Scientists uncover how lymph nodes' development is controlled by the Hippo pathway, shedding light on their role in regulating immune responses. The research found that impaired Hippo signaling can lead to fibrosis or transformation of fat cells, highlighting potential therapeutic targets for diseases affecting systemic immunity.
Researchers found that linker histone H1 undergoes liquid-liquid phase separation in the nucleus, forming droplets with densely packed DNA and enriching with protein HP1α. This process segregates heterochromatin from euchromatin, revealing a new function of histones in gene regulation.
Researchers at the Institute for Basic Science have developed a new strategy to convert CO2 into oxygen and pure carbon monoxide using nanoparticles. The hybrid catalyst, made of blue titania, tungsten trioxide, and silver, shows 200 times higher performance than previous versions.
Researchers at IBS have engineered a new biological tool that controls calcium signaling in the brain of mice using blue light. The study found that this non-invasive approach triggers memory and emphatic fear responses, indicating its potential for studying Ca2+ signaling and its role in neurodegenerative diseases.
IBS researchers successfully grow large-area, single crystal bilayer and trilayer graphene films on Cu/Ni(111) alloy foils with specific stacking patterns. The resulting graphene sheets exhibit exceptional thermal conductivity, mechanical performance, and electrical transport properties.
Researchers have developed a new cobalt-based catalyst that enables an eightfold increase in hydrogen peroxide (H2O2) production, a major electronic cleaning chemical. The catalyst, Co1-NG(O), is highly stable and efficient, producing up to 8 times more H2O2 than existing noble metal-based electrocatalysts.
A new study published in Nature Climate Change concludes that future subtropical warming is the main culprit behind accelerated tropical climate change. This phenomenon originates from the interaction of atmospheric and oceanic circulation changes, as well as cloud processes between subtropical and tropical regions.
Researchers discovered that Parkinson's disease symptoms begin when dopaminergic neurons are in a dormant state, not just after death. Treatment targeting excessive astrocytic GABA may alleviate symptoms by awakening dormant neurons.
ATAD5 plays a crucial role in counteracting DNA replication stress by regulating PCNA unloading and promoting RAD51 recruitment. This study reveals ATAD5's fundamental mechanism of replication stress control, contributing to the development of cancer therapy.
The study introduces a universal detection method utilizing thermal radiation's intrinsic super-linearity for high-resolution imaging of objects at all scales. This technique enables arbitrarily cranked-up super-resolution factor and applications in various fields such as thermal imaging, self-driving cars, and stealth object detection.
Researchers have found that alloy metal nanoparticles facilitate faster carbon nanotube growth by attracting more active metal atoms to the growth front. This leads to a larger carbon concentration and quicker addition of carbon atoms, preventing precursor accumulation around the nanoparticle.
The new method enables the creation of tall-and-narrow nanostructures with controllable dimensions, including transparent nanoelectrodes with high optical transmission and tunable conductivity. Researchers achieved this by adding 'table salt' to the polymer solution, improving electrostatic attraction between nanofibers.
Scientists have developed a method to synthesize carbon nanotubes (CNTs) with a selectivity of 90%, challenging existing theories. The new approach allows for the production of specific types of CNTs, such as (2n, n) CNTs, which are ideal for electronic applications.
Researchers have successfully converted large-area bilayer graphene into the thinnest possible diamond-like material, F-diamane, under moderate pressure and temperature conditions. This flexible and strong material has potential for industrial applications in nano-optics and nanoelectronics.
Researchers at the Institute for Basic Science discovered a carrier multiplication process in 2D semiconductors that could improve the efficiency of solar cells. The phenomenon is more efficient in 2D materials than in bulk semiconductors and has the potential to increase the maximum power conversion efficiency up to 46%
Researchers have synthesized a novel sponge-like 2D material with interesting electrical conductivity and magnetic properties. The material, NiTAA-MOF, can conduct electricity when doped with iodine, making it potentially useful for optoelectronics and energy storage.
Researchers developed optogenetic platform 'optobody' that activates antibody fragments with blue light, enabling temporal control over protein functions in living cells. The tool has great clinical promise for therapeutic strategies in cancer and inflammatory diseases.
Researchers have identified the mechanism underlying ultrasonic brain stimulation's neuromodulation effect, revealing that TRPA1 channels in astrocytes play a crucial role. This non-invasive approach has shown promise for treating movement disorders and may also be useful for conditions like dementia, concussions, and depression.
Scientists have identified an unusual electron scattering phenomenon in hybrid systems of Bose-Einstein condensates and 2D electron gases. This discovery opens up new possibilities for designing high-temperature superconductors by exploiting the unique interactions between electrons and Bogoliubov quanta.
A novel targeting strategy using a click reaction-assisted immune cell targeting (CRAIT) method enables deep tumor penetration of drug-loaded nanoparticles. This approach has shown promising results in reducing tumor burden in aggressive breast cancer models, offering new hope for cancer treatment.
New research finds that unusual ocean temperatures in the tropical Pacific and Atlantic can increase April tornado occurrences over the Great Plains. Climate researchers discovered a link between ocean temperatures and atmospheric conditions that enhance thunderstorms and tornado-favorable environments.
Researchers created stretchable metal composites with high electric conductivity that can be 3D printed on soft substrates at room temperature. This breakthrough technology enables the production of compact and slim wearable devices with improved data recording capabilities.
New research found that Antarctic icebergs can weaken and delay the effect of Global Warming in the Southern Hemisphere. The study suggests that icebergs persist for years, cooling ocean waters and impacting currents by lowering ocean salinity.
Researchers used a novel super-resolution microscopy technique to directly observe depletion layers in polymer solutions flowing through microchannels. The study found that changes to the depletion layer dimension occurred at unexpectedly low flow rates, and hydrodynamic lift forces played a key role in this phenomenon.
Researchers identified astrocytic mu-opioid receptors as key to conditioned place preference, a mechanism underlying addictive behaviors. The study found that astrocytic MORs in the hippocampus release glutamates, increasing synaptic transmissions and inducing long-term potentiation, which is responsible for spatial memory acquisition.
Researchers have found that basal meningeal lymphatic vessels function as the main plumbing pipes for cerebrospinal fluid drainage, and their integrity is impaired with aging. This study highlights the role of basal meningeal lymphatic vessels in the development of age-related neurodegenerative diseases such as Alzheimer's disease.
In acoustoelectronics, surface acoustic waves generate electric currents with conventional and unconventional components. The Valley Acoustoelectric Effect creates a warping-based current and a Hall current with distinct characteristics.
Researchers find that introducing a controlled amount of fluorine enhances the growth rate of 2D materials like graphene, h-BN, and WS2. This allows for faster production of high-quality films, reducing synthesis time by up to 70%. The study demonstrates a promising approach to controlling the growth of 2D materials.
A new statistical approach calculates the likelihood of an ice-free Arctic Ocean at different warming levels, finding a 6% chance at 1.5°C and 28% at 2°C. The research suggests a sea ice-free summer Arctic Ocean is most likely to occur at 2-2.5°C warming.
Researchers at IBS have successfully fabricated a single layer graphene film on large area copper foils with no adlayers, achieving adlayer-free and single crystal graphene. This breakthrough enables the creation of high-performance devices with consistent uniformity in the number of layers over large areas.
Researchers at QNS have developed a technique to visualize the magnetic field of single atoms with unprecedented resolution. This breakthrough enables the mapping of spin distribution in complex structures such as molecules and magnetic materials.
A novel molecular mechanism for regulating PCNA cycling during DNA replication has been discovered. The ATAD5-RFC-Like-Complex (ATAD5-RLC) is a PCNA unloader that opens the PCNA ring to remove it from DNA.
Researchers at Institute for Basic Science synthesize hBN single crystals of 10*10 cm2 using a new substrate with lower symmetry. The study reveals that the substrate's symmetry affects crystal alignment and provides a general guideline for synthesizing various 2D materials.
Researchers have developed an enzyme-like heterogeneous TiO2 photocatalyst with high catalytic activity for hydrogen production. The catalyst's unique enzymatic characteristics enable it to efficiently convert light energy into H2, rivaling the performance of expensive Pt-TiO2 photocatalysts.
Researchers at IBS report discovering spontaneous oscillations in microfluidic droplet networks, similar to our blood capillaries. Adding irregularities to the network relieves blood traffic cloggings, suggesting cell collisions or diameter variations help avoid dangerous oscillations.
A new study reveals that recent intensification of the equatorial Pacific wind system known as Walker Circulation is unrelated to human influences and can be explained by natural processes. The observed strengthening of the Walker circulation from about 1990-2013 was a naturally occurring phenomenon, contrary to projections of anthropo...
Researchers at IBS have identified the mistake-rate of DNA editing tools using CRISPR and adenine base editors. The study reveals that ABE7.10, a widely used gene engineering tool, has an average of 60 off-target mistakes in the human genome.
Researchers developed a new iridium catalyst for the selective synthesis of chiral lactams, which are key building blocks in pharmaceutical agents. The catalyst achieves high selectivity by inducing hydrogen bonding between substrate and catalyst, leading to the production of desired compounds with minimal waste.
A team of researchers found that as the temperature increases, the ergodization time-scale becomes huge, but the time-scales necessary for chaoticity remain practically unchanged. This phenomenon is known as dynamical glass, which emerges from the fragmentation of frozen and seemingly inert regions.
Scientists have identified a brain pathway that underlies an effective therapy for sustainably reducing traumatic memories. The study found that alternating bilateral sensory stimulation (ABS) induces a persistent fear reduction by activating the superior colliculus and mediodorsal thalamic nucleus pathways, which suppresses fear expre...
Researchers discovered that cancer cells growing in lymph nodes prefer to use fatty acids rather than glucose as an energy source. The metabolic adaptation was found to be triggered by the activation of yes-associated protein (YAP), which stimulates fatty acid oxidation in metastatic tumor cells.
Researchers at IBS confirmed wave spreading mechanisms in a cloud of quantum particles, extending computational horizons from one day to 60 years. They used novel toolbox and Discrete Time Quantum Walks for fast simulations, revealing subdiffusive cloud spreading up to record timescales.
The study reports the observation of an XY-type antiferromagnetic material whose magnetic order becomes unstable when reduced to one-atom thickness. This finding is consistent with theoretical predictions dating back to the 1970s.
Researchers discover Ets1 gene's role in autoimmune disease lupus; found that faulty gene leads to Tfh2 cell expansion and autoantibody production. Blocking IL4 pathway mitigates SLE features.
The COSINE-100 experiment has released its first results, confirming the absence of a dark matter signal in the data. The study challenges the DAMA claim as a WIMP signal, significantly challenging the traditional Standard Halo Model for dark matter.
A study by IBS researchers found that Foxp1 protein stabilizes induced Treg (iTreg) cells, which play a crucial role in regulating the immune response. The lack of Foxp1 led to increased susceptibility to colitis and intestinal inflammation in mice.
A new study reveals that Arctic amplification is primarily driven by local carbon dioxide forcing and polar feedbacks, outweighing other processes. This finding highlights the importance of understanding Arctic processes in controlling sea-ice retreat and ecosystem sensitivity to global warming.
Researchers at IBS discover ferroelectrically tunable skyrmions, promising faster data storage density and speed. The discovery enables the creation of nanoscale, non-volatile, and reversible skyrmion memories.
Scientists at Institute for Basic Science achieved a breakthrough in shielding quantum properties by packing two atoms together, protecting fragile states 20 times longer than one atom. This development enables the exploration of single atoms as quantum bits for future information processing.
Researchers have discovered that metastatic cancer cells follow a Lévy walk movement pattern, like sharks searching for food, which aids in their rapid spread and direction. The team was able to reprogram this behavior using chemical inhibitors, changing it back to more typical diffusive motion