Researchers from the University of Cincinnati presented findings on the effectiveness of a two-component enzyme replacement therapy for late-onset Pompe disease. The study showed that patients treated with this regimen experienced improvement or stability in motor function, pulmonary function, and muscle strength. Additionally, experts...
Researchers at the University of Cincinnati Cancer Center presented abstracts on new potential drugs and targets for treating various types of cancer. A study found that a brain-permeable drug called AM-101 sensitizes brain metastatic tumors to radiation, improving survival in preclinical animal models.
The University of Cincinnati Cancer Center team has opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas, a deadly form of brain tumors. The treatment uses letrozole, a drug that targets an enzyme present in breast cancer cells, and temozolomide, a chemotherapy drug already approved as a GBM treatment.
A new AI system can predict people's attitudes towards vaccines using a small set of demographic and judgment variables. The study, which analyzed 3,476 adults in the US, found that the predictive model was accurate with moderate to high precision.
A phase 3 trial co-led by a University of Cincinnati researcher found that subcutaneous levodopa delivery through an infusion pump is safe and effective in reducing symptoms for longer periods. The study resulted in almost two hours of additional 'on time' compared to traditional oral medication, paving the way for potential FDA approval.
A new University of Cincinnati study compares pregnancy rates in patients on two types of dialysis, finding a higher rate with home hemodialysis. The study found an overall pregnancy rate of almost 9 people per thousand, with black women and younger age associated with a higher likelihood of pregnancy.
Researchers at the University of Cincinnati Cancer Center have identified a new protein called p47 that helps prevent breast cancer metastasis. The study found that lower p47 expression was correlated with higher breast cancer metastasis, and that increasing p47 function could potentially lead to new therapies.
A University of Cincinnati study found liraglutide to be efficacious and safe for weight loss in individuals with stable bipolar disorder, without destabilizing the illness. The drug reduced binge eating behavior and significantly lowered hemoglobin A1C levels.
A University of Cincinnati study found real-time navigation enhances precision in liver cancer ablation, with improved accuracy for less experienced surgeons. The technology provides detailed information on tumor location, reducing damage to surrounding healthy tissue.
Researchers from the University of Cincinnati found that nearly half of patients with nasal allergies also have chronic rhinosinusitis (CRS), a condition often misdiagnosed as allergies. The study suggests that specific counseling and education are needed to raise awareness of CRS, especially in regions with high prevalence of environm...
The rover has discovered primary igneous rocks and hydrated magnesium sulfate, hinting at the presence of ancient life on Mars. The mission aims to retrieve samples that may answer the question about whether we are alone in the universe.
UC economists found that fire protection funding has a significant impact on housing values, with cuts resulting in an average decrease of $15,000. However, prices return to normal within a few years. In contrast, parks and recreation funding is associated with higher home values three years after renewal.
Engineers at the University of Cincinnati have created a more efficient way to convert carbon dioxide into ethylene, producing a pivotal platform chemical globally. The process, using a modified copper catalyst, holds promise for one day producing ethylene through green energy instead of fossil fuels.
A new study from the University of Cincinnati finds that being in prison is a significant driver of multidrug-resistant tuberculosis (MDR-TB) transmission. The researchers identified molecular resistance patterns and defined recent transmissions, highlighting the need for targeted interventions to control the MDR-TB epidemic in prisons.
Researchers discovered two new genetic pathways associated with worse ICH outcomes, including a pathway affecting blood coagulation and cellular interactions. Population data showed a decrease in aneurysmal SAH strokes and a rise in non-aneurysmal subarachnoid hemorrhages, offering encouraging evidence for intervention success.
A clinical trial is underway to help patients with opioid use disorder (OUD) and post-traumatic stress disorder (PTSD) stick with medication treatment. The trial uses a patient-administered wearable device that delivers mild electrical stimulation to alleviate symptoms of both conditions.
Researchers at the University of Cincinnati have identified a molecule that plays a role in asthma and could be targeted for treatment in the future. The study found that blocking this molecule could reduce airway constriction without affecting other key features of the disease.
Researchers found that wolf spiders can't easily signal others or perceive danger from predators on rain-soaked leaves compared to dry ones. Male spiders use visual and vibratory signals for courtship, but vibrations are better received in dry leaves.
High levels of copper linked to poorer patient outcomes in clear cell renal cell carcinoma (ccRCC) patients, according to NIH-funded University of Cincinnati Cancer Center research. The study aims to identify copper's mechanisms and test potential new treatments for ccRCC.
A recent study by University of Cincinnati Blue Ash students found that individuals with clinically significant levels of OCD are more prone to problematic smartphone use. The research also highlighted the impact of fear of missing out, boredom proneness, and inhibitory anxiety on the relationship between OCD and PSU.
Researchers at the University of Cincinnati are testing a new tongue exercise approach to improve swallowing function in stroke patients. The trial aims to provide concrete evidence-based recommendations for treating dysphagia, a common post-stroke complication that can have significant impacts on patients' health and quality of life.
A recent University of Cincinnati study found nicotine and a potent carcinogen called NNK on surfaces in children's homes, highlighting the persistence of thirdhand smoke pollutants even in homes with voluntary indoor smoking bans. The research emphasizes the importance of protecting children from tobacco exposure.
Researchers at the University of Cincinnati's Lindner Center of HOPE have developed a novel approach to treating depression using spinal cord stimulation. The study found that electrical stimulation of the spinal cord decreased depressive symptoms and showed therapeutic potential.
A newly described mosasaur, the Wakayama Soryu (blue dragon), had a distinctive shark-like dorsal fin and massive flippers that defied classification. The specimen, discovered in Japan, is the most complete mosasaur skeleton found in the country, with features that challenge current understanding of its swimming abilities.
Researchers at University of Cincinnati Cancer Center present Phase 2 clinical trial results for a new BTK inhibitor treatment that offers potential for improved efficacy and safety in chronic lymphocytic leukemia. The study also explores the use of IRAK4 inhibitors to target acute myeloid leukemia cells, with promising results.
A Phase 2 clinical trial will study the effectiveness of a monoclonal antibody treatment, TS23, in reducing brain injury and improving outcomes for patients with acute ischemic stroke. The SISTER study aims to provide new hope for treatment and recovery for patients where time and access may have been limited.
A recent study found that public gardens and arboretums are inadvertently spreading nonnative, invasive plants to wild areas, threatening native ecosystems. Many examples were cited from Spring Grove Cemetery in Cincinnati, Ohio, including the spread of exotic trees and shrubs with seeds dispersed by wind or birds.
The University of Cincinnati is conducting a clinical trial to test the safety and effectiveness of lattice therapy, a method of delivering radiation that targets specific areas of tumors. The trial aims to enroll 37 adult patients and analyze the underlying biology of tumor and immune responses to lattice therapy radiation.
A paper by Anthony Chemero explains how AI thinking differs from human thinking, highlighting the limitations of large language models trained on biased data. Despite generating impressive text, these models can make up facts and produce biased outputs due to their lack of embodiment and understanding of context.
Multimodal neuromonitoring (MNM) tracks blood flow, pressure, oxygen and glucose levels in the brain to inform treatment decisions. MNM has improved clinical outcomes for patients with severe traumatic brain injuries at the University of Cincinnati.
New research at UC disrupts conventional wisdom that people take cocaine for positive reinforcement, suggesting a pharmacological equation behind the behavior. The study suggests low doses produce reinforcing effects, while high doses have rate-limiting effects, revealing a shift in understanding of cocaine self-administration.
A recent study published in Nutrients found that daily strawberry consumption can improve cognitive performance and reduce depressive symptoms in middle-aged adults. The research, led by Professor Robert Krikorian, suggests that strawberries contain antioxidants and micronutrients that may help mitigate the risk of dementia.
Researchers at the University of Cincinnati Cancer Center found that SmartClips, a wireless localization method for breast tumors, is safe and effective. The devices reduce patient discomfort and improve surgery efficiency by allowing surgeons to locate tumors more accurately.
The University of Cincinnati will continue to oversee U.S. NIH-funded stroke trials for the next five years, with Pooja Khatri, MD, MSc, leading as Lead PI. The renewed infrastructure includes new features such as patient representation and advocacy initiatives, aiming to advance stroke care worldwide.
A large-scale study found that metformin can reduce weight gain and increase adherence to treatment in youth with bipolar disorder. The medication, typically used for Type 2 diabetes, was effective in preventing weight gain and showed promise as a potential solution to this common side effect of SGAs.
The University of Cincinnati Cancer Center will support up to nine early-stage researchers with up to $80,000 in funding each over three years. This Institutional Research Grant aims to mentor junior faculty and advance cancer research.
Researchers studied the transformation of beetle-mimic cockroaches that give birth to live young, discovering similar changes in human pregnancy and immune systems. The study sheds light on the link between the immune system and pregnancy, with potential implications for treating fibromyalgia and autoimmune disorders.
Researchers are testing a single target to weaken tumors and strengthen immune cells in pediatric brain tumor patients. The goal is to improve the effectiveness of CAR-T therapy, which has shown promise but also leads to exhaustion of immune cells.
Researchers developed three new two-photon probes that can visualize organelles in cells, enabling better understanding of cellular functions and tissue imaging. The probes are designed to detect pH levels, viscosity, and ionic species, providing more specific insights into cell viability and treatment responses.
Cancer researchers at University of Cincinnati Cancer Center are exploring a new method called lattice therapy, which delivers higher doses to tumors and lower doses to surrounding tissues. The approach has shown promise in reducing treatment time and improving patient outcomes for head and neck, lung, and brain tumors.
A University of Cincinnati study found that exposure to PFAS may delay the onset of puberty in girls by an average of five or six months. The researchers also discovered decreased hormone levels consistent with the delay, raising concerns about negative long-term health outcomes such as breast cancer and renal disease.
A recent study by University of Cincinnati researchers found that a community-wide naloxone distribution program did not significantly reduce opioid overdose deaths. The study, which ran from 2017 to 2019, saw no significant change in median monthly opioid overdose rates despite widespread availability of the medication.
A new study from the University of Cincinnati explores the molecular mechanism of psychological loss through enrichment removal, identifying a key area of the brain that plays a role in this experience. The research highlights the importance of understanding how loss affects mental health and may lead to novel therapeutic targets.
A team of UC researchers, led by Ashley Kubley, have received a $2.5 million state grant to continue research on improving firefighter protective gear. The project aims to develop a firefighter jacket liner that brings down body temperature through advanced cooling technology and protects against external hazards.
Experts convened at the Stroke Treatment Academic Industry Roundtable XII meeting to address key issues hindering enrollment in acute stroke trials. Broadening emergency consent procedures and adopting efficient trial designs are recommended to enhance participant recruitment.
A recent study published in JAMA found that lowering blood pressure after mechanical clot removal may not be safe or effective among patients with acute ischemic stroke. Researchers recommend allowing blood pressure to auto-regulate after endovascular treatment, but individualized approach may be necessary for specific conditions.
Researchers at the University of Cincinnati have developed a new at-home test that uses saliva to detect early signs of gingivitis, the earliest form of gum disease. The device can identify periodontal disease caused by bacteria in saliva, providing an opportunity for consumers to protect their oral health.
A new battery design without a membrane has been developed by researchers at the University of Cincinnati, offering higher energy density and lower costs. The battery can generate nearly 4 volts of power, eliminating costly and inefficient membrane-separators.
A study by UC professor Gary Painter found that rent-burdened households in Los Angeles face significant trade-offs, including cuts to healthcare, education, and entertainment. The survey, conducted in 2019, revealed that nearly 85% of respondents made consumption cutbacks to make life more affordable.
A new study published in International Journal of Radiation Oncology, Biology, Physics found that multiple beams and intervals in delivery during FLASH proton therapy treatment reduced skin-saving effects in preclinical models.