Researchers from Shinshu University identified citrullination as a key mechanism in lung cancer metastasis. A novel CitFbg peptide was developed to block metastatic cell homing and reduce the risk of cancer spread.
Researchers developed a novel approach called 'countercation engineering' to impart thermoresponsiveness to graphene-oxide nanosheets. The method involves synthesizing GO nanosheets with specific countercations, resulting in inherent thermoresponsive behavior without the need for thermoresponsive polymers.
Researchers from Shinshu University have developed a novel neuromodulation approach that incorporates gait-combined closed-loop transcranial electrical stimulation, demonstrating significant gait improvements in patients with Parkinson's disease. The treatment showed encouraging results after just ten repetitions, improving speed, gait...
Researchers from Shinshu University develop a novel polymer interlocking mechanism to produce tough and additive-free latex films. The rotaxane-based strategy results in unusual crack propagation behavior, increasing tear resistance and preserving flexibility.
A novel technique allows for the observation of colloidal particle degradation in real-time, providing valuable insight into the mechanisms of micro- and nanoplastics origin and change over time. The study demonstrates the potential to assess temperature variations, ultraviolet light, and stress on nanoscale particles.
Researchers at Shinshu University developed high-performance source-shifters using acrylonitrile butadiene styrene (ABS) resin, employing inverse design and topology optimization. The optimized structures can reduce the difference between emitted pressure fields to as low as 0.6%, enabling effective acoustic location camouflaging.
Researchers at Shinshu University developed a microfluidic device using acoustic focusing to collect microplastics from water. The device achieved a 105-fold enrichment of MPs, making it an efficient solution for removing microplastics from laundry and industrial wastewater.
Researchers at Shinshu University have developed a closed-loop recycling process for polymers using microparticles, resulting in fully recyclable films with high mechanical stability and fracture energy. The strategy enables the reuse of polymer materials, reducing plastic waste and environmental pollution.
A bilayer, nonwoven PET microfiber/polyvinylidene fluoride nanofiber membrane acts as a separator for LIB systems and prevents short circuits. The substrate significantly improves the mechanical and thermal properties of solid polymer electrolytes, enabling cells to operate over 2000 hours.
Researchers discovered polyphenol PCB2DG reduces inflammatory responses by inhibiting glutamine uptake in CD4+ T cells, promoting gene expression to synthesize amino acids. The study's findings offer potential for dietary polyphenol treatment of autoimmune diseases.
Scientists at Shinshu University have created a new method for achieving structural coloring through plasma irradiation of graphite, eliminating the need for harmful color dyes. The technique produces erasable and stable colors that can be manipulated using various factors, offering a sustainable solution for the art world.
Researchers have used a technique called QCM-D to observe the interplay between hydration structures and ion configurations in layered materials. The study found that the hydration structure plays a crucial role in determining the material's ion-storage capacity, with flexible layers helping to stabilize the structure.
Researchers have documented cases of Japanese macaques hunting and eating fish in the Kamikochi region of Japan, suggesting an evolutionary adaptation to harsh winter conditions. The behavior appears to be an extension of existing feeding habits on vegetation and aquatic plants, with potential implications for future generations.
Researchers found that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis in mice, leading to the promotion of hepatic tumors. This process is driven by the JNK-HIF1α-VEGF-C axis.
A Japanese research group found that people with psychiatric disorders tend to hold negative self-schemas, which can renew themselves through feedback and cognitive reactivity. This self-perpetuation process can lead to the development of mental illnesses even in good environments.
Researchers at Shinshu University demonstrate the transformation of isolated skyrmions into bimerons in a magnetic disk, showcasing a potential new operation for future computing architectures. The discovery opens up novel spintronic applications based on different topological spin textures.
Using 1980s environmental inventories, researchers found that disaster risk assessment could have predicted the damage from the Great East Japan Earthquake. The study compared composite risk maps from the 1980s with post-2011 hazard maps to show a significant increase in high-risk areas.
Researchers developed a fabric with nano-scale threads containing phase-change materials to regulate body temperature. The textile combines electrothermal and photothermal coatings for enhanced thermal regulation. It has the potential to alleviate heat or cold stress in workers and travelers, offering improved comfort and safety.
Researchers have discovered a novel antimicrobial compound, evybactin, that selectively targets Mycobacterium tuberculosis, a bacteria that causes tuberculosis. This breakthrough could lead to the development of new treatments for tuberculosis without contributing to antibiotic resistance.
Scientists at Shinshu University created an ultrathin fiber-mesh thermistor that improves the performance of wearable medical sensors. The new technology provides overheat protection, gas-permeability, and transparency, making it suitable for on-skin or implantable devices.
A study found that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells. Inhibition of EGFR by lapatinib therapy in combination with lenvatinib enhanced growth inhibitory effect and inhibited tumor growth more remarkably than monotherapy.
A team of researchers found that the internal donut-shaped structure of quasars can affect the ionization level of intergalactic gas in different directions. The study suggests that a dust torus is likely to be responsible for this anisotropic effect.
Research found that acidic activated charcoal from Shinshu Ina's specialty Akamatsu tree suppresses weight gain due to a high-fat diet by increasing bile acid, cholesterol, triglyceride, and fatty acid excretion. No damage to the gastrointestinal mucosa or lungs was observed.
Researchers at Shinshu University have developed a new method to remove nanoplastics from water using apples and pectin. The study found that the method was able to remove 95% of nanoplastics in just 24 hours.
Researchers investigated the cell adhesion behavior on spider silk fibers, films, and nanofibers. The study found that native spider silk exhibits superior properties for medical use, preventing blood clots and enduring repetitive loading and unloading.
A mass survey of Japanese citizens aged 50-89 years found that sagittal spinal balance measurement can detect cognitive decline. The study discovered associations between anteriorization of the spine and lower cognitive function in both males and females, with greater risks detected in cases of SVA ≥ 70mm regardless of age.
A study identified an 18-base osteogenetic ODN (iSN40) that promotes the differentiation of mouse osteoblasts and induces the expression of genes required for bone formation. This discovery offers a promising treatment option for osteoporosis, which affects 200 million people worldwide.
Researchers have developed a new type of separation membrane that can separate hydrogen from methane at speeds 100 times faster than conventional membranes. The graphene-wrapped zeolite membrane achieves a high separation factor of 245, making it suitable for energy-saving separation technologies in various industries.
The study found that freshwater pearl mussels significantly affected biofilm bacterial dynamics, particularly with increased Bacteroidales and Clostridiales abundance. The presence of mussels also alleviated nitrogen deficiencies by recycling nutrients.
Researchers at Shinshu University have elucidated a new molecular mechanism controlling the survival of cerebral nerve cells. Neurexin regulates cerebellar granule cell survival independently of synapses, playing a crucial role in neurodevelopmental disorders such as autism and schizophrenia.
A study examines the applicability of Cauchy and Cauchy-Froude laws to multi-storey masonry structures with flexible diaphragms. The findings suggest that these laws may be inadequate for heavy structures unless gravity is scaled.
Researchers found that tree spacing can control the likelihood of tree survival and reduce forest damage risk. Trees in forests with closer spacing are more vulnerable to strong winds due to reduced energy transfer buffering between trees.
Researchers have achieved triple-wave cloaking for both sound and light using computational inverse design method. This breakthrough expands the functionality of biphysical cloaks, enabling a wider range of materials to be used, including those beyond traditional metals.
A team of researchers from Shinshu University has developed a precise numerical model of butterfly flight dynamics, revealing the intricate relationship between wing movement and air flow. The study's findings have significant implications for designing micro air vehicles (MAVs), which could lead to breakthroughs in aerospace engineering.
Researchers used an SIR model to show COVID-19 convergence in Japan, with growth rates initially high then decreasing as cumulative infected people increase. The study aims to control infections and mitigate economic impact through risk management.
Research finds GNAO1 expression affects calcium ion regulation in cardiomyocytes, leading to cardiac dysfunction and heart failure progression. Suppression of GNAO1 improves pathology in multiple mouse models.
Research reveals Japanese macaques in Kamikochi feed on aquatic insects and molluscs, supplementing their winter diet with high-nutritional value food sources. The unique behavior is attributed to the region's topography and hydrological environment, providing a stable food source for the macaques.
Researchers at Shinshu University developed a novel detection principle for stimulants, including methamphetamine, using electrochemiluminescence (ECL) emission. The method allows for accurate and selective screening of stimulants with high sensitivity and selectivity.
A recent study by Shinshu University explores the early adoption of GitHub Discussions, revealing its utility for managing project discussions and identifying key factors for improvement, including guidelines for participation and encouraging core members.
A team of researchers at Shinshu University has successfully observed proton transfer between the titania surface and a dye molecule during UV light irradiation. The study used time-resolved fluorescence spectroscopy to measure the formation of basic hydroxyl groups on the titania surface, which accepts protons from the dye.
Researchers at Shinshu University discovered a new type of amyloidosis associated with duodenal neuroendocrine tumors that produce somatostatin. Laser microdissection and liquid chromatography-tandem mass spectrometry techniques were used to identify the amyloid formation.
Research on the giant water bug found a mismatch between its phylogenetic distance and reproductive isolation. The species' genetic differentiation is consistent with the formation of the Tsushima Strait, which separated Japan from mainland Eurasia about 1.55 million years ago.
A team of scientists created a uniform protein nanoparticle, TIP60, with a diameter of 22 nm, which can be modified to target specific molecules. The 3D structure of TIP60 was elucidated using cryo-electron microscopy, revealing an icosahedral 60-meric structure with porous properties.
Researchers successfully split water using a powder photocatalyst and solar rays in a 100m2 outdoor area, producing solar hydrogen. The system's design and separation performance require improvement to achieve low costs and high efficiency.
A 15-year study found that the availability of beech nuts can predict bear intrusions into human habitats. The research used numerical modeling and observed beech flowering patterns to forecast bear activity, reducing direct conflicts between humans and bears.
Researchers at Shinshu University successfully insert Mg2+ between graphite layers, achieving a large reversible capacity of ~200 mA h g-1. This breakthrough paves the way for developing magnesium secondary batteries with high energy density and long lifespan.
Researchers developed direct cellulose fuel cells that directly use cellulose as fuel without reforming processes. The study found that gold is highly active in the cleavage reaction at negative potential and nickel and palladium are active in decomposition reactions at positive potential.
Heavy rainfall accelerates radiocesium leaching from forest litter, increasing dissolved cesium in stream water. The study suggests that expansion of the contact area between water and litter due to groundwater table rise is the main factor.
Researchers at Shinshu University discovered that fruit by-products, often discarded due to their high phytochemical content, possess significant anti-degranulation and bile acid-binding properties. The study highlights the potential for utilizing these previously wasted resources as valuable anti-allergic agents.
Researchers found that felled trees should be worked on to avoid physical contact with conservation targets, minimizing damage to understory trees. The study used a spatial grid and Geographic Information System to model damage and predict potential losses for harvesting.