Researchers mapped eight tree species in Forest Park using satellite imaging data and machine learning techniques. The data will help inform best practices for managing healthy green spaces and trimming programs to avoid power outages following storms. By analyzing tree health and species, experts can track growth rates and identify tr...
A study found that patients enrolled in both Medicare and Medicaid had higher healthcare costs, cognitive impairments, and social support needs. Researchers propose adjusting reimbursement to account for risk factors in this population.
The researcher will collect data from 1,500 patients using prescription opioids to identify factors that may increase the risk of opioid-related depression. Long-term opioid analgesic use is associated with increased risk for depression and impairs depression treatment and recovery.
A new technology aims to bridge the gap for visually impaired students in STEM fields by using robotics, touchscreen technology, and sound. The project focuses on developing graphics and simulations that can be felt and heard, enabling equal access to math, engineering, and science concepts.
Researchers at SLU found that a Mediterranean diet improves athletes' endurance exercise performance after just four days. The diet's anti-inflammatory and antioxidant effects may lead to improved exercise performance.
A study by Saint Louis University's College for Public Health and Social Justice found that nearly two-thirds of low-income women cannot afford menstrual hygiene supplies like pads or tampons, with 46% unable to buy both food and period-related products. The researchers advocate for broader education and policy shifts surrounding menst...
Researchers propose using sound-based network management for tasks like datacenter server fan failure detection, authentication, load balancing and congestion notification. Music-defined networking leverages sounds from real or virtual devices to augment existing network components with sound capabilities.
A SLU researcher suggests focusing on high-risk tuberculosis patients to improve treatment completion rates and accelerate the US goal of eliminating the disease. By identifying latent patients at highest risk of active infection, doctors can better communicate the importance of completing treatment regimens.
Researchers studying fetal exposure to inflammation aim to understand its impact on infant immune responses and potential prevention methods. High levels of Th17 cells in pregnancy-inflammation mothers and preterm babies have been linked to tissue damage, but their role in infection protection is unclear.
Head and neck cancer survivors are at a higher risk of death by suicide, with the rate being two times that of other cancer survivors and four times that of the general population. The study found that approximately one-half of head and neck cancer survivors become functionally disabled after completing treatment.
SLU scientist Daniela Salvemini is studying chemotherapy-induced cognitive impairment and opioid addiction to develop new treatments. Her research aims to identify novel therapeutic approaches to mitigate chemo-brain and improve quality of life for cancer patients.
A new project aims to increase HIV testing among Nigerian youth by developing and implementing innovative tools for self-testing. Researchers will use open challenges and entrepreneurship training to engage youth in creating effective HIV services.
A SLU scientist is using a $150,000 grant to research human pancreas cells and develop new therapies for people at risk of life-threatening hypoglycemia. The goal is to mimic a protein that drives glucagon release in response to low blood sugar.
A new study from Saint Louis University found that ketogenic diets negatively impact exercise performance in activities dependent on anaerobic energy systems. The research suggests athletes should avoid low-carb diets for weight loss or improved performance unless medically necessary.
Saint Louis University professor Simone Bregni uses video games like Assassin's Creed II to teach Italian, reinforcing vocabulary and grammar while introducing cultural data. His students made significant progress, exceeding traditional Italian courses by 3-5 points in a single semester.
Researchers at Saint Louis University discovered a method to block chemotherapy-induced neuropathic pain by supplementing a key signaling pathway. The study found that oxaliplatin, a widely used cancer drug, causes debilitating side effects due to increased adenosine kinase expression in astrocytes.
Researchers at Saint Louis University have uncovered new answers about why cells rapidly age in children with a rare disease called Hutchinson-Gilford Progeria Syndrome. The team found that cellular replication stress and a mistaken innate immune response are culprits, and successfully blocked these processes with vitamin D.
SLU researchers determined the structure of calcium-independent phospholipase A2β, a key enzyme involved in the body's inflammatory response. This discovery opens up possibilities for developing new therapies for neurodegenerative disorders like Parkinson's disease.
A Saint Louis University study found that treating depression can increase the likelihood of successful opioid cessation in non-cancer pain patients. Patients who adhered to antidepressant medications were more likely to stop opioids and experience a rapid decline in depression symptoms.
Researchers at Saint Louis University have discovered a link between elevated chlorinated lipids and severe outcomes in sepsis patients. The study found that high levels of these lipids can predict acute respiratory distress syndrome and death within 30 days, suggesting they may serve as an early warning sign of the condition.
Researchers at Saint Louis University report promising results slowing DMD progression using SR8278, a nuclear receptor regulator drug that increases lean mass and muscle function while decreasing fibrosis and protein degradation.
A new Zika vaccine has demonstrated well-tolerability and induced potentially protective immune responses in three phase 1 clinical trials. The vaccine, called ZPIV, was developed by the Walter Reed Army Institute of Research and is being evaluated in several trials to determine its safety and efficacy.
Researchers at Saint Louis University have discovered a new defense mechanism in BRCA-deficient cancer cells that allows them to survive and thrive despite chemotherapy drugs. The study reveals the role of nucleases in degrading DNA replication forks, leading to increased chemotherapy sensitivity.
A Saint Louis University researcher has identified two classes of drugs that could turn off the DUX4 protein responsible for facioscapulohumeral muscular dystrophy (FSHD). The first class of drugs inhibits bromodomain and extra-terminal proteins, while the second class turns on beta-2 adrenergic signaling. These discoveries offer hope ...
Researchers have uncovered secrets of how bacteria turn off protein biosynthesis to conserve energy and survive under stressful conditions. Hibernating ribosomes, found in Gram-positive bacteria like Staph, help them survive by suppressing translation, making them a potential target for new antibiotics.
Bacterial ribosomes can take an inactive form called hibernating 100S ribosome, helping bacteria conserve energy under stressful conditions. A SLU researcher discovered the protein factor HflX that triggers the transition back to active 70S form, essential for protein synthesis.
Saint Louis University's civil engineering students will design and test steel beams and concrete frames at full-scale thanks to a recent National Science Foundation grant. The new lab aims to provide experiential learning opportunities, enabling students to better prepare for the workforce.
Kasey Fowler-Finn's research explores how temperature variation affects treehoppers' ability to recognize potential mates and reproduce. The study aims to understand the potential impact on ecosystems if some species drop out due to temperature changes.
Saint Louis University chemist Paul Bracher has received a $597,380 NSF grant to investigate the origins of life on Earth and potentially in oily environments like Titan. The research aims to develop new biochemistry that can function in organic solvents.
Researchers found that conscious sedation allowed for real-time brain function monitoring, enabling adjustments mid-surgery to reduce ischemic injury risk. The study shows promise in improving outcomes and decreasing risk associated with brain aneurysm surgery.
SLU researchers have made a breakthrough in understanding muscle regeneration, identifying the nuclear receptor REV-ERB as a key player. By targeting this receptor, scientists may be able to develop new drugs to treat a range of muscle disorders and injuries, including muscular dystrophy and sarcopenia.
Researchers at SLU have identified a key molecular pathway driving cancer-related bone pain and discovered a potential solution with an existing drug. A new study provides hope for patients suffering from this debilitating condition.
Researchers study how baleen whales use crossflow filtration to separate prey from water without contact, shedding light on whale evolution and conservation. The study finds that larger body size enhances this form of filtration, affecting a whale's drag and energy needs.
Yuna Ayala's research team discovers how TDP-43 protein causes damaging plaque buildup in neurodegenerative diseases like ALS and frontotemporal dementia. They found that phosphorylation regulates TDP-43's activity, location, and processing, which may be crucial for cellular metabolism.
In a recent editorial, Saint Louis University cardiologist Paul J. Hauptman emphasizes the need for patient-centric symptom relief as a primary goal in treating worsening heart failure. His review of the TRUE-AHF trial suggests that ularitide has limited short-term effects and may not improve longer-term survival.
Saint Louis University researchers identified high-risk areas for Zika transmission in the US, including the Mississippi delta, southern states, and California. The study projected up to 41.7 million people at risk of contracting the virus, with pregnant women being the highest at-risk group.
Researchers at Saint Louis University are developing a potential exercise pill for diabetes and obesity by targeting nuclear receptors. The study aims to optimize two drug compounds, REV-ERB and ERR, which have shown promising results in improving muscle metabolism and reducing the risk of chronic diseases.
Researchers found that targeting REV-ERB nuclear receptor can suppress cholesterol-related enzyme genes, leading to reduced LDL cholesterol levels. The study suggests that this approach may be an effective method for treating diseases associated with high cholesterol.
A Saint Louis University study found nearly 50% of adolescents thought it was 'probably impossible' to acquire heroin in 2014, compared to 39% in 2002. The number of teens who believed it was easy or very easy to get heroin also declined between 2002 and 2014.
A Saint Louis University researcher is using a $363,000 grant to test two molecules as potential biomarkers for four debilitating health conditions: chemotherapy-induced peripheral neuropathy, endometriosis, interstitial cystitis, and vulvodynia. The goal is to develop new painkillers that target these pathways.
Saint Louis University research suggests that formal volunteering in civic service programs can improve the health, mental health, and social life of US veterans. After participating in a six-month volunteer program, more than half of the participants reported better health and emotional well-being.
Researchers at SLU are working on a potential cure for hepatitis B, building on recent advances and partnering with experts in medicinal chemistry. The goal is to develop a new drug that can kill the virus, reducing levels to zero to cure patients.
Researchers at Saint Louis University found that silencing a protein in liver and adipose tissue significantly improves blood sugar levels and reduces body fat in animal models. This breakthrough could lead to new treatments for insulin-resistant obese or overweight patients.
A Saint Louis University study found significant price variations for generic heart failure drugs, with a month's supply costing $20.19-$256.77, affecting 7.3 million Americans underinsured or uninsured. This variability can hinder patients' adherence to treatment, particularly those in low-income areas.
Researchers found that a divergent plate boundary can be forced to converge, leading to the formation of a new subduction zone. The study suggests that buoyant but weak plate material at a divergent boundary can resist subduction, but eventually gives way to denser older material, creating a self-sustaining subduction zone.
Researchers discover that tolerance is induced only when antigens are acquired and presented to T cells by specialized dendritic cells. Dendritic cells also cause short-term activation of T cells under non-infection conditions, but without long-term effects. This improved understanding may lead to new ways to control the immune response.
Researchers found that Th17 cells protect against the Trypanosoma cruzi parasite, which causes Chagas disease, by activating the immune system. This discovery offers a new approach to developing more protective vaccines for these diseases.
A Saint Louis University researcher is studying the impact of treating post-traumatic stress disorder (PTSD) on cardiovascular and metabolic health. The study aims to determine if patients who have been successfully treated for PTSD are more likely to adopt a healthier lifestyle.
The author of a SLU commentary proposes a comprehensive model for improving mental health among medical students, highlighting the importance of creating an environment that nurtures rather than punishes. The approach includes tweaking the curriculum, offering electives and learning communities, teaching resilience training, and coping...
A Saint Louis University study found that modest weight loss via diet, exercise, or both reduces cardiovascular disease risk by 10%, regardless of the strategy. The researchers suggest a combination of healthy eating and exercise is key to heart health.