Researchers found that propylene glycol and vegetable glycerol cause gut inflammation by breaking down zipper-like junctions between cells. Chronic e-cigarette use can lead to a 'leaky gut,' allowing microbes and molecules to seep out, resulting in chronic inflammation.
Researchers developed a novel probe to study how a 'matchmaker' molecule generates a 'wait' signal at kinetochores, ensuring accurate chromosome inheritance. This discovery provides insight into how accuracy of chromosome inheritance can be lowered in diseases like cancer.
Researchers have broken down the genomic and life history traits of three classes of RNA viruses, identifying natural products that could disrupt their spread. The study highlights potential treatment strategies, including the use of compounds produced by marine and terrestrial organisms with demonstrated antiviral activity.
A three-year study in Del Mar, California has uncovered the relationship between wave impacts and coastal cliff erosion, with waves affecting the base of cliffs and rain impacting the upper region. The findings provide a new opportunity to improve forecasts and predict cliff retreat.
Researchers found that chromothripsis breaks up chromosomes, leading to the formation of rearranged genomes and extra-chromosomal DNA that promotes cancer cell growth and drug resistance. This phenomenon enables cancer cells to evade treatment and become more aggressive.
A new study published in the journal Nursing Forum found a distinct shift in the method of nurse suicides, with firearm use increasing among female nurses between 2014 and 2017. The study suggests that removing firearms from homes and providing increased social support may help prevent such deaths.
New research from the University of California San Diego found that modern crop varieties introduced in 1961 reduced infant mortality rates by up to 5.3 percentage points globally, resulting in around 3-6 million infant deaths averted per year by 2000.
A multidisciplinary coalition proposes a framework for field trials of gene drive organisms to ensure safe, transparent, and publicly accountable implementation. The core commitments address fair partnership and transparency, product efficacy and safety, regulatory evaluation and risk/benefit assessment, and monitoring and mitigation.
A new study finds that hearing loss and high blood sugar are associated with poor cognitive performance among middle-aged and older Latinos. The research, published in JAMA Otolaryngology-Head & Neck Surgery, suggests that evidence-based interventions, such as hearing aid use, may help mitigate this risk.
A new study provides the first-of-its-kind model for how massive icebergs from Antarctica decay and affect ocean currents. The research found that these icebergs deliver freshwater to the Southern Ocean, influencing climate patterns.
Researchers at UC San Diego used wearable devices to detect fevers in participants with COVID-19, showing promise for an early warning system. The study collected temperature data from over 50 participants and demonstrated that wearables can identify fever peaks more accurately than traditional spot checks.
UC San Diego researchers found that e-cigarette flavoring chemicals can damage lungs and affect immune system function. The study discovered irregular protein levels in saliva and airways of vapers compared to non-vapers, suggesting regular use of flavored e-cigarettes harms lung health.
A multi-university team identified a family of enzymes called GCK-IV kinases that inhibit robustly neuroprotective while allowing axon regeneration. This finding suggests strong therapeutic possibilities for treating neurodegenerative diseases such as glaucoma and Alzheimer's.
A new study from Scripps Institution of Oceanography at UC San Diego and the University of Chicago sheds light on the hotly contested debate of when plate subduction began. The research suggests that this process started around 3.75 billion years ago, reshaping Earth's surface and setting the stage for life.
Researchers have found a new network of routes that can transport spacecraft and comets at unprecedented speeds, reaching Jupiter's distance in under a decade. The 'celestial autobahn' or 'celestial highway' acts on several decades, allowing for faster exploration and monitoring of near-Earth objects.
A recent study suggests that a unique human genetic mutation may contribute to the high risk of advanced cancers, with approximately 30% of people still producing dysfunctional Siglec-12 proteins. These individuals are at twice the risk of developing advanced cancer compared to those who cannot produce the protein.
Researchers at UC San Diego found that weaker E.coli strains outcompete stronger ones in a microbial game of rock-paper-scissors, challenging the traditional notion that strength prevails. The study's findings have implications for understanding microbiome imbalances and potentially developing new life-saving treatments.
Scientists created brain organoids from patients with Rett syndrome to study the disease and identify potential treatments. The study found two drug candidates, Nefiracetam and PHA 543613, that restored calcium levels, neurotransmitter production, and electrical impulse activity in the organoids.
A study by University of California San Diego biologists demonstrates that honey bees use a contagious and honest visual signal to deter Asian hornet attacks. The 'I see you' (ISY) signal involves guard bees shaking their abdomens laterally, increasing in intensity as the threat intensifies.
Researchers at University of California San Diego have created a flexible, rechargeable silver oxide-zinc battery with areal energy density five to ten times greater than state-of-the-art batteries. The device can be used in wearables and soft robotics.
Researchers developed virus-like probes that can validate rapid COVID-19 tests across the globe. These stable probes are made from viral particles and have improved accuracy, stability, and cost-effectiveness compared to existing positive controls.
Researchers found that counties with above median income show significant compliance increase after receiving stimulus funds, while economically disadvantaged communities remain non-compliant. The study suggests targeted economic relief may limit COVID-19 spread among vulnerable populations.
The UC San Diego-led Collaborative Clinical Trials Unit (CTU) will investigate therapeutic strategies for a cure and functional cure of HIV. The CTU will also evaluate viral persistence and latent reservoirs, as well as new antiretroviral drugs and treatments for co-infections.
Researchers at University of California - San Diego found a connection between gut bacteria diversity and active vitamin D levels in older men. The study suggests that microbiome diversity is closely associated with active vitamin D, while the precursor form has no significant link.
Scientists at UC San Diego have identified a biological switch, or receptor, that sounds an alarm in plants when herbivores attack, enabling plant recognition of danger. The discovery offers new strategies for improving plant health and resistance to crop pest damage.
Researchers found a significant association between COVID-19 infection and an increased risk of mortality due to blood clots. The study suggests that thromboembolism may be a critical factor in COVID-19-related deaths, particularly among hospitalized patients.
Researchers found that triclosan disrupts metabolism and the gut microbiome, leading to accelerated development of fatty liver and fibrosis. The study provides new insights into risk factors for non-alcoholic fatty liver disease (NAFLD) in humans.
Researchers aim to fill knowledge gaps on spina bifida by setting up an international registry of patients and investigating the role of folic acid in disease risk. The grant will also fund whole genome sequencing to identify potential causes and underlying mechanisms of the disease.
Researchers at UC San Diego are launching an experiment to the ISS to study mudslides in microgravity and develop technologies to prevent them. They hope to create a protective layer using Xanthan gum, a common food additive.
A new radar system developed by UC San Diego engineers can accurately predict object shapes and sizes in various weather conditions. The two-sensor setup improves imaging quality compared to traditional single-radar systems.
An international team has received a 10 million euro grant to investigate the evolution of human quantification. The QUANTA project will analyze quantification as a bio-cultural phenomenon, combining insights from anthropology, linguistics, archaeology, and cognitive science.
Researchers found that masks have minimal effects on lung function, even in healthy individuals, and do not increase the risk of shortness of breath or difficulty breathing. The study suggests that wearing a mask can be uncomfortable but does not impact cardiopulmonary function.
Researchers identified mechanisms in Alzheimer's disease that cause neurons to de-differentiate and lose synaptic connections, resulting in cognitive decline. The study found changes in chromatin structure trigger these effects.
A new environmentally friendly method for restoring spent cathodes to mint condition could make it more economical to recycle lithium-ion batteries. Researchers at the University of California San Diego have developed a process that uses inexpensive and benign chemicals, consumes 80-90% less energy, and emits 75% less greenhouse gases.
UC San Diego's integration of student medical records with its electronic health record platform improved care coordination, access to vital medical information, and resources. The system enabled same-day video visits, rapid turnaround of radiology results, and accessible COVID-19 testing.
A recent study published in the Journal of Clinical Psychiatry found that loneliness is highest in the 20s due to lower empathy, compassion, and self-efficacy. Levels of loneliness decrease in the 60s, with smaller social networks and sleep disturbances being consistent predictors across all age groups.
Researchers at the University of California San Diego have identified 20 cell types in teratomas, which could offer insights into human development and tissue engineering. The team also developed a method to 'molecularly sculpt' teratomas to be enriched in specific lineages.
African American men with low-risk prostate cancer can safely undergo active surveillance without increased risk of disease progression, metastasis, or death. The study found that African Americans experienced higher rates of disease progression and treatment compared to white men, but comparable mortality rates.
Researchers analyzed viral load on Halloween candy handled by COVID-19 patients, finding SARS-CoV-2 on 60% of samples handled normally with unwashed hands. Washing hands before handling candy and washing the candy with household detergent significantly reduced the virus's presence.
A study published in the Journal of Psychiatric Research found that spirituality is a significant component of wisdom, correlated positively with age and sex. The researchers used a self-report-based measure of wisdom and spirituality, finding that both components were associated with better mental health and well-being.
Researchers created an experimental AI platform called DrugCell that matches tumors to the best drug combinations. The system was trained on over 500,000 cell line/drug pairings and validated in laboratory experiments, showing promise for precision cancer therapy.
Researchers at University of California San Diego School of Medicine discovered a molecule called Girdin (GIV) that acts as a brake on macrophages. The GIV-mimic peptide can shut down immune cells' overreaction, supporting a mechanism critical for survival in mouse models of sepsis and colitis.
Two studies from UC San Diego found that standing and light physical activity significantly reduce the risk of death, even for just 30 minutes a day. The research team also compared sedentary time in Americans to farmers in Malawi, finding substantially higher levels of activity among the latter group.
Research from the University of California San Diego reveals that Democratic control of state houses leads to significant improvement in women's incomes and wages relative to men. Women's wages average only 70% of men's wages but decline by 3.6 percentage points after Democrats are elected in a state.
A recent study found that 61% of patients who used cannabis began using it after age 60, primarily for medical purposes. The most common reasons for cannabis use were pain, insomnia, and anxiety, with patients reporting relief from these issues. The study highlights the need for healthcare professionals to be aware of cannabis use amon...
Researchers at the University of California San Diego have developed a squid-like robot that can swim rapidly and efficiently, taking photos of coral and fish in the process. The soft robot uses jet propulsion to maneuver and achieve speeds of up to half a mile per hour.
A group of leading researchers emphasizes the importance of clarifying COVID-19 terminology related to aerosols and droplets. They stress that public health officials should highlight the risk of airborne transmission and recommend improving ventilation and moving activities outdoors. By doing so, they aim to reduce transmission and pr...
Researchers found that patients receiving personalized cancer therapy had improved survival rates and longer progression-free periods compared to those with unmatched treatment plans. The use of next-generation sequencing allows for more precise targeting of cancer cells.
A recent study published in Aging and Mental Health suggests that wisdom is a strong protective factor against loneliness. The research, conducted in both San Diego and Cilento, Italy, found a significant inverse correlation between loneliness and wisdom across different age groups.
Researchers used satellite imaging to map groundwater use in California's San Joaquin Valley, finding that field crops and pasture crops have higher rates of subsidence than fruit and nut crops. This study provides new insights for irrigation policymaking and sustainable groundwater management in agricultural regions worldwide.