allowing them to selectively destroy tumor cells in pediatric brain cancer DMG. The new therapy, B-SYNC CAR-T, has shown promise in laboratory tests, with the cells persisting and fighting cancer for over 70 days.
A new UV light-based technique has revealed that one-quarter of data centers are located in water-stressed areas, while analyzing mineral deposits in 37,000-year-old cave paintings. The technique, developed by researchers, has applications in forensic science and monitoring biofilms on the International Space Station.
Children with MGJWS may face greater risks of impaired visual development and reduced hyperopic reserve, underscoring the need for individualized assessment of surgical timing. The study found that pupil obstruction was associated with poorer visual development, and that this effect appeared more pronounced in children with MGJWS.
A new study by an international team of researchers shows the Amazon rainforest is a net source of global carbon emissions. Human drivers of land-use change, such as deforestation and wildfires, are the dominant control on the Amazon's net carbon balance.
Mayo Clinic Platform Accelerate has welcomed its largest cohort of digital health companies, with 31 companies participating in the program. The companies will have access to de-identified clinical data and expert mentorship to advance their digital health solutions. The program aims to support health tech companies at different stages...
Researchers found that sotagliflozin reduces excessive platelet activation, a process that can lead to dangerous blood clots that block flow to the heart and brain. The drug also makes platelets less likely to stick together and form blood clots, potentially lowering the risk of heart attack and stroke.
Human enhancement technologies, such as exoskeletons, drugs, and wearables, are becoming increasingly common in the workplace, promising to improve safety and productivity. However, they also pose risks on security, equality, and privacy, as well as challenges on traditional concepts of occupational health and work capacity.
New research shows that rising healthcare costs cause patients to anticipate greater physical pain, leading to delayed medical appointments. Financial anxiety amplifies this reaction, particularly among low-income individuals.
A University of Oklahoma researcher is using a $1.9 million NIH award to study how the body moves drugs into the liver and how other medications can disrupt that process. The goal is to develop a strategy that better predicts transporter-related drug interactions before patients are harmed.
Researchers have developed a novel microscopy platform called Three-photon Ultra-Deep Imaging (TrUDI) that pushes the depth limits of optical imaging of brain activity. The platform increases imaging efficiency by 250-fold, allowing for recording of neural activity in deep brain regions without surgically removing the overlying tissue.
A University of Bath-led study estimates that humans produce 2.05 billion tonnes of CO2 annually, a 74% rise over 30 years, primarily due to population growth. This finding can help scientists better understand human carbon production and its impact on the environment.
The Brain & Behavior Research Foundation will host its 2026 International Mental Health Research Symposium, showcasing the latest research on suicide prevention and child adolescent mental health. The event will feature presentations by Outstanding Achievement Prizewinners and the Pardes Humanitarian Prize recipient.
Research on Chornobyl dogs reveals genetic differences indicating directional selection, not mutation, in response to environmental variables. Genomic analysis identified over 100 locations with genes associated with cancer development and immune function.
A new study led by Dr. John Stewart from Bournemouth University solved the 150-year-old mystery of the extinct giant crane's identity. The researchers found that the bones were from larger versions of the current common crane, not a separate extinct species.
A research team has developed a scalable nanoimprint manufacturing method for achromatic metalenses, achieving high-resolution and low-cost fabrication. The novel photoresist and fast-curing stamp materials enable precise dimensional control and high-performance metalenses.
A new EUV grazing-reflection ptychography system enables full-pose self-calibration for high-resolution imaging in semiconductor inspection. The method combines physical modeling, computational optimization, and experimental validation to achieve high reconstruction fidelity and computational efficiency.
Researchers screened three yeast strains isolated from grapes, finding Debaryomyces hansenii rapidly established itself on tobacco leaves. PT-1 treatment simplified fungal communities and increased sugar, sweetness, and sensory scores, while modulating bacterial community structure.
Researchers successfully isolate stable oxoboranes, a challenge that has stood for over 60 years, using a novel method. The team's discovery opens up new possibilities for preparing elusive molecules across the periodic table.
A team proposed disturbance-introduced interferometry (DII), which utilizes mechanical disturbances to modulate optical path difference and encode surface phase information. Numerical simulations show strong robustness across a wide disturbance range, outperforming conventional four-step PSI.
The study found that fungal communities show clearer differences across elevations, with a higher Shannon diversity index for fungi. Dominant microbial groups also vary with elevation, with Ascomycota being the dominant fungal phylum and Pseudomonadota the dominant bacterial phylum. These findings provide a basis for investigating suit...
The report highlights the importance of integrating long-term ecological evidence, locally grounded practices, and diverse knowledge systems into biodiversity monitoring and restoration planning. It demonstrates how ecosystems have been shaped by human interactions and knowledge systems over thousands of years.
Researchers found that inoculating tea seedlings with beneficial fungi boosts their natural defenses against insect pests, reducing the need for chemical pesticides. The fungus primes the plant's immune system, tuning key genes to mount a faster response to insect attacks.
Researchers developed a ruthenium catalyst that achieves hydrogen production performance comparable to platinum while using significantly less precious metal. The catalyst's unique 'atom-layer neighbor' structure maximizes the use of each atom, enabling efficient and sustained hydrogen production.
A recent study found that a greater reduction in dorsal lung ventilation is independently associated with postoperative pulmonary complications in laparoscopic colorectal cancer surgery. Patients with a reduction of dorsal lung ventilation ≥14.5% had a higher incidence of postoperative pulmonary complications.
The team's research on reducing environmental noise in AI and generating diverse synthetic training data for large language models has been accepted to top AI conferences. Their methods have been shown to improve AI performance and efficiency across various fields, including robotics, reinforcement learning, and quantum AI.
Cereibacter azotoformans exhibits coordinated nitrogen-and-phosphorus removal through denitrification and polyphosphate accumulation. The NtrX/Y two-component regulatory system plays a crucial role in this process, influencing denitrification, PHA production, and energy metabolism.
Researchers successfully engineered E. coli to produce high-efficiency L-histidine through a four-part strategy, achieving a 127% yield increase and reduced carbon loss. The optimized strain reached a L-histidine titer of 34.84 g/L, with improved energy status, redox balance, and nitrogen-precursor supply.
A new study from the University of Eastern Finland found that higher animal protein intake is associated with lower blood testosterone levels, while higher plant protein intake is linked to higher levels. The study included 2,546 men aged 42–60 years and living in eastern Finland, and found that dairy protein intake was associated with...
Researchers use AI to enable spectrometer to learn best pulse sequence directly from sample, improving signal detection in NMR analysis. This approach shows promise for developing better magnetic-resonance-based quantum sensors and advanced laboratory applications.
Exercise improves depressive-like behaviors and alters gut microbiota composition in mice. Fecal microbiota transplantation from exercise-trained donors to stressed mice shows significant improvements in behavior and histological analyses. The study suggests a potential link between exercise, gut microbiota, and the gut-brain axis.
A study by Heidelberg University and the Finnish Geospatial Research Institute tracked the movement of dead tree branches in a forest plot, revealing a systematic pattern of daily movement driven by humidity changes. The research suggests that these movements can be quantified using autonomous laser scanning systems and tracking algori...
Researchers develop a simpler way to assess reinforced concrete floors' response to sudden column failure, enabling buildings to better withstand structural damage. The method, validated through a real-world case study, could support future improvements to structural design guidance and reduce the risk of progressive collapse.
A new study by the Vodafone Institute and University of Bonn reveals that Europe's digital dependence has increased by 0.5 percentage points between 2010 and 2023, with China reducing its dependence by nearly 11 percentage points and the US by 6 percentage points. European countries exhibit moderate to high levels of digital dependence...
Researchers developed a privacy-friendly AI technique for radiation therapy, combining multiple hospitals' data without exchanging sensitive patient data. The approach reduces computing costs and CO2 emissions, enabling access to powerful models for smaller facilities.
A study found that body composition, particularly fat-free mass percentage and body fat distribution, is associated with inflammation and growth hormone levels in middle-aged men. However, these associations disappeared after adjusting for body fat, suggesting that body fat may help explain the observed relationships.
A new study finds that Antarctic sea ice melt has led to an increase in salinity in the Antarctic Intermediate Water (AAIW), a major water mass that affects ocean circulation. This change has implications for the ocean's structure and carbon cycle, potentially contributing to increased warming.
Francis Peyton Rous identifies transmissible cancer agent in chickens, challenging established ideas about cancer. His discovery leads to the development of viral oncology and modern understanding of cancer as a genetic disease.
A Chinese Neurosurgical Journal review clarifies neuroanatomical variations, neurological and neurosurgical risk factors, and perioperative considerations for gender dysphoria treatment. The review aims to improve neurosurgeon knowledge and holistic care for individuals with gender dysphoria.
A study found that nearly half of severely distressed generative AI users seek emotional support from platforms like ChatGPT and Gemini. This raises concerns about the risks of relying on AI during periods of emotional vulnerability. The study highlights the need for better understanding of AI's benefits and risks in mental health supp...
Researchers create ultrathin multiferroic bismuth ferrite films that retain key properties and exhibit emergent properties, enabling ultra-low power computing. The technique overcomes the 'dead layer' effect, allowing for densely integrated and fast devices.
Researchers found that short, controlled exposure to low-oxygen air reduces cortisol and leptin levels, increases adiponectin, and improves inflammation markers in people with Parkinson's disease. However, more in-depth studies are needed to confirm the effects on sleep and reorganize the sleep-wake cycle.
A study finds that topography dominates GNSS-R coherence, with smooth, wet, and moderately vegetated surfaces strengthening coherence, while rough, steep, and densely vegetated terrain weakens it. Empirical transition ranges provide an interpretable observational basis for GNSS-R land applications.
A new report by ECDC suggests that universal RSV immunization of newborns could prevent up to 61% of RSV-related hospitalizations in the first two months of life. The strategy aims to reduce the burden on healthcare systems during the winter season, when RSV, influenza, and other respiratory infections are most prevalent.
Researchers mapped 5 million individual immune cells from 2,000 people, identifying nearly 1,500 genes linked to a range of diseases. The findings provide a detailed map of how genetic variation shapes the immune system, enabling targeted treatments and precision medicine.
The heart uses two carbohydrate energy sources, glucose and lactate, at the same time due to a unique cell-level difference that allows both energy-generating reactions to happen simultaneously.
Researchers found that replacing just four amino acids in a plant defense molecule can increase its toxicity against pests, paving the way for creating more resistant commercial cultivars. The study, published in Nature Communications, analyzed the biochemical origin of the difference between wild and cultivated tomatoes.
A national survey found that 43% of teenagers gambled in the past year, with exposure to family gambling increasing high-risk teen gamblers. Researchers identified risk starts early, isn't limited to boys, and newer activities like prediction markets and social casino games pose significant threats.
A new study found that the gender gap in AP exam scores is narrowing, but not across all subjects, with boys dominating STEM fields and girls excelling in humanities. The study analyzed over 70 million exam results and found that participation in AP tests was often split along gender lines.
Ambassador Mark Dybul has been appointed as the new executive director of the Global Fund to Fight AIDS, Tuberculosis and Malaria, succeeding his previous term from 2013 to 2017. Dybul is a Georgetown University professor and alumnus who has dedicated his career to improving global health.
Researchers at the University of Oxford have identified a novel semiconductor material, bismuth sulfide, that overcomes a key limitation in capturing solar energy. This material absorbs light strongly while losing its electrical charges more slowly, enabling more efficient solar panels with higher outputs.
Physicists have observed electrons jumping across energy gaps in graphene, defying classical physics. The team used a novel combination of laser technology and electron microscopy to visualize ultrafast dynamics of Landau-Zener-Majorana transitions, shedding light on their role in high-speed semiconductor electronics.
Nicotine pouch use among US adult tobacco users rose sharply between 2021 and 2024, with