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John Innes Centre


What sea cucumbers can teach us about self-defense

Researchers have discovered how sea cucumbers produce defensive chemicals using genome mining techniques. The animals' unique ability to biosynthesize toxins has been found to be linked to the diversion of a sterol-producing enzyme, resulting in the production of valuable medicinal compounds.

SourceJohn Innes Centre·JournalNature Chemical Biology·TypeExperimental study·DateJun 27, 2022

Gene-edited tomatoes could be a new source of vitamin D

Researchers have developed gene-edited tomatoes that can produce vitamin D3 through exposure to UVB light. The tomato leaves naturally contain provitamin D3, which accumulates in the fruit after editing. This breakthrough could help millions of people with vitamin D insufficiency and provide a plant-based source of vitamin D3.

SourceJohn Innes Centre·JournalNature Plants·TypeExperimental study·DateMay 23, 2022

The hardy wild grass that could save our bread

A team of researchers identified a stem rust resistance gene from wild goat grass species Aegilops sharonensis, which can be cross-bred into wheat for immunity against deadly crop pathogens. The genetic potential of this hardy relative has been largely unexplored and holds promise for reducing the threat of the stem rust disease.

SourceJohn Innes Centre·JournalNature Communications·TypeExperimental study·DateMar 25, 2022

Scientists solve the grass leaf conundrum

Researchers used computational modeling and developmental genetic techniques to study grass leaf formation, finding that current theories are likely incorrect and a 19th-century proposal is closer to the truth. The discovery sheds light on how simple growth rules can generate diverse leaf shapes.

SourceJohn Innes Centre·JournalScience·TypeComputational simulation/modeling·DateDec 9, 2021

How bread wheat got its gluten: Tracing the impact of a long-lost relative on modern bread wheat

Researchers sequenced DNA from 242 accessions of Aegilops tauschii, a wild relative of bread wheat, and discovered a distinct lineage that contributed to the modern wheat genome. This ancient contribution has provided valuable genetic diversity for improving disease resistance, yield, and environmental resilience in modern wheat.

SourceJohn Innes Centre·JournalNature Biotechnology·TypeExperimental study·DateNov 1, 2021

The microbial molecule that turns plants into zombies

Parasitic bacteria manipulate plant development by hijacking molecular machinery, causing abnormal growth and reprogramming the plant's lifecycle. Researchers identified a key protein that facilitates this process, opening doors to genetic editing technologies for durable resistance against phytoplasmas.

SourceJohn Innes Centre·JournalCell·TypeExperimental study·DateSep 17, 2021

How plants become good neighbors in times of stress

Scientists from the John Innes Centre and University of Bristol found that deep shade triggers changes in plant circadian clocks, suppressing stem elongation. This adaptation allows plants to coexist in dense forests and crop canopies without wasting energy.

SourceJohn Innes Centre·JournalProceedings of the National Academy of Sciences·DateJun 29, 2021

Landmark field trials show potential of gene-editing

Researchers have successfully used CRISPR-Cas9 gene editing technology to manipulate glucosinolate levels in broccoli, reducing their accumulation in the leaves and florets. This study highlights the potential of gene editing to improve crop health and adaptability in challenging environments.

SourceJohn Innes Centre·JournalThe CRISPR Journal·DateJun 21, 2021

How cells measure themselves

Researchers found that cells regulate their own size by using DNA content as an internal scale. Cells with too little KRP4 delay DNA replication until they catch up, while those with too much dilute KRP4 to speed up the process. This mechanism keeps meristem cells within a narrow size range.

SourceJohn Innes Centre·JournalScience·DateJun 10, 2021

Virus infection cycle revealed in dynamic detail

Researchers have developed a pioneering plant-based technology to study the virus maturation process, revealing large structural rearrangements that enable chemical reactions necessary for infection. The study provides valuable insights into the dynamics of an essential part of a virus infection cycle.

SourceJohn Innes Centre·JournalCommunications Biology·DateMay 24, 2021

Long search finds grain of hope in the glume

Researchers at the John Innes Centre identified a key gene controlling grain elongation and glume characteristics in Polish wheat, which could lead to improved productivity and sustainability in wheat production. The discovery highlights the importance of understanding genetic control of agronomic traits for major crops like wheat.

SourceJohn Innes Centre·JournalThe Plant Cell·DateMay 19, 2021

The first frost is the deepest

Researchers discovered that the first frost triggers a molecular response in plants, called COOLAIR, which helps regulate flowering. This finding has implications for understanding how plants adapt to fluctuating temperatures and could lead to improved crop yields.

SourceJohn Innes Centre·JournalGenes & Development·DateMay 13, 2021

Winning gene combination takes all

Scientists have successfully identified the complete avenacin biosynthetic pathway in oats, which provides resistance to soil-borne diseases like take-all. This discovery has implications for creating disease-resistant lines of wheat using modern technologies.

SourceJohn Innes Centre·JournalNature Communications·DateMay 7, 2021

Research pinpoints unique drug target in antibiotic resistant bacteria

Scientists have pinpointed a critical mechanism allowing deadly bacteria to resist antibiotics, and discovered a potential new target for effective treatment. The study identified quinolone antibiotic resistance mechanisms, including the production of pentapeptide repeat proteins, and revealed how they inhibit bacterial enzymes.

SourceJohn Innes Centre·JournalProceedings of the National Academy of Sciences·DateMar 8, 2021

Bacteria can tell the time

Researchers discovered that free-living non-photosynthetic bacteria, such as Bacillus subtilis, possess circadian rhythms that adjust to light and temperature cycles. This finding has implications for biotechnology and could lead to optimized drug delivery and crop protection strategies.

SourceJohn Innes Centre·JournalScience Advances·DateJan 8, 2021

Research gets to the heart of organ shape in nature

A new study by John Innes Centre researchers sheds light on the evolution and function of diverse shapes in nature, using Capsella seed pods as a model. The discovery reveals a post-translational effect beyond gene expression, controlling organ-shape formation through protein modification.

SourceJohn Innes Centre·JournalCurrent Biology·DateAug 13, 2020

Slow growth the key to long term cold sensing

Researchers have found a new temperature sensing mechanism in plants that uses slow growth to measure long-term changes in temperature. The study reveals that the protein NTL8 plays a crucial role in this process, accumulating slowly over time and being diluted by faster growth rates.

SourceJohn Innes Centre·JournalNature·DateJul 15, 2020

Self-isolation or keep calm and carry on -- the plant cell's dilemma

Plant cells must balance trade-offs between communication, resource exchange, and protection against pathogens like fungi and bacteria. Researchers discovered that chitin perception in plasmodesmata triggers specific signaling pathways that allow cells to isolate themselves, regulating vital processes independently of immune responses.

SourceJohn Innes Centre·JournalProceedings of the National Academy of Sciences·DateApr 14, 2020

How three genes rule plant symbioses

A study published in Nature Plants reveals that three genes are shared exclusively by plants forming intracellular symbiosis with different microbial partners. This finding demonstrates a conserved genetic program underlying diverse types of symbioses, allowing plants to access additional nutrients.

SourceJohn Innes Centre·JournalNature Plants·DateMar 2, 2020

How plants are built to be strong and responsive

Plant researchers have discovered a dual guidance system that enables plants to grow stronger and respond more flexibly to environmental cues. This autonomous system allows cellulose synthase complexes to interact with chemical trails left by other complexes, guiding the arrangement of cellulose fibres.

SourceJohn Innes Centre·JournalCurrent Biology·DateFeb 6, 2020

Nature's secret recipe for making leaves

Researchers from the John Innes Centre discovered that simple shifts in gene activity in the leaf bud provide a flexible mechanism for forming leaves of all shapes and sizes. The study reveals how cup-shaped leaves evolved from flat sheets through simple genetic changes, offering a simple mechanistic explanation for diverse leaf forms.

SourceJohn Innes Centre·JournalScience·DateNov 21, 2019