The University of Cincinnati Cancer Center is testing approaches to neutralize an enzyme complex that enables cell division in KRAS-mutated lung cancers. The grant aims to identify the best strategy to suppress this enzyme and prevent long-term tumor growth.
The University of Cincinnati College of Medicine has been awarded a $1.1 million AMA Transforming Lifelong Learning Through Precision Education grant to develop an AI-powered system for personalized learning and feedback. The project aims to improve the quality of medical education by providing real-time feedback on clinical reasoning ...
A new study by University of Cincinnati researchers found that men's sense of fulfillment at work is linked to their partners' views on money. Couples who align on the values of money tend to have higher job satisfaction, while those with differing perspectives experience lower job fulfillment.
A new research review identifies key barriers faced by military-affiliated workers in the civilian workforce. Employers can improve employee performance by offering targeted support to help bridge the gap between military and civilian life.
Medical students used ChatGPT to analyze survey responses and identify common themes, finding method three yielded the highest accuracy. The study showcases the potential for AI to assist with qualitative research in medical education.
Researchers at the University of Cincinnati have solved a long-standing problem in particle physics, using fusion reactors to produce subatomic particles called axions. This breakthrough has implications for understanding dark matter, which is thought to make up most of the universe's mass.
Researchers at the University of Cincinnati present a new BTK degrader called Bexobrutideg, showing an 83% overall response rate in relapsed CLL patients. The treatment also shows efficacy in patients with CNS involvement and those with BTK mutations that none of currently approved BTK inhibitors are effective against.
Researchers have identified critical cellular targets to improve pancreatic tumor sensitivity to KRAS inhibitors. The team found that certain patient populations may preferentially respond to anti-KRAS and anti-EGFR combination therapies.
A new clinical trial enrolls patients at the University of Cincinnati to study the effects of extended tranexamic acid dosing on recovery outcomes for young athletes after ACL reconstruction. The trial aims to test whether this approach can reduce pain, swelling and promote earlier movement in patients.
Researchers observed monk parakeets gradually approaching strangers before forming relationships, with caution escalating into friendly behaviors. This study reveals the benefits of 'testing the waters' in social interactions, potentially applicable to human friendships and social bonding.
The University of Cincinnati has received a $985,000 grant to test Healthy Eating for My Infant (HEMI), a community-based intervention promoting healthy eating and feeding practices for children 0-12 months. HEMI aims to address specific risk factors and barriers faced by low-income families. The NIH-funded study will enroll 60 infants...
A study published in The Lancet Psychiatry found that metformin can help manage weight gain in overweight or obese youth taking medication for bipolar disorder, making it a potential standard of care treatment. The MOBILITY trial showed modest but significant benefits of metformin over no treatment, with well-tolerated side effects.
Researchers at the University of Cincinnati have developed a new technique to treat cancer by altering the physical structure of subcellular organelles, specifically lipid droplets. By grouping and locking up lipid droplets, they can starve cancer cells of energy, slowing tumor progression.
Researchers at the University of Cincinnati Cancer Center found a promising combination of immunotherapy medications that helps overcome treatment resistance in refractory melanoma patients. The IGNYTE trial results showed increased immune response and tumor activation in approximately one-third of patients.
A new study from the University of Cincinnati College of Medicine calls for more extensive nephrology fellowship training on reproductive health. Females with CKD face increased risks of high-risk pregnancies, preeclampsia, and preterm births, yet their contraceptive use remains relatively low.
In a new Stroke article, Dr. Joseph Broderick predicts stroke care advancements by 2050, with a focus on patient-wearable diagnosis tools and AI-driven treatments for ischemic and hemorrhagic strokes. Researchers will overcome the challenge of neuroprotection and develop smaller, safer clot removal devices.
Researchers at the University of Cincinnati developed a flapping wing drone that can hover like a moth around a light source using an extremum-seeking feedback system. The drone makes fine adjustments to maintain stability and distance, without relying on AI or complex calculations.
The University of Cincinnati's Center for Clinical & Translational Science & Training has received a seven-year, $37.2 million grant renewal to support its mission in advancing translational science and research. The center will transform into an integrated Clinical and Translational Learning System to accelerate the discovery, dissemi...
Researchers highlight the importance of designing 'human-in-the-loop' systems with expert input for AI model training and validation. Machine learning models offer more interpretable results, but generative AI requires robust safeguards to protect patient data.
A University of Cincinnati study found increased neutrophil-driven inflammation after intracerebral hemorrhage (ICH) seven days post-stroke, compared to earlier time points. The researchers also identified miR-3613 and miR-3690 as key regulators of this process, suggesting potential new treatment targets.
Researchers found that drivers are significantly more likely to honk at vehicles bearing opposing political bumper stickers, particularly those from the opposing party. This study explores how partisan divisions influence driving behavior in apolitical settings.
Andrea Ford's research aims to support preschoolers with autism by adapting the Extensions of Community Health Outcomes (ECHO) model. She plans to engage educators and caregivers in mixed-methods research and build a community of practice to shape the model and provide professional development opportunities.
The University of Cincinnati Cancer Center is conducting a study on combining KRAS inhibitors with HER3 targeted agents to treat colorectal cancers. The goal is to extend patient lives and reduce toxic treatments. Researchers hope to develop new, less-toxic options for patients whose cancer has spread.
The University of Cincinnati Cancer Center researchers are presenting several studies on radiation oncology, including the evaluation of efficacy and safety of proton re-irradiation in head and neck cancers, significant variation in oropharyngeal cancer treatment approaches, and severe toxicity rare following liver cancer ablative radi...
Researchers at the University of Cincinnati Cancer Center have developed a new drug targeting Hsp70, a key protein aiding tumor resistance, reducing tumor size and increasing survival in animal models.
A new study by University of Cincinnati researchers finds that foster caregivers across the US need more accessible, ongoing and community-driven training. They want sustainable learning, consistent support and meaningful connection with peers and experts to help them care for vulnerable children.
The SHARE initiative aims to increase regional research opportunities by creating regional research consortia, sharing expertise and infrastructure. The program will reduce facilities and administrative costs, providing support and infrastructure across the state and potentially country.
Researchers investigate the role of mast cells in eosinophilic esophagitis, a chronic disease causing inflammation and scarring. The study aims to identify new treatments to improve quality of life for patients with EoE.
A recent University of Cincinnati study reveals that employees with high self-confidence are less affected by societal stigma, while supportive management can help mitigate emotional exhaustion. The research suggests that pride in one's job is crucial to offsetting negative judgments from others.
The University of Cincinnati has established the Center for Explainable, Ethical and Trustworthy AI (CEET) with a $498,430 federal grant. The center will explore AI explainability, ethics, and trustworthiness through research and public engagement initiatives.
A young investigator has received prestigious grants to continue research on using RAS inhibitors to treat blood cancers. The studies aim to understand the role of RAS mutations in acute myeloid leukemia and explore potential combination therapies.
A new study by University of Cincinnati researcher Ashley Merianos reveals a troubling connection between adverse childhood experiences and tobacco smoke exposure in US school-aged children. Adverse childhood experiences, such as parental divorce or financial hardship, increase the likelihood of children living with tobacco users and b...
Researchers found that chronic disturbance of a mother cockroach's sleep harms baby development by prolonging gestation and interfering with milk production. This study uses the Pacific beetle-mimic cockroach as an animal model to explore connections between pregnancy and sleep in humans.
Researchers at the University of Cincinnati are developing drones that can optimize wind in real time using a principle called dynamic soaring, inspired by albatrosses. The project aims to turn wind into an advantage for drones, reducing energy loss and increasing efficiency.
A University of Cincinnati researcher is investigating how excess sugar impacts cardiovascular structure and function in people with diabetes. The study focuses on a protein called GLUT1, which becomes overactive in diabetes, leading to harmful changes at the cellular level.
Researchers discovered that male peacock spiders use sensory exploitation to deceive female spiders by mimicking a wasp's face through visual trickery. The illusion is most effective at longer distances or in the female's peripheral vision, allowing males to initiate courtship without being rejected.
University of Cincinnati graduate Perry Li has been awarded a Fulbright grant to teach English in rural Taiwan while bridging cultural gaps through music. With a unique perspective as a Chinese American, Li aims to connect Taiwanese culture with American traditions.
A UC study finds that murals are associated with higher foot traffic, denser housing, and increased cultural identity in Cincinnati's neighborhoods. The research also highlights the potential for murals to contribute to urban policy decisions, guiding investments in public art to achieve broader community development goals.
A team of researchers, led by Bibek R. Karki, traced the evolutionary history of the PRPS enzyme complex to understand its functions and importance in cellular biochemistry. They found that all four enzymes are crucial for cell function and work together to form a large complex.
A new study from the University of Cincinnati College of Medicine examines pregnancy outcomes in women with kidney transplants who use assisted reproductive technology. The research found increased rates of hypertension and preterm birth, but no significant difference in live birth rates or two-year kidney transplant survival.
Researchers identified five distinct patterns of disordered eating behaviors among college students, linked to anxiety, distress tolerance, and alcohol use. The study challenges the idea that disordered eating only exists in extreme forms, suggesting a need for customized support systems.
A phase 1 clinical study will assess the safety and efficacy of JBZ-001 in patients with AML. The study is supported by a $3.4 million grant from the National Cancer Institute and aims to improve efficiency for the therapeutic pipeline.
Researchers at the University of Cincinnati are exploring ways to target the lifecycle of Trypanosoma cruzi, the parasite behind Chagas disease. By studying the parasite's complex lifecycle and vulnerabilities, scientists aim to develop new treatments for this deadly disease, which affects millions worldwide.
A study published in Redox Biology sheds light on the role of phosphoribosyl pyrophosphate synthetase (PRPS) enzymes in maintaining redox homeostasis in cancer cells. Researchers found that PRPS1 and PRPS2 work together to drive lymphoma growth, providing a potential target for novel therapies.
A new study by University of Cincinnati criminologist Francis Cullen found that 40% of Americans agree the prison system is racist and that public punitiveness has declined. The study suggests a shift in 'penal sensibility' as Americans become less favorable towards mass incarceration.
A study published in Ecology and Evolution found that the digestion process of birds of prey, such as owls and hawks, can significantly impact the ratios of isotopes in their pellets and droppings. This means that previous studies relying on these samples may have inaccurate results when trying to determine an animal's diet or environm...
Researchers examined baseline characteristics of adolescent and young adult (AYA) cancer survivors seen in oncology primary care clinic, finding high rates of comorbidities and cardiovascular disease. They also studied the overexpression of IRAK4 protein in acute myeloid leukemia (AML) cells, with potential implications for treatment.
Researchers from the University of Cincinnati have engineered bacteria to deliver antiviral therapies and vaccines orally, bypassing traditional methods. The engineered bacteria use outer-membrane vesicles as self-propelled delivery vehicles, targeting mucosal surfaces to provide mucosal immunity.
A new study by University of Cincinnati researcher Edson Chipalo found that children who experienced adverse childhood experiences are at a higher risk of homelessness during their childhood. The study highlights the need for prevention and early support to reduce long-term risks associated with childhood trauma.
A new UC lab-on-a-chip device developed by engineers measures the stress hormone cortisol from a patient's saliva, helping doctors diagnose depression and anxiety. The device provides objective evidence for clinicians to supplement traditional screenings, raising red flags about patients' levels of stress.