An international team of scientists proposes strategies to overcome obstacles posed by the blood-brain barrier, a gate-keeping system protecting the brain from toxins and letting in nutrients. The review article highlights the importance of understanding the blood-brain barrier in treating brain diseases such as Alzheimer's, multiple s...
Researchers found that Secretoneurin (SN) increases production in brain cells following ischemia, improving survival of primary brain cell cultures. In animal models, SN treatment reduced cerebral tissue death, improved motor performance, and enhanced brain function.
Research by University of Florida scientists found that using club drugs triggers a similar chemical chain reaction in the brain as a traumatic brain injury, resulting in cell death and memory loss. The study suggests that methamphetamine use can cause irreversible brain damage.
A recent study using PET scans shows that an experimental gene therapy can normalize brain function in Parkinson's patients. The treatment was found to alter brain activity in a favorable way, primarily affecting motor networks.
Researchers found that the NF1 gene regulates the development of astrocytes and neurons by controlling two signaling pathways. This discovery may lead to separate treatments for the condition's two major symptoms: brain cancers and learning disabilities.
Research suggests that genetic factors significantly influence human brain structure and intelligence, particularly in regions involved in attention, language, and visual processing. Heritability estimates range from 70-90% for gray matter volume and 40-69% for the hippocampus.
New research on glutaric acidemia type I reveals that young mice are more susceptible to brain damage due to lysine uptake, which can be mitigated with a novel treatment strategy. Mast cells play a role in abdominal aortic aneurysm development, and blocking LAG-3 might enhance cancer vaccine effectiveness.
Researchers have made significant progress in understanding the mechanisms underlying injury and age-dependent susceptibility to glutaric acidemia type I. By using a mouse model of the disease, scientists discovered that limiting lysine uptake can substantially decrease brain damage caused by exposure to the amino acid.
Scientists are studying the mechanics of brain folding in higher mammals to better understand its relationship with cognitive ability and neurological diseases. They have found that tension in axons may play a key role in driving this process, which could lead to new insights into conditions such as schizophrenia and autism.
A recent study by Wake Forest University School of Medicine has found that autistic individuals have deficient connections within single brain regions, contradicting previous assumptions. The discovery was made using magnetoencephalography brain imaging technology and may lead to earlier diagnosis and targeted medications for autism.
A Stanford study using fMRI scans found that music engages brain areas involved with paying attention, making predictions, and updating memory. Peak brain activity occurred during silence between musical movements, a process called event segmentation.
Scientists have developed a new method to deliver therapeutic molecules across the blood-brain barrier using a short protein from the rabies virus. This approach protects mice from infection caused by the Japanese encephalitis virus, suggesting potential for treating various brain infections and diseases.
Researchers have discovered that stroke or traumatic brain injury can trigger Alzheimer's disease by enhancing the formation of brain-clogging amyloid plaques. Key findings include the role of caspase-mediated depletion of GGA3 in stabilizing BACE and increasing amyloid protein production.
Indiana University neuroscientists Olaf Sporns and Christopher Honey found that the brain's spontaneous activity is shaped by its wiring diagram. Their computational model of a macaque monkey's brain shows how fluctuations in activity emerge from chaotic neural interactions, revealing rich temporal structure at multiple time scales.
A study suggests that new adult brain cells play a crucial role in lifelong learning by exhibiting plasticity similar to young brains. The researchers found that these cells have a critical period of adaptability before settling into mature properties, enabling them to contribute to specific brain functions throughout life.
Research suggests that heavy drinkers have smaller brains than non-drinkers, with moderate to high drinkers showing significant reductions in brain volume. The study found a 1.6% decrease in brain volume for those who consumed over 14 drinks per week.
A recent study by Carnegie Mellon scientists found that a mouse brain can significantly compensate when limited to sensing the world through one whisker. The results provide new understanding of brain adaptability in response to sensory deprivation, which can be applied to stroke or traumatic brain injury treatment.
A new computer model developed at the McGovern Institute for Brain Research at MIT has been shown to perform as well as humans on rapid visual categorization tasks, even making similar errors. The model follows the organization of the brain's visual system and can help neuroscientists explore brain mechanisms involved in human visual p...
A recent study found that the extent of brain tissue loss and lesion load at diagnosis can predict the rate of brain atrophy over two years in MS patients. Baseline MRI variables, including brain volume and T2 lesions, are associated with subsequent brain volume change.
Researchers at UCLA suggest that the brain uses physical changes to cells to monitor time, rather than a clock-like mechanism. The team's computer model showed that the brain-cell network can encode time through the context of preceding events, which was tested in a study with research volunteers.
Researchers at the University of Vermont have clarified the cellular process responsible for signaling regional blood flow changes in the brain. Astrocytes play a crucial role in communicating with blood vessels through potassium ions, leading to rapid dilation and increased local blood flow.
Despite rapid brain growth, human brain genes have slowed down evolution since the split from chimpanzees. Complexity and gene-gene interactions place constraints on brain genes, hindering change. Genes in humans evolve more slowly than in other primates or mice.
A population-based study of 13,613 brain tumor cases in Sweden found that people with four or more siblings were twice as likely to develop a brain tumor. Children under 15 with three or more younger siblings had a two to fourfold increase in brain tumors compared to those with no siblings.
Researchers at Wake Forest University School of Medicine have identified changes in brain chemistry associated with post-cancer radiation-induced dementia. They found that whole-brain radiation causes changes in glutamate receptors, which may lead to cognitive deficits.
A new UCLA study shows that chemotherapy causes persistent changes in brain function, leading to cognitive symptoms like forgetfulness and confusion. PET scans reveal a link between chemo-brain symptoms and lower brain metabolism, suggesting that monitoring brain activity could help prevent these effects.
Researchers identified brain circuits motivating desire to overeat in obese individuals, linked to the same circuits that cause addicted individuals to crave drugs. The study found significant changes in brain metabolism associated with emotional behaviors and eating habits.
Functional magnetic resonance imaging (fMRI) identifies critical brain regions prior to surgery, leading to more effective tumor removal and reduced surgical time. In 49% of cases, surgeons altered their treatment plans after fMRI findings, with no reported neurological deficits.
Scientists from the University of Florida have found that ordinary human brain cells can generate new brain tissue in mice and produce large amounts of new brain cells in culture. This discovery could potentially be used to fight Parkinson's disease, Alzheimer's disease, stroke, and other brain disorders.
Researchers used trans-cranial magnetic stimulation to trigger activity in specific brain regions, enhancing peripheral vision and altering visual cortex activity. The study suggests potential applications for treating neurological conditions that impair vision.
A recent study using diffusion tensor imaging found no significant differences in brain integrity and volume between cannabis smokers and non-smokers. The findings suggest that moderate cannabis use may not have a direct impact on brain structure and integrity, but more research is needed to confirm these results.
A study published in NeuroImage found that alcohol selectively suppresses cognitive activity in the frontal and posterior parietal brain regions, leading to poor coordination. This suppression is due to impaired feedback processing in brain areas critical for updating mental models for motor action.
Researchers found that younger children's brains involved more brain areas during language exercises, indicating greater flexibility. As children matured, brain activity concentrated on the left side, offering hope for rehabilitation of brain function after stroke or traumatic brain injuries.
Researchers at Cedars-Sinai Medical Center have developed a novel gene therapy strategy that modifies the brain microenvironment to induce an effective immune response against deadly brain tumors and infections. The treatment uses Flt3 Ligand to recruit antigen-presenting cells, which can destroy tumors and combat brain infections.
A new MRI study found a nearly perfect correlation between iron levels in brain regions and those reported by past post-mortem studies. The study suggests that age-related brain iron accumulation is a modifiable risk factor for degenerative brain diseases, including Alzheimer's disease.
Scientists at Johns Hopkins Medicine have created a detailed map of the lateral wall of the subventricle zone, suggesting the potential existence of human brain stem cells. The discovery also reveals displaced ependymal cells that may be related to cancer or neurodegenerative diseases.
Researchers at U of MN develop novel method to assess dynamic brain network interactions using magnetoencephalography (MEG). This breakthrough allows for better evaluation of brain function in diseases like Alzheimer's and monitoring treatment effects.
Researchers found that anandamide, a brain's own cannabis compound, protects neurons from inflammation after damage. Adding AEA to damaged brain tissue abolished inflammatory damage, but not primary excitotoxic damage.
A new study by McMaster University found a significant correlation between brain size and intelligence in women. In contrast, men's spatial ability was not strongly related to overall brain size. The study suggests that sex differences may play a role in cognitive processes.
A new study reveals that targeting the brain chemical methionine enkephalin (Met-Enk) with antisense molecules can alter brain function and increase alcohol consumption in mice. This breakthrough could lead to a new class of drugs for treating Alzheimer's disease and possibly even alcoholism.
Treating four or more brain tumors with radiosurgery is safe and effective, translating to a survival benefit of up to 18 months for some patients. The study's findings suggest that tumor volume rather than the number of brain metastases should be used as a criterion for radiosurgery.
Researchers found that language activity in the brain becomes more evenly distributed between both hemispheres with age, allowing for potential rehabilitation. This shift may explain why young children who have had a portion of their brain removed can recover completely.
Researchers have found a way to get drugs past the blood-brain barrier to treat brain cancer. The compound JV-1-36, an antagonist of the hypothalamic growth hormone-releasing hormone, has shown promising results in treating malignant glioblastomas.
Researchers found that astrocytes can generate seizure activity by releasing the brain chemical glutamate, which hypes up neurons and causes them to fire uncontrollably. This discovery offers new hope for treating epilepsy by targeting overlooked brain cells instead of just reducing brain function.
Researchers Marcel Just and Tom Mitchell use computer models to interpret fMRI brain scans, developing a computational theory of brain activity during language processing. They also demonstrate how reading different words and sentences influences brain activity and identify specific brain regions involved in language comprehension.
Researchers used fMRI to study brain activity under hypnosis for pain suppression, finding reduced activity in pain network areas and increased activity in other regions. This suggests that hypnosis blocks the pain signal from reaching the brain's perception centers.
A recent study found that nicotine can eliminate the differences in brain activity between men and women during hostile or impulsive acts. Brain imaging research conducted by UCI showed that when participants were given nicotine, the brain-metabolism activity was virtually identical for both sexes.
Researchers used transferrin protein to attach medicines to iron-containing proteins, allowing them to pass through the blood-brain barrier. This technique enables larger molecules to reach the brain, opening up new possibilities for treating brain diseases.
Scientists have created a comprehensive map of brain genes that regulate brain development, linking specific genes to specific brain locations. The Mahoney Transcription Factor Atlas will aid researchers in studying brain tumors and other disorders.
Researchers found that brain surface stimulation significantly reduced Parkinson's symptoms in animals, restoring normal activity in the striatum and motor cortex. The study suggests that this method could be an effective alternative to deep-brain stimulation with major advantages in simplicity and safety.
Studies using functional magnetic resonance imaging (fMRI) show that individuals with brain deficits can relearn matching visual input with sensory input. This study used fMRI and a cyber glove to demonstrate the effectiveness of remapping motor commands, a crucial step in stroke recovery.
A study published in The Journal of Neuroscience found that chronic back pain is associated with a significant decrease in gray matter volume in the brain, particularly in regions involved in processing information and memory. This suggests that proper treatment may reverse some of the brain changes caused by chronic pain.
Researchers at Sick Kids confirm that cancer stem cells are responsible for initiating and growing brain tumors in a mouse model. This discovery opens the door for new therapeutic targets to conquer brain tumors.
A study published in American Journal of Obstetrics and Gynecology found that infections occur around birth are associated with an increased risk of periventricular leukomalacia (PVL), a condition causing brain tissue death. PVL is the most common form of brain injury in premature infants, resulting in cerebral palsy.
A study by St. Jude Children's Research Hospital found that the protein Mrp4 limits penetration of topotecan into the brain, which could improve treatment for brain cancer. Over-expression of Mrp4 in tumors contributes to topotecan resistance in patients.
Researchers found abnormalities in brain activity among people with normal IQs who have autism, indicating a deficiency in coordination among brain areas. The study proposes the underconnectivity theory, which suggests that autism is a distributed system-wide disorder limiting integration among brain areas.
A comprehensive brain-scan study of intelligence has identified certain brain regions and their gray matter volume as key determinants of general human intelligence. The research reveals that multiple brain areas are related to IQ scores, with only about 6% of all gray matter appearing crucial for intelligence.
Researchers used MRI to study myelin insulation in brain connections, finding they deteriorate three times faster in older adults with Alzheimer's disease. This breakdown disrupts brain function and leads to cognitive decline.
Researchers have developed an iron oxide nanoparticle that can outline brain tumors and other lesions for up to five days under MRI, providing a new imaging marker. This contrast agent has the potential to assist in image-guided brain surgery and improve diagnosis of neurological disorders.
A new study found that moderate alcohol intake may promote brain atrophy, which can lead to lower cognition and reduced extremity function. The research, published by the American Heart Association, used magnetic resonance imaging (MRI) to assess brain abnormalities in middle-aged adults.
Researchers at Washington University developed a non-invasive fMRI technique to better evaluate brain surgery risks and guide operations to avoid sensitive language areas. This breakthrough holds promise for safer surgeries for nearly 200,000 Americans diagnosed with brain tumors annually.