Dr. Robert D. Schreiber receives AACR-CRI Lloyd J. Old Award in Cancer Immunology for his groundbreaking contributions to the field of cancer immunology, including identifying IFNγ as a key cytokine and developing the cancer immunoediting concept.
A study led by Dr. Sergio A. Lira found that removing gut bacteria reduced polyp formation and inflammation in mice, potentially reducing colorectal cancer risk. The researchers propose a new approach to understanding the interplay between genetic mutations, gut bacteria, and inflammation.
Researchers at The Scripps Research Institute have mapped the severe immune overreaction known as a cytokine storm in flu virus infections. The study found that a potent new class of anti-inflammatory compounds can quiet this reaction, allowing infected hosts to mount an effective immune response.
Female Pacific salmon that mate with their chosen partner produce healthier babies than those with selected mates, according to research by the University of Waterloo. This allows for a more robust stock, reducing the use of antibiotics and vaccines, which benefits both producers and fish health.
A study published in The Journal of Immunology found that Interleukin 21 (IL-21) contributes to fatal inflammatory disease, particularly when another cytokine is deficient. Removing IL-21 can greatly subdue the inflammatory response and may help people with chronic inflammation due to defective T cell regulation.
A genetic variation near an area that encodes for interferon-lamda3 (IFNL3) is responsible for the differences between those who can and cannot effectively clear HCV. Individuals with a favorable IFNL3 genotype have a better outcome in fighting HCV.
A La Jolla Institute researcher has discovered that mast cells and a cellular protein called STAT5 play a crucial role in causing eczema by triggering increases in mast cells. The study opens new therapeutic avenues to prevent or treat eczema, including blocking STAT5 in mast cells.
A study led by Albert Einstein College of Medicine found that including at least one woman on the team organizing a scientific symposium increases female speaker proportion by 72%. This strategy can help women advance in their careers and reduce underrepresentation in senior academic positions.
TB-causing bacteria mask their molecular patterns using cell surface lipids, evading immune detection. The presence of lipid molecule PGL promotes the recruitment of permissive macrophages that allow TB to establish an infection in deeper lung tissue.
A new study investigates the potential toxicity of nanoparticles on human immune cells, finding that eosinophils respond to nanoparticle contact. The research aims to establish standards for worker protection and regulation of nanoparticle use.
A study published in the Journal of Allergy and Clinical Immunology found that bronchial thermoplasty reduces severe asthma exacerbations, emergency department visits, medication use, and missed workdays for at least 5 years. The treatment also shows stable rates of respiratory adverse events and respiratory-related hospitalizations.
Researchers have successfully transformed human stem cells into functional lung and airway cells, opening up new possibilities for regenerative medicine. The breakthrough has significant implications for modeling lung diseases, screening drugs, and studying human lung development.
Researchers found that loss of TSC1 in T cells disrupted the balance between regulatory and effector T cells, leading to severe inflammation. The study suggests that fine-tuning mTOR activity through regulators like TSC1 may be beneficial for treating autoimmune and inflammatory diseases.
Researchers have identified how golden staph bacteria target and destroy key immune cells, disrupting the body's defense against infection. By visualizing this process using advanced microscopy techniques, the team gained insights into how golden staph evades the immune system and causes tissue damage.
Scientists at A*STAR's Singapore Immunology Network discovered the exact mode of action of plerixafor, a drug that stimulates immune responses in patients with neutropenia. The study found that the inhibition of CXCR4 by the drug plays a dual role, increasing neutrophil count in the blood and promoting retention in the bloodstream.
Three researchers at the Walter and Eliza Hall Institute have been awarded ARC Future Fellowships to study how the body controls errant immune cells causing type 1 diabetes and coeliac disease. They aim to develop new treatments using cell signalling pathways and targeted vaccines or drugs.
Researchers at Tel Aviv University have discovered a powerful mechanism that regulates the lifecycle of eosinophils, a type of white blood cell involved in allergies and autoimmune diseases. By targeting a specific receptor, scientists may be able to develop new treatments for eosinophilic disorders like asthma.
Researchers have identified a new pathway that kills eosinophils before they can cause harm. The study found that targeting this pathway could lead to new therapies for devastating eosinophilic disorders.
Researchers at Northwestern University have successfully tested a nontoxic therapy that suppresses Lupus in blood samples of people with the autoimmune disease. The study found that the peptides can block and reduce autoantibody production to almost baseline levels, showing potential as a vaccine-like therapy.
A study by the American College of Allergy, Asthma and Immunology found that children in southeastern and southern states are more likely to develop hay fever. Climate factors such as temperature, precipitation, and UV index contribute to this increase.
A new study suggests that asthma inhalers with dose counters can significantly reduce emergency room visits by 55 percent. The study found that patients who use these inhalers are more likely to know if they have enough medication left and receive timely treatment, resulting in fewer severe attacks. According to the American College of...
Anaphylaxis from shrimp allergy is rare in children, affecting only 7.8 percent of cases, according to a study. The most common reactions are angioedema and skin symptoms like hives, with asthma being a potential risk factor for anaphylactic reactions.
Individuals with a known gelatin allergy can experience mild to severe reactions from the flu shot, including hives, sneezing, and difficulty breathing. Precautions should be taken when receiving the vaccine, such as having a board-certified allergist administer it.
Researchers suggest that specific parts of food can be safe for consumption in individuals with food allergies, and substitutes can be eaten safely. For example, someone with an egg allergy may be able to tolerate egg yolk but not the whites.
Adult females are more prone to allergies, asthma and autoimmune diseases compared to males, with gender differences changing after puberty. Genetics play a role in determining allergy and asthma risk, with personalized medicine being key to effective treatment.
Researchers have found a rare case where a bone marrow transplant cured a child's peanut allergy. The study suggests genetic modification during immune cell development may play a role in causing allergies.
Research suggests that pregnant women who receive allergy shots may reduce their child's risk of asthma, food allergies, and eczema. Allergy shots, also known as immunotherapy, can modify and prevent disease progression.
A study by the American College of Allergy, Asthma and Immunology reveals that asthma sufferers allergic to cats has more than doubled over an 18-year period. Those with asthma are also 32% more likely to be allergic to cats than those without asthma.
Use of ACE inhibitors can cause a life-threatening allergic reaction in oral allergy syndrome sufferers, characterized by extreme facial swelling and difficulty breathing. Hay fever sufferers often mistake oral allergy symptoms for food allergies, but it's not a food allergy and can be treated with cooked foods.
Researchers warn of the dangers of neglecting to clean reed instruments, which can lead to Saxophone Lung, an allergic pulmonary disease caused by specific fungi. Proper diagnosis is crucial, as corticosteroids alone are insufficient in treating this condition.
A study by Timothy Craig, MD, found that allergy shots decrease anxiety and depression in those allergic to wasp, bee, and ant stings. Allergy shots are the only treatment known to modify disease progression, making them life-saving for severe allergy sufferers.
Allergy expert Dr. David Stukus debunks common myths, including artificial dyes, vaccines, at-home blood tests, dietary restrictions, and pet allergies. He emphasizes the importance of consulting a board-certified allergist for proper evaluation and treatment.
Researchers found that disrupting the circadian clock in mice increases susceptibility to inflammatory disease by controlling the development of key immune cells called interleukin-17-producing CD4+ T helper cells. This discovery could lead to new ways to regulate the immune response and prevent autoimmune diseases.
Lysophosphatidic acid (LPA) inhibits immune response against cancer by binding to killer T cells, preventing them from recognizing and attacking nascent tumors. The LPA5 receptor is responsible for this inhibition, which can halt tumor growth.
A study published in Nature Immunology has identified two key proteins, KLF2 and S1P1, that influence immune response strategies. The findings suggest that cytokines play a major role in determining whether lymphocytes become resident memory cells or recirculate.
Researchers found that Itch maintains the stability of regulatory T cells (Tregs), which promotes Th2 inflammatory responses and severe airway inflammation in mice. This study highlights the importance of Itch in regulating immune responses and preventing allergic diseases.
Carl Nathan, MD, receives $20,000 prize for discoveries in immunology; monograph published in Molecular Medicine explores inspiration and purpose in scientific inquiry. The Anthony Cerami Award aims to document innovations and discoveries in medicine and healthcare.
Researchers have discovered that mucus in the large intestine has anti-inflammatory properties, helping to prevent bacterial-induced inflammation. The study proposes that mucus could be used to treat various diseases, including IBD and cancer, and may even be manufactured for oral administration.
Researchers found no evidence of an increased risk for specific major birth defects in mothers who received the flu shot. However, there was a slight increase in preterm delivery rates among vaccinated women during certain seasons.
Scientists at Walter and Eliza Hall Institute identify IRF4 protein as key regulator of elite killer T cells, which recognize and fight infections. Enhanced IRF4 production boosts immune response against HIV and other chronic infections.
Researchers at Scripps Research Institute discovered that an antibody binding to HIV likely targets the body's own proteins, complicating its development as a vaccine. The finding raises concerns about potential autoimmune diseases and self-reactivity in 4E10 antibodies.
Researchers have developed a novel treatment for gonorrhea that works like a live vaccine, reversing immunosuppression and preventing reinfection. The treatment, administered intravaginally, uses microsphere technology to stimulate an immune response against the bacterium.
Scientists at A*STAR's Singapore Immunology Network have discovered a new mechanism involving p53, the famous tumor suppressor, to fight against aggressive cancers. The strategy works by sabotaging cancer cells' ability to hide from the immune system, opening a new avenue for targeted therapy.
A recent Penn study found that fish skin and gut immune responses are similar, with key components resembling those in mammals. The study suggests IgT plays a crucial role in regulating host-microbiota homeostasis and may be involved in developing improved fish vaccines.
A recent study by La Jolla Institute scientist Shane Crotty found that follicular helper T (Tfh) cells play a key role in generating broad neutralizing antibodies against HIV. The research showed a correlation between Tfh cell levels and antibody response, suggesting these cells may serve as an indicator for vaccine development.
Researchers at A*STAR's Singapore Immunology Network have discovered a novel protein called Butyrophilin 3A1 that activates human gamma delta cells, which then coordinate an immune response to clear infections. This breakthrough opens doors to developing new treatments for cancer therapy and infectious diseases.
A new study found that certain immune cells help cancer stem cells survive and thrive. This finding has significant implications for the development of targeted therapies to eliminate cancer.
Four UCLA researchers received significant funding to advance promising stem cell therapies for HIV/AIDS, prostate cancer, and sickle cell disease. Drs. Jerome Zack, Robert Reiter, Donald Kohn, and Gerald Lipshutz will use the grants to develop innovative treatments with potential to revolutionize disease care.
Researchers at the Children's Hospital of Philadelphia developed a new approach to cancer immunotherapy by adjusting the function of immune cells. They showed that inhibiting the enzyme p300 can reduce Treg cell function and limit tumor growth in mice, offering potential for anti-tumor therapy.
Researchers at Helmholtz Centre for Infection Research found that lymph nodes in certain locations produce more regulatory T cells, which mediate tolerance to harmless substances. This 'location-specific memory' is crucial for maintaining the balance of the immune system and preventing autoimmune diseases.
Scientists at Helmholtz Centre for Infection Research discovered natural killer cells have optimal immune response balance, having less active NK cells during early stages of infection improves survival. The overproduction of interferon IFN-γ can block recruitment of neutrophilic granulocytes, leading to fatal sepsis.
Scientists at A*STAR's Singapore Immunology Network discovered a new class of white blood cells that play a critical role in the first line of defense against harmful fungal and bacterial infections. The findings have significant impact on vaccine design and targeted immunotherapies.
Researchers have uncovered the cell death processes that determine regulatory T cell numbers, which can lead to better treatments for autoimmune diseases. The discovery of Bcl-2 family proteins as determinants of regulatory T cell numbers offers new ways to control these cells and potentially suppress autoimmune disease.
A team of scientists at Scripps Research Institute identified a family of tiny RNA molecules that work as powerful regulators of the immune response in mammals. These RNA molecules enable the differentiation of T cells into follicular helper T cells, which assist B cells in producing antibodies.
Researchers at Turku Centre for Biotechnology and Aalto University have discovered a new epigenetic mechanism that regulates lymphocyte function. This breakthrough provides insight into the emergence of immune-mediated diseases such as type 1 diabetes, rheumatoid arthritis, and inflammatory bowel disease.
A recent study published in Nature reveals that septins play a crucial role in activating the calcium channel on T cell surfaces, allowing them to fight disease. This discovery provides new insights into the intricate pathways involved in turning on T cells and could lead to the development of more targeted drugs.
Frank Leo van de Veerdonk has received a 2013 ICAAC Young Investigator Award for his groundbreaking research on fungal immunology. He discovered that mutations in STAT1 are responsible for autosomal dominant chronic mucocutaneous candidiasis, a major breakthrough in diagnosing immunodeficiencies with fungal infections.
Joshua Obar has been honored with the ICAAC Young Investigator Award for his groundbreaking research on immunological memory responses. His work focuses on understanding how latent viral infections affect CD8 T cells and the formation of immune memories.
Researchers at Washington University School of Medicine have identified a way to trigger the reproduction of human insulin-producing beta cells in a laboratory setting, potentially removing a significant obstacle to transplanting these cells as a treatment for patients with type 1 diabetes. This new technique uses a cell conditioning s...
Researchers from La Jolla Institute, Dana-Farber and BloodCenter of Wisconsin are launching Phase II clinical trials to investigate a potential new therapy for reducing sickle cell anemia symptoms. The trial is testing Lexiscan, an existing drug with anti-inflammatory effects.