A study published in The Lancet Psychiatry found that metformin can help manage weight gain in overweight or obese youth taking medication for bipolar disorder, making it a potential standard of care treatment. The MOBILITY trial showed modest but significant benefits of metformin over no treatment, with well-tolerated side effects.
Researchers at the University of Cincinnati have developed a new technique to treat cancer by altering the physical structure of subcellular organelles, specifically lipid droplets. By grouping and locking up lipid droplets, they can starve cancer cells of energy, slowing tumor progression.
Researchers at the University of Cincinnati Cancer Center found a promising combination of immunotherapy medications that helps overcome treatment resistance in refractory melanoma patients. The IGNYTE trial results showed increased immune response and tumor activation in approximately one-third of patients.
A new study from the University of Cincinnati College of Medicine calls for more extensive nephrology fellowship training on reproductive health. Females with CKD face increased risks of high-risk pregnancies, preeclampsia, and preterm births, yet their contraceptive use remains relatively low.
In a new Stroke article, Dr. Joseph Broderick predicts stroke care advancements by 2050, with a focus on patient-wearable diagnosis tools and AI-driven treatments for ischemic and hemorrhagic strokes. Researchers will overcome the challenge of neuroprotection and develop smaller, safer clot removal devices.
Researchers at the University of Cincinnati developed a flapping wing drone that can hover like a moth around a light source using an extremum-seeking feedback system. The drone makes fine adjustments to maintain stability and distance, without relying on AI or complex calculations.
The University of Cincinnati's Center for Clinical & Translational Science & Training has received a seven-year, $37.2 million grant renewal to support its mission in advancing translational science and research. The center will transform into an integrated Clinical and Translational Learning System to accelerate the discovery, dissemi...
Researchers highlight the importance of designing 'human-in-the-loop' systems with expert input for AI model training and validation. Machine learning models offer more interpretable results, but generative AI requires robust safeguards to protect patient data.
A University of Cincinnati study found increased neutrophil-driven inflammation after intracerebral hemorrhage (ICH) seven days post-stroke, compared to earlier time points. The researchers also identified miR-3613 and miR-3690 as key regulators of this process, suggesting potential new treatment targets.
Researchers found that drivers are significantly more likely to honk at vehicles bearing opposing political bumper stickers, particularly those from the opposing party. This study explores how partisan divisions influence driving behavior in apolitical settings.
Andrea Ford's research aims to support preschoolers with autism by adapting the Extensions of Community Health Outcomes (ECHO) model. She plans to engage educators and caregivers in mixed-methods research and build a community of practice to shape the model and provide professional development opportunities.
The University of Cincinnati Cancer Center is conducting a study on combining KRAS inhibitors with HER3 targeted agents to treat colorectal cancers. The goal is to extend patient lives and reduce toxic treatments. Researchers hope to develop new, less-toxic options for patients whose cancer has spread.
The University of Cincinnati Cancer Center researchers are presenting several studies on radiation oncology, including the evaluation of efficacy and safety of proton re-irradiation in head and neck cancers, significant variation in oropharyngeal cancer treatment approaches, and severe toxicity rare following liver cancer ablative radi...
Researchers at the University of Cincinnati Cancer Center have developed a new drug targeting Hsp70, a key protein aiding tumor resistance, reducing tumor size and increasing survival in animal models.
A new study by University of Cincinnati researchers finds that foster caregivers across the US need more accessible, ongoing and community-driven training. They want sustainable learning, consistent support and meaningful connection with peers and experts to help them care for vulnerable children.
The SHARE initiative aims to increase regional research opportunities by creating regional research consortia, sharing expertise and infrastructure. The program will reduce facilities and administrative costs, providing support and infrastructure across the state and potentially country.
Researchers investigate the role of mast cells in eosinophilic esophagitis, a chronic disease causing inflammation and scarring. The study aims to identify new treatments to improve quality of life for patients with EoE.
A recent University of Cincinnati study reveals that employees with high self-confidence are less affected by societal stigma, while supportive management can help mitigate emotional exhaustion. The research suggests that pride in one's job is crucial to offsetting negative judgments from others.
The University of Cincinnati has established the Center for Explainable, Ethical and Trustworthy AI (CEET) with a $498,430 federal grant. The center will explore AI explainability, ethics, and trustworthiness through research and public engagement initiatives.
A young investigator has received prestigious grants to continue research on using RAS inhibitors to treat blood cancers. The studies aim to understand the role of RAS mutations in acute myeloid leukemia and explore potential combination therapies.
A new study by University of Cincinnati researcher Ashley Merianos reveals a troubling connection between adverse childhood experiences and tobacco smoke exposure in US school-aged children. Adverse childhood experiences, such as parental divorce or financial hardship, increase the likelihood of children living with tobacco users and b...
Researchers found that chronic disturbance of a mother cockroach's sleep harms baby development by prolonging gestation and interfering with milk production. This study uses the Pacific beetle-mimic cockroach as an animal model to explore connections between pregnancy and sleep in humans.
Researchers at the University of Cincinnati are developing drones that can optimize wind in real time using a principle called dynamic soaring, inspired by albatrosses. The project aims to turn wind into an advantage for drones, reducing energy loss and increasing efficiency.
A University of Cincinnati researcher is investigating how excess sugar impacts cardiovascular structure and function in people with diabetes. The study focuses on a protein called GLUT1, which becomes overactive in diabetes, leading to harmful changes at the cellular level.
Researchers discovered that male peacock spiders use sensory exploitation to deceive female spiders by mimicking a wasp's face through visual trickery. The illusion is most effective at longer distances or in the female's peripheral vision, allowing males to initiate courtship without being rejected.
University of Cincinnati graduate Perry Li has been awarded a Fulbright grant to teach English in rural Taiwan while bridging cultural gaps through music. With a unique perspective as a Chinese American, Li aims to connect Taiwanese culture with American traditions.
A UC study finds that murals are associated with higher foot traffic, denser housing, and increased cultural identity in Cincinnati's neighborhoods. The research also highlights the potential for murals to contribute to urban policy decisions, guiding investments in public art to achieve broader community development goals.
A team of researchers, led by Bibek R. Karki, traced the evolutionary history of the PRPS enzyme complex to understand its functions and importance in cellular biochemistry. They found that all four enzymes are crucial for cell function and work together to form a large complex.
A new study from the University of Cincinnati College of Medicine examines pregnancy outcomes in women with kidney transplants who use assisted reproductive technology. The research found increased rates of hypertension and preterm birth, but no significant difference in live birth rates or two-year kidney transplant survival.
Researchers identified five distinct patterns of disordered eating behaviors among college students, linked to anxiety, distress tolerance, and alcohol use. The study challenges the idea that disordered eating only exists in extreme forms, suggesting a need for customized support systems.
A phase 1 clinical study will assess the safety and efficacy of JBZ-001 in patients with AML. The study is supported by a $3.4 million grant from the National Cancer Institute and aims to improve efficiency for the therapeutic pipeline.
Researchers at the University of Cincinnati are exploring ways to target the lifecycle of Trypanosoma cruzi, the parasite behind Chagas disease. By studying the parasite's complex lifecycle and vulnerabilities, scientists aim to develop new treatments for this deadly disease, which affects millions worldwide.
A study published in Redox Biology sheds light on the role of phosphoribosyl pyrophosphate synthetase (PRPS) enzymes in maintaining redox homeostasis in cancer cells. Researchers found that PRPS1 and PRPS2 work together to drive lymphoma growth, providing a potential target for novel therapies.
A new study by University of Cincinnati criminologist Francis Cullen found that 40% of Americans agree the prison system is racist and that public punitiveness has declined. The study suggests a shift in 'penal sensibility' as Americans become less favorable towards mass incarceration.
A study published in Ecology and Evolution found that the digestion process of birds of prey, such as owls and hawks, can significantly impact the ratios of isotopes in their pellets and droppings. This means that previous studies relying on these samples may have inaccurate results when trying to determine an animal's diet or environm...
Researchers examined baseline characteristics of adolescent and young adult (AYA) cancer survivors seen in oncology primary care clinic, finding high rates of comorbidities and cardiovascular disease. They also studied the overexpression of IRAK4 protein in acute myeloid leukemia (AML) cells, with potential implications for treatment.
Researchers from the University of Cincinnati have engineered bacteria to deliver antiviral therapies and vaccines orally, bypassing traditional methods. The engineered bacteria use outer-membrane vesicles as self-propelled delivery vehicles, targeting mucosal surfaces to provide mucosal immunity.
A new study by University of Cincinnati researcher Edson Chipalo found that children who experienced adverse childhood experiences are at a higher risk of homelessness during their childhood. The study highlights the need for prevention and early support to reduce long-term risks associated with childhood trauma.
A new UC lab-on-a-chip device developed by engineers measures the stress hormone cortisol from a patient's saliva, helping doctors diagnose depression and anxiety. The device provides objective evidence for clinicians to supplement traditional screenings, raising red flags about patients' levels of stress.
A team of researchers used machine learning to analyze changes in astrocyte cells' structure, shedding light on heroin addiction and relapse. The study, published in Science Advances, found that specific subpopulations of astroglia exhibit more pronounced morphological changes during drug use.
A University of Cincinnati study found large, opposite moves in housing prices between low-income and high-income communities when analyzing police budgeting. Low-income areas saw a 13% increase in housing prices after increasing police spending, while high-income areas saw a 14% decrease.
Researchers from the University of Cincinnati Cancer Center presented abstracts highlighting contrasting effects of a protein on head and neck, breast, and lung cancers. The study found increased levels of IL-9 in patients with head and neck cancer correlated with decreased survival, while elevated IL-9 was associated with smaller tumo...
A University of Cincinnati study explores the link between health literacy and fear surrounding cataract surgery, revealing no correlation between the two. The research emphasizes the importance of open communication and building relationships to overcome fear.
David Niven, a University of Cincinnati political scientist, has been awarded a $200,000 Andrew Carnegie Corporation fellowship to investigate the American polling system. His research aims to analyze how voters' experiences at the polls impact their views on voting.
University of Cincinnati researchers, in collaboration with end users, develop a user-centered, easy-to-use assistive device to help restore hand grasping motions. The team aims to combine an exoskeleton device with functional electrical stimulation (FES) technology to create a hybrid system.
Researchers found that fruit flies that successfully evade mite attacks at night lose valuable sleep, sacrificing energy and nutrients. The study's lead author noted that sleep deprivation can have detrimental effects on animal health and behavior.
The US opioid epidemic has shifted its epicenter from the Northwest to the East, with a significant increase in fentanyl-related deaths. The study found that populations affected by substance use disorder have changed over time, with Black communities now disproportionately affected.
Researchers studying ancient rhino teeth found at Nebraska's Ashfall Fossil Beds State Historical Park discovered that prehistoric rhinos lived in large herds. The animals' limited mobility suggests they didn't respond to the volcanic eruption or migrate seasonally, instead likely dying from prolonged exposure to ash and lack of food.
A Phase 3 trial found that ChemoID improves objective response rates, median progression-free survival, and duration of response in patients with recurrent platinum-resistant ovarian cancer. The test identifies effective treatments by challenging cancer stem cells against specific anticancer drugs.
A University of Cincinnati study found that machine learning models can aid clinicians in treating patients with spreading depolarizations (SDs), a condition that can cause significant brain damage. The algorithm was able to identify SD events with high sensitivity and specificity, detecting many events not identified by human scoring.