Researchers directly observed how metallic nanoparticles activate catalytic processes by identifying defect sites on the surface of single particles. These findings validate a longstanding hypothesis and provide insights into controlling catalyst reactivity.
Researchers discovered that phages can invade bacteria by transferring attachment molecules via membrane vesicles, facilitating horizontal gene transfer and expansion of the phage host range. This mechanism enables phages to deliver DNA into new species, promoting attachment to non-host species and potentially transmitting antibiotic r...
Researchers found that human pyramidal neurons have a specific membrane capacitance that is half of the universal value for biological membranes, improving signal processing and communication within and between cortical neurons. This unique property may be an evolutionary adaptation to compensate for the larger brain and cells in humans.
A study of Israeli adolescents found that higher BMI in late adolescence and long-term cumulative burden of BMI predict poorer cognitive function later in life. Taller stature was associated with better global cognitive function, independent of socioeconomic position.
Archaeologists have discovered a collection of 55 species of edible plants, including seeds, fruits, nuts, and tubers, at the Gesher Benot Ya'aqov site in Israel. The finds, dated to 780,000 years ago, provide evidence of the plant-based diet of early humans during the Acheulian culture.
A study published in Science reveals a key role for the protein H1.0 in turning cancer tumor cells into cancer stem cells with the ability to sustain long-term growth and cause recurring disease outbreaks. The discovery could lead to medical interventions targeting these cells to prevent cancer spread.
Researchers identify genetic switches controlling metabolic response to HCV infection and show how these genes affect virus lifecycle. Blocking certain metabolic processes can actually increase HCV replication, presenting a new approach to treat virus infections by targeting metabolic regulation.
Researchers at The Hebrew University of Jerusalem show for the first time how bacterial superantigen toxins work and how short peptides can block them. A novel host-oriented therapeutic approach prevents lethal immune responses, remaining effective against antibiotic-resistant strains.
Researchers have discovered a biological link between anxiety and metabolic disorders, revealing microRNAs as key regulators of inflammation and metabolism. This finding offers novel opportunities for innovative diagnoses and treatments, including manipulation of microRNA activity through DNA-based drugs.
A large-scale migrant cohort study found that being born in Israel significantly increases the risk of nodular sclerosis HL, with elevated risks also observed among women, those born more recently, and taller stature. The study suggests exposure to unidentified elements of the Israeli environment may contribute to the disease's etiology.
Researchers in Jerusalem found that small and medium-sized HDL particles were more closely associated with protection against coronary atherosclerosis. The study, led by Dr. Chobufo Ditah, suggests that these particles may be better markers of coronary heart disease risk than traditional HDL-C.
Scientists developed a novel peptide that protects cognitive function after mild traumatic brain injury by reducing inflammation, cell death, and cognitive impairments in mice. The peptide, called TXM-peptide, mimics the antioxidant activity of thioredoxin and inhibits the inflammatory pathway.
A 12,000-year-old funeral feast in northern Israel provides insight into the dynamics of ritual performance and community engagement. The discovery sheds light on the Natufian period's significant pre-planning and socially complex rituals.
Researchers from Hebrew University of Jerusalem discovered that social time cues override light exposure in regulating honeybees' natural body clock. This finding highlights the complexity of clock regulation in natural habitats and has implications for understanding circadian rhythms in other species.
Research reveals snoRNAs control ribosome modification and regulate alternative splicing, leading to wrong protein variants. This discovery explains the cause of diseases like Prader-Willi syndrome and cancer, and offers a possible therapy for genetic hyperphagia.
Researchers from Hebrew University of Jerusalem developed an efficient and compact single photon source that can operate on a chip at ambient temperatures. The device enhances the collection efficiency of single photons by more than a factor of 10 compared to a single nanocrystal without the antenna.
A study published in Tourism Management found that personal photos of Airbnb hosts are critical to their business success, affecting consumers' decisions and prices. The research suggests that the level of trust inferred from a host's photo has a stronger impact on consumer choice than reputation.
A new study found that consuming produce grown in treated wastewater-irrigated soil leads to higher levels of carbamazepine excretion. The researchers discovered that the production and consumption of such veggies pose a potential risk for consumers, despite the low quantities involved.
A nationwide study of 2.3 million Israeli adolescents found an association between elevated BMI in late adolescence and subsequent cardiovascular mortality in midlife. Even BMI considered 'normal' during adolescence was associated with a graded increase in cardiovascular and all-cause mortality.
A new species of extinct rodent, Sayimys negevensis, has been discovered in Israel's Negev desert, providing insights into the early dispersal route of mammals from Asia to Africa. The discovery bridges the gap between primitive ctenodactylines and gundis, highlighting Israel's unique paleogeographic position.
New research reveals honey bee colonies adapt their diet to counter nutritional deficiencies, prioritizing diets that complement specific amino acid deficiencies. This ability allows bees to maintain a balanced nutrition level when alternative floral resources are scarce.
Researchers developed a new Liver-on-Chip device with glucose and lactate micro-sensors to track metabolic function in real-time, enabling detection of chemical toxicity before cellular damage. The technology has the potential to redefine studies on neurodegenerative diseases, cancer, and drug discovery.
Archaeologists discovered a 11,000-year-old quarry in central Israel that demonstrates the significant impact of humans on the landscape during the transition to farming. The site, dated to the Pre-Pottery Neolithic A culture, shows evidence of large-scale quarrying activities for flint and limestone tool manufacturing.
Researchers at The Hebrew University of Jerusalem have successfully generated a new type of embryonic stem cell carrying a single copy of the human genome. These haploid stem cells are pluripotent and retain a single set of chromosomes, offering a powerful tool for genetic analysis and potential therapies for diseases.
A new method detects multiple diseases via methylation patterns of circulating DNA from dying cells, identifying cell death in specific tissues and offering a minimally-invasive window for monitoring and diagnosis. The approach has vast possibilities for diagnostic medicine and can be adapted to identify cfDNA derived from any cell type.
Researchers use satellite data to quantify cloud base updraft speeds and aerosol particles' ability to create cloud droplets, providing critical information for understanding climate change. The study aims to reduce the uncertainty around global warming estimates by 1.5 to 4.5 degrees by the end of the 21st century.
Researchers found that a cell aging program increases insulin secretion in human and mouse pancreatic beta cells, improving their function. This discovery suggests that cellular aging can bring unexpected benefits to the production of insulin, potentially leading to new insights and treatments for diabetes.
Researchers at The Hebrew University of Jerusalem have developed a nanotechnology-based delivery system that activates the body's natural defense against free radicals. This system could control various skin pathologies and disorders by inducing antioxidant enzymes and maintaining skin cell redox balance.
Researchers discovered that E. coli uses bio-films to protect itself from the bacterial predator Bdellovibrio bacteriovorus, allowing it to survive in fragmented environments. This finding could lead to the development of alternative antibiotics that target specific harmful bacteria while leaving benign ones untouched.
Excavations in the Jordan Valley revealed a prehistoric village with cultural characteristics typical of both the Old Stone Age and the New Stone Age. The site shows evidence of artistic tradition, size, and investment in architecture more typical of early agricultural communities.
Scientists create photo-bioelectrochemical cells that harness natural photosynthesis to generate electrical power from sunlight. The system uses glucose as a fuel and provides a new method for photonically driving biocatalytic fuel cells.
Researchers develop algorithm to quantify brain map continuity, finding pathological processing reflected by discontinuity rather than signal reduction. This discovery may serve as biomarker for neurological pathologies and enable early detection of Alzheimer's disease.
A team from The Hebrew University of Jerusalem suggests that rare mergers of binary neutron stars are the origin of naturally occurring radioactive plutonium-244. This theory resolves the Galactic radioactive plutonium puzzle by explaining why only a small amount of plutonium has reached Earth in recent 100 million years.
A new technique has enabled the rapid expansion of functional human liver cells in the lab, opening up new avenues for studying drug toxicity, liver disease, and more. The method, known as the 'upcyte' process, allows for the generation of liver cells from multiple donors with similar characteristics to primary human hepatocytes.
Researchers discover a link between colorectal cancer and melanoma treatment NT157, targeting both tumor cells and microenvironment to suppress cancer growth. The compound's dual mechanism of action shows promise in treating colon cancer with minimal damage to non-cancer cells.
Researchers found that ancient venomous groups evolve slowly under purifying selection, while recent lineages diversify rapidly under positive selection. This reveals a new theory of venom evolution, proposing a 'two-speed' mode where toxins expand and then are preserved through purifying selection.
Researchers identified a novel pathway in the normal development and maintenance of the ovary, discovering a mutation in the Nucleoporin 107 gene linked to ovarian dysgenesis. This finding has significant implications for diagnosing infertility and lack of puberty in women.
Researchers propose that Alzheimer's disease is a collection of diseases stemming from similar molecular mechanisms. They identified a key protein, cyclophilin B, responsible for its manifestation in distinct neurodegenerative disorders. This study aims to develop novel therapies tailored to individual disease subtypes.
Researchers from Hebrew University of Jerusalem suggest that microglia cells may be a key to causing depression, leading to potential new treatments. The study proposes a personalized medical approach using drugs that restore normal microglia function to diagnose and treat depression.
Researchers have successfully converted skin cells into stable and fully functional placenta-generating cells, overcoming two major bottlenecks in regenerative medicine. This breakthrough resolves ethical and immune rejection issues, offering new hope for women with recurrent miscarriage and placental dysfunction diseases.
A new study using bionic liver micro-organs explains the off-target toxicity of acetaminophen, a breakthrough that could transform drug development. The device detected small changes in cellular respiration, revealing a faster and lower-dose mechanism than previously thought.
Researchers have successfully created functional liver cells from human embryonic and genetic engineered stem cells. The new method enables unlimited production of liver cells with high accuracy, revolutionizing pharmaceutical drug discovery and potentially improving treatment outcomes.
A team of researchers has found a way to measure the aging process in young adults, revealing that some people are aging three times faster than their peers. The study used biomarkers such as kidney function, liver health, and telomere length to determine biological age and pace of aging.
Researchers have developed a new tool that uses phylogenetic profiling to identify genes associated with genetic diseases and cancer. This approach can be used to analyze genes within the same network as known disease-related genes, such as BRCA1, and predict their biological functions.
Leading researchers from Canada and Israel are working together to uncover the molecular landscape of pancreatic cancer and develop new biomarkers for detection and diagnostics. The collaboration aims to improve patient outcomes by discovering targeted therapies.
The Azrieli Foundation donated $10 million to fund groundbreaking stem cell and genetic research at the Hebrew University of Jerusalem's newly inaugurated center. Researchers will focus on developing therapies for Down syndrome, Prader-Willi syndrome, and Fragile X syndrome, among other conditions.
The Edmond and Lily Safra Philanthropic Foundation has donated $30 million to the Hebrew University's Edmond and Lily Safra Center for Brain Sciences, bringing the total funding to $50 million. The center will continue to grow and recruit top researchers to advance brain research and development.
Scientists have developed a 'Neuronal Positioning System' that maps the axonal wiring of individual neurons, revealing organizational principles of neuronal networks. This new approach enables researchers to study how specific neurons are wired to other types and regions, providing insights into brain function and development.
Researchers found that the brain's visual cortex retains fundamental topographical and functional connectivity organizational principles, including retinotopic mapping, in people born blind. The study dispels the notion that blindness impairs brain development.
Researchers found that young mice don't possess cellular machinery for regeneration after weaning, leading to reduced insulin secretion and replication of beta cells. A new developmental step in beta cell maturation is triggered by dietary change from high-fat milk to chow.