A new study reveals the molecular mechanism behind bacterial DNA repair, showing that RNA polymerase plays a key role in identifying and fixing errors. Researchers found that RNaseHII cooperates with RNA polymerase to scan for misincorporated ribonucleotides in living bacterial cells.
Adults with sleep apnea are at greater risk for long COVID, according to a new study. The research team found that patients with sleep apnea had a 12% increase in risk for long-term symptoms after their initial infection, and a 75% increase in risk compared to those without sleep apnea.
A study found that restoring gamma oscillations in brain regions processing smells can counter depression, suggesting a potential new treatment approach. The research involved mice and rats, who showed increased depressive behaviors when gamma signals were suppressed, but returned to normal after receiving amplified signals.
Researchers found that resistance to leukemia treatment occurs due to rapid increase in mitochondria breakdown and turnover, allowing cells to evade death signals. A new combination of chloroquine and venetoclax restores the drug's ability to kill cancer cells by targeting a specific mitochondrial process.
Researchers developed a bioengineered drug candidate that counteracts <em>Staphylococcus aureus</em> infections, including MRSA. The mAbtyrins treatment targets multiple disease-causing mechanisms without killing the bacteria.
Researchers found that melanocyte stem cells, responsible for hair color, lose their ability to mature and maintain hair color as people age due to getting stuck in the skin. The study showed that these 'stuck' cells cease regenerative behavior when they're no longer exposed to WNT signaling, leading to graying and loss of hair color.
A new vaccine type, mRNA-4157/V940, added to immunotherapy significantly reduced melanoma recurrence and death rates. The combination was found to be effective in 22.4% of patients compared to 40% without the vaccine.
A new study found that the COVID-19 pandemic led to steeper declines in fertility rates in some US states than others, with factors like income inequality, racial composition, and political leaning playing a significant role. States with stronger social distancing responses and liberal politics experienced larger fertility rate declines.
Researchers identified key Hox genes as controllers of stem cells involved in both forming and repairing bone. Increasing the activity of these genes restored fracture repair capacity in aging mice by 32.5%, highlighting their potential for treating bone-healing deficiencies.
Researchers at NYU Grossman School of Medicine found that automated systems with alert banners increased MRA therapy prescriptions for heart failure patients by 30%. The system aims to improve care and reduce costs by streamlining medical information in one place. The study tested two notification types, finding that banner-like alerts...
Researchers found that patients with greater buildup of fatty plaque deposits in the heart's three largest blood vessels had higher chances of developing serious health issues following surgery. This study suggests using existing chest scans to estimate patients' risk of heart attack or death during major surgeries.
A new study found that chemotherapy alters the immune cell landscape in pancreatic cancer, reducing checkpoint molecules and increasing tumor growth. The research suggests that this may lead to resistance to subsequent immunotherapy, highlighting the need for further study on combining chemotherapy with immunotherapy.
Researchers found that combining a chemical blocker of immune cell exit with immunotherapy stopped melanoma tumor enlargement in over half of mice tested. The study showed that T cells circulate out of tumors, reshaping scientific views of tumor immunology.
Researchers found that community health worker partnerships led to significant improvements in blood pressure control among South Asian patients, who face unique social and cultural barriers to healthcare. After six months, 68% of treatment group participants had controlled blood pressure, compared to 42% of the control group.
A study reveals how CBD reduces seizures in pediatric epilepsy by blocking signals carried by lysophosphatidylinositol (LPI), a molecule that can amplify nerve signals and promote seizures. The research provides new insights into the mechanisms behind seizures and suggests potential targets for future drugs.
Researchers at NYU Langone Health and the University of Toronto have developed a new AI tool called ZFDesign, which enables customizable protein editing for treating genetic diseases. The tool promises to accelerate gene therapy development on a large scale, offering a potentially safer alternative to CRISPR.
Researchers at NYU Langone Health identified the genetic basis of VEXAS syndrome in 2020, now estimating its prevalence among US men and women over 50. The study found that approximately 1 in 4,269 American men over age 50 and 1 in 26,238 women may develop the syndrome.
Researchers at NYU Langone Health developed an iScore system that correlates inflammation levels with survival rates in patients with acute myeloid leukemia (AML), with those having low scores surviving the longest.
Researchers at NYU Grossman School of Medicine found that subway stations near river tunnels have significantly higher concentrations of hazardous particles in the air. The study suggests increasing ventilation and cleaning efforts to improve air quality in these areas.
Researchers at NYU Langone Health have identified a gene that drives development of lung squamous carcinoma, a common type of lung cancer. Deleting this gene causes normal cells to transform into cancerous cells, providing potential targets for new therapies.
A new study in deaf rats demonstrates that stimulating the locus coeruleus region of the brain can improve how quickly they learn to use their cochlear implants. The findings suggest that differences in neuroplasticity may contribute to variations in hearing improvements among implant recipients.
A new study shows that paying cash to people with obesity for losing a specific amount of weight works better than offering free tools like weight-loss programs and wearable fitness trackers. Incentives tied to actual weight lost were most effective in the short term, while goal-focused financial rewards performed better in the long run.
Researchers found that a gene mutation in mice resulted in increased plaque deposits and larger clumps, suggesting the gene plays a critical role in immune defenses. The study may lead to new therapies targeting this gene mutation to slow progression of Alzheimer's disease.
Researchers found that patients with more genetic material on chromosome 9 in their cancer cells survive longer after receiving immunotherapy. The discovery suggests a genetically defined axis that determines which HNSC patients will respond well or poorly to checkpoint inhibitors.
A recent study by NYU Langone Health found that adult patients with severe stressors, such as death of a loved one or financial insecurity, are more likely to experience depression, brain fog, fatigue, and other long-term COVID-19 symptoms. These stressors were also strong predictors of worse functional status, sleep quality, and reduc...
Patients who survived cardiac arrest and received CPR reported lucid experiences of death, including separation from the body and meaningful evaluation of life. Researchers discovered rhythmic brain waves suggestive of near-death experiences, providing evidence for a unique human experience on the brink of death.
A new study found that COVID-19 infection directly interferes with the healthy balance of microbes in the gut, further endangering patients. The research revealed that antibiotic-resistant species can escape into the bloodstream, putting patients at greater risk for life-threatening secondary infections.
A new study combines targeted and immune therapies to overcome limitations in treating cancer. The approach uses antibodies to recognize and target cancer cells, increasing the efficacy of any cancer drug when attached to its disease-related target.
Researchers at NYU Grossman School of Medicine have discovered a new treatment approach that suppresses allergic asthma without compromising the body's defenses against flu viruses. The treatment, which targets calcium channels in immune cells, has shown promise in reducing asthmatic inflammation and mucus build-up in mice.
A new study found that a protein called apoptosis inhibitor five (API5) protects most people with the mutation linked to Crohn's disease from developing the illness. Norovirus infection blocks API5 production in mice with Crohn's, killing gut-lining cells and tipping the balance towards autoimmune disease.
A new study identified a remdesivir-resistant version of COVID-19 in two kidney transplant patients treated with immunosuppressive drugs. The virus developed the V7921 gene mutation, which allows it to resist antiviral therapy, highlighting the need for continued monitoring and potential development of additional treatments.
A new study found that a single research test can predict which patients are likely to experience severe side effects or have their cancer recur after treatment with immunotherapies. The test uses autoantibody signatures to identify patients at risk of immune-related adverse effects.
A recent study found that COVID-19 vaccination rates in NYC schools differed significantly by race and ethnicity, with majority Asian students having the highest rate at 66.2%. Vaccination rates also varied by borough, with Manhattan having the highest rate and Staten Island the lowest. The study suggests that understanding these diffe...
Researchers discovered that dense liquid droplets in human cells can act as 'computers' by recognizing and calculating responses to incoming chemical signals. The formation of these condensates is driven by molecular crowding and can influence the activity of enzymes called kinases, which are involved in various cellular processes.
A new study found that psilocybin, combined with psychotherapy, significantly reduced heavy drinking among participants with alcohol dependence. Eight months after treatment, nearly half of those who received psilocybin stopped drinking altogether.
A new study found that neurons with the same birthdate show distinct connectivity and activity throughout adulthood, forming cooperative signaling circuits. This suggests that the brain may exploit orderly neuronal layer formation to establish neural templates that match each new experience to an existing template.
A new study found that 86.6% of people with opioid use disorder are not receiving life-saving medications like methadone, buprenorphine, and extended-release naltrexone. The researchers recommend expanding treatment access by removing barriers, eliminating stigma, and ensuring evidence-based medications are used.
A new study estimates that exposure to PFAS chemicals may result in $5.5-63 billion in lifetime health costs due to conditions like low birth weight, childhood obesity, kidney cancer, and hypothyroidism. The study supports the EPA's decision to lower safe allowable levels of these substances.
A new study found that COVID-19 vaccine boosters significantly reduce the risk of breakthrough infections in patients with systemic lupus erythematosus. The research showed that those who received a booster dose had an immediate rise in antibody levels, but still required additional protection against severe disease.
A new study found that exposure to high levels of outdoor air pollution increases the risk of death by 20%, while living far from specialty medical clinics and near busy roads also poses a significant risk. The study's predictive model can help policymakers reduce disease burden in communities by mitigating environmental risk factors.
A new study demonstrates a computer tool, PrimSeq, that accurately identifies and counts arm movements in people undergoing stroke rehabilitation. The tool has shown to be 77% effective in tracking the intensity of patients' movements during therapy.
A new study reveals that prolonged immune reactions in olfactory tissue contribute to long COVID symptoms, including depression, anxiety, and brain fog. The research found a unique inflammatory response in hamsters previously infected with SARS-CoV-2, which corresponded with behavior changes and brain cell biology abnormalities.
Researchers found that exercise increased levels of adrenalin, reprogramming the immune system to recognize and attack cancer cells. This led to a 50% reduction in cancer formation and 25% decrease in tumor weight in mouse models. In human patients, exercising before surgery also improved overall survival rates.
Researchers found that neuronal damage in Alzheimer's disease originates from within brain cells' lysosomes, where amyloid beta appears. This discovery could explain why drugs designed to remove amyloid deposits have failed to stop the disease.
Nemvaleukin alfa, a new immunotherapy drug, has shown potential in treating late-stage cancers. The drug, used alone or in combination with pembrolizumab, stopped tumor growth or resulted in shrinkage for some patients with advanced kidney and melanoma cancers.
A study found that 70% of women who froze eggs at age 38 and thawed had a baby, compared to fewer than 30% undergoing IVF at age 40. Egg freezing resulted in higher pregnancy success rates than using fresh embryos.
A new study published in Gastroenterology found that using computer-aided detection during colonoscopies can significantly increase the detection of adenoma, or cancerous and precancerous polyps. The research, led by Dr. Aasma Shaukat, showed a 27% increase in the overall rate of detection in average-risk patients. This technology has ...
A new study reveals that running increases dopamine release and brain-derived neurotrophic factor (BDNF) levels, leading to improved learning, memory, and motor skills. The findings provide insight into the long-term effects of exercise on the brain and may lead to new treatments for Parkinson's disease.
A new study found that access to modernized supermarkets with fresh foods in NYC's poorest neighborhoods led to a 1% decline in obesity rates and reductions of 4-10% in BMI-z scores. The results suggest that supermarket subsidies could play an effective role in addressing childhood obesity, especially among Hispanic and Black children.
A new study published in Surgical Endoscopy found that adolescents with obesity who underwent laparoscopic sleeve gastrectomy benefited from reduced obesity and concomitant organ damage, regardless of their age at the time of surgery. Additionally, adolescents with a family history of bariatric surgery had a higher weight prior to weig...